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Find hotels in La Crosse, FL from $81

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    Check prices for these dates, December 15 – 16, 2026

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    Our top choices for La Crosse hotels

    1. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

    A hotel with a covered entrance, stone facade, and blue lighting accents.

    2. Sleep Inn & Suites University/Shands

    A Sleep Inn & Suites hotel with a modern entrance, parking lot, and a clear sky.

    3. Hampton Inn & Suites Alachua I-75

    A reception desk with a "Welcome to the Sun Shine State" sign, a "Treats" sign, and a minibar area with a "Hilton" sign.

    4. Best Western Gateway Grand

    A spacious dining area with multiple tables and chairs, a kitchen area with a coffee station, and large windows allowing natural light.

    5. La Quinta by Wyndham Gainesville

    A modern hotel with a prominent 'La Quinta' sign, a covered entrance, and a well-maintained outdoor area with a parking lot.

    6. Clarion Pointe Alachua - Gainesville Area

    A hotel room with a large bed, a TV, a desk, and a mural of a landscape.

    7. Hotel Indigo Gainesville-Celebration Pointe by IHG

    An outdoor seating area with a fire feature, chairs, and tables.

    8. Country Inn & Suites by Radisson, Gainesville, FL

    A multi-story hotel with a central entrance, palm trees, and a clear sky.

    9. Quality Inn Alachua - Gainesville Area

    A spacious lobby with a dining area, a kitchen, and a large window providing a view of the outdoors.

    10. Hyatt Place Gainesville Downtown

    A spacious lobby with a modern staircase, a seating area, and large windows allowing natural light.

    11. Drury Inn & Suites Gainesville

    A spacious lobby with a sectional sofa, a wooden cabinet, and a television mounted on the wall.

    12. Holiday Inn Express & Suites Gainesville I-75 by IHG

    A swimming pool with lounge chairs and a gazebo, surrounded by palm trees and a building with a stone facade.

    13. TownePlace Suites by Marriott Gainesville Northwest

    An outdoor patio with a stone fire pit, wicker chairs, and a pergola with lights.

    14. Best Western Waldo Inn and Suites

    A hotel with a covered entrance, a sign indicating a 14-foot clearance, and a parking lot.

    15. HOM Hotel Gainesville, SureStay Collection by Best Western

    Lobby sitting area

    16. Aloft by Marriott Gainesville University Area

    A modern hotel with a flat roof, multiple floors, and a prominent 'aloft' sign.

    17. Depot Village

    A yellow house with a porch, a staircase, and a small garden area with artificial grass and pebbles.

    18. Hampton Inn & Suites Gainesville Downtown University

    A hotel lobby with a seating area, a sofa, a table, and a lamp.

    19. Hilton University of Florida Conference Center Gainesville

    A modern lobby with a reception desk, a seating area, and a wall displaying definitions of words.

    20. Comfort Inn Gainesville - University Area

    A hotel room with two beds, a desk, a TV, and a window with curtains.

    Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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    Compare top hotels in La Crosse

    A hotel with a covered entrance, stone facade, and blue lighting accents.

    Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

    Alachua View

    A Sleep Inn & Suites hotel with a modern entrance, parking lot, and a clear sky.

    Sleep Inn & Suites University/Shands

    Gainesville View

    A reception desk with a "Welcome to the Sun Shine State" sign, a "Treats" sign, and a minibar area with a "Hilton" sign.

    Hampton Inn & Suites Alachua I-75

    Alachua View

    A spacious dining area with multiple tables and chairs, a kitchen area with a coffee station, and large windows allowing natural light.

    Best Western Gateway Grand

    Gainesville View

    A modern hotel with a prominent 'La Quinta' sign, a covered entrance, and a well-maintained outdoor area with a parking lot.

    La Quinta by Wyndham Gainesville

    Gainesville View
    9.4Exceptional1,002 reviews8.8Excellent1,336 reviews9.4Exceptional572 reviews8.6Excellent1,532 reviews9.2Wonderful1,393 reviews
    $100 nightly $113 total Dec 14 - Dec 15Total with taxes and fees$82 nightly $92 total Dec 6 - Dec 7Total with taxes and fees$110 nightly $123 total Dec 15 - Dec 16Total with taxes and fees$85 nightly $95 total Nov 22 - Nov 23Total with taxes and fees$99 nightly $111 total Dec 1 - Dec 2Total with taxes and fees
    • Breakfast included
    • Pool
    • Spa
    • Pet friendly
    • WiFi included
    • Parking
    • Breakfast included
    • Pool
    • Spa
    • Pet friendly
    • WiFi included
    • Parking
    • Breakfast included
    • Pool
    • Spa
    • Pet friendly
    • WiFi included
    • Parking
    • Breakfast included
    • Pool
    • Spa
    • Pet friendly
    • WiFi included
    • Parking
    • Breakfast included
    • Pool
    • Spa
    • Pet friendly
    • WiFi included
    • Parking

    Hotels recommended for families in La Crosse

    Tiny House on The Grove

    A rectangular swimming pool with a tiled deck, surrounded by a fence and trees.

    Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

    A hotel with a covered entrance, stone facade, and blue lighting accents.

    La Quinta by Wyndham Gainesville

    A modern hotel with a prominent 'La Quinta' sign, a covered entrance, and a well-maintained outdoor area with a parking lot.

    Sleep Inn & Suites University/Shands

    A Sleep Inn & Suites hotel with a modern entrance, parking lot, and a clear sky.

    Best Western Gateway Grand

    A spacious dining area with multiple tables and chairs, a kitchen area with a coffee station, and large windows allowing natural light.

    Hampton Inn & Suites Alachua I-75

    A reception desk with a "Welcome to the Sun Shine State" sign, a "Treats" sign, and a minibar area with a "Hilton" sign.

    Hotel Indigo Gainesville-Celebration Pointe by IHG

    An outdoor seating area with a fire feature, chairs, and tables.

    Clarion Pointe Alachua - Gainesville Area

    A hotel room with a large bed, a TV, a desk, and a mural of a landscape.

    Top La Crosse Hotel Reviews

    Depot Village

    A yellow house with a porch, a staircase, and a small garden area with artificial grass and pebbles.

    Drury Inn & Suites Gainesville

    A spacious lobby with a sectional sofa, a wooden cabinet, and a television mounted on the wall.

    La Quinta by Wyndham Gainesville

    A modern hotel with a prominent 'La Quinta' sign, a covered entrance, and a well-maintained outdoor area with a parking lot.

    Hampton Inn & Suites Alachua I-75

    A reception desk with a "Welcome to the Sun Shine State" sign, a "Treats" sign, and a minibar area with a "Hilton" sign.

    Holiday Inn Express Starke by IHG

    A modern lobby with a sofa, chairs, a desk, and a map mural.

    Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

    A cabin with a cozy interior, a dining area, and a view of the forest.

    Country Inn & Suites by Radisson, Gainesville, FL

    A multi-story hotel with a central entrance, palm trees, and a clear sky.

    Hotel Indigo Gainesville-Celebration Pointe by IHG

    An outdoor seating area with a fire feature, chairs, and tables.

    Hyatt Place Gainesville Downtown

    A spacious lobby with a modern staircase, a seating area, and large windows allowing natural light.

    Best Western Gateway Grand

    A spacious dining area with multiple tables and chairs, a kitchen area with a coffee station, and large windows allowing natural light.

    Sleep Inn & Suites University/Shands

    A Sleep Inn & Suites hotel with a modern entrance, parking lot, and a clear sky.

    Fairfield Inn & Suites by Marriott Gainesville I-75

    A modern living room with a fireplace, comfortable seating, and a large TV.

    Sweetwater Branch Inn

    A garden with a stone fountain, a gazebo, and a winding brick path.

    Comfort Suites Gainesville near University

    A modern living room with a fireplace, comfortable seating, a flat-screen TV, and a large window.

    BlueGem Motel

    A stone water feature with cascading water, surrounded by a brick wall and greenery.

    Vista Verde Farm Retreat

    A wooden cabin with a fire pit and four Adirondack chairs in a grassy area surrounded by trees.

    Aloft by Marriott Gainesville University Area

    A modern hotel with a flat roof, multiple floors, and a prominent 'aloft' sign.

    Best Western Waldo Inn and Suites

    A hotel with a covered entrance, a sign indicating a 14-foot clearance, and a parking lot.

    Frequently Asked Questions

    When is the best time to go to La Crosse?

    The best time to go to La Crosse, Florida, is during the spring (March to May) and fall (September to November) when the weather is most pleasant.

    During spring, you'll find comfortable temperatures, typically ranging from the low 60s to high 70s Fahrenheit, making it ideal for outdoor activities like exploring nearby natural parks or visiting local farms. The humidity is also lower during these months, providing a more enjoyable experience for travelers seeking relaxation and outdoor exploration.

    Fall offers similarly mild weather, with temperatures from the high 50s to mid-70s Fahrenheit.

    Can I cancel my hotel reservation on Expedia?

    You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in La Crosse.

    How much is the nightly rate at a La Crosse hotel?

    Prices for hotels in La Crosse often vary, but you can find a great deal from $81 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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