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Find hotels in Southeast Missouri, MO from $62

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Our top choices for Southeast Missouri hotels

1. Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
Farmington
United States
stewart
$54 nightly
$62 total
Nov 1 - Nov 2
Total with taxes and fees
Baymont Inn and Suites by Wyndham Farmington, MO

2. Quality Inn Farmington

Quality Inn Farmington
Farmington
United States
Tracy
$58 nightly
$66 total
Nov 12 - Nov 13
Total with taxes and fees
Quality Inn Farmington

3. Wilderness Lodge

Wilderness Lodge
Lesterville
United States
Jill
Wilderness Lodge

4. Shepherd Mountain Inn

Shepherd Mountain Inn
Ironton
United States
Michael
$137 nightly
$150 total
Oct 16 - Oct 17
Total with taxes and fees
Shepherd Mountain Inn

5. Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington
Farmington
United States
Marisa
$60 nightly
$68 total
Oct 23 - Oct 24
Total with taxes and fees
Super 8 by Wyndham Farmington

6. Hampton Inn Farmington

Hampton Inn Farmington
Farmington
United States
Charlie
$100 nightly
$114 total
Nov 15 - Nov 16
Total with taxes and fees
Hampton Inn Farmington

7. Holiday Inn Express & Suites Farmington by IHG

Holiday Inn Express & Suites Farmington by IHG
Farmington
United States
Sheila
$115 nightly
$132 total
Nov 15 - Nov 16
Total with taxes and fees
Holiday Inn Express & Suites Farmington by IHG

8. Madison Inn Lodge

Madison Inn Lodge
Fredericktown
United States
Bawan
$89 nightly
$97 total
Oct 16 - Oct 17
Total with taxes and fees
Madison Inn Lodge

9. Black River Motel and Restaurant

Black River Motel and Restaurant
Lesterville
United States
Douglas
$129 nightly
$136 total
Oct 18 - Oct 19
Total with taxes and fees
Black River Motel and Restaurant

10. Fort Davidson Hotel

Fort Davidson Hotel
Ironton
United States
richard
$125 nightly
$137 total
Oct 18 - Oct 19
Total with taxes and fees
Fort Davidson Hotel

11. Baymont Inn And Suites By Wyndham Farmington Mo

Baymont Inn And Suites By Wyndham Farmington Mo
Farmington
Baymont Inn And Suites By Wyndham Farmington Mo

12. Alpaca Farm Stay

Alpaca Farm Stay
Arcadia
United States
Keith
Alpaca Farm Stay

13. The Lookout Bunk | Fire Pit | Sleeps 7

The Lookout Bunk | Fire Pit | Sleeps 7
Fredericktown
United States
Meggie B.
$197 nightly
$213 total
Oct 18 - Oct 19
Total with taxes and fees
The Lookout Bunk | Fire Pit | Sleeps 7

14. Huckleberry Hideaway | Yurt | Fire Pit

Huckleberry Hideaway | Yurt | Fire Pit
Fredericktown
$180 nightly
$191 total
Oct 18 - Oct 19
Total with taxes and fees
Huckleberry Hideaway | Yurt | Fire Pit

15. The Millstream Oasis | Fire Pit | Yurt

The Millstream Oasis | Fire Pit | Yurt
Fredericktown
$288 nightly
$312 total
Oct 19 - Oct 20
Total with taxes and fees
The Millstream Oasis | Fire Pit | Yurt
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Vacation Rentals in Southeast Missouri

Cabin

Sam A Baker State Park

Sam A Baker State Park
Patterson
"Pet friendly, great staff. "
Sam A Baker State Park
Cottage

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

'turtle Rock' - Ironton Cabin w/ Furnished Patio!
Ironton
"Stroller, pack n play and high chair. This was amazing "
'turtle Rock' - Ironton Cabin w/ Furnished Patio!
Aparthotel

The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel
Perryville
"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."
The Atrium - A Boutique Hotel
Vacation Home

Tiny Houses of French Village

Tiny Houses of French Village
French Village
"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "
Tiny Houses of French Village
Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
French Village
"The stay here gets better every time."
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Cabin

Lake Wappapello

Lake Wappapello
Williamsville
"Pet friendly. Family-friendly "
Lake Wappapello
Aparthotel

Urban Lofts

Urban Lofts
Perryville
"Beautiful place and staff was amazing!"
Urban Lofts
Cottage

Walk to Dtwn: Ironton Home in Historic District

Walk to Dtwn: Ironton Home in Historic District
Ironton
"Clean and comfortable "
Walk to Dtwn: Ironton Home in Historic District
Cottage

Walk to Current River: Ozarks Adventure Home!

Walk to Current River: Ozarks Adventure Home!
Van Buren
"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."
Walk to Current River: Ozarks Adventure Home!
Cottage

Cozy Belgrade Cottage w/ Wood-burning Stove!

Cozy Belgrade Cottage w/ Wood-burning Stove!
Belgrade
Cozy Belgrade Cottage w/ Wood-burning Stove!
Cottage

Cottage w/ Yard, Walk to Historic Attractions

Cottage w/ Yard, Walk to Historic Attractions
Ste Genevieve
"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "
Cottage w/ Yard, Walk to Historic Attractions
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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.
Photo by Pat Long

Elephant Rocks State Park

9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
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A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
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A sunset over a lake with boats and ducks.
Photo by JG Morris

Lake Wappapello

8.8/10 (54 reviews)
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)
Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.
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Century Casino Caruthersville

7.0/10 (57 reviews)
Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.
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Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri
A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.
Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

10/10 Excellent
"We have visited the area many times in the past few years and have had terrible luck at hotels all around the area. This was such a breath of fresh air. The property was beautiful, the room was super clean, the staff was so pleasant and helpful. Breakfast was tasty and the bed was super comfortable. We have found out hotel when we come to town."
Stacy 1-night trip
Posted 2 hours ago
Drury Inn & Suites Hayti Caruthersville
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

10/10 Excellent
"The staff at checking was pleasant but one older man kept downgrading the governor of my state. Although I agreed with much of east he said I thought it was inappropriate to push without knowing where I stood. The actual young man who checked me in was very nice and was not part of the political conversation. With that said I would still stay at this hotel in the future as it was otherwise a very pleasant stay. Good breakfast in the morning. The room was very quiet."
Colleen 1-night trip
Posted 4 hours ago
Hampton Inn Poplar Bluff
Hampton Inn Sikeston

Hampton Inn Sikeston

10/10 Excellent
"Everyone was so nice. The rooms were clean and the breakfast had a good variety ."
Brad 1-night trip
Posted 5 hours ago
Hampton Inn Sikeston
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"Always the best!"
John 5-night trip
Posted 11 hours ago
Drury Inn & Suites Sikeston, MO
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

8/10 Good
"bring spare plastic bags for trash and dirty laundry."
W 1-night trip
Posted 11 hours ago
Pear Tree Inn Cape Girardeau West
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

8/10 Good
"They let pets stay free!!! No deposit no size limits."
keith 2-night trip
Posted 12 hours ago
Motel 6 Poplar Bluff, MO
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent
"good, clean, affordable :)"
Nicholas 1-night trip
Posted 1 day ago
Super 8 by Wyndham Sikeston/Miner Area
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"The food was excellent"
DENNIS 2-night trip
Posted 2 days ago
Drury Inn & Suites Cape Girardeau
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

10/10 Excellent
"The room was clean and the staff was very helpful. A great getaway for anyone who likes nature"
Davonne 3-night trip
Posted 5 days ago
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO
$54 nightly
$62 total
Nov 1 - Nov 2
Total with taxes and fees
Baymont Inn and Suites by Wyndham Farmington, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO
$66 nightly
$76 total
Nov 1 - Nov 2
Total with taxes and fees
Days Inn and Suites by Wyndham Sikeston
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO
$72 nightly
$81 total
Oct 25 - Oct 26
Total with taxes and fees
9.2/10 Wonderful! (1,002 reviews)
Pear Tree Inn Cape Girardeau West
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO
$73 nightly
$83 total
Nov 4 - Nov 5
Total with taxes and fees
Comfort Inn Festus - St Louis South
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO
$77 nightly
$86 total
Oct 16 - Oct 17
Total with taxes and fees
8/10 Very Good! (1,001 reviews)
Motel 6 Poplar Bluff, MO
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff MO
$91 nightly
$102 total
Nov 1 - Nov 2
Total with taxes and fees
9.4/10 Exceptional! (985 reviews)
Hampton Inn Poplar Bluff

Hotels in Southeast Missouri with star-rating

Find out more about Southeast Missouri

Top reasons to visit Southeast Missouri

  • Outdoor Adventures: Southeast Missouri is perfect for nature lovers, offering recreational areas, scenic hikes, and various outdoor activities.
  • Charming Cape Girardeau: Explore this vibrant city known for its picturesque riverfront, southern charm, and family-friendly atmosphere.
  • Historic and Cultural Experiences: Delve into the region's history through its historic civic buildings and local cultural attractions.
  • Excellent Golfing: Challenge your skills at top-notch golf courses surrounded by stunning scenery.
  • Diverse Accommodation Options: Enjoy a wide range of lodging choices from budget-friendly hotels to luxurious stays.

Find great hotels near Southeast Missouri

In Southeast Missouri, you'll discover a variety of lodging options, including hotels and lodges that cater to both business travelers and vacationers seeking adventure or romance. From affordable accommodations to luxurious stays, this region offers something for everyone. Whether you're looking for cheap hotels or upscale options, you'll find a range of choices that make your visit comfortable and memorable.

  • Madison Inn Lodge: Located 16 miles from Southeast Missouri, Madison Inn Lodge is a budget-friendly motel perfect for business travelers and pet owners. With a welcoming atmosphere, this accommodation allows pets on-site with specific policies in place, making it an excellent choice for those wanting to travel with their furry friends. Amenities include various pet-friendly features, ensuring a comfortable stay for both guests and their pets.
  • Shepherd Mountain Inn: Just 21 miles from Southeast Missouri, Shepherd Mountain Inn boasts a remarkable guest rating of 9.2 out of 10. This budget-friendly hotel is ideal for those on business trips, providing a peaceful environment conducive to work and relaxation. With comfortable accommodations and a focus on guest satisfaction, visitors can expect a pleasant experience during their stay.
  • Alpaca Farm Stay: Nestled only 8 miles from Southeast Missouri, Alpaca Farm Stay is a unique lodge with a perfect guest rating of 10.0 out of 10. This enchanting property is tailored for those seeking adventure, romantic getaways, or family vacations. Guests can enjoy a variety of outdoor activities, including birdwatching, mountain climbing, and kayaking. The lodge also features amenities for children, such as a shared playground, and offers breathtaking views of the lake and mountains. With romance packages available, it's an ideal spot for couples looking to create lasting memories.

Where to stay near Southeast Missouri

Southeast Missouri offers a delightful blend of outdoor adventures and charming scenery, making it an ideal vacation spot. Explore the vibrant city of Cape Girardeau, known for its picturesque riverfront and southern charm. Enjoy family-friendly activities, friendly locals, and a welcoming atmosphere near Southeast Missouri State University. Whether you seek relaxation or recreation, this region has something for everyone, ensuring a memorable travel experience.

  • Central Fredericktown: Nestled 10 miles from Southeast Missouri, Central Fredericktown is a charming village that offers a delightful mix of outdoor adventures and family activities. Visitors are drawn here year-round, with peak arrivals during the summer months of June to August. The area is perfect for those seeking city-themed experiences, with highlights including a recreational area, a golf course, and an arena entertainment facility. Don't miss the local landmarks such as the urban park and visitor center, which provide a great way to relax and enjoy the natural beauty of the region.
  • Annapolis: Located 14 miles from Southeast Missouri, Annapolis is a vibrant city known for its stunning scenery and adventurous spirit. The influx of travelers peaks in June to July and again in September, making it an ideal spot for outdoor enthusiasts. Visitors can explore a range of activities, including recreational areas and an arena entertainment facility. The nearby national state park and river offer picturesque views and opportunities for adventure, making Annapolis a must-visit destination for those looking to immerse themselves in nature.
  • Des Arc: Just 11 miles from Southeast Missouri, Des Arc is a lively city that attracts seasonal visitors, particularly during the summer months of June to August. Known for its outdoor and scenic experiences, travelers can enjoy a variety of activities, including recreational areas and thrilling motor racing. The proximity of the national state park, river, and lake makes Des Arc an inviting destination for adventure seekers and nature lovers alike. With its picturesque landscapes and fun-filled activities, Des Arc is sure to enhance your vacation experience.

Things to do in Southeast Missouri

Southeast Missouri offers a wealth of outdoor activities and scenic adventures, making it a perfect destination for nature lovers. Explore recreational areas and enjoy educational experiences, or visit entertainment facilities for a fun-filled day. Golf enthusiasts will find excellent golf courses to challenge their skills while soaking in the beautiful surroundings. Whether you seek relaxation or adventure, Southeast Missouri has something for everyone.

Shopping

In Southeast Missouri, visit the Cape Girardeau Mall, home to popular retailers and dining options. For a unique experience, check out the bustling downtown shops in Jackson, offering local crafts and gifts. Don't miss the Farmers Market in Cape Girardeau for fresh produce and handmade goods.

Recreation

Lake Wappapello State Park offers tranquil hiking trails, fishing spots, and picturesque views, perfect for relaxation. For a rejuvenating experience, visit the local spas in Cape Girardeau, where you can indulge in massages and wellness treatments amidst a soothing atmosphere.

Adventure

Explore the stunning Ozark National Scenic Riverways for canoeing and kayaking along clear rivers, surrounded by breathtaking landscapes. Visit Elephant Rocks State Park to hike among massive granite boulders, providing unique photo ops and a chance to connect with nature.

Nightlife

Southeast Missouri boasts a vibrant nightlife with venues like The Blue Note in Cape Girardeau, featuring live music and a lively atmosphere. The River City Casino in St. Louis offers gaming and entertainment, while local bars and breweries provide a relaxed setting for socializing and enjoying craft beverages.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Southeast Missouri

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around Southeast Missouri are November to January, where the prices are slightly lower. This is in comparison to April, June and August, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around Southeast Missouri is Tuesday. The most expensive day to stay around Southeast Missouri is Saturday.
  • Find cheap hotels on Expedia: Utilize Expedia’s search tool to customize your preferences, such as your budget, desired location, and preferred hotel type. To find the best prices and deals, simply arrange the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your hotel stay in Southeast Missouri with your flights and activities through an Expedia package deal.

Find the best attractions near Southeast Missouri

Southeast Missouri is a fantastic destination for outdoor enthusiasts and adventure seekers. With a variety of attractions including urban parks, nature preserves, and historic civic buildings, visitors can enjoy a rich blend of outdoor activities, cultural experiences, and stunning scenery. Whether you're looking to explore nature or delve into the area's history, Southeast Missouri offers something for every traveler.

  • K Bridge Recreation Area: Located 17 miles from Southeast Missouri, this urban park offers a family-friendly atmosphere with plenty of outdoor activities. Enjoy picnicking, hiking, and exploring nature in a vibrant setting perfect for both relaxation and fun.
  • Millstream Gardens Conservation Area: Just 15 miles away, this serene reserve is ideal for adventure seekers and families alike. With friendly locals and relaxing trails, you can immerse yourself in nature while discovering the area’s rich history.
  • Madison County Courthouse: This historic civic government building, located 17 miles from Southeast Missouri, showcases local culture and architecture. Explore its beautiful surroundings and appreciate its significance in the community’s history.

Best time to go to Southeast Missouri

The best time to visit Southeast Missouri can depend on the weather and when visitor numbers rise and fall. The hottest average temperature around Southeast Missouri falls in July, when visitor numbers are slightly high and weather is mostly sunny with light rain. The coolest average temperature around Southeast Missouri falls in January, visitor numbers are slightly low and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January34.9°F (1.6°C)Light RainMostly SunnySlightly LowSlightly Low
February38.1°F (3.4°C)Light RainMostly SunnySlightly LowAverage
March48.0°F (8.9°C)Light RainMostly SunnyAverageAverage
April57.6°F (14.2°C)Light RainMostly SunnyAverageSlightly High
May67.3°F (19.6°C)Light RainMostly SunnyAverageAverage
June76.5°F (24.7°C)Light RainMostly SunnySlightly HighSlightly High
July79.2°F (26.2°C)Light RainMostly SunnySlightly HighAverage
August77.2°F (25.1°C)Light RainMostly SunnySlightly HighSlightly High
September71.6°F (22.0°C)Light RainMostly SunnyAverageAverage
October59.9°F (15.5°C)Light RainMostly SunnyAverageAverage
November47.5°F (8.6°C)Light RainMostly SunnyAverageSlightly Low
December39.4°F (4.1°C)Light RainMostly SunnySlightly LowSlightly Low

The nearest major airports for your trip to Southeast Missouri

Traveling to Southeast Missouri can be conveniently done via several major airports. St. Louis Lambert International Airport (STL) is 96 miles away, with nearby hotels like The Ritz-Carlton and Ameristar Casino Resort & Spa, both 7 miles from the airport. Columbia Regional Airport (COU), located 140 miles away, offers hotels such as The Broadway Columbia and voco The Tiger Hotel, each 11 miles from the airport. Lastly, McKellar-Sipes Regional Airport (MKL) in Jackson, TN, is 148 miles away, featuring accommodations like DoubleTree by Hilton, just 5 miles from the airport. Each hotel provides easy access to their respective airports for a seamless travel experience.

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