A tropical island with palm trees and a clear blue sky.

Cheap Flights to Panama from $218

View $218 flight on Thu, Apr 1, 2027Opens in a new window

Popular airlines to Panama

  • Avianca

  • American Airlines

  • United

  • Copa

  • Delta

  • Aeromexico

  • KLM

  • Be in the know

    Get alerts if flight prices drop or rise*

  • Book smarter

    Save up to 30% on select hotels after you book a flight*

  • Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

How much is the cheapest flight to Panama?

Prices were available within the past 7 days and start at $218 for one-way flights and $398 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

avianca
avianca
avianca
avianca
avianca
avianca
Copa
United
American Airlines
Delta

Trending flights to Panama

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

avianca

Book with confidence

Enjoy extra legroom, flight flexibility, and a seamless travel experience.

Travel information

*Flight schedules are subject to change.

*Available to One Key members.

*Flight schedules are subject to change.

*Available to One Key members.

Explore a world of travel with Expedia