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Our top choices for Defiance hotels

The Wildwood Hotel

The Wildwood Hotel
3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1,633 reviews)
"Parking was a cinch. The location is serene. A darling wine bar across the street."
United States
Kathleen
15 days ago
$84 nightly
The price is $98
May 13 - May 14
Total with taxes and fees
The Wildwood Hotel

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay
3.5 star property
Clayton
9.0 out of 10, Wonderful, (3,146 reviews)
"Breakfast was excellent. Parking was a bit cumbersome."
United States
Anjana
18 hours ago
$100 nightly
The price is $116
May 3 - May 4
Total with taxes and fees
Clayton Plaza Hotel & Extended Stay

Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport
2.5 star property
St. Ann
9.4 out of 10, Exceptional, (2,916 reviews)
"Pillows were super comfortable. I had a very nice day."
United States
Erika R
1 day ago
$87 nightly
The price is $103
Apr 20 - Apr 21
Total with taxes and fees
Pear Tree Inn St. Louis Airport

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
4.5 star property
St. Charles
8.4 out of 10, Very Good, (1,003 reviews)
"Great restaurant choices. Rooms are amazing. Very friendly staff. Great river view."
United States
Terri Sue
11 days ago
$193 nightly
The price is $226
Apr 26 - Apr 27
Total with taxes and fees
Ameristar Casino Resort and Spa

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,002 reviews)
"The breakfast was decent. Room appeared clean. Staff was good."
United States
Kimberly
March 10th, 2026
$82 nightly
The price is $97
Apr 14 - Apr 15
Total with taxes and fees
Sleep Inn & Suites O'Fallon MO - Technology Drive

Inns at St. Albans

Inns at St. Albans
3.0 star property
Saint Albans
10.0 out of 10, Exceptional, (4 reviews)
"Feeling wonderfully secluded the perfect anniversary spot. Fireplace sitting common area."
United States
scott
$226 nightly
The price is $242
Apr 14 - Apr 15
Total with taxes and fees
Inns at St. Albans

Staybridge Suites O'Fallon Chesterfield by IHG

Staybridge Suites O'Fallon Chesterfield by IHG
3.0 star property
O'Fallon
8.6 out of 10, Excellent, (431 reviews)
"The room was very comfortable I particularly liked the choice of pillows."
United States
Terry
March 11th, 2026
$121 nightly
The price is $143
Apr 26 - Apr 27
Total with taxes and fees
Staybridge Suites O'Fallon Chesterfield by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
O'Fallon
8.6 out of 10, Excellent, (905 reviews)
"Room was nice. I would recommend this hotel."
United States
Sherrill
23 days ago
$110 nightly
The price is $129
Apr 16 - Apr 17
Total with taxes and fees
Holiday Inn Express St. Louis West - O'Fallon by IHG

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis
3.5 star property
Maryland Heights
8.4 out of 10, Very Good, (2,200 reviews)
"The room was clean. Check in worked well. It was a great experience."
United States
Stanley
4 days ago
$122 nightly
The price is $143
Apr 14 - Apr 15
Total with taxes and fees
Hollywood Casino & Hotel St. Louis

Courtyard by Marriott St Louis Creve Coeur

Courtyard by Marriott St Louis Creve Coeur
3.0 star property
Creve Coeur
8.8 out of 10, Excellent, (1,003 reviews)
"We did eat the breakfast there parking was good plenty of space."
United States
Winny
21 hours ago
$131 nightly
The price is $152
May 3 - May 4
Total with taxes and fees
Courtyard by Marriott St Louis Creve Coeur

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
2.5 star property
Chesterfield
9.0 out of 10, Wonderful, (1,002 reviews)
"The room was clean and the air conditioner worked great!"
United States
Martha
20 days ago
$122 nightly
The price is $142
May 3 - May 4
Total with taxes and fees
Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
8.0 out of 10, Very Good, (1,202 reviews)
"Staff was very nice. The breakfast was really good."
United States
Kathy
5 days ago
$89 nightly
The price is $103
Apr 14 - Apr 15
Total with taxes and fees
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Motel 6 Hazelwood, MO

Motel 6 Hazelwood, MO
2.0 star property
Hazelwood
8.6 out of 10, Excellent, (1,924 reviews)
"Room was clean, staff was nice. Parking was good."
United States
Amy
20 hours ago
$64 nightly
The price is $79
Apr 14 - Apr 15
Total with taxes and fees
Motel 6 Hazelwood, MO

Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield
3.0 star property
Chesterfield
9.6 out of 10, Exceptional, (1,138 reviews)
"Clean place to stay. Will definitely be staying there again soon."
United States
Rebekah
3 days ago
$136 nightly
The price is $158
Apr 19 - Apr 20
Total with taxes and fees
Drury Plaza Hotel St. Louis Chesterfield

Courtyard by Marriott St. Louis Chesterfield

Courtyard by Marriott St. Louis Chesterfield
3.0 star property
Chesterfield
9.0 out of 10, Wonderful, (612 reviews)
"As i like a softer bed."
United States
Roger
26 days ago
$129 nightly
The price is $150
May 3 - May 4
Total with taxes and fees
Courtyard by Marriott St. Louis Chesterfield

Hilton Garden Inn St. Louis/O'Fallon MO

Hilton Garden Inn St. Louis/O'Fallon MO
3.0 star property
O'Fallon
8.8 out of 10, Excellent, (731 reviews)
"All was good especially the staff."
United States
Troy
15 days ago
$124 nightly
The price is $147
Apr 20 - Apr 21
Total with taxes and fees
Hilton Garden Inn St. Louis/O'Fallon MO

TownePlace Suites by Marriott St. Louis Chesterfield

TownePlace Suites by Marriott St. Louis Chesterfield
3.0 star property
Chesterfield
9.0 out of 10, Wonderful, (292 reviews)
"Breakfast availability helps save time looking for places to go."
United States
Floyd and Linda
December 2nd, 2025
$130 nightly
The price is $153
May 3 - May 4
Total with taxes and fees
TownePlace Suites by Marriott St. Louis Chesterfield

Hampton Inn & Suites St. Louis/Chesterfield

Hampton Inn & Suites St. Louis/Chesterfield
3.5 star property
Chesterfield
8.8 out of 10, Excellent, (870 reviews)
"Room very clean. Breakfast had good variety and staff very helpful and friendly."
United States
Pamela
1 day ago
$103 nightly
The price is $119
May 3 - May 4
Total with taxes and fees
Hampton Inn & Suites St. Louis/Chesterfield

Best Western St. Louis-Kirkwood Route 66

Best Western St. Louis-Kirkwood Route 66
3.5 star property
Kirkwood
8.4 out of 10, Very Good, (1,444 reviews)
"Parking, custom service and breakfast was great."
United States
Henry
2 days ago
$92 nightly
The price is $108
May 11 - May 12
Total with taxes and fees
Best Western St. Louis-Kirkwood Route 66

Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel
4.0 star property
Berkeley
8.4 out of 10, Very Good, (1,084 reviews)
"Staff was very welcoming when we arrived. Rooms were nice. Hotel shuttle was on time."
United States
Fritz
1 day ago
$122 nightly
The price is $143
May 8 - May 9
Total with taxes and fees
Renaissance St. Louis Airport Hotel
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Where to stay in and around Defiance

Defiance, MO, offers a charming getaway with its welcoming community and outdoor adventures. Explore nearby towns for family-friendly entertainment, romantic spots, and cultural experiences. Stroll through scenic areas adorned with flags nearby, and enjoy the vibrant atmosphere just next door. Make unforgettable memories in this captivating region!

Chesterfield

Chesterfield is the ultimate neighborhood for travelers seeking a vibrant mix of entertainment and family-friendly experiences. With attractions like the Hollywood Casino Amphitheatre, Westport Plaza, and the St. Charles Convention Center, visitors can enjoy concerts, dining, and events throughout the year. Located about 12 miles by car from Defiance, Chesterfield offers easy access for a weekend getaway or business trip. Choosing Chesterfield as your base ensures a dynamic stay filled with fun and excitement.

Saint Albans

Plan your stay in Saint Albans, a top-rated choice for families and outdoor enthusiasts looking for a delightful mix of adventure and relaxation. Enjoy thrilling experiences at nearby attractions like Six Flags St. Louis and Purina Farms, or explore the scenic landscapes around local lakes. Just about 5 miles by car from Defiance, Saint Albans offers easy access to a variety of recreational activities, making it a smart choice for your getaway.

Hamburg

If you are a weekend getaway seeker, look no further than Hamburg, located in Defiance, Missouri, which features a blend of outdoor adventures and family-friendly attractions. You can explore the thrilling rides at Six Flags St. Louis, enjoy the serene nature trails at the August A. Busch Memorial Conservation Area, or hit the slopes at Show Me ski run. With its proximity to these highlights, Hamburg is a smart choice for your stay, offering a memorable experience amid the beauty of nature.

St. Peters

Immerse yourself in St. Peters, where families and weekend travelers can easily access a vibrant blend of entertainment and leisure. This city offers a plethora of attractions, including the St. Charles Convention Center for events, the Hollywood Casino Amphitheatre for live performances, and the scenic local parks for outdoor enjoyment. Located about 15 miles by car from Defiance, St. Peters is a smart choice for your stay, providing both comfort and convenience for a memorable getaway.

Pacific

Travelers visiting the area often choose Pacific, Missouri, especially families and adventure seekers looking for a dynamic getaway. With attractions like Six Flags St. Louis for thrilling rides, Purina Farms for a unique farm experience, and the nearby Show Me ski run for winter fun, Pacific offers a variety of activities to enjoy year-round. Located about 30 miles by car from Defiance, it makes for an easy trip. Pacific is a smart choice for your hotel booking, ensuring a memorable stay.

Stay near popular attractions in and around Defiance

Defiance offers a charming blend of outdoor adventures, romantic escapes, and vibrant entertainment. With scenic parks, captivating farms, and family-friendly activities, it's the perfect destination for those seeking a refreshing getaway that combines nature and community spirit. Explore the beauty of Defiance and create lasting memories!

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

More cheap stays in Defiance

Hotels in Defiance with star-rating

Find out more about Defiance

Top reasons to visit Defiance

  • Scenic Outdoor Activities: Enjoy hiking on the beautiful Defiance Studio Trail and explore nearby state and urban parks.
  • Romantic Getaways: Perfect for couples, Defiance offers a charming atmosphere for a memorable escape.
  • Live Music and Entertainment: Unwind with local live music performances, enhancing your vacation experience.
  • Family-Friendly Attractions: Visit amusement parks and engage in activities suitable for visitors of all ages.
  • Diverse Accommodations: Choose from pet-friendly and LGBTQIA-friendly lodging options to suit your needs.

Find great hotels near Defiance

Defiance, Missouri, offers a variety of lodging options to cater to every traveler's needs, from business trips to leisurely getaways. Whether you prefer a comfortable hotel, a cozy apartment, or a welcoming motel, you'll find accommodations that are pet-friendly and LGBTQIA-friendly. Explore the charm of Defiance while enjoying amenities tailored for a memorable stay, whether you're visiting for work or pleasure.

  • Sonesta ES Suites St. Louis - Chesterfield: This 3-star hotel boasts a guest rating of 8.0 and is located 12 miles from Defiance. Sonesta ES Suites St. Louis - Chesterfield is ideal for pet lovers, offering a range of pet-friendly amenities including food and water bowls, and a variable pet fee. The hotel features spacious suites with fully equipped kitchens, perfect for guests seeking a home-like experience. Its convenient location allows easy access to local attractions, making it a comfortable retreat for travelers looking to explore the area with their furry friends.
  • The Wildwood Hotel: With a 3.5-star rating and an impressive guest rating of 9.2, The Wildwood Hotel is located 9 miles from Defiance and is perfect for adventure enthusiasts. Guests can easily access ski lifts and shuttles, along with nearby options for biking, hiking, and mountain climbing. The hotel features cozy accommodations and various recreational activities both on-site and in the surrounding area. This hotel is a fantastic choice for those seeking an exhilarating outdoor vacation amid beautiful surroundings.
  • Sleep Inn & Suites O'Fallon MO - Technology Drive: This budget-friendly option holds a guest rating of 9.0 and is situated 7 miles from Defiance. Designed with business travelers in mind, Sleep Inn & Suites O'Fallon MO offers modern amenities and a comfortable atmosphere for working professionals. Guests can enjoy complimentary breakfast, free Wi-Fi, and convenient access to local business hubs. The hotel combines practicality with comfort, ensuring a pleasant stay for those visiting the area for work.

Where to stay in and around Defiance

Defiance, Missouri, offers a delightful blend of outdoor adventures and romantic escapes. Nestled near the scenic Missouri River, visitors can explore charming neighborhoods and enjoy family-friendly activities. Just a short drive from St. Louis, the area is rich in history and friendly vibes, making it perfect for both relaxation and exploration. Whether you seek entertainment or a peaceful retreat, Defiance and its surroundings promise a memorable vacation experience.

  • Chesterfield: Located 12 miles away from Defiance, Chesterfield is a vibrant city that offers a mix of family-friendly and entertainment-themed experiences. With peak visitor numbers in April and the summer months, Chesterfield is a hub for fun activities. Travelers can enjoy a variety of attractions, including theaters, music concerts, and an arcade adventure zone. Additionally, the city boasts prominent landmarks such as a theme park and a sports facility stadium, making it an ideal destination for those seeking a lively atmosphere.
  • Saint Albans: Just 4 miles from Defiance, Saint Albans is a charming city that appeals to outdoor enthusiasts and families alike. With peak visitation in spring and summer, this area offers adventure-filled experiences, including an amusement park and recreational areas perfect for picnics and outdoor activities. Visitors can also explore nearby attractions like a convention center and a picturesque lake, making it a great spot for those looking to connect with nature while enjoying family time.
  • Hamburg: Nestled within the area of Defiance, Hamburg is a quaint village that provides a romantic and outdoor-oriented experience. Although the number of travelers remains fairly stable throughout the year, peak visits occur during the summer months. Hamburg is perfect for couples and families seeking a peaceful retreat, with plenty of opportunities for outdoor activities. Enjoy the serene surroundings and local entertainment options that make this village a delightful stop on your vacation.

Things to do near Defiance

Defiance, Missouri, is perfect for outdoor and romantic getaways, offering a variety of activities like hiking on the scenic Defiance Studio Trail and enjoying the beautiful recreational areas. Visitors can immerse themselves in outdoor experiences and unwind with live music, making it an ideal destination for entertainment and adventure.

Shopping

In Defiance, you can enjoy local shops and boutiques offering unique gifts and souvenirs. If you're up for a drive, visit the nearby Mid Rivers Mall for a wider selection, including popular brands and specialty stores perfect for finding that special keepsake.

Recreation

Experience luxury at Bellerive Country Club, located 16 miles from Defiance. Enjoy world-class amenities, indulge in fine dining, and relax in a serene environment. Engage in recreational activities like golfing and spa treatments, perfect for rejuvenating your mind and body amidst beautiful surroundings.

Adventure

Defiance offers thrilling outdoor adventures, including kayaking along the scenic Missouri River, where you can explore its beautiful banks and wildlife. For hiking enthusiasts, the nearby Klondike Park features trails with stunning views and opportunities for birdwatching among native flora and fauna.

Nightlife

Defiance offers a charming nightlife with cozy bars like the Defiance Ridge Vineyards, where you can enjoy local wines. For a more social vibe, visit The Defiance House, featuring live music and a warm atmosphere perfect for mingling with locals.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Defiance

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Defiance are December to February, where the prices are slightly lower. This is in comparison to May to July, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Defiance is Monday. The most expensive day to stay in Defiance is Saturday.
  • Find cheap hotels on Expedia: Utilize Expedia's search tool to tailor your options based on your budget, desired location, and preferred hotel type. For instance, selecting the Eco-certified filter will highlight sustainable and eco-friendly hotels that are currently available. To find the best prices and deals, simply sort the price filter from low to high.
  • Consider bundling your trip: You can save money by combining your hotel reservations in Defiance with your flights and activities through an Expedia package deal.

Find the best attractions in and around Defiance

Defiance, Missouri, is perfect for outdoor enthusiasts and couples seeking a romantic getaway. Visitors can explore nearby attractions like state parks, urban parks, and amusement parks, offering a variety of experiences for families and city adventurers alike. Whether you're hiking scenic trails or enjoying thrilling rides, Defiance has something for everyone looking to unwind and enjoy the great outdoors.

  • August A. Busch Memorial Conservation Area: Explore this beautiful reserve located in Defiance, perfect for families and nature lovers. Enjoy walking trails, wildlife viewing, and engaging excursions that connect you with friendly locals and the great outdoors.
  • Six Flags St. Louis: Just 10 miles from Defiance, this thrilling amusement park offers a wide range of rides and attractions for all ages. Experience the excitement of roller coasters and live entertainment, making it a perfect destination for adventure seekers and families alike.
  • Purina Farms: Also situated 10 miles from Defiance, this charming farm features scenic views and interactive experiences with animals. Enjoy hands-on activities and learn about farm life, making it a delightful outing for visitors of all ages.

Best time to go to Defiance

The best time to visit Defiance can depend on the weather and when visitor numbers rise and fall. The hottest average temperature in Defiance falls in July, when visitor numbers are moderately high and weather is mostly sunny with light rain. The coolest average temperature in Defiance falls in January, visitor numbers are moderately low and weather is mostly cloudy with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January31.6°F (-0.2°C)Light RainMostly CloudyModerately LowSlightly Low
February34.7°F (1.5°C)Light RainMostly SunnyAverageSlightly Low
March46.4°F (8.0°C)Light RainMostly SunnyAverageAverage
April55.9°F (13.3°C)Light RainMostly SunnyModerately HighAverage
May66.2°F (19.0°C)Light RainMostly SunnyAverageSlightly High
June75.9°F (24.4°C)Light RainMostly SunnyAverageSlightly High
July79.0°F (26.1°C)Light RainMostly SunnyModerately HighSlightly High
August77.2°F (25.1°C)Light RainMostly SunnyAverageAverage
September70.9°F (21.6°C)Light RainMostly SunnyModerately HighAverage
October58.5°F (14.7°C)Light RainMostly SunnyAverageAverage
November46.2°F (7.9°C)Light RainMostly SunnyModerately LowAverage
December37.6°F (3.1°C)Light RainMostly SunnyModerately LowSlightly Low

The nearest major airports for your trip to Defiance

To reach Defiance, Missouri, the nearest major airport is St. Louis Lambert International Airport (STL), located 23 miles away. Recommended hotels nearby include The Ritz-Carlton, St. Louis and Ameristar Casino Resort and Spa, both 7 miles from the airport. Another option is The Royal Sonesta Chase Park Plaza St. Louis, situated 9 miles away. Columbia Regional Airport (COU) is 79 miles from Defiance, with good hotel choices like The Broadway Columbia and voco The Tiger Hotel, both 11 miles away. For those traveling to Fort Leonard Wood Regional Airport (TBN), located 97 miles away, Z Loft Extended Stay Hotel is a convenient option, just 6 miles from the airport.

Frequently asked questions

What is the best area to stay in Defiance?
The best area to stay in Defiance is the immediate vicinity of the Katy Trail State Park, particularly near the heart of the village. This area offers convenient access to Defiance's main attractions and outdoor activities.

The village of Defiance is small and picturesque, centered around its historic general store and a few local eateries. Hotels here are typically smaller, independently owned establishments or bed and breakfasts, providing a personalized experience. The Katy Trail, a popular walking and cycling path, runs directly through the village, making it an excellent base for outdoor enthusiasts.

Couples looking for a relaxing getaway will appreciate staying in this area. It's quiet and offers direct access to scenic walks and bike rides along the Missouri River.
When is the best time to go to Defiance?
The best time to visit Defiance is during the spring (April to June) and fall (September to October) months.

These seasons offer pleasant weather conditions, with comfortable temperatures that are ideal for outdoor activities like cycling or exploring the Katy Trail. In spring, the local vineyards begin to bloom, and in autumn, the changing leaves provide scenic views along the Missouri River. Traveling during these times also allows you to enjoy local events and festivals without the peak summer crowds.

For travelers looking to experience the region's natural beauty and participate in outdoor recreation, spring and fall provide the most agreeable climate.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Defiance.
How can I save on a Defiance hotel booking with Expedia?
With Expedia, you earn OneKeyCash™* on eligible Defiance hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Defiance hotel?
Prices for hotels in Defiance often vary, but you can find a great deal from $70 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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