Cheap Flights from Cheyenne (CYS) to Florence (FLO)

Popular airlines from Cheyenne, WY (CYS-Cheyenne Regional) to Florence, SC (FLO-Florence Regional)

  • Be in the know

    Get alerts if flight prices drop or rise*
  • Book smarter

    Save up to 30% on select hotels after you book a flight*
  • Earn twice

    Earn your airline miles on top of our OneKeyCash

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.

Frequently asked questions

How much does a flight from Cheyenne Regional Airport (CYS) to Florence Regional Airport (FLO) cost?
Get a cheap one-way flight or cheap return flight from Cheyenne Regional Airport (CYS) to Florence Regional Airport (FLO) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Cheyenne Regional Airport (CYS) to Florence Regional Airport (FLO)?
Planning your getaway for may help you find better deals, as it's the cheapest month for flights between CYS and FLO. You'll usually find the lowest fares during off-peak months.
What is the cheapest airline that flies from Cheyenne Regional Airport (CYS) to Florence Regional Airport (FLO)?
Expedia's filter tool lets you easily compare different airlines, flight durations and fares all in one place. Choose your preferences, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest CYS to FLO flight.
How many flights per day from Cheyenne Regional Airport (CYS) to Florence Regional Airport (FLO)?
There aren't any daily direct flights available from Cheyenne Regional Airport (CYS) to Florence Regional Airport (FLO). But you can choose flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be soaring above the clouds in no time at all.
What day of the week has the most flights from CYS to FLO?
Generally you'll find the greatest selection of flight options on a Friday. Tuesdays tend to be the quietest.* However, this can change depending on the time of year, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Cheyenne Regional Airport (CYS) to Florence Regional Airport (FLO)?
To avoid potential delays on the Cheyenne Regional Airport (CYS) to Florence Regional Airport (FLO) route, travel before 3 PM. Flights after this time are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Cheyenne Regional Airport (CYS) to Florence Regional Airport (FLO) last-minute?
Holding off until just before your trip to book a ticket from CYS to FLO generally means paying more. While you may find some last-minute offers, they aren't always guaranteed. Keep your travel schedule open for a better chance of scoring a bargain.
Is it cheaper to book a CYS to FLO flight and hotel package?
You'll generally save money by booking a CYS to FLO flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one convenient place. After choosing your ideal flights and accommodations, consider adding extras including activities, car rentals and tours.
Can I cancel or change the date of my flight from Cheyenne Regional Airport (CYS) to Florence Regional Airport (FLO)?
Typically, you're able to cancel or reschedule your CYS to FLO flight. However, additional fees may apply, especially if your booking was made over 24 hours ago. Check your itinerary for the airline's fees and policies on flight changes, or if you want further details, head to our Customer Service portal.

Travel information

Origin airport
Cheyenne Regional
Destination airport
Florence Regional
Distance
1447 mi

Book with confidence

*Flight schedules are subject to change.

Explore a world of travel with Expedia

*Available to One Key members.