Florida Keys National Marine Sanctuary is the perfect place kick off your day in Key West. This protected ocean area is recommended by fellow travelers, but it isn't the only thing to do here. Pencil in time for other sights like Ernest Hemingway Home and Museum, Audubon House and Tropical Gardens, and Mallory Square to make the most of what's on offer in the area.
Florida Keys National Marine Sanctuary Tours

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The Reach Key West, Curio Collection by Hilton
Old Town Key West
Save 100% on your flight
per person
Sep 30 - Oct 4
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Key West (EYW)
8.4/10 Very Good! (998 reviews)
Beach access was great! Rooms very clean and all staff was friendly and helpful. Be prepared for the $50/day valet charge and no self parking available.
We were SO glad we stayed here versus the nearby Southernmost resort. Beach seaweed was cleaned up and maintained. The beach at Southernmost was a mess and not usable.
Reviewed on Jul 6, 2025

Almond Tree Inn Hotel - Adults Only
Old Town Key West
Save 100% on your flight
per person
Sep 30 - Oct 4
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Key West (EYW)
10/10 Exceptional! (1,002 reviews)
This is my second stay at Almond Tree and since it was so nice the first time I’ll just keep going back. The hotel is great and the location can’t be beat.
Reviewed on Jul 9, 2025

Orchid Key Inn - Adults Only
Old Town Key West
Save 100% on your flight
per person
Sep 30 - Oct 4
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Key West (EYW)
9.8/10 Exceptional! (1,002 reviews)
The staff was very friendly and helpful. The room was very clean. The pool was very clean as well. When you are in the room or pool, you feel like you are in your own little world where you get to take a break from the hustle and bustle of Duval street. Not noisy at night, very peaceful.
Reviewed on Jul 11, 2025
Browse tours and tickets to explore Florida Keys National Marine Sanctuary
Tours & day trips
See all 169 activities
Day trip to Paradise from Miami: Key West Tour with Snorkeling, Open bar
Activity duration is 16 hours and 30 minutes
7.8 out of 10 with 15 reviews
History & culture
See all 59 activities
Key West Day Trip & Glass Bottom-Boat Tour from Miami
Activity duration is 12 hours
5.0 out of 10 with 27 reviews
Free cancellation available
Wildlife & nature
See all 58 activities
Key West Morning Snorkel Adventure with Bottomless Mimosas & Breakfast
Activity duration is 3 hours
9.2 out of 10 with 122 reviews
Free cancellation available
Private & custom tours
See all 36 activities
Dry Tortugas National Park Day Trip by Luxury Boat: Axopar 37 XC
Activity duration is 8 hours
Free cancellation available
Adventure & outdoor
See all 26 activities
Key West Half-Day Fishing Charter
Activity duration is 5 hours
9.2 out of 10 with 14 reviews
Free cancellation available
Reviews of Florida Keys National Marine Sanctuary
4.5
Top Destination
3/5 - Okay
Verified traveler
Was the only place we went that didn't charge admission. Great volunteers!
Popular places to visit

Florida Keys Eco - Discovery Center
4.5/5(115 reviews)
Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

Fort Zachary Taylor Historic State Park
4.5/5(962 reviews)
The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.

Truman Beach
Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.

Jackson Square
4.5/5(81 reviews)
You can learn about the history of Key West with a stop at Jackson Square. Stroll along the beautiful beaches or discover the area's beautiful sunsets.

Harry S. Truman Little White House
4.5/5(834 reviews)
Visit the winter home of President Harry S. Truman to see where some of America’s most important post-war decisions were made.

Key West Lighthouse and Keeper's Quarters Museum
4.5/5(438 reviews)
Climb to the top of this historic lighthouse for unparalleled photo opportunities and then visit the former home of Key West’s lighthouse keepers.
Best Lodging Options Near Florida Keys National Marine Sanctuary
Check availability on hotels close to Florida Keys National Marine Sanctuary

Southernmost Beach Resort and Guesthouses
1319 Duval Street, Key West, FL

La Concha Key West, Autograph Collection
430 Duval St, Key West, FL

Casa Marina Key West, Curio Collection by Hilton
1500 Reynolds Street, Key West, FL

Duval House
815 Duval St, Key West, FL

The Southernmost Inn - Adults Only
525 United Street, Key West, FL

The Reach Key West, Curio Collection by Hilton
1435 Simonton Street, Key West, FL

Pier House Resort & Spa
1 Duval St, Key West, FL

Lighthouse Hotel - Key West Historic Inns
902 Whitehead St, Key West, FL

Winslow's Bungalows - Key West Historic Inns
725 Truman Avenue, Key West, FL
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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- San Carlos Institute - Casa Cuba
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