Title: Top New Madrid County Hotels: 2026 Best Hotels in New Madrid County - Expedia.com [Vacation Rentals in New Madrid County](https://expedia.com/Destinations-In-New-Madrid-County.d553248635976433157.Vacation-Rental-Destinations)[New Madrid County Flights](https://expedia.com/Destinations-In-New-Madrid-County.d553248635976433157.Flight-Destinations)[Car Rentals in New Madrid County](https://expedia.com/Destinations-In-New-Madrid-County.d553248635976433157.Car-Rental-Destinations)[New Madrid County Vacations](https://expedia.com/New-Madrid-County.d553248635976433157.Destination-Travel-Guides) ![Lodging Image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ## Top Cities in New Madrid County ![Pre-teen girl walking through corn maze during fall](https://images.trvl-media.com/place/6058766/0353751e-5978-48d0-a913-84533caba2b0.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Sikeston [](https://expedia.com/Sikeston-Hotels.d6058766.Travel-Guide-Hotels) ![Mississippi River Walk at New Madrid. A magnificent view of the Mississippi river from atop of the levee. A steamboat is docked down river. . ](https://images.trvl-media.com/place/3000445315/970b11d9-266d-426a-9577-5e745e0939b7.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### New Madrid [](https://expedia.com/New-Madrid-Hotels.d3000445315.Travel-Guide-Hotels) ## Check prices for these dates Tonight [Feb 27 - Feb 28](https://www.expedia.com/Hotel-Search?regionId=553248635976433157&startDate=2026-02-27&endDate=2026-02-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Feb 28 - Mar 1](https://www.expedia.com/Hotel-Search?regionId=553248635976433157&startDate=2026-02-28&endDate=2026-03-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Feb 27 - Mar 1](https://www.expedia.com/Hotel-Search?regionId=553248635976433157&startDate=2026-02-27&endDate=2026-03-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=553248635976433157&startDate=2026-03-06&endDate=2026-03-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for New Madrid County hotels ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/95135562.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/978331d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Sikeston, MO [](https://www.expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) Sikeston 9.4/10 Exceptional (1,005 reviews) "As always it was a perfect visit" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John $94 nightly $108 total Mar 8 - Mar 9 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Free daily full breakfast](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/327b8d22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/42667f54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/13d95c8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Sikeston I-55 [](https://www.expedia.com/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information) Sikeston 8.4/10 Very Good (1,002 reviews) "Great stay, everything was clean and comfortable. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Charles $82 nightly $93 total Mar 26 - Mar 27 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/4abadc7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/432f7137.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Sikeston [](https://www.expedia.com/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) Sikeston 9.0/10 Wonderful (487 reviews) "Very Clean room, friendly staff, breakfast in the morning. Will be staying again! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Affinity $96 nightly $109 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![1 bedroom, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/be0d2e33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/8fe9a2cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/7335ffbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/717baff4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn and Suites by Wyndham Sikeston [](https://www.expedia.com/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information) Sikeston 7.2/10 Good (1,001 reviews) "Everything was excellent" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James $71 nightly $80 total Mar 2 - Mar 3 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/a2f06e13.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/945fac08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/8fe6deab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/0c032f4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pear Tree Inn Sikeston [](https://www.expedia.com/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information) Sikeston 9.4/10 Exceptional (1,001 reviews) "Rooms were very clean and comfortable " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lydia [](https://www.expedia.com/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information) ![Individually decorated, individually furnished, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/47690ac7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/f91b29ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/d5d0cfa0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/bf40a512.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) [](https://www.expedia.com/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information) Sikeston 8.4/10 Very Good (744 reviews) "Room was clean. Fairly quiet room. Front desk was kind. Would stay here again. ." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Becky $65 nightly $75 total Mar 1 - Mar 2 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information) ![Premier Room, 1 Bedroom, Non Smoking | Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/2d9e6936.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/91bb8871.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, free toiletries, towels, soap](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/1d8642af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premier Room, 1 Bedroom, Non Smoking | Bathroom | Combined shower/tub, free toiletries, towels, soap](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/5fa7b845.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### New Orleans Inn Portageville [](https://www.expedia.com/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information) Portageville 8.0/10 Very Good (746 reviews) "Parking was good, staff was great " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Corey $60 nightly $65 total Mar 1 - Mar 2 Total with taxes and fees [](https://www.expedia.com/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/f2cf9c54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/e959f8b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/27c728aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/7d2010d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Sikeston [](https://www.expedia.com/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information) Sikeston 9.4/10 Exceptional (60 reviews) "Clean rooms great staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) IRA $101 nightly $114 total Mar 6 - Mar 7 Total with taxes and fees [](https://www.expedia.com/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information) ![Room, 1 King Bed, Accessible, Non Smoking | Desk, laptop workspace, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/1000000/860000/855500/855478/d9ee28fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/1000000/860000/855500/855478/97dfc357.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking | Desk, laptop workspace, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/1000000/860000/855500/855478/715f35ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/860000/855500/855478/55187aa2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Sikeston/Miner Area [](https://www.expedia.com/Sikeston-Hotels-Super-8-By-Wyndham-SikestonMiner-Area.h855478.Hotel-Information) Sikeston 6.8/10 (597 reviews) "Great place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Misty $63 nightly $72 total Mar 1 - Mar 2 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Super-8-By-Wyndham-SikestonMiner-Area.h855478.Hotel-Information) ![Soundproofing, free WiFi, bed sheets](https://images.trvl-media.com/lodging/17000000/16090000/16087600/16087543/5bb06af8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Gazebo](https://images.trvl-media.com/lodging/17000000/16090000/16087600/16087543/501c540f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/17000000/16090000/16087600/16087543/825a993b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast area](https://images.trvl-media.com/lodging/17000000/16090000/16087600/16087543/f23217d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travel Inn [](https://www.expedia.com/Hayti-Hotels-Travel-Inn.h16087543.Hotel-Information) Marston 6.0/10 (118 reviews) "Had a great time loved it " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shyianne $50 nightly $57 total Mar 14 - Mar 15 Total with taxes and fees [](https://www.expedia.com/Hayti-Hotels-Travel-Inn.h16087543.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/1fd79e2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, down comforters, desk, iron/ironing board](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/4b95ba78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 8 AM to 11 PM, sun loungers](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/65f9cbe7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/3aa729da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Sikeston Southwest by IHG [](https://www.expedia.com/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information) Sikeston 8.6/10 Excellent (447 reviews) "Stay was excellent " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kourtney $93 nightly $105 total Mar 8 - Mar 9 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information) ![Room, 1 Queen Bed, Non Smoking | Desk, laptop workspace, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/5b4d84d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/ef46b494.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/0acd5e5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/7d06bc03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 By Wyndham Marston [](https://www.expedia.com/Marston-Hotels-Super-8-By-Wyndham-Marston.h108416635.Hotel-Information) Marston 8.2/10 Very Good (50 reviews) "Room clean bed comfortable, breakfast simple but good." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James $67 nightly $76 total Mar 2 - Mar 3 Total with taxes and fees [](https://www.expedia.com/Marston-Hotels-Super-8-By-Wyndham-Marston.h108416635.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/w3995h2667x0y0-6f8601de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio, 1 King Bed with Sofa bed | Hypo-allergenic bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/w3995h2667x0y0-c8905780.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/w4000h2662x0y0-82d0e62d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/de7767c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### TownePlace Suites by Marriott Sikeston [](https://www.expedia.com/Towneplace-Suites-By-Marriott-Sikeston.h111247452.Hotel-Information) Sikeston 9.2/10 Wonderful (12 reviews) "This hotel was great. Good location. Awesome staff. Hopefully I get the opportunity to stay here again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jason $114 nightly $129 total Mar 8 - Mar 9 Total with taxes and fees [](https://www.expedia.com/Towneplace-Suites-By-Marriott-Sikeston.h111247452.Hotel-Information) ![Iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/91000000/90830000/90821500/90821467/fa4ef12a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/91000000/90830000/90821500/90821467/980dd49e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/91000000/90830000/90821500/90821467/392abeff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/91000000/90830000/90821500/90821467/b7350700.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Yard Inn and Suite [](https://www.expedia.com/Sikeston-Hotels-Country-Yard-Inn-And-Suite.h90821467.Hotel-Information) Sikeston 6.8/10 (124 reviews) "Great spot en route home from Mississippi. Staff put me in a room that ended up being in a quiet section of the hotel. Great sleep." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Andrew $49 nightly $55 total Mar 16 - Mar 17 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Country-Yard-Inn-And-Suite.h90821467.Hotel-Information) ![Desk, free WiFi, bed sheets, alarm clocks](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/4da73ae3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/1fa29b5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/07d69819.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free WiFi, bed sheets, alarm clocks](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/7657c6fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Sikeston I-55 [](https://www.expedia.com/Sikeston-Hotels-Comfort-Inn-Suites-Sikeston-I-55.h1804447.Hotel-Information) Sikeston 8.4/10 Very Good (287 reviews) "The hotel was very clean, beds were comfortable, and staff was friendly and helpful." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) aileen $94 nightly $107 total Mar 8 - Mar 9 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Comfort-Inn-Suites-Sikeston-I-55.h1804447.Hotel-Information) ![Property entrance](https://images.trvl-media.com/lodging/24000000/23270000/23265800/23265745/265f8d2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/24000000/23270000/23265800/23265745/f0392825.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking | Iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/24000000/23270000/23265800/23265745/d74f45af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/24000000/23270000/23265800/23265745/220e39ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### OYO Malden Airport Inn [](https://www.expedia.com/Malden-Hotels-Malden-Airport-Inn.h23265745.Hotel-Information) Malden 6.8/10 (69 reviews) "Clean room, quiet. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer $59 nightly $63 total Mar 6 - Mar 7 Total with taxes and fees [](https://www.expedia.com/Malden-Hotels-Malden-Airport-Inn.h23265745.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/121000000/120470000/120467300/120467279/w1060h720x0y199-6f809fb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/121000000/120470000/120467300/120467279/w1080h809x0y1-d7340261.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/121000000/120470000/120467300/120467279/w1050h1619x0y1-13beb152.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/121000000/120470000/120467300/120467279/w1080h1439x0y1-2bafdfca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room! [](https://www.expedia.com/New-Madrid-Hotels-Spacious-3-Bedroom-2-Story-House-In-New-Madrid-Near-Boat-Ramp-With-A-Toy-Room.h120467279.Hotel-Information) New Madrid 10/10 Exceptional (1 review) "The host was very quick to respond and so great to work with for on our stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jessica S. $343 nightly $369 total Mar 2 - Mar 3 Total with taxes and fees [](https://www.expedia.com/New-Madrid-Hotels-Spacious-3-Bedroom-2-Story-House-In-New-Madrid-Near-Boat-Ramp-With-A-Toy-Room.h120467279.Hotel-Information) ![Living area](https://images.trvl-media.com/lodging/77000000/76030000/76020500/76020481/aab8c593.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, blender](https://images.trvl-media.com/lodging/77000000/76030000/76020500/76020481/c7fd89d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, WiFi](https://images.trvl-media.com/lodging/77000000/76030000/76020500/76020481/f956f55c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, blender](https://images.trvl-media.com/lodging/77000000/76030000/76020500/76020481/6045fc50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Modern and Cozy Apartment with large windows and sunlight. [](https://www.expedia.com/Sikeston-Hotels-Modern-And-Cozy-Apartment-With-Large-Windows-And-Sunlight.h76020481.Hotel-Information) Sikeston [](https://www.expedia.com/Sikeston-Hotels-Modern-And-Cozy-Apartment-With-Large-Windows-And-Sunlight.h76020481.Hotel-Information) ![Standard Room, 2 Double Beds, Non Smoking | Blackout drapes, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/543bd231.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Handicap Room | Blackout drapes, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/6128b6d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/45782657.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/60633b31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Reelfoot Lake Inn [](https://www.expedia.com/Union-City-Hotels-Reelfoot-Lake-Inn.h16769945.Hotel-Information) Tiptonville 7.2/10 Good (467 reviews) "Nice in clean room" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jayla $68 nightly $79 total Mar 19 - Mar 20 Total with taxes and fees [](https://www.expedia.com/Union-City-Hotels-Reelfoot-Lake-Inn.h16769945.Hotel-Information) ![Smart TV](https://images.trvl-media.com/lodging/102000000/101880000/101879200/101879138/0d61a825.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/102000000/101880000/101879200/101879138/8341e2b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/102000000/101880000/101879200/101879138/5fe9a626.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/102000000/101880000/101879200/101879138/342c28ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tiny house on the lake with tv free internet walk shower [](https://www.expedia.com/Tiptonville-Hotels-Tiny-House-On-The-Lake-With-A-Seventy-Five-Inch-T-V-Free-Internet-Walk-Shower.h101879138.Hotel-Information) Tiptonville 10/10 Exceptional (1 review) "Dave was very accommodating and the home was clean." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Katherine P. $219 nightly $248 total Mar 1 - Mar 2 Total with taxes and fees [](https://www.expedia.com/Tiptonville-Hotels-Tiny-House-On-The-Lake-With-A-Seventy-Five-Inch-T-V-Free-Internet-Walk-Shower.h101879138.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-14&endDate=2026-03-15®ionId=553248635976433157&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=HTG_SPRING_PROMO_553248635976433157) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-New-Madrid-County.d553248635976433157.Hotel-Destinations)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-New-Madrid-County.d553248635976433157.Hotel-Destinations) ## Top New Madrid County Hotel Reviews ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg) ### Drury Inn & Suites Sikeston, MO 10/10 Excellent "Yes" [](https://expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/e12b74a2_y.jpg) ### Days Inn and Suites by Wyndham Sikeston 10/10 Excellent "Great clean and quiet room " [](https://expedia.com/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information) ![Best Western Plus Sikeston](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg) ### Best Western Plus Sikeston 10/10 Excellent "Very nice folks who manage the hotel!!" [](https://expedia.com/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759_y.jpg) ### Hampton Inn Sikeston 10/10 Excellent "CLEAN ROOM, CLEAN FACILITY, FREINDLY STAFF" [](https://expedia.com/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![Fairfield Inn & Suites by Marriott Sikeston](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/cffe72cf_y.jpg) ### Fairfield Inn & Suites by Marriott Sikeston 10/10 Excellent "Amazing staff, super clean and easy checkin/out! Traveled for our Glow for Hope challenge sparking the conversation on Suicide and Mental Health! They talked, shared and joined the challenge!! Thank you for making me feel welcomed!!" [](https://expedia.com/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information) ![The Farmstead Hotel](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/26d97631_y.jpg) ### The Farmstead Hotel 10/10 Excellent "DeNeisha was very nice! Clean room!" [](https://expedia.com/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information) ![Drury Inn & Suites Hayti Caruthersville](https://images.trvl-media.com/lodging/1000000/50000/42200/42109/ff3e4031_y.jpg) ### Drury Inn & Suites Hayti Caruthersville 10/10 Excellent "The room was clean. The breakfast selection was great." [](https://expedia.com/Hayti-Hotels-Drury-Inn-Suites-Hayti-Caruthersville.h42109.Hotel-Information) ![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/f91b29ea_y.jpg) ### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) 10/10 Excellent "Very friendly and had an amazing stay so peaceful " [](https://expedia.com/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information) ![ For Larger Groups Up To 24, Right on Reelfoot Lake--Private Dock And Pier.](https://images.trvl-media.com/lodging/35000000/34330000/34322400/34322352/537131b5_y.jpg) ### For Larger Groups Up To 24, Right on Reelfoot Lake--Private Dock And Pier. 10/10 Excellent "Clean and convenient! Great stay, we will be back!" [](https://expedia.com/Hornbeak-Hotels-For-Larger-Groups-Right-On-Reelfoot-Lake-Private-Dock-And-Pier.h34322352.Hotel-Information) ## Explore a world of travel with Expedia - Explore a world of travel with Expedia ### Top cities in New Madrid County - [Marston Hotels ](https://expedia.com/Marston-Hotels.d55824.Travel-Guide-Hotels) - [New Madrid Hotels ](https://expedia.com/New-Madrid-Hotels.d3000445315.Travel-Guide-Hotels) - [Matthews Hotels ](https://expedia.com/Matthews-Hotels.d553248634983428760.Travel-Guide-Hotels) - [Lilbourn Hotels ](https://expedia.com/Lilbourn-Hotels.d553248634983590625.Travel-Guide-Hotels) - [Gideon Hotels ](https://expedia.com/Gideon-Hotels.d3000349377.Travel-Guide-Hotels) - [Morehouse Hotels ](https://expedia.com/Morehouse-Hotels.d553248634983462037.Travel-Guide-Hotels) - [Tallapoosa Hotels ](https://expedia.com/Tallapoosa-Hotels.d553248634983263480.Travel-Guide-Hotels) - [Howardville Hotels ](https://expedia.com/Howardville-Hotels.d553248634983363505.Travel-Guide-Hotels) - [Risco Hotels ](https://expedia.com/Risco-Hotels.d3000349516.Travel-Guide-Hotels) - [Canalou Hotels ](https://expedia.com/Canalou-Hotels.d3000349311.Travel-Guide-Hotels) ### Hotels near popular Attractions - [Hotels near Marston Community Center ](https://expedia.com/Marston-Community-Center-Hotels.0-l553248622945532712-0.Travel-Guide-Filter-Hotels) - [Hotels near New Madrid Historical Museum ](https://expedia.com/New-Madrid-Historical-Museum-Hotels.0-l553248621532655748-0.Travel-Guide-Filter-Hotels) - [Hotels near River Ridge Winery ](https://expedia.com/River-Ridge-Winery-Hotels.0-l553248621532655749-0.Travel-Guide-Filter-Hotels) - [Hotels near Hunter-Dawson State Historic Site ](https://expedia.com/Hunter-Dawson-State-Historic-Site-Hotels.0-l553248621532655794-0.Travel-Guide-Filter-Hotels) - [Hotels near Mississippi River ](https://expedia.com/Mississippi-River-Hotels.0-l6209928-0.Travel-Guide-Filter-Hotels) - [Hotels near Reelfoot Lake ](https://expedia.com/Reelfoot-Lake-Hotels.0-l553248635976195913-0.Travel-Guide-Filter-Hotels) - [Hotels near Century Casino Caruthersville ](https://expedia.com/Century-Casino-Caruthersville-Hotels.0-l553248621532655201-0.Travel-Guide-Filter-Hotels) - [Hotels near Columbus-Belmont State Park ](https://expedia.com/Columbus-Belmont-State-Park-Hotels.0-l6091579-0.Travel-Guide-Filter-Hotels) - [Hotels near Dexter Welcome Center Depot and Museum ](https://expedia.com/Dexter-Welcome-Center-Depot-And-Museum-Hotels.0-l553248621592342445-0.Travel-Guide-Filter-Hotels) - [Hotels near Big Oak Tree State Park ](https://expedia.com/Big-Oak-Tree-State-Park-Hotels.0-l553248621532655754-0.Travel-Guide-Filter-Hotels) ### More Accommodation Types in New Madrid County - [Vacation Homes in New Madrid County ](https://expedia.com/New-Madrid-County-Private-Vacation-Homes.d553248635976433157-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [Lodges in New Madrid County ](https://expedia.com/New-Madrid-County-Lodges.d553248635976433157-aaLodges.Travel-Guide-Accommodation) - [Motels in New Madrid County ](https://expedia.com/New-Madrid-County-Motels.d553248635976433157-aaMotels.Travel-Guide-Accommodation) - [Cottages in New Madrid County ](https://expedia.com/New-Madrid-County-Cottages.d553248635976433157-aaCottages.Travel-Guide-Accommodation) - [Apartments in New Madrid County ](https://expedia.com/New-Madrid-County-Apartments.d553248635976433157-aaApartments.Travel-Guide-Accommodation) - [Cabin Rentals in New Madrid County ](https://expedia.com/New-Madrid-County-Cabins.d553248635976433157-aaCabins.Travel-Guide-Accommodation) - [RV Parks in New Madrid County ](https://expedia.com/New-Madrid-County-RV-Parks.d553248635976433157-aaRVParks.Travel-Guide-Accommodation) - [Condo Rentals in New Madrid County ](https://expedia.com/New-Madrid-County-Condos.d553248635976433157-aaCondos.Travel-Guide-Accommodation) ### Hotels near New Madrid County Airports - [Cape Girardeau Municipal Airport Hotels ](https://expedia.com/Cape-Girardeau-Municipal-Airport-Hotels.0-aCGI-0.Travel-Guide-Filter-Hotels) - [Cairo Regional Airport Hotels ](https://expedia.com/Cairo-Regional-Airport-Hotels.0-aCIR-0.Travel-Guide-Filter-Hotels) ### Explore more hotels - [Hampton Inn Sikeston ](https://expedia.com/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) - [New Orleans Inn Portageville ](https://expedia.com/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information) - [Fairfield Inn & Suites by Marriott Sikeston ](https://expedia.com/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information) - [Holiday Inn Express & Suites Sikeston Southwest by IHG ](https://expedia.com/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information) - [Super 8 By Wyndham Marston ](https://expedia.com/Marston-Hotels-Super-8-By-Wyndham-Marston.h108416635.Hotel-Information) - [Travel Inn ](https://expedia.com/Hayti-Hotels-Travel-Inn.h16087543.Hotel-Information) - [TownePlace Suites by Marriott Sikeston ](https://expedia.com/Towneplace-Suites-By-Marriott-Sikeston.h111247452.Hotel-Information) - [Drury Inn & Suites Sikeston, MO ](https://expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) - [The Farmstead Hotel ](https://expedia.com/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information) - [Drury Inn & Suites Hayti Caruthersville ](https://expedia.com/Hayti-Hotels-Drury-Inn-Suites-Hayti-Caruthersville.h42109.Hotel-Information) [See a list of all hotels in New Madrid County](https://expedia.com/All-New-Madrid-County-Hotels.d553248635976433157.Travel-Guide-City-All-Hotels) ### Expedia's Latest Trends Hotels - [Hotels in Country Club Plaza](https://expedia.com/Country-Club-Plaza-Kansas-City-Hotels.0-n6143482-0.Travel-Guide-Filter-Hotels) - [Best Hotels in St. Charles](https://expedia.com/St-Charles-Hotels.d9786.Travel-Guide-Hotels) - [Hotels in Power and Light District](https://expedia.com/Power-And-Light-District-Kansas-City-Hotels.0-n6162504-0.Travel-Guide-Filter-Hotels) - [Six Flags St. Louis hotels](https://expedia.com/Six-Flags-St-Louis-Hotels.0-l6147083-0.Travel-Guide-Filter-Hotels) - [Pet-friendly Hotels in St. Charles County](https://expedia.com/Destinations-In-St-Charles-County-Pet-Friendly-Hotel.0-0-d553248635083913790-tPetfriendlyHotel.Hotel-Filter-Destinations) - 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[Hotels with a Lazy River in St. Louis County](https://expedia.com/Destinations-In-St-Louis-County-Hotels-With-A-Lazy-River.0-0-d553248635083900521-tHotelswithaLazyRiver.Hotel-Filter-Destinations) - [Hotels in Butler County](https://expedia.com/Destinations-In-Butler-County.d553248635976434259.Hotel-Destinations) - [Fort Leonard Wood hotels](https://expedia.com/Fort-Leonard-Wood-Hotels.0-l553248621562507101-0.Travel-Guide-Filter-Hotels) - [Hotels in Downtown St. Louis](https://expedia.com/Downtown-St-Louis-St-Louis-Hotels.0-n800136-0.Travel-Guide-Filter-Hotels) Flights - [Flights from Benton County](https://expedia.com/lp/flights/553248635976431626/flights-from-benton-county) - [Cheap Flights to St Louis City County](https://expedia.com/Destinations-In-St-Louis-City-County.d553248635976432800.Flight-Destinations) - [Flights from Chariton County](https://expedia.com/lp/flights/553248635976429751/flights-from-chariton-county) - [Flights from Saline County](https://expedia.com/lp/flights/553248635976433051/flights-from-saline-county) - 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