Find spa resorts & hotels in Matlacha Isles, Cape Coral from $201

Start date: Check-in selected.
To Date
End date: Check-out

  • Upfront pricing

    Our total price for your stay includes taxes and fees

  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

Check availability on Matlacha Isles Resorts & Hotels with Spas

Our top choices for Matlacha Isles hotels with a spa

Massages
Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers
4.0 star property
Fort Myers Beach
9.0 out of 10, Wonderful, (1697)
"Great place "
United States
Debra Sue
$210 nightly
The price is $235
Dec 14 - Dec 15
Total with taxes and fees
Margaritaville Beach Resort Fort Myers
Outdoor pool, open 8:00 AM to 10:00 PM, cabanas (surcharge)
The Westin Cape Coral Resort At Marina Village

The Westin Cape Coral Resort At Marina Village

The Westin Cape Coral Resort At Marina Village
4.0 star property
Pelican
9.0 out of 10, Wonderful, (1002)
"Excellent stay over Thanksgiving holiday!"
United States
Nicole
$180 nightly
The price is $201
Dec 21 - Dec 22
Total with taxes and fees
The Westin Cape Coral Resort At Marina Village
Couples treatment rooms, sauna, steam room, body treatments
Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa
4.0 star property
Punta Rassa
8.4 out of 10, Very Good, (1003)
"This was thr best place that we have ever stayed at. "
United States
Matthew
$221 nightly
The price is $247
Dec 14 - Dec 15
Total with taxes and fees
Marriott Sanibel Harbour Resort & Spa
Couples treatment rooms, body treatments, deep-tissue massages
Sundial Beach Resort & Spa

Sundial Beach Resort & Spa

Sundial Beach Resort & Spa
5.0 star property
Mid Island
8.6 out of 10, Excellent, (2584)
"wonderful family friendly and spotless resort"
United States
Mary Anne
$405 nightly
The price is $452
Jan 10 - Jan 11, 2026
Total with taxes and fees
Sundial Beach Resort & Spa
Lobby
Tween Waters Island Resort & Spa

Tween Waters Island Resort & Spa

Tween Waters Island Resort & Spa
3.0 star property
Captiva
8.6 out of 10, Excellent, (1001)
"Stunning Beach View great Staff "
United States
Robert
$299 nightly
The price is $333
Dec 25 - Dec 26
Total with taxes and fees
Tween Waters Island Resort & Spa
Outdoor pool, a heated pool, sun loungers
Resort Harbour Properties

Resort Harbour Properties

Resort Harbour Properties
3.5 star property
Punta Rassa
9.6 out of 10, Exceptional, (363)
"10/10 would stay there again"
United States
Kristie
$583 nightly
The price is $650
Dec 18 - Dec 19
Total with taxes and fees
Resort Harbour Properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Matlacha Isles Hotel Reviews

Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina

10/10 Excellent
"It’s a beautiful place"
daniel 5-night trip
Posted 1 day ago
Pink Shell Beach Resort and Marina

Frequently asked questions

Looking to vacation at a spa hotel in Matlacha Isles?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Spa hotels are a great way to break away from your daily routine and add a layer of luxury to your vacation.
What's there to see and do in Matlacha Isles?
Experience Matlacha Isles and visit Key West Express, Sun Splash Water Park, and Tarpon Point. If you have a bit of extra time while you're in the area, you might want to check out Four Mile Cove Ecological Preserve and Pine Island Shopping Center.
What is a Matlacha Isles spa hotel?
Spa hotels in Matlacha Isles have full on-site spas offering services like massages and a range of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are a must if you want to give yourself an extra treat while on vacation.

Explore a world of travel with Expedia