Florida Keys National Marine Sanctuary is the perfect place kick off your day in Key West. This protected ocean area is recommended by fellow travelers, but it isn't the only thing to do here. Pencil in time for other sights like Ernest Hemingway Home and Museum, Audubon House and Tropical Gardens, and Mallory Square to make the most of what's on offer in the area.
Florida Keys National Marine Sanctuary Tours

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Hyatt Vacation Club at Beach House, Key West
Save 100% on your flight
Price was $1,182, price is now $718 per person
$718
per person
Nov 16 - Nov 21
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Key West (EYW)
9.4/10 Exceptional! (1,025 reviews)
The 2 bedroom villa was great. It was spacious and comfortable. The master bathroom was a dream! I also enjoyed the screened in balcony with a view of the ocean and pool. I highly recommend this place!
Reviewed on Sep 30, 2025

Ella's Cottages - Key West Historic Inns
Old Town Key West
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Price was $5,036, price is now $2,949 per person
$2,949
per person
Dec 27 - Jan 3
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Key West (EYW)
9.4/10 Exceptional! (375 reviews)
We really enjoyed our stay at Ella’s Cottages. It is a short walk to Duvall Street with lots of dining options close by. The suites were tucked into a beautifully landscaped property. I truly felt transported to a tropical island sanctuary. There were beach/pool towels on the lounge chairs by the pool. The pool itself is small but very clean and refreshing after a hot day. There were also tables in the pool area to dine or gather.
We upgraded our room to a larger room with a patio. The bathroom was nicely updated and very clean. Our bedroom area also was nicely updated and clean. The window AC unit worked hard to cool our room on the lowest setting. The ceiling fan helped.
The staff was very friendly and helped us find good suggestions of places to eat.
The continental breakfast was: essentially it’s a basket of croissants or bagels, bottled orange juice, yogurt cups, coffee, cheese packets, detox shots and two egg bites.
I would highly recommend Ella’s Cottages and would stay here again.
Reviewed on Sep 30, 2025

Winslow's Bungalows - Key West Historic Inns
Old Town Key West
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Price was $4,456, price is now $2,744 per person
$2,744
per person
Dec 27 - Jan 3
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Key West (EYW)
9.2/10 Wonderful! (1,005 reviews)
We loved being the historic part of town. Our bungalow was beautifully appointed. The location offered access to restaurants and night life while being a quiet retreat when we were tired. The morning breakfast was good, but it didn't change from day to day. We stayed 7 nights and skipped the breakfast several mornings for its lack of variety. The morning coffee ran out before 10am on Sunday and was not replenished. The 24/7 coffee maker was stocked only with decaf.
Reviewed on Oct 9, 2025
Browse tours and tickets to explore Florida Keys National Marine Sanctuary
Tours & day trips
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Key West Express Day Trip from Miami
Activity duration is 12 hours and 15 minutes
8.6 out of 10 with 390 reviews
Free cancellation available
Wildlife & nature
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Key West Morning Snorkel Adventure with Bottomless Mimosas & Breakfast
Activity duration is 3 hours
9.2 out of 10 with 134 reviews
Free cancellation available
History & culture
See all 45 activities
Key West Day Trip & Glass Bottom-Boat Tour from Miami
Activity duration is 12 hours
5.0 out of 10 with 27 reviews
Free cancellation available
Private & custom tours
See all 33 activities
Dry Tortugas National Park Day Trip by Luxury Boat: Axopar 37 XC
Activity duration is 8 hours
Free cancellation available
Food, drink & nightlife
See all 26 activities
Key West Morning Snorkel Adventure with Bottomless Mimosas & Breakfast
Activity duration is 3 hours
9.2 out of 10 with 134 reviews
Free cancellation available
Reviews of Florida Keys National Marine Sanctuary
4.5
Top Destination
3/5 - Okay
Verified traveler
Was the only place we went that didn't charge admission. Great volunteers!
Popular places to visit

Florida Keys Eco - Discovery Center
Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

Fort Zachary Taylor Historic State Park
The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.

Truman Beach
Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.

Jackson Square
You can learn about the history of Key West with a stop at Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.

Harry S. Truman Little White House
Visit the winter home of President Harry S. Truman to see where some of America’s most important post-war decisions were made.

Key West Lighthouse and Keeper's Quarters Museum
Climb to the top of this historic lighthouse for unparalleled photo opportunities and then visit the former home of Key West’s lighthouse keepers.
Best Lodging Options Near Florida Keys National Marine Sanctuary
Check availability on hotels close to Florida Keys National Marine Sanctuary

Southernmost Beach Resort and Guesthouses
1319 Duval Street, Key West, FL

La Concha Key West, Autograph Collection
430 Duval St, Key West, FL

Hyatt Centric Key West Resort and Spa
601 Front St, Key West, FL

Pier House Resort & Spa
1 Duval St, Key West, FL

Casa Marina Key West, Curio Collection by Hilton
1500 Reynolds Street, Key West, FL

Opal Key Resort & Marina, Key West
245 Front Street, Key West, FL

Lighthouse Hotel - Key West Historic Inns
902 Whitehead St, Key West, FL

The Southernmost Inn - Adults Only
525 United Street, Key West, FL

Margaritaville Beach House Key West
2001 South Roosevelt Boulevard, Key West, FL
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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