Top 10 Hotels in Center, MO (from $64) 2026 - Competitive Prices

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Our top choices for Center hotels

A hotel room with a bed, a sofa, a desk, and a lamp.

A Comfort Inn & Suites hotel with a stone facade, a covered entrance, and a clear blue sky.

A restaurant with multiple tables and chairs, an exit sign, and a counter area.

A hotel reception area with a wooden reception desk, a red chair, and a carpeted floor.

1. Comfort Inn & Suites - Hannibal

Hannibal

Jerry

$80 nightly

$92 total

Oct 11 - Oct 12

Total with taxes and fees

An indoor swimming pool with a tiled floor, a rock wall, and a palm tree.

A hotel room with a bed, desk, chair, and a bathroom with a bathtub.

A spacious dining area with wooden flooring and tables, surrounded by glass walls and wooden paneling.

A lobby with leather sofas, a fireplace, a flat-screen TV, and a reception desk.

2. Quality Inn & Suites Hannibal West

Hannibal

Gayle

$76 nightly

$88 total

Nov 1 - Nov 2

Total with taxes and fees

A Sleep Inn & Suites building with a covered entrance, stone facade, and a flag.

A modern lobby with a brown sofa, beige armchairs, a round table, and a floor lamp.

A lobby with a reception desk, a seating area with sofas and armchairs, a large potted plant, and a door leading outside.

An indoor swimming pool with a lifeguard chair, poolside chairs, and a table with chairs.

3. Sleep Inn & Suites Hannibal West

Hannibal

Patricia

$118 nightly

$137 total

Nov 1 - Nov 2

Total with taxes and fees

A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.

A spacious hotel lobby with a central wooden table, seating, a treadmill, and a large potted plant.

A hotel kitchen with a buffet setup, including a coffee station and various food items.

A multi-level indoor pool area with a visible water slide, a towel rack, and a notice board.

4. Best Western On The River

Hannibal

Wei

$110 nightly

$127 total

Oct 11 - Oct 12

Total with taxes and fees

A spacious lobby with a black leather sofa, a matching armchair, a coffee table, and a chandelier.

A building with a covered entrance and a sign indicating a clearance height of 13 feet.

A hotel room with two beds, a window with red curtains, an air conditioning unit, and two bedside lamps.

A spacious lobby with a fireplace, leather sofas, a coffee table, and a large window with blinds.

5. Motel 6 Hannibal, MO

Hannibal

Donna B

$58 nightly

$67 total

Oct 14 - Oct 15

Total with taxes and fees

An indoor swimming pool with a tiled ceiling, multiple levels with windows, and seating areas around the pool.

A kitchen with a granite countertop, wooden cabinets, and a herringbone-patterned floor.

A gym with cardio equipment, mirrored walls, and a view of a Pepsi store outside.

A hotel room with a bed, a desk with a chair, a television, and a desk lamp.

6. Baymont by Wyndham Hannibal

Hannibal

brian

$55 nightly

$64 total

Oct 12 - Oct 13

Total with taxes and fees

A reception area with a marble counter, a 'Days Inn' sign, and a welcome mat.

A hotel room with a bed, a desk, a chair, a television, and a bathroom.

A hotel with a covered entrance, a parking lot, and a clear sky.

A hotel room with a dining area, kitchenette, and a door leading to a hallway.

7. Days Inn by Wyndham Hannibal

Hannibal

Christian

$62 nightly

$72 total

Oct 18 - Oct 19

Total with taxes and fees

A cozy, wooden-floored room with a blue patterned chair, a round glass table, and a variety of decorative items and knick-knacks on shelves and walls.

A cozy room with a fireplace, a sofa, and various decorative items including clocks and a sign that says "Plus".

A red barn with a balcony, a hammock, and outdoor seating.

A red barn with a porch and white chairs, labeled "VACANCY".

8. Kennedys Red Barn Inn

Perry

Dennis

$91 nightly

$97 total

Oct 16 - Oct 17

Total with taxes and fees

A modern hotel with a flat roof, multiple windows, and a sign indicating it is a Super 8 hotel.

A patio with red Adirondack chairs and a table, surrounded by a pebble border.

A long hallway with a patterned carpet, wooden paneling on the walls, and a ceiling light.

A modern dining area with round tables and chairs, a flat-screen TV mounted on the wall, and a brick accent wall.

9. Super 8 by Wyndham Hannibal

Hannibal

Betty

$62 nightly

$71 total

Oct 21 - Oct 22

Total with taxes and fees

A hotel room with two beds, a nightstand, and a lamp.

A parking lot with a building that has a clock tower and arched windows.

A hotel room with two beds, a nightstand, and a bathroom visible through an open door.

A bathroom with a bathtub, a shower, and a towel rack.

10. The Junction Inn

Perry

"There was a terrible mold stall smell in the room…It said it was redone…It didn’t seem any changed since the last time 13 years ago…The bed was extremely comfortable though…The Junction Restaurant was Awesome…Possibly they could figure out what is causing the stall smell and correct it and not try to cover it up…We got to event safely and I thank God for this & family…Not trying to put the owners down…Just a suggestion…Have An Amazing Rest of this Year"

Gloria

$74 nightly

$79 total

Nov 1 - Nov 2

Total with taxes and fees

A park with a pond, picnic tables, and a gazebo.

A small, well-lit kitchen with a dining table, chairs, a refrigerator, a microwave, and a television mounted on the wall.

A row of rustic, single-story buildings with a grassy lawn and picnic tables.

11. Cannon Dam Cabins

Perry

"Amazing place to stay! You can’t beat the indoor pool whether it is storming or feels like the fires from hell are raining on earth you can still enjoy a great swim without worrying about lightning or burning to death. The people are incredibly kind and on top of anything you may need and the cabins are a perfect relaxing get away with nice a/c and plenty of sleeping space! Thank you for another amazing stay!"

Erika

$103 nightly

$109 total

Oct 11 - Oct 12

Total with taxes and fees

A living room with a sofa, coffee table, and patterned rug. There are large windows with blinds, a chandelier, and a view of the outside.

A hotel room with two beds, a television, a lamp, and a painting on the wall.

A dining area with multiple tables and chairs, a kitchen area with a refrigerator and various kitchen items, and a window with curtains.

A hotel hallway with a patterned carpet, doors, and a sign indicating room number 101.

12. FairBridge Inn Express, Monroe City

Monroe City

Lona

$85 nightly

$92 total

Oct 25 - Oct 26

Total with taxes and fees

A large indoor swimming pool with multiple levels of balconies, surrounded by seating areas and potted plants.

A hotel room with two beds, a desk, a chair, and a telephone.

A clean, modern reception area with a reception desk, a clock, and a potted plant.

A kitchen with wooden cabinets, a granite countertop, and various food items and kitchen appliances.

13. Howard Johnson BY Wyndham Hannibal

Hannibal

Debbie

$59 nightly

$68 total

Oct 21 - Oct 22

Total with taxes and fees

A wooden staircase with a handrail, a small table with a lamp, and a chair in a room with a door and windows.

A large, two-story house with a porch and a sign indicating 'ONE WAY'.

A fireplace with decorative elements, framed pictures, and a vase of red flowers.

A cozy living room with a fireplace, a red armchair, a globe, and various framed pictures on the mantel.

14. Garden House Bed and Breakfast

Hannibal

Edward

$93 nightly

$107 total

Oct 12 - Oct 13

Total with taxes and fees

A room with a beige leather sofa, a wooden coffee table, a floor lamp, and a patterned carpet.

A hotel room with a bed, two bedside lamps, a headboard, and a patterned carpet.

A historic building with a stone facade and multiple windows, featuring a sign about Tom Sawyer's fence.

A compact kitchen with a refrigerator, microwave, and sink.

15. Riverside Inn Hannibal

Hannibal

Janee

$201 nightly

$232 total

Oct 11 - Oct 12

Total with taxes and fees

A hotel room with a large bed, two bedside lamps, a modern bathroom, and a vibrant abstract painting on the wall.

A modern living room with a grey sofa, a white armchair, a coffee table, and a patterned rug. There is a kitchen in the background with white cabinets and a black door.

A compact kitchen with white cabinets, a microwave, a coffee maker, and a sink.

A swimming pool with lounge chairs and a covered seating area.

16. Lighthouse Inn & Suites

Hannibal

Connie

$192 nightly

$221 total

Oct 11 - Oct 12

Total with taxes and fees

A rooftop terrace with a brick wall, a metal railing, and a table with chairs.

A rustic living room with exposed brick walls, wooden beams, and a cozy fireplace. There are two leather sofas with throw pillows and a fluffy rug.

A storefront with a red and gray facade, large windows, and various beer advertisements.

A bedroom with a brick wall, wooden beams, a bed, two sofas, and a small table with a lamp.

17. Deck + River View: Loft in Downtown Hannibal

Hannibal

$230 nightly

$265 total

Oct 11 - Oct 12

Total with taxes and fees

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Hotels recommended for families in Center

Comfort Inn & Suites - Hannibal

Hannibal

$80 nightly

$92 total

Oct 11 - Oct 12

Total with taxes and fees

Sleep Inn & Suites Hannibal West

Hannibal

$118 nightly

$137 total

Nov 1 - Nov 2

Total with taxes and fees

Quality Inn & Suites Hannibal West

Hannibal

$76 nightly

$88 total

Nov 1 - Nov 2

Total with taxes and fees

Motel 6 Hannibal, MO

Hannibal

$58 nightly

$67 total

Oct 14 - Oct 15

Total with taxes and fees

FairBridge Inn Express, Monroe City

Monroe City

$85 nightly

$92 total

Oct 25 - Oct 26

Total with taxes and fees

Best Western On The River

Hannibal

$110 nightly

$127 total

Oct 11 - Oct 12

Total with taxes and fees

Super 8 by Wyndham Hannibal

Hannibal

$62 nightly

$71 total

Oct 21 - Oct 22

Total with taxes and fees

Days Inn by Wyndham Hannibal

Hannibal

$62 nightly

$72 total

Oct 18 - Oct 19

Total with taxes and fees

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Top Center Hotel Reviews

Peaceful, Country Cottage with Open Floor Plan

8/10 Good

"Nice home but traffic is VERY loud and woke us up early each morning. There are no curtains on the very large window in the kitchen so it’s very bright and no privacy. There was only enough coffee for one morning. The bath gel and shampoo is only one very small tube of each. We had to buy these and the coffee. No big deal but we would have brought some if we would have known. We really liked that luggage racks were provided in the bedrooms."

Garden House Bed and Breakfast

8/10 Good

"Beautiful Queen Ann B&B, was reasonably priced and within walking distance to the river and down town Hannibal attractions."

Best Western On The River

10/10 Excellent

"fun town to stay and visit"

Days Inn by Wyndham Hannibal

10/10 Excellent

"Everything was 5 star rating except the coffee from the automatic coffee dispenser."

Riverside Inn Hannibal

10/10 Excellent

"Beautiful view of the river! Easy access to downtown and shops/restaurants. The jacuzzi was wonderful and a nice bonus! We’ll definitely stay there again if we’re back in the area."