Title: TOP 10 Hotels in Defiance, MO (from $70) - COMPETITIVE PRICES | Expedia.com [Defiance Travel Guide](https://expedia.com/Defiance.dx6353634)[Vacation Rentals in Defiance](https://expedia.com/Defiance-Vacation-Rentals.d6353634.Travel-Guide-VacationRentals)[Flights to Defiance](https://expedia.com/Cheap-Flights-To-Defiance.d6353634.Travel-Guide-Flights)[Car Rentals in Defiance](https://expedia.com/Car-Rentals-In-Defiance.d6353634.Car-Rental-Guide)[Defiance Vacation Packages](https://expedia.com/Defiance.d6353634.Destination-Travel-Guides) ![A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri](https://images.trvl-media.com/place/6353634/33b2b915-0d1b-4946-ae10-3b89e88434a7.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6353634/33b2b915-0d1b-4946-ae10-3b89e88434a7.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Defiance Pool [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-21&d1=2026-04-21&endDate=2026-04-23&d2=2026-04-23&amenities=POOL) Cabin [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-21&d1=2026-04-21&endDate=2026-04-23&d2=2026-04-23&lodging=CABIN) Family friendly [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-21&d1=2026-04-21&endDate=2026-04-23&d2=2026-04-23&travelerType=family_friendly) Pet friendly [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-21&d1=2026-04-21&endDate=2026-04-23&d2=2026-04-23&amenities=PETS) Apart hotel [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-21&d1=2026-04-21&endDate=2026-04-23&d2=2026-04-23&lodging=APART_HOTEL) Hot tub [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-21&d1=2026-04-21&endDate=2026-04-23&d2=2026-04-23&amenities=HOT_TUB) Apart­ment [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-21&d1=2026-04-21&endDate=2026-04-23&d2=2026-04-23&lodging=APARTMENT) Condo [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-21&d1=2026-04-21&endDate=2026-04-23&d2=2026-04-23&lodging=CONDO) Waterpark [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-21&d1=2026-04-21&endDate=2026-04-23&d2=2026-04-23&amenities=WATER_PARK) Chalet [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-21&d1=2026-04-21&endDate=2026-04-23&d2=2026-04-23&lodging=CHALET) Cottage [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-21&d1=2026-04-21&endDate=2026-04-23&d2=2026-04-23&lodging=COTTAGE) ## Check prices for these dates Tonight [Apr 7 - Apr 8](https://www.expedia.com/Hotel-Search?regionId=6353634&startDate=2026-04-07&endDate=2026-04-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Apr 8 - Apr 9](https://www.expedia.com/Hotel-Search?regionId=6353634&startDate=2026-04-08&endDate=2026-04-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Apr 10 - Apr 12](https://www.expedia.com/Hotel-Search?regionId=6353634&startDate=2026-04-10&endDate=2026-04-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Apr 17 - Apr 19](https://www.expedia.com/Hotel-Search?regionId=6353634&startDate=2026-04-17&endDate=2026-04-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Defiance hotels ![Property entrance](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/035dee6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/9fbd251c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Jetted Tub | Jetted tub](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/801c113b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Ballroom](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/800a6847.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Wildwood Hotel [](https://www.expedia.com/St-Louis-Hotels-The-Wildwood-Hotel.h1768149.Hotel-Information) Wildwood 9.2/10 Wonderful (1,634 reviews) "Parking was a cinch. The location is serene. A darling wine bar across the street." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kathleen 9 days ago $92 nightly $107 total Apr 12 - Apr 13 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-The-Wildwood-Hotel.h1768149.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/18200/18144/b3c5d3cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, a heated pool, open 10:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/18200/18144/5c61cbf8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18200/18144/a7d1479b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/20000/18200/18144/13e26dd3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Clayton Plaza Hotel & Extended Stay [](https://www.expedia.com/St-Louis-Hotels-Clayton-Plaza-Hotel-Extended-Stay.h18144.Hotel-Information) Clayton 8.8/10 Excellent (3,147 reviews) "The hotel is very good, and clean." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nadia 1 day ago $94 nightly $110 total Apr 19 - Apr 20 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Clayton-Plaza-Hotel-Extended-Stay.h18144.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1100000/1096600/1096579/fc156cf2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1100000/1096600/1096579/68c9f9ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1100000/1096600/1096579/4d0e3d47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds | Desk, blackout drapes, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/2000000/1100000/1096600/1096579/30c70db6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pear Tree Inn St. Louis Airport [](https://www.expedia.com/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Airport.h1096579.Hotel-Information) St. Ann 9.4/10 Exceptional (2,900 reviews) "Best shuttle ever. Employees make this a great stay. Taria is wonderful." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maria 3 days ago $86 nightly $101 total Apr 13 - Apr 14 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Airport.h1096579.Hotel-Information) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/70b128db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Nightclub](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/4519749c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/502ee41b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![6 restaurants, breakfast served](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/d825c5c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ameristar Casino Resort and Spa [](https://www.expedia.com/St-Louis-Hotels-Ameristar-Casino-Resort-And-Spa.h1873292.Hotel-Information) St. Charles 8.4/10 Very Good (1,010 reviews) "Great restaurant choices. Rooms are amazing. Very friendly staff. Great river view." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Terri Sue 5 days ago $193 nightly $226 total Apr 26 - Apr 27 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Ameristar-Casino-Resort-And-Spa.h1873292.Hotel-Information) ![Premium bedding, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/16000000/15590000/15583900/15583887/07f8c63c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/16000000/15590000/15583900/15583887/c413cfac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/16000000/15590000/15583900/15583887/f94e59bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/16000000/15590000/15583900/15583887/5cdbca92.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sleep Inn & Suites O'Fallon MO - Technology Drive [](https://www.expedia.com/St-Louis-Hotels-Sleep-Inn-Suites-OFallon-MO-Technology-Drive.h15583887.Hotel-Information) O'Fallon 9.0/10 Wonderful (1,004 reviews) "The breakfast was decent. Room appeared clean. Staff was good." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kimberly 27 days ago $84 nightly $99 total Apr 15 - Apr 16 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Sleep-Inn-Suites-OFallon-MO-Technology-Drive.h15583887.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/119000000/118200000/118192700/118192676/a2892e05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Cottage | Living area](https://images.trvl-media.com/lodging/119000000/118200000/118192700/118192676/w950h640x10y0-79d0486f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, free WiFi, bed sheets](https://images.trvl-media.com/lodging/119000000/118200000/118192700/118192676/6dbee164.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family House | Premium bedding, free WiFi, bed sheets](https://images.trvl-media.com/lodging/119000000/118200000/118192700/118192676/753bab7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Inns at St. Albans [](https://www.expedia.com/Saint-Albans-Hotels-Inns-At-St-Albans.h118192676.Hotel-Information) Saint Albans 10/10 Exceptional (4 reviews) "Feeling wonderfully secluded the perfect anniversary spot. Fireplace sitting common area." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) scott $226 nightly $242 total Apr 8 - Apr 9 Total with taxes and fees [](https://www.expedia.com/Saint-Albans-Hotels-Inns-At-St-Albans.h118192676.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1290000/1287800/1287747/71e54d85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/2000000/1290000/1287800/1287747/73e16cad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/2000000/1290000/1287800/1287747/6b16372f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Bedrooms, Mobility Accessible, Kitchen (Communications) | In-room safe, blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/2000000/1290000/1287800/1287747/90b4b8ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Staybridge Suites O'Fallon Chesterfield by IHG [](https://www.expedia.com/St-Louis-Hotels-Staybridge-Suites-OFallon-Chesterfield.h1287747.Hotel-Information) O'Fallon 8.6/10 Excellent (430 reviews) "The room was very comfortable I particularly liked the choice of pillows." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Terry 27 days ago $121 nightly $143 total May 3 - May 4 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Staybridge-Suites-OFallon-Chesterfield.h1287747.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1210000/1206500/1206489/3e0ca2c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/2000000/1210000/1206500/1206489/b0c1520e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/2000000/1210000/1206500/1206489/c06ddb8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Double Beds | Hypo-allergenic bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/2000000/1210000/1206500/1206489/68a661e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express St. Louis West - O'Fallon by IHG [](https://www.expedia.com/St-Louis-Hotels-Holiday-Inn-Express-St-Louis-West-OFallon.h1206489.Hotel-Information) O'Fallon 8.6/10 Excellent (901 reviews) "Room was nice. I would recommend this hotel." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sherrill 17 days ago $101 nightly $119 total Apr 12 - Apr 13 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Holiday-Inn-Express-St-Louis-West-OFallon.h1206489.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/90000/82600/82568/7188325f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges](https://images.trvl-media.com/lodging/1000000/90000/82600/82568/76ca3207.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Casino](https://images.trvl-media.com/lodging/1000000/90000/82600/82568/cb1b5cb1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hair dryer, towels](https://images.trvl-media.com/lodging/1000000/90000/82600/82568/65d5873d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hollywood Casino & Hotel St. Louis [](https://www.expedia.com/St-Louis-Hotels-Hollywood-Casino-Hotel-St-Louis.h82568.Hotel-Information) Maryland Heights 8.4/10 Very Good (2,194 reviews) "Room very clean pretty plain for a suite very spacious and comfortable." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) rashaunn 5 days ago $122 nightly $143 total Apr 8 - Apr 9 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Hollywood-Casino-Hotel-St-Louis.h82568.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/20000/11100/11052/0bf2fb85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily cooked-to-order breakfast for a fee](https://images.trvl-media.com/lodging/1000000/20000/11100/11052/4e1a356b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/20000/11100/11052/62378dc9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11100/11052/96f17f89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott St Louis Creve Coeur [](https://www.expedia.com/St-Louis-Hotels-Courtyard-By-Marriott-St-Louis-Creve-Coeur.h11052.Hotel-Information) Creve Coeur 8.8/10 Excellent (1,003 reviews) "Clean hotel in a safe area right off Interstate 270." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rhonda 3 days ago $122 nightly $142 total May 3 - May 4 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Courtyard-By-Marriott-St-Louis-Creve-Coeur.h11052.Hotel-Information) ![Free daily full breakfast](https://images.trvl-media.com/lodging/24000000/23060000/23052900/23052829/5099c288.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/24000000/23060000/23052900/23052829/debc97ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/24000000/23060000/23052900/23052829/bf6e22bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/24000000/23060000/23052900/23052829/167de89c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites St. Louis - Chesterfield by IHG [](https://www.expedia.com/St-Louis-Hotels-Holiday-Inn-Express-Suites-St-Louis-Chesterfield.h23052829.Hotel-Information) Chesterfield 9.0/10 Wonderful (1,001 reviews) "The room was clean and the air conditioner worked great!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Martha 14 days ago $127 nightly $148 total Apr 19 - Apr 20 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Holiday-Inn-Express-Suites-St-Louis-Chesterfield.h23052829.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/50000/42200/42122/b53f4594.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Bedroom, Non Smoking | Living area | LCD TV](https://images.trvl-media.com/lodging/1000000/50000/42200/42122/49aae62b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/42200/42122/70cee110.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/50000/42200/42122/c9087452.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham [](https://www.expedia.com/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Fenton.h42122.Hotel-Information) Fenton 8.0/10 Very Good (1,185 reviews) "Good breakfast happy they had a hot tub." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ryan 4 days ago $89 nightly $103 total Apr 12 - Apr 13 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Fenton.h42122.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/500/457/e9658959.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/500/457/063f8641.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/500/457/a113d3b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, hydromassage showerhead, free toiletries, towels](https://images.trvl-media.com/lodging/1000000/10000/500/457/587d91e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Hazelwood, MO [](https://www.expedia.com/St-Louis-Hotels-Motel-6-Hazelwood.h457.Hotel-Information) Hazelwood 8.6/10 Excellent (1,906 reviews) "Very welcoming staff. Nice spacious rooms. Very quiet place. Overall very good place to stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) cristy 14 days ago $68 nightly $83 total Apr 8 - Apr 9 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Motel-6-Hazelwood.h457.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1350000/1346800/1346760/69d580ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/2000000/1350000/1346800/1346760/199cb80a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/2000000/1350000/1346800/1346760/3b98f0e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/2000000/1350000/1346800/1346760/fee9b391.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Plaza Hotel St. Louis Chesterfield [](https://www.expedia.com/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-Chesterfield.h1346760.Hotel-Information) Chesterfield 9.6/10 Exceptional (1,132 reviews) "Staff was very friendly and accommodating. Good variety at breakfast." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tracie 1 day ago $136 nightly $158 total Apr 12 - Apr 13 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-Chesterfield.h1346760.Hotel-Information) ![BBQ/picnic area](https://images.trvl-media.com/lodging/18000000/17850000/17844200/17844145/de4eca49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/18000000/17850000/17844200/17844145/3090367e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/18000000/17850000/17844200/17844145/0acd9715.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, desk, laptop workspace](https://images.trvl-media.com/lodging/18000000/17850000/17844200/17844145/55a7ca44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott St. Louis Chesterfield [](https://www.expedia.com/St-Louis-Hotels-Courtyard-By-Marriott-St-Louis-Chesterfield.h17844145.Hotel-Information) Chesterfield 9.0/10 Wonderful (610 reviews) "As i like a softer bed." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Roger 19 days ago $129 nightly $150 total Apr 19 - Apr 20 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Courtyard-By-Marriott-St-Louis-Chesterfield.h17844145.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/930000/921500/921433/e9a336ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/930000/921500/921433/8c65749f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/930000/921500/921433/58294714.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/930000/921500/921433/277a54cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn St. Louis/O'Fallon MO [](https://www.expedia.com/St-Louis-Hotels-Hilton-Garden-Inn-St-LouisOFallon-MO.h921433.Hotel-Information) O'Fallon 8.8/10 Excellent (731 reviews) "All was good especially the staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Troy 9 days ago $131 nightly $155 total Apr 20 - Apr 21 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Hilton-Garden-Inn-St-LouisOFallon-MO.h921433.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/33000000/32870000/32863900/32863801/w3996h2667x0y0-9ce14874.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio, 1 King Bed with Sofa bed | Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/33000000/32870000/32863900/32863801/211f1549.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/33000000/32870000/32863900/32863801/130a8945.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/33000000/32870000/32863900/32863801/1716156f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### TownePlace Suites by Marriott St. Louis Chesterfield [](https://www.expedia.com/St-Louis-Hotels-TownePlace-Suites-By-Marriott-St-Louis-Chesterfield.h32863801.Hotel-Information) Chesterfield 9.0/10 Wonderful (292 reviews) "Breakfast availability helps save time looking for places to go." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Floyd and Linda December 2nd, 2025 $134 nightly $157 total May 3 - May 4 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-TownePlace-Suites-By-Marriott-St-Louis-Chesterfield.h32863801.Hotel-Information) ![Courtyard](https://images.trvl-media.com/lodging/1000000/480000/471500/471447/w2880h2092x0y14-c9fd3208.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/480000/471500/471447/9b27b1f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/480000/471500/471447/59f38509.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/480000/471500/471447/0256085b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites St. Louis/Chesterfield [](https://www.expedia.com/St-Louis-Hotels-Hampton-Inn-Suites-St-LouisChesterfield.h471447.Hotel-Information) Chesterfield 8.8/10 Excellent (865 reviews) "This was a great stay. From the friendly greeting at front desk." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gail 8 days ago $115 nightly $134 total Apr 15 - Apr 16 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Hampton-Inn-Suites-St-LouisChesterfield.h471447.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/500/415/b788e069.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/10000/500/415/6e3c31b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/10000/500/415/a17b50b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/500/415/2ff308fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western St. Louis-Kirkwood Route 66 [](https://www.expedia.com/St-Louis-Hotels-Best-Western-Kirkwood-Inn.h415.Hotel-Information) Kirkwood 8.4/10 Very Good (1,440 reviews) "Customer service was very good. The property was clean." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Balaji 8 days ago $92 nightly $108 total Apr 21 - Apr 22 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Best-Western-Kirkwood-Inn.h415.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/4700/4672/a81cbeae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/4700/4672/879431a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/4700/4672/95983c36.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/4700/4672/9ce7fa7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Renaissance St. Louis Airport Hotel [](https://www.expedia.com/St-Louis-Hotels-Renaissance-St-Louis-Airport-Hotel.h4672.Hotel-Information) Berkeley 8.4/10 Very Good (1,080 reviews) "Staff was great. Our waitress at the restaurant was delightful." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) erin 10 days ago $122 nightly $143 total May 8 - May 9 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Renaissance-St-Louis-Airport-Hotel.h4672.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-21&endDate=2026-04-22®ionId=6353634&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDefiance-Hotels.d6353634.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDefiance-Hotels.d6353634.Travel-Guide-Hotels) ## Stay near popular Defiance attractions ![](https://images.trvl-media.com/place/553248621532648567/f82f9409-75a2-47f3-a8fc-2d7c278cc07c.jpg) Photo by Pages of Travel ### Chandler Hill Vineyards This elegant Missouri winery showcases local and California wines from its hillside setting. Savor varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648567) ![Wetlands landscape with a bird blind and cloudy sky reflected in a lake at the August A. Busch Memorial Conservation Area in St. Charles County Missouri](https://images.trvl-media.com/place/6160337/5138d652-49fb-41de-8fd4-a7bb27471f3e.jpg) ### August A. Busch Memorial Conservation Area This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6160337) ### Historic Daniel Boone Home and Heritage Center 4.8/5 (4 reviews) Step into the limestone home where Daniel Boone's son Nathan crafted a frontier masterpiece with seven fireplaces. Explore the surrounding historic village for an authentic glimpse into 19th-century pioneer life. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648566) ### Matson Hill Park Trailhead Wander through 475 acres of rugged forest terrain with challenging hiking paths and gravity-flow mountain bike trails. The historic 1830s Hays Home offers a glimpse into pioneer life amid the natural splendor. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=641530089696399360) ### Sugar Creek Winery Sip award-winning Missouri wines at this hillside vineyard along the scenic Katy Trail. Relax on covered decks with your own picnic while enjoying live weekend music and panoramic countryside views. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648612) ### Yellow Farmhouse Winery This boutique winery in Defiance, Missouri was known for its distinctive unfiltered wines and relaxed atmosphere. Visitors could enjoy tastings with live music while picnicking on scenic grounds with vineyard views. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648568) ### Broemmelsiek Park This 494-acre natural playground offers nine miles of trails through forests and around serene lakes. Attend a monthly stargazing event at the astronomy viewing area for a uniquely celestial park experience. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621561876810) ### Hamburg Trail Trailhead This moderate 6.9-mile loop winds through the scenic Weldon Spring Conservation Area, connecting to the Katy Trail State Park. Spot native wildlife while traversing diverse landscapes of shaded woodlands and open fields. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=641529175733194752) ## Learn more about Defiance Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside. [See all hotels in Defiance](https://www.expedia.com/Hotel-Search?startDate=2026-04-21&endDate=2026-04-22&adults=2®ionId=6353634) ![A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri](https://images.trvl-media.com/place/6353634/33b2b915-0d1b-4946-ae10-3b89e88434a7.jpg?impolicy=fcrop&w=900&h=600&p=1&q=high) ## Top Defiance Hotel Reviews ![Drury Plaza Hotel St. Louis St. Charles](https://images.trvl-media.com/lodging/19000000/18760000/18754300/18754262/79d56802_y.jpg) ### Drury Plaza Hotel St. Louis St. Charles 8/10 Good "The bed was comfortable and the room was clean. The breakfast however was not great, I guess pretty standard hotel food, but not very tasty." [](https://expedia.com/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-St-Charles.h18754262.Hotel-Information) ![Drury Plaza Hotel St. Louis Chesterfield](https://images.trvl-media.com/lodging/2000000/1350000/1346800/1346760/69d580ec_y.jpg) ### Drury Plaza Hotel St. Louis Chesterfield 10/10 Excellent "Staff was very friendly and helpful. Property was well maintained and clean with plenty of amenities above regular hotel standard at an affordable price. " [](https://expedia.com/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-Chesterfield.h1346760.Hotel-Information) ![Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham](https://images.trvl-media.com/lodging/1000000/50000/42200/42122/b53f4594_y.jpg) ### Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham 10/10 Excellent "The room and hotel was clean. The staff was very helpful and friendly. Only complaint was that the pool was very cold! To be inside I wish it was a little warmer " [](https://expedia.com/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Fenton.h42122.Hotel-Information) ![Drury Plaza Hotel St. Louis Creve Coeur](https://images.trvl-media.com/lodging/1000000/80000/74700/74657/b9326e72_y.jpg) ### Drury Plaza Hotel St. Louis Creve Coeur 10/10 Excellent "Clean room. Pool was cloudy. Hot tub was great." [](https://expedia.com/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Creve-Coeur.h74657.Hotel-Information) ![La Quinta Inn & Suites by Wyndham St. Louis Westport](https://images.trvl-media.com/lodging/1000000/70000/62900/62842/2d27fd02_y.jpg) ### La Quinta Inn & Suites by Wyndham St. Louis Westport 6/10 Okay "Breakfast were really good, the room was clean and roomie. However, there was a lot of noise at night on the third floor. Kids were running around naked up there celebrating the 18 year-old party there was no supervision and running up and down the halls in the wee hours of the morning, smoking dope the whole hallways melt of marijuana and it was very offensive to me and my husband. " [](https://expedia.com/St-Louis-Hotels-La-Quinta-Inn-Suites-By-Wyndham-St-Louis-Westport.h62842.Hotel-Information) ![Drury Inn & Suites St. Louis St. Peters](https://images.trvl-media.com/lodging/1000000/50000/41500/41453/68bc6d17_y.jpg) ### Drury Inn & Suites St. Louis St. Peters 8/10 Good "Good not Fantastic Great flawless not Horrible either Etc but nice overall " [](https://expedia.com/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-St-Peters.h41453.Hotel-Information) ![Hollywood Casino & Hotel St. Louis](https://images.trvl-media.com/lodging/1000000/90000/82600/82568/76ca3207_y.jpg) ### Hollywood Casino & Hotel St. Louis 6/10 Okay "It is an ok place " [](https://expedia.com/St-Louis-Hotels-Hollywood-Casino-Hotel-St-Louis.h82568.Hotel-Information) ![Embassy Suites by Hilton St. Louis St. Charles](https://images.trvl-media.com/lodging/2000000/1140000/1131200/1131105/ac68aac2_y.jpg) ### Embassy Suites by Hilton St. Louis St. Charles 2/10 Terrible "Room was dirty with hair in the bathroom and the bed had hair on the sheets. There was a church convention going on with lots of teenagers. There were signs posted numerous places regarding quiet time. This was severely overlooked and not enforced. It was well past 1:00 am when we last called the front desk to complain. The staff did nothing to enforce quiet time. " [](https://expedia.com/St-Louis-Hotels-Embassy-Suites-St-Louis-St-Charles.h1131105.Hotel-Information) ![Crowne Plaza St. Louis Airport by IHG](https://images.trvl-media.com/lodging/1000000/10000/3100/3010/90ecdcdc_y.jpg) ### Crowne Plaza St. Louis Airport by IHG 10/10 Excellent "Yes" [](https://expedia.com/St-Louis-Hotels-Crowne-Plaza-St-Louis-Airport.h3010.Hotel-Information) ## More cheap stays in Defiance ![Relax Inn Saint Charles ](https://images.trvl-media.com/lodging/2000000/1010000/1000800/1000712/49b4298c_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Relax Inn Saint Charles 3800 Harry S Truman Blvd St. Charles MO $61 nightly $70 total Apr 27 - Apr 28 Total with taxes and fees 6.8/10 (1,001 reviews) [](https://expedia.com/St-Louis-Hotels-Relax-Inn-Saint-Charles.h1000712.Hotel-Information) ![Days Inn and Suites by Wyndham St. Louis/Westport Plaza](https://images.trvl-media.com/lodging/1000000/60000/55200/55161/40483d14_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Days Inn and Suites by Wyndham St. Louis/Westport Plaza 1970 Craig Rd Maryland Heights MO $68 nightly $79 total Apr 12 - Apr 13 Total with taxes and fees 4.6/10 (1,002 reviews) [](https://expedia.com/St-Louis-Hotels-Days-Inn-And-Suites-By-Wyndham-St-LouisWestport-Plaza.h55161.Hotel-Information) ![Sleep Inn & Suites O'Fallon MO - Technology Drive](https://images.trvl-media.com/lodging/16000000/15590000/15583900/15583887/07f8c63c_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Sleep Inn & Suites O'Fallon MO - Technology Drive 1147 Technology Drive O'Fallon MO $84 nightly $99 total Apr 15 - Apr 16 Total with taxes and fees 9/10 Wonderful! (1,004 reviews) [](https://expedia.com/St-Louis-Hotels-Sleep-Inn-Suites-OFallon-MO-Technology-Drive.h15583887.Hotel-Information) ![Comfort Suites St Charles - St Louis](https://images.trvl-media.com/lodging/1000000/670000/664500/664414/6093d918_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Comfort Suites St Charles - St Louis 1400 S 5th St St. Charles MO $90 nightly $103 total May 3 - May 4 Total with taxes and fees 8.4/10 Very Good! (1,004 reviews) [](https://expedia.com/St-Louis-Hotels-Comfort-Suites-St-Charles-St-Louis.h664414.Hotel-Information) ![Best Western Plus St. Louis West-Westport](https://images.trvl-media.com/lodging/1000000/50000/41500/41448/00255b25_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Best Western Plus St. Louis West-Westport 12220 Dorsett Rd Maryland Heights MO $93 nightly $107 total May 3 - May 4 Total with taxes and fees 8/10 Very Good! (1,058 reviews) [](https://expedia.com/St-Louis-Hotels-Best-Western-Plus-St-Louis-West-Westport.h41448.Hotel-Information) ![Country Inn & Suites by Radisson, St. Charles Historic District](https://images.trvl-media.com/lodging/2000000/1340000/1330400/1330309/001d26f2_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Country Inn & Suites by Radisson, St. Charles Historic District 1190 S Main St St. Charles MO $135 nightly $155 total May 3 - May 4 Total with taxes and fees 9.4/10 Exceptional! (1,006 reviews) [](https://expedia.com/St-Louis-Hotels-Country-Inn-Suites-By-Radisson.h1330309.Hotel-Information) ## Hotels in Defiance with star-rating ![4 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/23700/23677/6ae928dd_z.jpg) 4 Star Hotels 7 properties [](https://expedia.com/4Star-Defiance-Hotels.s40-0-d6353634.Travel-Guide-Filter-Hotels) ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 114 properties [](https://expedia.com/3Star-Defiance-Hotels.s30-0-d6353634.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 156 properties [](https://expedia.com/2Star-Defiance-Hotels.s20-0-d6353634.Travel-Guide-Filter-Hotels) ## Find out more about Defiance ### Top reasons to visit Defiance - **Scenic Outdoor Activities:** Enjoy hiking on the beautiful Defiance Studio Trail and explore nearby state and urban parks. - **Romantic Getaways:** Perfect for couples, Defiance offers a charming atmosphere for a memorable escape. - **Live Music and Entertainment:** Unwind with local live music performances, enhancing your vacation experience. - **Family-Friendly Attractions:** Visit amusement parks and engage in activities suitable for visitors of all ages. - **Diverse Accommodations:** Choose from pet-friendly and LGBTQIA-friendly lodging options to suit your needs. ### Find great hotels near Defiance Defiance, Missouri, offers a variety of lodging options to cater to every traveler's needs, from business trips to leisurely getaways. Whether you prefer a comfortable hotel, a cozy apartment, or a welcoming motel, you'll find accommodations that are pet-friendly and LGBTQIA-friendly. Explore the charm of Defiance while enjoying amenities tailored for a memorable stay, whether you're visiting for work or pleasure. - **[Sonesta ES Suites St. Louis - Chesterfield: ](https://www.expedia.com/St-Louis-Hotels-Sonesta-ES-Suites-St-Louis-Chesterfield.h422.Hotel-Information)** This 3-star hotel boasts a guest rating of 8.0 and is located 12 miles from Defiance. Sonesta ES Suites St. Louis - Chesterfield is ideal for pet lovers, offering a range of pet-friendly amenities including food and water bowls, and a variable pet fee. The hotel features spacious suites with fully equipped kitchens, perfect for guests seeking a home-like experience. Its convenient location allows easy access to local attractions, making it a comfortable retreat for travelers looking to explore the area with their furry friends. - **[The Wildwood Hotel: ](https://www.expedia.com/St-Louis-Hotels-The-Wildwood-Hotel.h1768149.Hotel-Information)** With a 3.5-star rating and an impressive guest rating of 9.2, The Wildwood Hotel is located 9 miles from Defiance and is perfect for adventure enthusiasts. Guests can easily access ski lifts and shuttles, along with nearby options for biking, hiking, and mountain climbing. The hotel features cozy accommodations and various recreational activities both on-site and in the surrounding area. This hotel is a fantastic choice for those seeking an exhilarating outdoor vacation amid beautiful surroundings. - **[Sleep Inn & Suites O'Fallon MO - Technology Drive: ](https://www.expedia.com/St-Louis-Hotels-Sleep-Inn-Suites-OFallon-MO-Technology-Drive.h15583887.Hotel-Information)** This budget-friendly option holds a guest rating of 9.0 and is situated 7 miles from Defiance. Designed with business travelers in mind, Sleep Inn & Suites O'Fallon MO offers modern amenities and a comfortable atmosphere for working professionals. Guests can enjoy complimentary breakfast, free Wi-Fi, and convenient access to local business hubs. The hotel combines practicality with comfort, ensuring a pleasant stay for those visiting the area for work. ### Where to stay in and around Defiance Defiance, Missouri, offers a delightful blend of outdoor adventures and romantic escapes. Nestled near the scenic Missouri River, visitors can explore charming neighborhoods and enjoy family-friendly activities. Just a short drive from St. Louis, the area is rich in history and friendly vibes, making it perfect for both relaxation and exploration. Whether you seek entertainment or a peaceful retreat, Defiance and its surroundings promise a memorable vacation experience. - **[Chesterfield: ](https://www.expedia.com/Chesterfield-Hotels.d9530.Travel-Guide-Hotels)** Located 12 miles away from Defiance, Chesterfield is a vibrant city that offers a mix of family-friendly and entertainment-themed experiences. With peak visitor numbers in April and the summer months, Chesterfield is a hub for fun activities. Travelers can enjoy a variety of attractions, including theaters, music concerts, and an arcade adventure zone. Additionally, the city boasts prominent landmarks such as a theme park and a sports facility stadium, making it an ideal destination for those seeking a lively atmosphere. - **[Saint Albans: ](https://www.expedia.com/Saint-Albans-Hotels.d3000445473.Travel-Guide-Hotels)** Just 4 miles from Defiance, Saint Albans is a charming city that appeals to outdoor enthusiasts and families alike. With peak visitation in spring and summer, this area offers adventure-filled experiences, including an amusement park and recreational areas perfect for picnics and outdoor activities. Visitors can also explore nearby attractions like a convention center and a picturesque lake, making it a great spot for those looking to connect with nature while enjoying family time. - **[Hamburg: ](https://www.expedia.com/Hamburg-Hotels.d553248635975869538.Travel-Guide-Hotels)** Nestled within the area of Defiance, Hamburg is a quaint village that provides a romantic and outdoor-oriented experience. Although the number of travelers remains fairly stable throughout the year, peak visits occur during the summer months. Hamburg is perfect for couples and families seeking a peaceful retreat, with plenty of opportunities for outdoor activities. Enjoy the serene surroundings and local entertainment options that make this village a delightful stop on your vacation. ### Things to do near Defiance Defiance, Missouri, is perfect for outdoor and romantic getaways, offering a variety of activities like hiking on the scenic Defiance Studio Trail and enjoying the beautiful recreational areas. Visitors can immerse themselves in outdoor experiences and unwind with live music, making it an ideal destination for entertainment and adventure. **Shopping** In Defiance, you can enjoy local shops and boutiques offering unique gifts and souvenirs. If you're up for a drive, visit the nearby Mid Rivers Mall for a wider selection, including popular brands and specialty stores perfect for finding that special keepsake. **Recreation** Experience luxury at Bellerive Country Club, located 16 miles from Defiance. Enjoy world-class amenities, indulge in fine dining, and relax in a serene environment. Engage in recreational activities like golfing and spa treatments, perfect for rejuvenating your mind and body amidst beautiful surroundings. **Adventure** Defiance offers thrilling outdoor adventures, including kayaking along the scenic Missouri River, where you can explore its beautiful banks and wildlife. For hiking enthusiasts, the nearby Klondike Park features trails with stunning views and opportunities for birdwatching among native flora and fauna. **Nightlife** Defiance offers a charming nightlife with cozy bars like the Defiance Ridge Vineyards, where you can enjoy local wines. For a more social vibe, visit The Defiance House, featuring live music and a warm atmosphere perfect for mingling with locals. \*Distances are measured in a straight line; actual driving distances may vary depending on the route. ### Booking tips and Expedia advantages for Defiance - **The most and least expensive months on average to stay in a hotel:** The cheapest months to stay in Defiance are December to February, where the prices are slightly lower. This is in comparison to May to July, where prices are slightly higher. - **The most and least expensive days on average to stay in a hotel:** The least expensive day to stay in Defiance is Monday. The most expensive day to stay in Defiance is Saturday. - **Find cheap hotels on Expedia:** Utilize Expedia's search tool to tailor your options based on your budget, desired location, and preferred hotel type. For instance, selecting the Eco-certified filter will highlight sustainable and eco-friendly hotels that are currently available. To find the best prices and deals, simply sort the price filter from low to high. - **Consider bundling your trip:** You can save money by combining your hotel reservations in Defiance with your flights and activities through an Expedia package deal. ### Find the best attractions in and around Defiance Defiance, Missouri, is perfect for outdoor enthusiasts and couples seeking a romantic getaway. Visitors can explore nearby attractions like state parks, urban parks, and amusement parks, offering a variety of experiences for families and city adventurers alike. Whether you're hiking scenic trails or enjoying thrilling rides, Defiance has something for everyone looking to unwind and enjoy the great outdoors. - **[August A. Busch Memorial Conservation Area: ](https://www.expedia.com/August-A-Busch-Memorial-Conservation-Area-Hotels.0-l6160337-0.Travel-Guide-Filter-Hotels)** Explore this beautiful reserve located in Defiance, perfect for families and nature lovers. Enjoy walking trails, wildlife viewing, and engaging excursions that connect you with friendly locals and the great outdoors. - **[Six Flags St. Louis: ](https://www.expedia.com/Six-Flags-St-Louis-Hotels.0-l6147083-0.Travel-Guide-Filter-Hotels)** Just 10 miles from Defiance, this thrilling amusement park offers a wide range of rides and attractions for all ages. Experience the excitement of roller coasters and live entertainment, making it a perfect destination for adventure seekers and families alike. - **[Purina Farms: ](https://www.expedia.com/Purina-Farms-Hotels.0-l553248621532648557-0.Travel-Guide-Filter-Hotels)** Also situated 10 miles from Defiance, this charming farm features scenic views and interactive experiences with animals. Enjoy hands-on activities and learn about farm life, making it a delightful outing for visitors of all ages. ### Best time to go to Defiance The best time to visit Defiance can depend on the weather and when visitor numbers rise and fall. The hottest average temperature in Defiance falls in July, when visitor numbers are moderately high and weather is mostly sunny with light rain. The coolest average temperature in Defiance falls in January, visitor numbers are moderately low and weather is mostly cloudy with light rain. | **![calendar](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/calendar.png)Calendar Month** | **![temperature](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__hot.png)Temperature** | **![rain](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__rain.png)Precipitation** | **![mostly](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/weather__day_mostly_cloudy.png)Cloudiness** | **![occupation](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/peoplebex.png)Occupancy** | **![price](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/currency_dollar.png)Pricing** | | ---------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------------------------------------------- | ------------------------------------------------------------------------------------------------------------- | | January | 31.6°F (-0.2°C) | Light Rain | Mostly Cloudy | Moderately Low | Slightly Low | | February | 34.7°F (1.5°C) | Light Rain | Mostly Sunny | Average | Slightly Low | | March | 46.4°F (8.0°C) | Light Rain | Mostly Sunny | Average | Average | | April | 55.9°F (13.3°C) | Light Rain | Mostly Sunny | Moderately High | Average | | May | 66.2°F (19.0°C) | Light Rain | Mostly Sunny | Average | Slightly High | | June | 75.9°F (24.4°C) | Light Rain | Mostly Sunny | Average | Slightly High | | July | 79.0°F (26.1°C) | Light Rain | Mostly Sunny | Moderately High | Slightly High | | August | 77.2°F (25.1°C) | Light Rain | Mostly Sunny | Average | Average | | September | 70.9°F (21.6°C) | Light Rain | Mostly Sunny | Moderately High | Average | | October | 58.5°F (14.7°C) | Light Rain | Mostly Sunny | Average | Average | | November | 46.2°F (7.9°C) | Light Rain | Mostly Sunny | Moderately Low | Average | | December | 37.6°F (3.1°C) | Light Rain | Mostly Sunny | Moderately Low | Slightly Low | ### The nearest major airports for your trip to Defiance To reach Defiance, Missouri, the nearest major airport is St. Louis Lambert International Airport ([STL](https://www.expedia.com/Lambert-St-Louis-Intl-Airport-Hotels.0-aSTL-0.Travel-Guide-Filter-Hotels)), located 23 miles away. Recommended hotels nearby include [The Ritz-Carlton](https://www.expedia.com/St-Louis-Hotels-The-Ritz-Carlton.h6132.Hotel-Information), St. Louis and [Ameristar Casino Resort and Spa](https://www.expedia.com/St-Louis-Hotels-Ameristar-Casino-Resort-And-Spa.h1873292.Hotel-Information), both 7 miles from the airport. Another option is [ The Royal Sonesta Chase Park Plaza St. Louis](https://www.expedia.com/St-Louis-Hotels-The-Chase-Park-Plaza-Royal-Sonesta-St-Louis.h465749.Hotel-Information), situated 9 miles away. Columbia Regional Airport ([COU](https://www.expedia.com/Columbia-Regional-Airport-Hotels.0-aCOU-0.Travel-Guide-Filter-Hotels)) is 79 miles from Defiance, with good hotel choices like The Broadway Columbia and voco The Tiger Hotel, both 11 miles away. For those traveling to Fort Leonard Wood Regional Airport ([TBN](https://www.expedia.com/St-Robert-Regional-Airport-Hotels.0-aTBN-0.Travel-Guide-Filter-Hotels)), located 97 miles away, [Z Loft Extended Stay Hotel](https://www.expedia.com/Rolla-Hotels-Z-Loft-Extended-Stay-Hotel.h11603172.Hotel-Information) is a convenient option, just 6 miles from the airport. ## Frequently asked questions ### What is the best area to stay in Defiance? > The village of Defiance is small and picturesque, centered around its historic general store and a few local eateries. Hotels here are typically smaller, independently owned establishments or bed and breakfasts, providing a personalized experience. The Katy Trail, a popular walking and cycling path, runs directly through the village, making it an excellent base for outdoor enthusiasts. > > > Couples looking for a relaxing getaway will appreciate staying in this area. It's quiet and offers direct access to scenic walks and bike rides along the Missouri River. ### When is the best time to go to Defiance? > These seasons offer pleasant weather conditions, with comfortable temperatures that are ideal for outdoor activities like cycling or exploring the Katy Trail. In spring, the local vineyards begin to bloom, and in autumn, the changing leaves provide scenic views along the Missouri River. Traveling during these times also allows you to enjoy local events and festivals without the peak summer crowds. > > > For travelers looking to experience the region's natural beauty and participate in outdoor recreation, spring and fall provide the most agreeable climate. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Defiance hotel booking with Expedia? > \*Excludes taxes and fees. 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