Title: TOP 10 Hotels in Defiance, MO (from $71) - COMPETITIVE PRICES | Expedia.com

[Defiance Travel Guide](https://expedia.com/Defiance.dx6353634)[Vacation Rentals in Defiance](https://expedia.com/Defiance-Vacation-Rentals.d6353634.Travel-Guide-VacationRentals)[Flights to Defiance](https://expedia.com/Cheap-Flights-To-Defiance.d6353634.Travel-Guide-Flights)[Car Rentals in Defiance](https://expedia.com/Car-Rentals-In-Defiance.d6353634.Car-Rental-Guide)[Defiance Vacation Packages](https://expedia.com/Defiance.d6353634.Destination-Travel-Guides)

![A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri](https://images.trvl-media.com/place/6353634/33b2b915-0d1b-4946-ae10-3b89e88434a7.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6353634/33b2b915-0d1b-4946-ae10-3b89e88434a7.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Go beyond your typical stay in Defiance

Pet friendly

[](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-03-25&d1=2026-03-25&endDate=2026-03-27&d2=2026-03-27&amenities=PETS)

Family friendly

[](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-03-25&d1=2026-03-25&endDate=2026-03-27&d2=2026-03-27&travelerType=family_friendly)

Pool

[](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-03-25&d1=2026-03-25&endDate=2026-03-27&d2=2026-03-27&amenities=POOL)

Cabin

[](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-03-25&d1=2026-03-25&endDate=2026-03-27&d2=2026-03-27&lodging=CABIN)

Apart hotel

[](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-03-25&d1=2026-03-25&endDate=2026-03-27&d2=2026-03-27&lodging=APART_HOTEL)

Hot tub

[](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-03-25&d1=2026-03-25&endDate=2026-03-27&d2=2026-03-27&amenities=HOT_TUB)

Cottage

[](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-03-25&d1=2026-03-25&endDate=2026-03-27&d2=2026-03-27&lodging=COTTAGE)

Apart­ment

[](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-03-25&d1=2026-03-25&endDate=2026-03-27&d2=2026-03-27&lodging=APARTMENT)

Condo

[](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-03-25&d1=2026-03-25&endDate=2026-03-27&d2=2026-03-27&lodging=CONDO)

Waterpark

[](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-03-25&d1=2026-03-25&endDate=2026-03-27&d2=2026-03-27&amenities=WATER_PARK)

Chalet

[](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-03-25&d1=2026-03-25&endDate=2026-03-27&d2=2026-03-27&lodging=CHALET)

## Check prices for these dates

Tonight

[Mar 11 - Mar 12](https://www.expedia.com/Hotel-Search?regionId=6353634&startDate=2026-03-11&endDate=2026-03-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Mar 12 - Mar 13](https://www.expedia.com/Hotel-Search?regionId=6353634&startDate=2026-03-12&endDate=2026-03-13&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=6353634&startDate=2026-03-13&endDate=2026-03-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=6353634&startDate=2026-03-20&endDate=2026-03-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Defiance hotels

![Suite, 1 King Bed, Non Smoking (Upgraded) | In-room safe, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/860000/855500/855477/cc91e017.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/860000/855500/855477/5b621e3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/1000000/860000/855500/855477/390b6bf7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/860000/855500/855477/b0977ad8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham St. Clair MO

[](https://www.expedia.com/Washington-Hotels-Super-8-By-Wyndham-St-Clair-MO.h855477.Hotel-Information)

St. Clair

7.2/10

Good

(963 reviews)

"Room was okay, definitely not the best but good for the price. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mason

$65 nightly

$71 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/Washington-Hotels-Super-8-By-Wyndham-St-Clair-MO.h855477.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/2000000/1080000/1077200/1077183/3a1e3bea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/2000000/1080000/1077200/1077183/d4f404b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free full breakfast](https://images.trvl-media.com/lodging/2000000/1080000/1077200/1077183/70eb43b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, Multiple Beds, Non Smoking, Refrigerator & Microwave (with Sofabed) | Egyptian cotton sheets, premium bedding, pillowtop beds, desk](https://images.trvl-media.com/lodging/2000000/1080000/1077200/1077183/fecb1b2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Plus Washington Hotel

[](https://www.expedia.com/Washington-Hotels-Best-Western-Plus-Washington-Hotel.h1077183.Hotel-Information)

Washington

9.2/10

Wonderful

(664 reviews)

"Clean room and hotel with a nice breakfast, have stayed here two times while visiting family."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Brooks

$129 nightly

$147 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/Washington-Hotels-Best-Western-Plus-Washington-Hotel.h1077183.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489252/b1b83291.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, iron/ironing board, free cribs/infant beds, rollaway beds](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489252/f1837aa8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489252/0981c7c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free buffet breakfast](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489252/b8c4dabe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express Warrenton by IHG

[](https://www.expedia.com/Warrenton-Hotels-Holiday-Inn-Express-Warrenton.h1489252.Hotel-Information)

Warrenton

9.0/10

Wonderful

(526 reviews)

"Very helpful and friendly staff"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

TONY

$142 nightly

$162 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/Warrenton-Hotels-Holiday-Inn-Express-Warrenton.h1489252.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/670000/664500/664414/6093d918.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/670000/664500/664414/b493e570.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/670000/664500/664414/897465ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, Multiple Beds, Non Smoking (2 Queen, 2 Person Sofa Bed) | In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/670000/664500/664414/68f10652.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Comfort Suites St Charles - St Louis

[](https://www.expedia.com/St-Louis-Hotels-Comfort-Suites-St-Charles-St-Louis.h664414.Hotel-Information)

St. Charles

8.4/10

Very Good

(1,009 reviews)

"Great hotel for the money"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jere

$84 nightly

$97 total

Apr 5 - Apr 6

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Comfort-Suites-St-Charles-St-Louis.h664414.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/109000000/108930000/108922000/108921961/20625a7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/109000000/108930000/108922000/108921961/fadbec1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/109000000/108930000/108922000/108921961/aa17bcae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/109000000/108930000/108922000/108921961/e299ff16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### WoodSpring Suites St Peters-OFallon

[](https://www.expedia.com/St-Louis-Hotels-Woodspring-Suites-St-Peters-Ofallon.h108921961.Hotel-Information)

St. Peters

9.0/10

Wonderful

(49 reviews)

"Super clean , quiet place "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Phoenix

$91 nightly

$105 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Woodspring-Suites-St-Peters-Ofallon.h108921961.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/19000000/18760000/18754300/18754262/79d56802.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/19000000/18760000/18754300/18754262/25e461ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/19000000/18760000/18754300/18754262/7efb516b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/19000000/18760000/18754300/18754262/7f62e770.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Plaza Hotel St. Louis St. Charles

[](https://www.expedia.com/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-St-Charles.h18754262.Hotel-Information)

St. Charles

9.6/10

Exceptional

(1,000 reviews)

"Great hotel "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

John Christopher

$144 nightly

$167 total

Apr 3 - Apr 4

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-St-Charles.h18754262.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/2000000/1220000/1216300/1216259/9e4f56d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/2000000/1220000/1216300/1216259/2e3c4378.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Combined shower/tub, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/2000000/1220000/1216300/1216259/5d4de429.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Room, 1 King Bed, Non Smoking | In-room safe, iron/ironing board, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/2000000/1220000/1216300/1216259/82c13c9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Days Inn by Wyndham St Peters/St Charles

[](https://www.expedia.com/St-Louis-Hotels-Days-Inn-By-Wyndham-St-PetersSt-Charles.h1216259.Hotel-Information)

St. Peters

6.2/10

(1,000 reviews)

"Room was excellent and clean"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

catherine

$67 nightly

$77 total

Mar 22 - Mar 23

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Days-Inn-By-Wyndham-St-PetersSt-Charles.h1216259.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16300/16210/55269a5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16300/16210/34f8e499.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16300/16210/2adbd684.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Egyptian cotton sheets, premium bedding, pillowtop beds, desk](https://images.trvl-media.com/lodging/1000000/20000/16300/16210/140ce6ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Inn Foristell

[](https://www.expedia.com/Warrenton-Hotels-Quality-Inn.h16210.Hotel-Information)

Foristell

8.2/10

Very Good

(949 reviews)

"Clean rooms, pleasant staff."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Karen

$68 nightly

$77 total

Mar 22 - Mar 23

Total with taxes and fees

[](https://www.expedia.com/Warrenton-Hotels-Quality-Inn.h16210.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/2000000/1140000/1131200/1131105/ac68aac2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1140000/1131200/1131105/aa7a61ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/2000000/1140000/1131200/1131105/eaba7c94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/2000000/1140000/1131200/1131105/c8753b6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Embassy Suites by Hilton St. Louis St. Charles

[](https://www.expedia.com/St-Louis-Hotels-Embassy-Suites-St-Louis-St-Charles.h1131105.Hotel-Information)

St. Charles

8.8/10

Excellent

(1,000 reviews)

"A beautiful hotel. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jon Michael

$122 nightly

$140 total

Apr 5 - Apr 6

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Embassy-Suites-St-Louis-St-Charles.h1131105.Hotel-Information)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/70000000/69650000/69646200/69646123/353d0132.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, free cribs/infant beds, free rollaway beds](https://images.trvl-media.com/lodging/70000000/69650000/69646200/69646123/8bd53911.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/70000000/69650000/69646200/69646123/9481c58b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/70000000/69650000/69646200/69646123/d84a6664.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn & Suites St. Charles Old Town Area

[](https://www.expedia.com/St-Louis-Hotels-Hampton-Inn-Suites-St-Charles-Old-Town-Area.h69646123.Hotel-Information)

St. Charles

9.0/10

Wonderful

(662 reviews)

"Pleasant staff and clean room"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Michele

$114 nightly

$137 total

Apr 5 - Apr 6

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Hampton-Inn-Suites-St-Charles-Old-Town-Area.h69646123.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/460000/459500/459418/ff1a33b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/1000000/460000/459500/459418/0e791573.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Studio Suite, 1 King Bed, Non Smoking | In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/460000/459500/459418/6adb4ce9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Laundry room](https://images.trvl-media.com/lodging/1000000/460000/459500/459418/8d84cb6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham Washington

[](https://www.expedia.com/Washington-Hotels-Super-8-By-Wyndham-Washington.h459418.Hotel-Information)

Washington

8.4/10

Very Good

(710 reviews)

"The staff was extremely nice & accommodating."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Brenda

$83 nightly

$94 total

Mar 24 - Mar 25

Total with taxes and fees

[](https://www.expedia.com/Washington-Hotels-Super-8-By-Wyndham-Washington.h459418.Hotel-Information)

![Family Studio Suite (No Elevator Access) | Egyptian cotton sheets, premium bedding, down comforters, pillowtop beds](https://images.trvl-media.com/lodging/56000000/55080000/55078500/55078446/031df354.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Staircase](https://images.trvl-media.com/lodging/56000000/55080000/55078500/55078446/2af789de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/56000000/55080000/55078500/55078446/72d412b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Studio Suite (No Elevator Access) | Egyptian cotton sheets, premium bedding, down comforters, pillowtop beds](https://images.trvl-media.com/lodging/56000000/55080000/55078500/55078446/0b0d1f69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### River Sirens Hotel

[](https://www.expedia.com/Washington-Hotels-Sirens-Hotel.h55078446.Hotel-Information)

Washington

9.8/10

Exceptional

(191 reviews)

"The room was amazing!!! Would definitely stay again "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Katharine

$130 nightly

$148 total

Mar 12 - Mar 13

Total with taxes and fees

[](https://www.expedia.com/Washington-Hotels-Sirens-Hotel.h55078446.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/36000000/35850000/35848800/35848753/d38dcff4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/36000000/35850000/35848800/35848753/660bdaf5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, open 9:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/36000000/35850000/35848800/35848753/ac681623.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/36000000/35850000/35848800/35848753/da587b35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Wentzville St Louis West by IHG

[](https://www.expedia.com/St-Louis-Hotels-Holiday-Inn-Express-Suites-Wentzville-St-Louis-West.h35848753.Hotel-Information)

Wentzville

9.4/10

Exceptional

(876 reviews)

"Beautiful hotel, friendly staff, good breakfast."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Erika

$135 nightly

$161 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Holiday-Inn-Express-Suites-Wentzville-St-Louis-West.h35848753.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/210000/202300/202216/f60ef45e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/1000000/210000/202300/202216/639e641e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![BBQ/picnic area](https://images.trvl-media.com/lodging/1000000/210000/202300/202216/744b055b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 2 Bedrooms | Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/1000000/210000/202300/202216/393e7ccb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Candlewood Suites St Louis St Charles by IHG

[](https://www.expedia.com/St-Louis-Hotels-Towneplace-Suites-By-Marriott-St-Charles.h202216.Hotel-Information)

St. Charles

7.6/10

Good

(786 reviews)

"The staff was very professional and the room was clean. I will definitely book here again"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Ngozi

$84 nightly

$97 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Towneplace-Suites-By-Marriott-St-Charles.h202216.Hotel-Information)

![Lobby lounge](https://images.trvl-media.com/lodging/7000000/6580000/6575600/6575600/665da1a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/7000000/6580000/6575600/6575600/70696573.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/7000000/6580000/6575600/6575600/9b53533a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free continental breakfast](https://images.trvl-media.com/lodging/7000000/6580000/6575600/6575600/9c369e33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fairfield Inn & Suites Wentzville

[](https://www.expedia.com/Wentzville-Hotels-Fairfield-Inn-Suites-Wentzville.h6575600.Hotel-Information)

Wentzville

9.0/10

Wonderful

(659 reviews)

"Hotel staff was friendly and room was very clean "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Danielle

$132 nightly

$152 total

Mar 29 - Mar 30

Total with taxes and fees

[](https://www.expedia.com/Wentzville-Hotels-Fairfield-Inn-Suites-Wentzville.h6575600.Hotel-Information)

![In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/101000000/100830000/100826500/100826413/27c1cd34.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/101000000/100830000/100826500/100826413/c331ca7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/101000000/100830000/100826500/100826413/8219ef4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby lounge](https://images.trvl-media.com/lodging/101000000/100830000/100826500/100826413/270bcbee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### TownePlace Suites by Marriott Wentzville

[](https://www.expedia.com/St-Louis-Hotels-Towneplace-Suites-By-Marriott-Wentzville.h100826413.Hotel-Information)

Wentzville

9.4/10

Exceptional

(50 reviews)

"Clean room and the suite was nice. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Elizabeth

$150 nightly

$172 total

Apr 3 - Apr 4

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Towneplace-Suites-By-Marriott-Wentzville.h100826413.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/2000000/1340000/1330400/1330309/001d26f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/2000000/1340000/1330400/1330309/ad6cce96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/2000000/1340000/1330400/1330309/254f5b60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/2000000/1340000/1330400/1330309/0036679a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Country Inn & Suites by Radisson, St. Charles Historic District

[](https://www.expedia.com/St-Louis-Hotels-Country-Inn-Suites-By-Radisson.h1330309.Hotel-Information)

St. Charles Historic District

9.4/10

Exceptional

(1,001 reviews)

"Wonderful place staff awesome "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Chad

$116 nightly

$133 total

Apr 5 - Apr 6

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Country-Inn-Suites-By-Radisson.h1330309.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/10100/10074/b34d85ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, laptop workspace, soundproofing, iron/ironing board](https://images.trvl-media.com/lodging/1000000/20000/10100/10074/d5af958a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Business center](https://images.trvl-media.com/lodging/1000000/20000/10100/10074/58b9b7e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/10100/10074/c8120022.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Inn Near Six Flags St. Louis

[](https://www.expedia.com/Pacific-Hotels-Quality-Inn-Near-Six-Flags-St-Louis.h10074.Hotel-Information)

Pacific

8.4/10

Very Good

(366 reviews)

"Excellent staff & very clean room"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Karen

$99 nightly

$113 total

Mar 12 - Mar 13

Total with taxes and fees

[](https://www.expedia.com/Pacific-Hotels-Quality-Inn-Near-Six-Flags-St-Louis.h10074.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/23000000/22520000/22514800/22514757/ee03821d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/23000000/22520000/22514800/22514757/ca22fdb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/23000000/22520000/22514800/22514757/6809d9b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Queen Beds, Accessible, Bathtub | In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/23000000/22520000/22514800/22514757/ab3b2d8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Tru by Hilton St. Charles St. Louis, MO

[](https://www.expedia.com/St-Louis-Hotels-Tru-By-Hilton-St-Charles-St-Louis.h22514757.Hotel-Information)

St. Charles

8.6/10

Excellent

(801 reviews)

"Clean, great breakfast options."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kristy

$114 nightly

$132 total

Mar 22 - Mar 23

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Tru-By-Hilton-St-Charles-St-Louis.h22514757.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/1000000/30000/24200/24101/930f8b1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/24200/24101/w3997h2667x0y0-ed67d4f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Studio, Multiple Beds | Desk, iron/ironing board, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/1000000/30000/24200/24101/da5fdac7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby lounge](https://images.trvl-media.com/lodging/1000000/30000/24200/24101/959ce0c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Courtyard by Marriott St. Louis St. Peters

[](https://www.expedia.com/St-Louis-Hotels-Courtyard-By-Marriott-St-Louis-St-Peters.h24101.Hotel-Information)

St. Peters

9.0/10

Wonderful

(685 reviews)

"Clean spacious room, friendly staff, provided extra pillows upon request. Easy check in and check out! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Renee

$110 nightly

$131 total

Mar 22 - Mar 23

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Courtyard-By-Marriott-St-Louis-St-Peters.h24101.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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## 

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.

[Book now](https://expedia.com/deals?rfrr=HTG_SPRING_PROMO_6353634)

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Save an average of 15% on thousands of hotels when you're signed in

[Sign in

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## Stay near popular Defiance attractions

![Missouri wineries have some of the most superb wine we've ever tasted! We recommend sipping on some chambourcin while basking in the sunshine. ](https://images.trvl-media.com/place/553248621532648567/f82f9409-75a2-47f3-a8fc-2d7c278cc07c.jpg)

Photo by Pages of Travel

### Chandler Hill Vineyards

This elegant Missouri winery showcases local and California wines from its hillside setting. Savor varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen. 

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532648567)

![Wetlands landscape with a bird blind and cloudy sky reflected in a lake at the August A. Busch Memorial Conservation Area in St. Charles County Missouri](https://images.trvl-media.com/place/6160337/5138d652-49fb-41de-8fd4-a7bb27471f3e.jpg)

### August A. Busch Memorial Conservation Area

This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment. 

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6160337)

### Historic Daniel Boone Home and Heritage Center

Step into the limestone home where Daniel Boone's son Nathan crafted a frontier masterpiece with seven fireplaces. Explore the surrounding historic village for an authentic glimpse into 19th-century pioneer life. 

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532648566)

### Sugar Creek Winery

Sip award-winning Missouri wines at this hillside vineyard along the scenic Katy Trail. Relax on covered decks with your own picnic while enjoying live weekend music and panoramic countryside views. 

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532648612)

### Matson Hill Park Trailhead

Wander through 475 acres of rugged forest terrain with challenging hiking paths and gravity-flow mountain bike trails. The historic 1830s Hays Home offers a glimpse into pioneer life amid the natural splendor. 

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=641530089696399360)

### Yellow Farmhouse Winery

This boutique winery in Defiance, Missouri was known for its distinctive unfiltered wines and relaxed atmosphere. Visitors could enjoy tastings with live music while picnicking on scenic grounds with vineyard views. 

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532648568)

### Broemmelsiek Park

This 494-acre natural playground offers nine miles of trails through forests and around serene lakes. Attend a monthly stargazing event at the astronomy viewing area for a uniquely celestial park experience. 

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621561876810)

### Hamburg Trail Trailhead

This moderate 6.9-mile loop winds through the scenic Weldon Spring Conservation Area, connecting to the Katy Trail State Park. Spot native wildlife while traversing diverse landscapes of shaded woodlands and open fields. 

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=641529175733194752)

## Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

[See all hotels in Defiance](https://www.expedia.com/Hotel-Search?startDate=2026-03-25&endDate=2026-03-26&adults=2&regionId=6353634)

![A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri](https://images.trvl-media.com/place/6353634/33b2b915-0d1b-4946-ae10-3b89e88434a7.jpg?impolicy=fcrop&w=900&h=600&p=1&q=high)

## Top Defiance Hotel Reviews

![The Wildwood Hotel](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/035dee6c_y.jpg)

### The Wildwood Hotel

10/10 Excellent

"I picked this hotel because it was right in the middle of town easy to get everywhere I need to go. Very comfortable beds and pillows! Loved the shower also. Nice quiet stay. Didn't use any amenities but everything looked fine. . Room had a mini fridge and a microwave. I will return next trip."

[](https://expedia.com/St-Louis-Hotels-The-Wildwood-Hotel.h1768149.Hotel-Information)

![Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham](https://images.trvl-media.com/lodging/1000000/50000/42200/42122/b53f4594_y.jpg)

### Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

2/10 Terrible

"Wyndham rewards member was escorted off this property BY POLICE for reasons still unknown to me. They had a full turn out in the pool/sauna area, but ran out of towels at some point. They give 2 body towels for the rooms, no separate towels for the pool. A SOLD OUT HOTEL ran out of towels and no back up. I was upset but i didn't curse "Skye" and I didn't get aggressive. Yet i was told to leave and didn’t get my money back. I would like a full refund as we DID NOT stay here."

[](https://expedia.com/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Fenton.h42122.Hotel-Information)

![Drury Plaza Hotel St. Louis Chesterfield](https://images.trvl-media.com/lodging/2000000/1350000/1346800/1346760/69d580ec_y.jpg)

### Drury Plaza Hotel St. Louis Chesterfield

10/10 Excellent

"It’s a great place very happy!"

[](https://expedia.com/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-Chesterfield.h1346760.Hotel-Information)

![Drury Plaza Hotel St. Louis Creve Coeur](https://images.trvl-media.com/lodging/1000000/80000/74700/74657/b9326e72_y.jpg)

### Drury Plaza Hotel St. Louis Creve Coeur

10/10 Excellent

"We stayed because my husband had surgery and the rate was good and it was a comfortable stay. We would definitely stay again!"

[](https://expedia.com/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Creve-Coeur.h74657.Hotel-Information)

![Hollywood Casino & Hotel St. Louis](https://images.trvl-media.com/lodging/1000000/90000/82600/82568/76ca3207_y.jpg)

### Hollywood Casino & Hotel St. Louis

10/10 Excellent

"Only complaint is that we’re in 2026 and the tvs don’t come with Netflix "

[](https://expedia.com/St-Louis-Hotels-Hollywood-Casino-Hotel-St-Louis.h82568.Hotel-Information)

![Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West](https://images.trvl-media.com/lodging/2000000/1660000/1659000/1658956/a165f739_y.jpg)

### Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

6/10 Okay

"Had a long ottoman out in the living room that looked like people had had sex on it multiple times. Stains on the edges of both ends not like a spill. Chairs in the dining area had many stains in the cloth. "

[](https://expedia.com/St-Louis-Hotels-Larkspur-Landing-Extended-Stay-Suites-St-Louis-Riverport-Airport-West.h1658956.Hotel-Information)

![Comfort Suites St Charles - St Louis](https://images.trvl-media.com/lodging/1000000/670000/664500/664414/6093d918_y.jpg)

### Comfort Suites St Charles - St Louis

10/10 Excellent

"Yes "

[](https://expedia.com/St-Louis-Hotels-Comfort-Suites-St-Charles-St-Louis.h664414.Hotel-Information)

![Country Inn & Suites by Radisson, St. Charles Historic District](https://images.trvl-media.com/lodging/2000000/1340000/1330400/1330309/001d26f2_y.jpg)

### Country Inn & Suites by Radisson, St. Charles Historic District

10/10 Excellent

"Clean room"

[](https://expedia.com/St-Louis-Hotels-Country-Inn-Suites-By-Radisson.h1330309.Hotel-Information)

![Drury Inn & Suites Southwest St. Louis](https://images.trvl-media.com/lodging/1000000/980000/976200/976140/416a6a90_y.jpg)

### Drury Inn & Suites Southwest St. Louis

10/10 Excellent

"We did not get to enjoy the pool but breakfast was good, room was clean and we enjoyed our stay. "

[](https://expedia.com/St-Louis-Hotels-Drury-Inn-Suites-Southwest-St-Louis.h976140.Hotel-Information)

## More cheap stays in Defiance

![Relax Inn Saint Charles ](https://images.trvl-media.com/lodging/2000000/1010000/1000800/1000712/49b4298c_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Relax Inn Saint Charles 

3800 Harry S Truman Blvd St. Charles MO

$71 total

per night

Mar 18 - Mar 19

6.8/10 (1,000 reviews)

[](https://expedia.com/St-Louis-Hotels-Relax-Inn-Saint-Charles.h1000712.Hotel-Information)

![Days Inn and Suites by Wyndham St. Louis/Westport Plaza](https://images.trvl-media.com/lodging/1000000/60000/55200/55161/40483d14_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Days Inn and Suites by Wyndham St. Louis/Westport Plaza

1970 Craig Rd Maryland Heights MO

$75 total

per night

Mar 15 - Mar 16

4.6/10 (1,007 reviews)

[](https://expedia.com/St-Louis-Hotels-Days-Inn-And-Suites-By-Wyndham-St-LouisWestport-Plaza.h55161.Hotel-Information)

![Best Western Plus St. Louis West-Westport](https://images.trvl-media.com/lodging/1000000/50000/41500/41448/00255b25_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Best Western Plus St. Louis West-Westport

12220 Dorsett Rd Maryland Heights MO

$92 total

per night

Apr 5 - Apr 6

8/10 Very Good! (1,054 reviews)

[](https://expedia.com/St-Louis-Hotels-Best-Western-Plus-St-Louis-West-Westport.h41448.Hotel-Information)

![Comfort Suites St Charles - St Louis](https://images.trvl-media.com/lodging/1000000/670000/664500/664414/6093d918_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Comfort Suites St Charles - St Louis

1400 S 5th St St. Charles MO

$100 total

per night

Apr 5 - Apr 6

8.4/10 Very Good! (1,009 reviews)

[](https://expedia.com/St-Louis-Hotels-Comfort-Suites-St-Charles-St-Louis.h664414.Hotel-Information)

![Hampton Inn St. Charles St. Peters](https://images.trvl-media.com/lodging/1000000/30000/20200/20181/1d22ac52_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Hampton Inn St. Charles St. Peters

3720 W Clay St St. Charles MO

$116 total

per night

Apr 5 - Apr 6

8/10 Very Good! (1,000 reviews)

[](https://expedia.com/St-Louis-Hotels-Hampton-Inn-St-LouisSt-Charles.h20181.Hotel-Information)

![Country Inn & Suites by Radisson, St. Charles Historic District](https://images.trvl-media.com/lodging/2000000/1340000/1330400/1330309/001d26f2_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Country Inn & Suites by Radisson, St. Charles Historic District

1190 S Main St St. Charles MO

$133 total

per night

Apr 5 - Apr 6

9.4/10 Exceptional! (1,001 reviews)

[](https://expedia.com/St-Louis-Hotels-Country-Inn-Suites-By-Radisson.h1330309.Hotel-Information)

## Hotels in Defiance with star-rating

![4 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/23700/23677/6ae928dd_z.jpg)

4 Star Hotels

7 properties

[](https://expedia.com/4Star-Defiance-Hotels.s40-0-d6353634.Travel-Guide-Filter-Hotels)

![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg)

3 Star Hotels

114 properties

[](https://expedia.com/3Star-Defiance-Hotels.s30-0-d6353634.Travel-Guide-Filter-Hotels)

![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg)

2 Star Hotels

156 properties

[](https://expedia.com/2Star-Defiance-Hotels.s20-0-d6353634.Travel-Guide-Filter-Hotels)

## Find out more about Defiance

### Top reasons to visit Defiance

- **Outdoor Adventures:**  Defiance offers scenic recreational areas with hiking trails, perfect for nature enthusiasts.
- **Charming Downtown:**  Stroll through downtown Defiance, featuring charming shops and local eateries that embody small-town charm.
- **Family-Friendly Attractions:**  Enjoy a mix of state parks and amusement parks, catering to family fun and entertainment.
- **Romantic Escapes:**  Ideal for couples seeking peaceful retreats and memorable outdoor experiences.
- **Diverse Accommodations:**  A variety of inviting hotels, including pet-friendly and LGBTQIA-welcoming options, enhance your stay.

### Find great hotels near Defiance

Discover a range of inviting hotel accommodations in Defiance, Missouri, perfect for every type of traveler. Whether you're seeking business-friendly amenities, pet-friendly options, or an LGBTQIA-welcoming atmosphere, you'll find a variety of choices to enhance your stay. Explore the top hotels and available options that ensure a memorable vacation experience in this charming destination.

- **[Sonesta ES Suites St. Louis - Chesterfield: ](https://www.expedia.com/St-Louis-Hotels-Sonesta-ES-Suites-St-Louis-Chesterfield.h422.Hotel-Information)** This welcoming 3-star hotel is an ideal choice for pet lovers looking to explore the charming region of Defiance. Located 12 miles away, Sonesta ES Suites offers a home-like atmosphere with spacious suites featuring full kitchens, making it perfect for extended stays. The pet-friendly policy allows for a worry-free experience, as pets are permitted with certain restrictions. Guests appreciate the complimentary amenities, including free breakfast, Wi-Fi, and access to on-site fitness facilities. With a warm and inviting environment, this hotel ensures a comfortable and enjoyable vacation for both you and your furry friends.
- **[The Wildwood Hotel: ](https://www.expedia.com/St-Louis-Hotels-The-Wildwood-Hotel.h1768149.Hotel-Information)** A unique blend of nature and business, The Wildwood Hotel is a stylish 3.5-star lodging located 9 miles from Defiance. This stunning hotel is perfect for nature enthusiasts and business travelers alike, offering a serene escape with its rustic decor and lush surroundings. With a range of business amenities such as a 24-hour business center and multiple meeting rooms, this hotel caters to corporate needs while providing a tranquil retreat. The pet-friendly policy allows guests to bring their four-legged companions along, ensuring a memorable stay surrounded by nature's beauty.
- **[Hyatt Place St. Louis/Chesterfield: ](https://www.expedia.com/St-Louis-Hotels-Hyatt-Place-St-LouisChesterfield.h6583788.Hotel-Information)** This family-friendly 3-star hotel, situated 12 miles from Defiance, is a perfect choice for travelers looking for comfort and convenience. Hyatt Place St. Louis/Chesterfield features spacious rooms equipped with modern amenities and offers a variety of services for business guests, including a 24-hour business center and flexible meeting spaces. Families will appreciate the kid-friendly services, while pet owners can enjoy a welcoming atmosphere for their dogs. With complimentary breakfast and a convenient location, this hotel promises a delightful and hassle-free stay for all.

### Where to stay near Defiance

Defiance, Missouri, offers a delightful blend of outdoor adventures and romantic escapes, perfect for any traveler. Stroll through downtown Defiance, where charming shops and local eateries await. Enjoy leisurely walks that showcase the area's historical vibes and family-friendly atmosphere. Whether you're seeking a relaxing break or an adventurous outing, Defiance and its nearby regions promise memorable experiences that capture the essence of small-town charm and community spirit.

- **[Chesterfield: ](https://www.expedia.com/Chesterfield-Hotels.d9530.Travel-Guide-Hotels)** Located 12 miles from Defiance, Chesterfield is a vibrant city that offers a delightful mix of family-friendly entertainment and urban experiences. Known for its seasonal visitor peaks in April and from June to July, Chesterfield boasts attractions such as an arcade adventure zone, a local theater, and a bustling amusement park. The area is also home to a variety of popular landmarks, including a theme park and a stadium, making it an ideal destination for those seeking a fun-filled getaway.
- **[O'Fallon: ](https://www.expedia.com/OFallon-Hotels.d140195.Travel-Guide-Hotels)** Situated 13 miles away from Defiance, O'Fallon is another great city perfect for family outings and outdoor adventures. Like Chesterfield, O'Fallon sees a surge in visitors around April and during the summer months. The city features an array of entertainment options, including an arena entertainment facility, an arcade adventure zone, and a shopping mall center. With its urban parks and sports facilities, O'Fallon offers a dynamic blend of relaxation and excitement for visitors of all ages.
- **[Saint Albans: ](https://www.expedia.com/Saint-Albans-Hotels.d3000445473.Travel-Guide-Hotels)** Just 4 miles from Defiance, Saint Albans is a charming city that invites travelers to immerse themselves in outdoor adventures and family activities. Peak tourist seasons occur in April, July, and September, with visitors drawn to attractions like an arcade adventure zone, an amusement park, and a shopping center. The area is also notable for its scenic landmarks, including a beautiful lake and a convention center, making it a picturesque spot for both relaxation and exploration.

### Things to do in and around Defiance

Defiance, Missouri, is perfect for a romantic and adventurous getaway, offering a range of outdoor activities for an unforgettable experience. You can explore its scenic recreational areas, enjoy the hiking trails, and immerse yourself in nature. Whether you're looking for a peaceful retreat or an active vacation, Defiance provides the ideal backdrop for memorable moments in the great outdoors.

**Shopping**

The nearest shopping destination is [St. Louis Premium Outlets](https://www.expedia.com/St-Louis-Premium-Outlets-Hotels.0-l553248621561876860-0.Travel-Guide-Filter-Hotels), located 7 miles away, offering a variety of entertainment, shopping, and family-friendly vibes. If you're up for a drive, check out [Taubman Prestige Outlets](https://www.expedia.com/Taubman-Prestige-Outlets-Hotels.0-l553248621561876633-0.Travel-Guide-Filter-Hotels), 10 miles away, or the [Wentzville Flea Market](https://www.expedia.com/Wentzville-Flea-Market-Hotels.0-l553248621561876812-0.Travel-Guide-Filter-Hotels), 13 miles away, for unique finds.

**Recreation**

Catch a live show at [The Factory](https://www.expedia.com/The-Factory-Hotels.0-l769870834915799040-0.Travel-Guide-Filter-Hotels) for vibrant entertainment just 10 miles from Defiance. Enjoy a round of golf at [Missouri Bluffs Golf Course](https://www.expedia.com/Missouri-Bluffs-Golf-Course-Hotels.0-l553248621532648614-0.Travel-Guide-Filter-Hotels), surrounded by scenic landscapes, located 7 miles away. For relaxation, unwind at [Broemmelsiek Park](https://www.expedia.com/Broemmelsiek-Park-Hotels.0-l553248621561876810-0.Travel-Guide-Filter-Hotels), where wellness and tranquility await right in Defiance.

**Adventure**

At [Hidden Valley Ski Resort](https://www.expedia.com/Hidden-Valley-Ski-Resort-Hotels.0-l553248621592827639-0.Travel-Guide-Filter-Hotels), located 9 miles from Defiance, enjoy thrilling skiing adventures amid beautiful snowy landscapes. [Hurricane Harbor](https://www.expedia.com/Hurricane-Harbor-Hotels.0-l553248621532648581-0.Travel-Guide-Filter-Hotels), 10 miles away, offers water-based fun with slides and attractions perfect for family entertainment. Explore the scenic Matson Hill Park Trailhead right in Defiance for hiking and outdoor experiences.

**Nightlife**

Experience the excitement at [Chesterfield Sports Fusion](https://www.expedia.com/Chesterfield-Sports-Fusion-Hotels.0-l553248621532648590-0.Travel-Guide-Filter-Hotels), an arcade adventure zone 9 miles from Defiance. For a cultural night out, catch a show at the [New Jewish Theatre](https://www.expedia.com/New-Jewish-Theatre-Hotels.0-l553248621561876895-0.Travel-Guide-Filter-Hotels), 20 miles away. Don't miss Sky Zone Indoor Trampoline Park, an adventure zone 10 miles from Defiance for a fun evening.

\*Distances are measured in a straight line; actual driving distances may vary depending on the route.

### Booking tips and Expedia advantages for Defiance

To save money on your trip to Defiance, Missouri, consider visiting during the off-peak months of December to February, when prices are lower. Booking your stay on a Monday can also help you save, as Saturday is the most expensive day. Use Expedia to compare hotel prices, and consider booking a package that includes flights and activities for better deals. Joining Expedia's One Key membership can unlock exclusive discounts and allow you to earn rewards for future bookings. Look for free activities in the area to enhance your travel experience without breaking the bank.

- **The most and least expensive months on average to stay in a hotel:**  The cheapest months to stay in Defiance are December to February, where the prices are slightly lower. This is in comparison to May to July, where prices are slightly higher.
- **The most and least expensive days on average to stay in a hotel:**  The least expensive day to stay in Defiance is Monday. The most expensive day to stay in Defiance is Saturday.
- **Find cheap hotels on Expedia:**  Utilize Expedia's search tool to narrow down your options based on your budget, desired location, and preferred hotel type. To find the best prices and deals, simply arrange the price filter from lowest to highest.
- **Consider bundling your trip:**  You can save money by booking a package with Expedia that combines your Defiance hotel with flights and activities.
- **Become a One Key member:**  Join [Expedia's One Key membership](https://www.expedia.com/welcome-one-key) program for exclusive discounts and deals on hotel bookings. You can also earn OneKeyCash to use on future selected hotels.

### Find the best attractions in and around Defiance

Defiance, Missouri, offers a delightful mix of outdoor adventures and romantic escapes. Visitors can explore local attractions such as state and urban parks, as well as amusement parks, perfect for family fun. Whether you're seeking a nature hike, a thrilling ride, or a peaceful picnic, Defiance caters to travelers looking for both city experiences and serene landscapes, making it an ideal destination for entertainment-themed vacations.

- **[Six Flags St. Louis: ](https://www.expedia.com/Six-Flags-St-Louis-Hotels.0-l6147083-0.Travel-Guide-Filter-Hotels)** Experience the thrill of exhilarating rides and family-friendly entertainment at this vibrant amusement park, located 10 miles from Defiance. With a variety of attractions, it offers an adventurous atmosphere perfect for creating lasting memories.
- **[August A. Busch Memorial Conservation Area: ](https://www.expedia.com/August-A-Busch-Memorial-Conservation-Area-Hotels.0-l6160337-0.Travel-Guide-Filter-Hotels)** Nestled within Defiance, this beautiful reserve features scenic trails and friendly wildlife. It's an ideal spot for family outings and excursions, making it a perfect place to enjoy nature and connect with the outdoors.
- **[Purina Farms: ](https://www.expedia.com/Purina-Farms-Hotels.0-l553248621532648557-0.Travel-Guide-Filter-Hotels)** Located 10 miles away, this charming farm showcases beautiful scenery and offers interactive experiences with animals. It’s a delightful destination for animal lovers and families looking to enjoy a relaxing day in the countryside.

### Best time to go to Defiance

The best time to visit Defiance is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are moderately high and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are moderately low and weather is mostly cloudy with light rain. 

| **![calendar](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/calendar.png)Calendar Month** | **![temperature](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__hot.png)Temperature** | **![rain](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__rain.png)Precipitation** | **![mostly](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/weather__day_mostly_cloudy.png)Cloudiness** | **![occupation](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/peoplebex.png)Occupancy** | **![price](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/currency_dollar.png)Pricing** |
| ---------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------------------------------------------- | ------------------------------------------------------------------------------------------------------------- |
| January                                                                                                          | 31.6°F (-0.2°C)                                                                                                      | Light Rain                                                                                                       | Mostly Cloudy                                                                                                                | Moderately Low                                                                                                 | Slightly Low                                                                                                  |
| February                                                                                                         | 34.7°F (1.5°C)                                                                                                       | Light Rain                                                                                                       | Mostly Sunny                                                                                                                 | Average                                                                                                        | Slightly Low                                                                                                  |
| March                                                                                                            | 46.4°F (8.0°C)                                                                                                       | Light Rain                                                                                                       | Mostly Sunny                                                                                                                 | Average                                                                                                        | Average                                                                                                       |
| April                                                                                                            | 55.9°F (13.3°C)                                                                                                      | Light Rain                                                                                                       | Mostly Sunny                                                                                                                 | Moderately High                                                                                                | Average                                                                                                       |
| May                                                                                                              | 66.2°F (19.0°C)                                                                                                      | Light Rain                                                                                                       | Mostly Sunny                                                                                                                 | Average                                                                                                        | Slightly High                                                                                                 |
| June                                                                                                             | 75.9°F (24.4°C)                                                                                                      | Light Rain                                                                                                       | Mostly Sunny                                                                                                                 | Average                                                                                                        | Slightly High                                                                                                 |
| July                                                                                                             | 79.0°F (26.1°C)                                                                                                      | Light Rain                                                                                                       | Mostly Sunny                                                                                                                 | Moderately High                                                                                                | Slightly High                                                                                                 |
| August                                                                                                           | 77.2°F (25.1°C)                                                                                                      | Light Rain                                                                                                       | Mostly Sunny                                                                                                                 | Average                                                                                                        | Average                                                                                                       |
| September                                                                                                        | 70.9°F (21.6°C)                                                                                                      | Light Rain                                                                                                       | Mostly Sunny                                                                                                                 | Moderately High                                                                                                | Average                                                                                                       |
| October                                                                                                          | 58.5°F (14.7°C)                                                                                                      | Light Rain                                                                                                       | Mostly Sunny                                                                                                                 | Average                                                                                                        | Average                                                                                                       |
| November                                                                                                         | 46.2°F (7.9°C)                                                                                                       | Light Rain                                                                                                       | Mostly Sunny                                                                                                                 | Moderately Low                                                                                                 | Average                                                                                                       |
| December                                                                                                         | 37.6°F (3.1°C)                                                                                                       | Light Rain                                                                                                       | Mostly Sunny                                                                                                                 | Moderately Low                                                                                                 | Slightly Low                                                                                                  |

### The nearest major airports for your trip to Defiance

When visiting Defiance, Missouri, you have convenient access to two major airports. St. Louis Lambert International Airport ([STL](https://www.expedia.com/Lambert-St-Louis-Intl-Airport-Hotels.0-aSTL-0.Travel-Guide-Filter-Hotels)) is approximately 23 miles away and offers a variety of nearby hotels, including the 5-star Ritz-Carlton, St. Louis, and the 4.5-star Royal Sonesta Chase Park Plaza, both within 9 miles. The Spirit of St. Louis Airport ([SUS](https://www.expedia.com/Spirit-Of-St-Louis-Airport-Hotels.0-aSUS-0.Travel-Guide-Filter-Hotels)) is closer at about 7 miles from Defiance, with excellent accommodations such as the 4-star [DoubleTree by Hilton Hotel St. Louis - Chesterfield](https://www.expedia.com/St-Louis-Hotels-DoubleTree-By-Hilton-Hotel-St-Louis-Chesterfield.h3258.Hotel-Information) just 4 miles away. These hotels provide easy transportation options to both airports, ensuring a smooth start to your vacation.

## Frequently asked questions

### What is the best area to stay in Defiance?

> The village of Defiance is small and picturesque, centered around its historic general store and a few local eateries. Hotels here are typically smaller, independently owned establishments or bed and breakfasts, providing a personalized experience. The Katy Trail, a popular walking and cycling path, runs directly through the village, making it an excellent base for outdoor enthusiasts.
> 
>   
> Couples looking for a relaxing getaway will appreciate staying in this area. It's quiet and offers direct access to scenic walks and bike rides along the Missouri River.

### When is the best time to go to Defiance?

> These seasons offer pleasant weather conditions, with comfortable temperatures that are ideal for outdoor activities like cycling or exploring the Katy Trail. In spring, the local vineyards begin to bloom, and in autumn, the changing leaves provide scenic views along the Missouri River. Traveling during these times also allows you to enjoy local events and festivals without the peak summer crowds.
> 
>   
> For travelers looking to experience the region's natural beauty and participate in outdoor recreation, spring and fall provide the most agreeable climate.

### Can I cancel my hotel reservation on Expedia?

### How can I save on a Defiance hotel booking with Expedia?

> \*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.

### How much is the nightly rate at a Defiance hotel?

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- [August A. Busch Memorial Conservation Area ](https://www.expedia.com/August-A-Busch-Memorial-Conservation-Area-St-Louis.d6160337.Vacation-Attraction)
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