$435 Cheap Flights from Naples (NAP) to Des Moines (DSM)

View $435 flight on Mon, May 4, 2026Opens in a new window

Popular airlines from Naples Intl. Airport (NAP) to Des Moines International Airport (DSM)

Cheap Flights from Naples to Des Moines (NAP-DSM)

Prices were available within the past 7 days and start at $435 for one-way flights and $815 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

British Airways
Thu, Jan 15 - Sun, Jan 25
NAP
Naples
DSM
Des Moines
$815 Roundtrip, found 6 days ago
$815
Roundtrip
found 6 days ago
Select British Airways flight, departing Thu, Jan 15 from Naples to Des Moines, returning Sun, Jan 25, priced at $815 found 6 days ago
British Airways
Thu, Jan 15 - Sun, Jan 25
NAP
Naples
DSM
Des Moines
$850 Roundtrip, found 6 days ago
$850
Roundtrip
found 6 days ago
Select British Airways flight, departing Thu, Jan 15 from Naples to Des Moines, returning Sun, Jan 25, priced at $850 found 6 days ago
British Airways
Thu, Jan 15 - Sun, Jan 25
NAP
Naples
DSM
Des Moines
$856 Roundtrip, found 6 days ago
$856
Roundtrip
found 6 days ago
Select British Airways flight, departing Thu, Jan 15 from Naples to Des Moines, returning Sun, Jan 25, priced at $856 found 6 days ago
British Airways
Thu, Jan 15 - Sun, Jan 25
NAP
Naples
DSM
Des Moines
$862 Roundtrip, found 6 days ago
$862
Roundtrip
found 6 days ago
Select British Airways flight, departing Thu, Jan 15 from Naples to Des Moines, returning Sun, Jan 25, priced at $862 found 6 days ago
KLM
Wed, Mar 18 - Thu, Mar 26
NAP
Naples
DSM
Des Moines
$895 Roundtrip, found 13 hours ago
$895
Roundtrip
found 13 hours ago
Select KLM flight, departing Wed, Mar 18 from Naples to Des Moines, returning Thu, Mar 26, priced at $895 found 13 hours ago
KLM
Wed, Mar 18 - Thu, Mar 26
NAP
Naples
DSM
Des Moines
$905 Roundtrip, found 13 hours ago
$905
Roundtrip
found 13 hours ago
Select KLM flight, departing Wed, Mar 18 from Naples to Des Moines, returning Thu, Mar 26, priced at $905 found 13 hours ago
Air France
Wed, Mar 18 - Thu, Mar 26
NAP
Naples
DSM
Des Moines
$912 Roundtrip, found 13 hours ago
$912
Roundtrip
found 13 hours ago
Select Air France flight, departing Wed, Mar 18 from Naples to Des Moines, returning Thu, Mar 26, priced at $912 found 13 hours ago
Iberia
Thu, Jan 15 - Sun, Jan 25
NAP
Naples
DSM
Des Moines
$915 Roundtrip, found 6 days ago
$915
Roundtrip
found 6 days ago
Select Iberia flight, departing Thu, Jan 15 from Naples to Des Moines, returning Sun, Jan 25, priced at $915 found 6 days ago
Lufthansa
Mon, Jan 12 - Wed, Jan 21
NAP
Naples
DSM
Des Moines
$929 Roundtrip, found 6 days ago
$929
Roundtrip
found 6 days ago
Select Lufthansa flight, departing Mon, Jan 12 from Naples to Des Moines, returning Wed, Jan 21, priced at $929 found 6 days ago
Lufthansa
Mon, Jan 12 - Wed, Jan 21
NAP
Naples
DSM
Des Moines
$936 Roundtrip, found 6 days ago
$936
Roundtrip
found 6 days ago
Select Lufthansa flight, departing Mon, Jan 12 from Naples to Des Moines, returning Wed, Jan 21, priced at $936 found 6 days ago

Frequently asked questions

How much does a flight from Naples Intl. Airport (NAP) to Des Moines Intl. Airport (DSM) cost?
Secure a cheap one-way flight from $435 or cheap return flight from $815 from Naples Intl. Airport (NAP) to Des Moines Intl. Airport (DSM) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Naples Intl. Airport (NAP) to Des Moines Intl. Airport (DSM)?
January is the most affordable month to fly from NAP to DSM. Planning your trip for the off-season is often the key to better flight prices.
What is the cheapest airline that flies from Naples Intl. Airport (NAP) to Des Moines Intl. Airport (DSM)?
Expedia's filter tool lets you easily compare airlines, flight times and fares all in one place. Tailor the search to your trip, then sort by "Price (lowest to highest)" to find the carrier with the cheapest NAP to DSM flight.
How many flights per day from Naples Intl. Airport (NAP) to Des Moines Intl. Airport (DSM)?
Nonstop flights from Naples Intl. Airport (NAP) to Des Moines Intl. Airport (DSM) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filters. Enter your dates and click on either "1 Stop" or "2+ Stops."
What day of the week has the most flights from NAP to DSM?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can vary based on a number of factors, including the airline and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Naples Intl. Airport (NAP) to Des Moines Intl. Airport (DSM)?
Opt for a flight from Naples Intl. Airport (NAP) to Des Moines Intl. Airport (DSM) that leaves before 3 PM to reduce the risk of delays and cancellations. Departures later than this are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Naples Intl. Airport (NAP) to Des Moines Intl. Airport (DSM) last-minute?
Last-minute fares from NAP to DSM are usually more expensive. For the lowest prices, start looking for flights early. That being said, if you can play around with your travel dates, you may score a cheap fare right before your journey.
Is it cheaper to book a NAP to DSM flight and hotel package?
You'll generally save money by booking a NAP to DSM flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage it all in one convenient place. After choosing your ideal accommodations and flights, you can add extras like activities, car rentals and tours.
Can I cancel or change the date of my flight from Naples Intl. Airport (NAP) to Des Moines Intl. Airport (DSM)?
In most cases, you can cancel or reschedule your NAP to DSM flight. However, additional charges may apply, especially if you made your booking over 24 hours ago. Double-check your itinerary for the airline's fees and rules on flight changes, or if you'd like further information, visit our Customer Service portal.

Travel information

Origin airport
Naples Intl.
Destination airport
Des Moines Intl.
Airlines serving
Air France, American Airlines, Delta, Iberia, KLM, Lufthansa, United
Roundtrip price
$815
Distance
5178 mi

Book with confidence

Naples to Des Moines Flights

The cheapest times to fly from Naples to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Naples to Des Moines are during the month of January. You can find some of the cheapest flights from Naples to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Naples to Des Moines

Sunday is one of the best days to book for cheap flights from Naples to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Naples to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Naples to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $435 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Naples to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Naples to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Naples to Des Moines Flights

Explore a world of travel with Expedia

*Available to One Key members.