Title: Top Independent in Affton, MO - Expedia.com [Affton Travel Guide](https://expedia.com/Affton.dx72322)[Hotels in Affton](https://expedia.com/Affton-Hotels.d72322.Travel-Guide-Hotels)[Vacation Rentals in Affton](https://expedia.com/Affton-Vacation-Rentals.d72322.Travel-Guide-VacationRentals)[Flights to Affton](https://expedia.com/Cheap-Flights-To-Affton.d72322.Travel-Guide-Flights)[Car Rentals in Affton](https://expedia.com/Car-Rentals-In-Affton.d72322.Car-Rental-Guide)[Affton Vacation Packages](https://expedia.com/Affton.d72322.Destination-Travel-Guides) ![This is the skyline at sunrise. It is situated along the Mississippi River. There are riverboats on the water with the St. Louis Arch in clear view.](https://images.trvl-media.com/place/72322/4c76c201-b7fc-4275-b470-880dcff7f7cf.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/72322/4c76c201-b7fc-4275-b470-880dcff7f7cf.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Mar 10 - Mar 11](https://www.expedia.com/Hotel-Search?regionId=72322&startDate=2026-03-10&endDate=2026-03-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 11 - Mar 12](https://www.expedia.com/Hotel-Search?regionId=72322&startDate=2026-03-11&endDate=2026-03-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=72322&startDate=2026-03-13&endDate=2026-03-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=72322&startDate=2026-03-20&endDate=2026-03-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FAffton-Hotels-Independent.0-0-d72322--bIndependent.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FAffton-Hotels-Independent.0-0-d72322--bIndependent.Travel-Guide-Filter-Hotels) ## Top Affton Hotel Reviews ![Hotel Indigo St Louis - Central West End by IHG](https://images.trvl-media.com/lodging/1000000/30000/22100/22068/bd89b9ce_y.jpg) ### Hotel Indigo St Louis - Central West End by IHG 8/10 Good "nice" [](https://expedia.com/St-Louis-Hotels-Holiday-Inn-Express-St-Louis-Central-West-End.h22068.Hotel-Information) ![River City Casino & Hotel](https://images.trvl-media.com/lodging/7000000/6460000/6456500/6456459/71580e9e_y.jpg) ### River City Casino & Hotel 10/10 Excellent "greatstaff" [](https://expedia.com/St-Louis-Hotels-River-City-Casino-Hotel.h6456459.Hotel-Information) ![Pear Tree Inn St. Louis Airport](https://images.trvl-media.com/lodging/2000000/1100000/1096600/1096579/fc156cf2_y.jpg) ### Pear Tree Inn St. Louis Airport 10/10 Excellent "Everything was great" [](https://expedia.com/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Airport.h1096579.Hotel-Information) ![Best Western St. Louis-Kirkwood Route 66](https://images.trvl-media.com/lodging/1000000/10000/500/415/b788e069_y.jpg) ### Best Western St. Louis-Kirkwood Route 66 8/10 Good "Room was nice, clean, mostly quiet. As soon as we stepped off the elevator we could tell that someone had been smoking pot. That odor finally cleared after about 2 hours." [](https://expedia.com/St-Louis-Hotels-Best-Western-Kirkwood-Inn.h415.Hotel-Information) ![Drury Plaza Hotel St. Louis at the Arch](https://images.trvl-media.com/lodging/1000000/550000/546300/546271/e43b9580_y.jpg) ### Drury Plaza Hotel St. Louis at the Arch 10/10 Excellent "Very nice staff and great atmosphere. Quietest hotel room i have ever stayed in" [](https://expedia.com/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-At-The-Arch.h546271.Hotel-Information) ![Drury Inn & Suites St. Louis Union Station](https://images.trvl-media.com/lodging/1000000/40000/37700/37651/151222b4_y.jpg) ### Drury Inn & Suites St. Louis Union Station 8/10 Good "Everything was good even their happy hour " [](https://expedia.com/St-Louis-Hotels-Drury-Inn-St-Louis-At-Union-Station.h37651.Hotel-Information) ![Home2 Suites by Hilton St. Louis Downtown](https://images.trvl-media.com/lodging/77000000/76520000/76510800/76510729/104b5741_y.jpg) ### Home2 Suites by Hilton St. Louis Downtown 6/10 Okay "The room was mostly satisfactory, and the buffet breakfast was good, although not varied enough day to day, but the neighborhood was questionable. The hotel has an armed security guard, and I was cautioned about venturing out at night." [](https://expedia.com/St-Louis-Hotels-Home2-Suites-St-Louis-Downtown.h76510729.Hotel-Information) ![Renaissance St. Louis Airport Hotel](https://images.trvl-media.com/lodging/1000000/10000/4700/4672/a81cbeae_y.jpg) ### Renaissance St. Louis Airport Hotel 10/10 Excellent "Stay was great. Bed was slanted inward and Needs a refresh." [](https://expedia.com/St-Louis-Hotels-Renaissance-St-Louis-Airport-Hotel.h4672.Hotel-Information) ![21C Museum Hotel St Louis ](https://images.trvl-media.com/lodging/90000000/89170000/89164600/89164592/bd7064dc_y.jpg) ### 21C Museum Hotel St Louis 10/10 Excellent "So fun and eclectic! ! " [](https://expedia.com/St-Louis-Hotels-21C-Museum-Hotel-St-Louis.h89164592.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - Other - [St. Louis Hotels ](https://www.expedia.com/St-Louis-Hotels.d178309.Travel-Guide-Hotels) - [Hotels near Ulysses S. 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Grant National Historic Site ](https://www.expedia.com/Ulysses-S-Grant-National-Historic-Site-St-Louis.d6064095.Vacation-Attraction) - [Blackburn Park ](https://www.expedia.com/Blackburn-Park-St-Louis.d553248621559142154.Vacation-Attraction) - [Hawken House ](https://www.expedia.com/Hawken-House-St-Louis.d553248621561876678.Vacation-Attraction) - [Lindenwood Park ](https://www.expedia.com/Lindenwood-Park-St-Louis-Hills.d553248621555612592.Vacation-Attraction) - [Visit Sappington ](https://www.expedia.com/Sappington.dx3000445485) - [Webster University ](https://www.expedia.com/Webster-University-St-Louis.d502877.Vacation-Attraction) - [Visit Crestwood ](https://www.expedia.com/Crestwood.dx93759) - [Father Dickson Cemetery ](https://www.expedia.com/Father-Dickson-Cemetery-St-Louis.d553248621561876676.Vacation-Attraction) - [Visit Lemay ](https://www.expedia.com/Lemay.dx3000008297) - [Visit Webster Groves ](https://www.expedia.com/Webster-Groves.dx7660) - [Visit Lindenwood Park ](https://www.expedia.com/St-Louis-Lindenwood-Park.dx6351951) - [Car rentals near Lakeshire ](https://www.expedia.com/Car-Rentals-In-Lakeshire.d553248634983257686.Car-Rental-Guide) - [Car rentals near Grantwood Village ](https://www.expedia.com/Car-Rentals-In-Grantwood-Village.d553248634983507294.Car-Rental-Guide) - [Car rentals near Marlborough ](https://www.expedia.com/Car-Rentals-In-Marlborough.d553248634983449539.Car-Rental-Guide) - [Hertz Rental Cars in Green Park ](https://www.expedia.com/Hertz-Car-Rentals-In-Green-Park.d6252525-c40.Car-Rental-Guide-Suppliers) - [Car rentals near Green Park ](https://www.expedia.com/Car-Rentals-In-Green-Park.d6252525.Car-Rental-Guide) - [Car rentals near Blackburn Park ](https://www.expedia.com/Car-Rentals-In-Blackburn-Park.d553248621559142154.Car-Rental-Guide) - [Car rentals near Bella Villa ](https://www.expedia.com/Car-Rentals-In-Bella-Villa.d553248634983251333.Car-Rental-Guide) - [Car rentals near Sappington ](https://www.expedia.com/Car-Rentals-In-Sappington.d3000445485.Car-Rental-Guide) - [Car rentals near Webster University ](https://www.expedia.com/Car-Rentals-In-Webster-University.d502877.Car-Rental-Guide) - [Car rentals near Crestwood ](https://www.expedia.com/Car-Rentals-In-Crestwood.d93759.Car-Rental-Guide) - [Car rentals near Mehlville ](https://www.expedia.com/Car-Rentals-In-Mehlville.d132204.Car-Rental-Guide) - [Enterprise Rental Cars in Mehlville ](https://www.expedia.com/Enterprise-Car-Rentals-In-Mehlville.d132204-c15.Car-Rental-Guide-Suppliers) - [Car rentals near Concord ](https://www.expedia.com/Car-Rentals-In-Concord.d177681.Car-Rental-Guide) - [Car rentals near Lemay ](https://www.expedia.com/Car-Rentals-In-Lemay.d3000008297.Car-Rental-Guide) - [Car rentals near Webster Groves ](https://www.expedia.com/Car-Rentals-In-Webster-Groves.d7660.Car-Rental-Guide) - [Car rentals in Budget Rochester Mn Apt-7600 Helgerson Dr ](https://www.expedia.com/Budget-at-Rochester-Mn-Apt-7600-Helgerson-Dr-Rochester-Minnesota-USA.v7660.Car-Rental-Guide-Location) - [Car rentals near Oakland ](https://www.expedia.com/Car-Rentals-In-Oakland.d553248634983550471.Car-Rental-Guide) - [Crestwood Vacation Rentals ](https://www.expedia.com/Crestwood-Vacation-Rentals.d93759.Travel-Guide-VacationRentals) - [Webster Groves Vacation Rentals ](https://www.expedia.com/Webster-Groves-Vacation-Rentals.d7660.Travel-Guide-VacationRentals) - [Things to do in Lemay ](https://www.expedia.com/Things-To-Do-In-Lemay.d3000008297.Travel-Guide-Activities)