$216 Cheap Flights from Missoula (MSO) to Des Moines (DSM)

View $216 flight on Thu, Dec 4, 2025Opens in a new window

Popular airlines from Missoula Intl. Airport (MSO) to Des Moines International Airport (DSM)

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Cheap Flights from Missoula to Des Moines (MSO-DSM)

Prices were available within the past 7 days and start at $216 for one-way flights and $259 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Thu, Dec 4 - Tue, Dec 9
MSO
Missoula
DSM
Des Moines
$259 Roundtrip, found 5 hours ago
$259
Roundtrip
found 5 hours ago
Select Delta flight, departing Thu, Dec 4 from Missoula to Des Moines, returning Tue, Dec 9, priced at $259 found 5 hours ago
Delta
Mon, Nov 17 - Sun, Nov 23
MSO
Missoula
DSM
Des Moines
$269 Roundtrip, found 5 days ago
$269
Roundtrip
found 5 days ago
Select Delta flight, departing Mon, Nov 17 from Missoula to Des Moines, returning Sun, Nov 23, priced at $269 found 5 days ago
Delta
Tue, Oct 28 - Mon, Nov 3
MSO
Missoula
DSM
Des Moines
$274 Roundtrip, found 14 hours ago
$274
Roundtrip
found 14 hours ago
Select Delta flight, departing Tue, Oct 28 from Missoula to Des Moines, returning Mon, Nov 3, priced at $274 found 14 hours ago
Delta
Thu, Feb 26 - Tue, Mar 3
MSO
Missoula
DSM
Des Moines
$279 Roundtrip, found 2 days ago
$279
Roundtrip
found 2 days ago
Select Delta flight, departing Thu, Feb 26 from Missoula to Des Moines, returning Tue, Mar 3, priced at $279 found 2 days ago
Delta
Tue, Feb 24 - Tue, Mar 3
MSO
Missoula
DSM
Des Moines
$284 Roundtrip, found 2 days ago
$284
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Feb 24 from Missoula to Des Moines, returning Tue, Mar 3, priced at $284 found 2 days ago
United
Fri, Nov 21 - Mon, Nov 24
MSO
Missoula
DSM
Des Moines
$288 Roundtrip, found 4 days ago
$288
Roundtrip
found 4 days ago
Select United flight, departing Fri, Nov 21 from Missoula to Des Moines, returning Mon, Nov 24, priced at $288 found 4 days ago
Delta
Sat, Nov 1 - Thu, Nov 6
MSO
Missoula
DSM
Des Moines
$309 Roundtrip, found 14 hours ago
$309
Roundtrip
found 14 hours ago
Select Delta flight, departing Sat, Nov 1 from Missoula to Des Moines, returning Thu, Nov 6, priced at $309 found 14 hours ago
United
Mon, Oct 20 - Mon, Nov 3
MSO
Missoula
DSM
Des Moines
$314 Roundtrip, found 14 hours ago
$314
Roundtrip
found 14 hours ago
Select United flight, departing Mon, Oct 20 from Missoula to Des Moines, returning Mon, Nov 3, priced at $314 found 14 hours ago
Delta
Wed, Jan 7 - Tue, Jan 13
MSO
Missoula
DSM
Des Moines
$314 Roundtrip, found 19 hours ago
$314
Roundtrip
found 19 hours ago
Select Delta flight, departing Wed, Jan 7 from Missoula to Des Moines, returning Tue, Jan 13, priced at $314 found 19 hours ago
American Airlines
Wed, Jan 7 - Thu, Jan 22
MSO
Missoula
DSM
Des Moines
$339 Roundtrip, found 19 hours ago
$339
Roundtrip
found 19 hours ago
Select American Airlines flight, departing Wed, Jan 7 from Missoula to Des Moines, returning Thu, Jan 22, priced at $339 found 19 hours ago

Find the cheapest month to fly from Missoula (MSO) to Des Moines (DSM)

January is typically the cheapest month to fly

From $258 - $468 per traveler.

Alternative airports near Des Moines

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Des Moines Intl. DSM. Cheapest and Closest option available. Average driving time to city center is 10 minutes. Flights from $518
DSM
Des Moines Intl.
CheapestClosest
Average driving time to city center10 min
Flights from $518

Frequently asked questions

How much does a flight from Missoula Intl. Airport (MSO) to Des Moines Intl. Airport (DSM) cost?
Secure a cheap one-way flight from $216 or cheap return flight from $259 from Missoula Intl. Airport (MSO) to Des Moines Intl. Airport (DSM) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Missoula Intl. Airport (MSO) to Des Moines Intl. Airport (DSM)?
December is the least expensive month to fly from MSO to DSM. Traveling during an off-peak travel window is often the key to finding a great deal.
What is the cheapest airline that flies from Missoula Intl. Airport (MSO) to Des Moines Intl. Airport (DSM)?
Expedia's filter tool lets you easily compare travel time, airlines and fares all in one place. Customize the search to your preferences, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest MSO to DSM flight.
How many flights per day from Missoula Intl. Airport (MSO) to Des Moines Intl. Airport (DSM)?
You'll have to take a flight with a layover if you're traveling from Missoula Intl. Airport (MSO) to Des Moines Intl. Airport (DSM). Direct flights don't operate daily on this route. However, simply filter your search to include one or two stops to find an option that works for you.
What day of the week has the most flights from MSO to DSM?
You'll usually find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can vary from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Missoula Intl. Airport (MSO) to Des Moines Intl. Airport (DSM)?
Choose a flight from Missoula Intl. Airport (MSO) to Des Moines Intl. Airport (DSM) that leaves before 3 PM to reduce the risk of delays and cancellations. Later departures are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Missoula Intl. Airport (MSO) to Des Moines Intl. Airport (DSM) last-minute?
Waiting until right before your break to book a flight from MSO to DSM generally means paying more. Although you may find some last-minute discounts, they're not always guaranteed. Be flexible with your travel plans for the best chance of getting a bargain.
Is it cheaper to book a MSO to DSM flight and hotel package?
Compared with arranging flights and hotels separately, booking a MSO to DSM flight and hotel package with Expedia could result in significant savings. Better yet, having everything in one convenient place will take the hassle out of travel planning. Simply pick your flights and select from our wide range of stays, then personalize your trip with extras like tours, activities and car rentals.
Can I cancel or change the date of my flight from Missoula Intl. Airport (MSO) to Des Moines Intl. Airport (DSM)?
If you booked your MSO to DSM flight within the last 24 hours, you may be able to modify or cancel it without fees. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal if you'd like more information.

Travel information

Origin airport
Missoula Intl.
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$258
Distance
1074 mi

Book with confidence

Missoula to Des Moines Flights

The cheapest times to fly from Missoula to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Missoula to Des Moines are during the month of December. You can find some of the cheapest flights from Missoula to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Missoula to Des Moines

Sunday is one of the best days to book for cheap flights from Missoula to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Missoula to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Missoula to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $216 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Missoula to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Missoula to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Missoula to Des Moines Flights

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*Available to One Key members.