A calm lake with three trees with autumn foliage.

Vacation Rentals in Orangeburg County

Where to?

Dates

November 2026

December 2026

Top cities in Orangeburg County

A calm lake with autumn-colored trees and a clear blue sky.

Check prices for these dates

In two weeks

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Our top choices for Orangeburg County vacation rentals

A tent with a view of a lake and boats, a wooden chair, and a potted plant.

1. Bells Marina & Resort

Eutawville

Mark

$74 nightly

Nov 8 - Nov 9

Total with taxes and fees

A kitchen with wooden cabinets, a built-in dishwasher, a sink, and a ceiling fan.

2. Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301

Bowman

Joseph

$139 nightly

Nov 6 - Nov 7

Total with taxes and fees

A covered patio with outdoor furniture, a view of a lake, and a sunset.

3. LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks

Santee

Michelle H.

$417 nightly

Nov 8 - Nov 9

Total with taxes and fees

A modern kitchen with stainless steel appliances, white cabinetry, and a wooden floor.

4. Quiet 1-bedroom apartment in charming Elloree, SC

Elloree

$169 nightly

Nov 6 - Nov 7

Total with taxes and fees

A wooden deck with a white sofa, a wooden serving tray with snacks, and a pitcher of lemonade.

5. Pet friendly country cottage with large fenced-in yard & horses on property

Holly Hill

Thomas G.

$177 nightly

Nov 9 - Nov 10

Total with taxes and fees

A bedroom with a bed, a chair, a TV, a ceiling fan, and a painting on the wall.

6. Country Resting Spot just off I95. 12 miles west on hwy 6.

Elloree

Tom B.

$141 nightly

Nov 6 - Nov 7

Total with taxes and fees

A compact kitchen with wooden cabinets, a stainless steel refrigerator, and a gas stove.

7. Beautiful brick home w/ large porch and 3 bedrooms

Bowman

Troy K.

$242 nightly

Nov 6 - Nov 7

Total with taxes and fees

A spacious living room with a large sofa, two coffee tables, and a potted plant.

8. Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

Santee

Jessica C.

$275 nightly

Nov 11 - Nov 12

Total with taxes and fees

A living room with a sofa, two armchairs, a coffee table, and a lamp.

9. Modern apartment overlooking historic downtown Elloree, SC.

Elloree

$167 nightly

Nov 6 - Nov 7

Total with taxes and fees

A multi-story residential building with balconies, a stone retaining wall, and a wooden deck.

10. Lake Marion Condo, Boat Slip Included, Pet Friendly

Santee

Katie A.

$285 nightly

Nov 7 - Nov 8

Total with taxes and fees

A kitchen with dark blue cabinets, a granite countertop, stainless steel sink, and a microwave.

11. Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston

Holly Hill

Hayden S.

$137 nightly

Nov 7 - Nov 8

Total with taxes and fees

A wicker outdoor seating area with cushioned chairs and a matching ottoman on a porch.

12. Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!

Santee

Greg M.

$436 nightly

Nov 15 - Nov 16

Total with taxes and fees

13. Lakeside Glamping Tent with Kayaks & Spacious Deck in Eutaw Springs, South Carolina

Eutaw Springs

$188 nightly

Nov 8 - Nov 9

Total with taxes and fees

A modern kitchen with a central island, a dining area with a table and chairs, and a living room with a sofa and a coffee table.

14. ABCDE Properties: Rural, Woods, Activities Galore, Educational & Fun

North

Easy B.

$374 nightly

Nov 9 - Nov 10

Total with taxes and fees

A covered outdoor seating area with a view of a dock and boats, wooden furniture, and string lights.

15. Lakefront tiny cabin amazing view on Lake Marion! Pet friendly.

Summerton

Troy S.

$141 nightly

Nov 16 - Nov 17

Total with taxes and fees

A wooden cabin with a porch and picnic table in a wooded area.

16. Cozy Camping Cabin on Lake Marion near Congaree Nat Park

Rimini

Scott J.

$119 nightly

Nov 16 - Nov 17

Total with taxes and fees

A reception area with a counter, a number 6 sign, and a door.

17. 1 King Bed|Smoking,Micfridge

West Columbia

Anonymous traveler

$72 nightly

Nov 9 - Nov 10

Total with taxes and fees

A compact living space with a kitchen, dining area, and a small seating area.

18. Country living lake style near Santee

Summerton

John P.

$199 nightly

Nov 9 - Nov 10

Total with taxes and fees

A modern kitchen with a central island, dark wood cabinets, and a white refrigerator.

19. 2-bedroom cottage in adorable Summerville with AC comfort

Summerville

Tess W.

$191 nightly

Nov 30 - Dec 1

Total with taxes and fees

A hotel room with a bed, bedside tables, a desk, a TV, a window, and a door.

20. Premium King Bed|Walterboro SC

Walterboro SC

Anonymous traveler

$72 nightly

Dec 4 - Dec 5

Total with taxes and fees

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Find vacation rentals that suit your style

Top Orangeburg County Hotel Reviews

A patio area with wicker furniture, a stone fire pit, and outdoor seating.

Fairfield Inn & Suites by Marriott Santee

Santee

10/10 Excellent

Choose this hotel for a pet-friendly stop-over on our drive to Florida and had a great experience. This staff was super-friendly and this nearly-brand-new property was immaculate. They have us a great 1st floor room with easy access to the walking and parking area. We took advantage of the patio to have dinner (take-out from a local restaurant) and breakfast with our dog. The breakfast was excellent, including hot omelets, eggs, and sausage, and the 6 am start (on a Sunday) allowed us to get...

Douglas

A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.

Hampton Inn Santee-I-95

Santee

10/10 Excellent

Michael

A Hampton Inn & Suites hotel with a modern design, featuring a parking lot and a well-lit entrance.

Hampton Inn & Suites Orangeburg

Orangeburg

10/10 Excellent

Kevin

A dining room with a wooden table, white upholstered chairs, a chandelier, a large mirror, and a patterned rug.

Burrell and Flynn's Farm

Aiken

10/10 Excellent

Mike

A modern lobby with a blue sofa, teal chairs, and a wooden table.

Tru By Hilton Santee

Santee

10/10 Excellent

Rebecca

A spacious lobby with a fireplace, multiple seating areas, and a reception desk.

Comfort Suites Summerville

Summerville

10/10 Excellent

Carol

A modern hotel lobby with a bar area, seating arrangements, and large windows offering a view of the outdoors.

Courtyard by Marriott Columbia Cayce

Cayce

10/10 Excellent

amy

A hotel lobby with a dining area, sofas, and a large decorative wall piece.

Hampton Inn Summerville SC

Summerville

10/10 Excellent

Michael

A modern lounge area with a curved ceiling, a bar with a round wooden bar top, and a seating area with blue chairs and a dark sofa.

DoubleTree by Hilton Summerville Nexton

Summerville

10/10 Excellent

LaMonte

A hotel with a modern facade, featuring two prominent signage for Homewood Suites and Hilton Garden Inn.

Hilton Garden Inn Summerville

Summerville

10/10 Excellent

Anonymous traveler

A hotel entrance with a sign reading "Best Western PLISS."

Best Western Plus Santee Inn

Santee

10/10 Excellent

Richard

A modern cafe with a wooden table and chairs, a coffee machine, and a large window offering a view of the outdoors.

avid hotel Summerville by IHG

Summerville

10/10 Excellent

Mark

A circular fire pit with seating around it, set against a backdrop of trees and a pergola structure.

Courtyard by Marriott Charleston Summerville

Summerville

10/10 Excellent

Anonymous traveler

A hotel lobby with reception desks, seating areas, and a wooden ceiling.

Holiday Inn Express & Suites Summerville by IHG

Summerville

10/10 Excellent

nicole

A building with a well-lit entrance and a parking area.

Moncks Corner Inn

Moncks Corner

10/10 Excellent

Connie

Frequently Asked Questions

How many vacation rentals are available in Orangeburg County?

Expedia has plenty of vacation rentals to choose from in and around Orangeburg County, so you’re guaranteed to find the right one for you.

How much is a vacation rental in Orangeburg County?

The selection of Orangeburg County vacation rentals we have selected for you start as low as $81 per night. Entering your travel dates in the search wizard you might find even better deals!

What type of vacation rental can I get in Orangeburg County?

Vacation rentals in Orangeburg County come in all shapes and sizes, and your options depend on your chosen travel dates. You could entertain in a blissful vacation home, chill in a private apartment, or find family fun at a resort. Expedia offers a superb choice of Orangeburg County vacation rentals to suit everyone.

Why should I choose a vacation rental in Orangeburg County?

Expedia’s vacation rentals provide cozy comforts you can sink into on your own schedule. You’ll enjoy your own space in a property with a kitchen, a pool, a garden etc. Maybe you’ll prefer somewhere with a spa or kids activities. A Orangeburg County vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.

How do I find the best deal on a vacation rental in Orangeburg County?

Find vacation rentals in Orangeburg County by viewing Expedia’s latest deals, or enter your travel dates and use the filters to select by amenities, price, or rating. Dive into the reviews to get a true feeling of which is your favorite vacation rental in Orangeburg County.

What amenities are available in a vacation rental in Orangeburg County?

The choice is yours! Perhaps you love cooking in a well-equipped kitchen. Or maybe a late breakfast and a swimming pool is more your thing. Of course, there’s always the treat of having your own hot tub. Expedia has a vast range of amenities in Orangeburg County vacation rentals designed to suit every budget and trip type.

When is the best time to stay in a vacation rental in Orangeburg County?

Everytime is a great time to head to Orangeburg County! Staying in a Orangeburg County vacation rentals you will always find lots going on to keep you entertained.

Why book a vacation rental with Expedia?

Expedia has locked in amazing deals on a huge selection of impressive vacation rentals in Orangeburg County. We give you the information and inspiration you need all in one place. With so many properties to choose from, you know you can book your perfect Orangeburg County vacation rental with confidence. ANd don’t forget, if you bundle with a flight or a car rental in Orangeburg County, you can save even more.

Can I cancel my vacation rental through Expedia?

Yes, you can cancel or change your Orangeburg County vacation rental by contacting your property manager directly. Contact details are easy to find on your itinerary in Trips. For more information, check out our Customer Service Portal and we’ll help you get everything sorted.

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