Florida Keys National Marine Sanctuary is the perfect place kick off your day in Key West. This protected ocean area is recommended by fellow travelers, but it isn't the only thing to do here. Pencil in time for other sights like Ernest Hemingway Home and Museum, Audubon House and Tropical Gardens, and Mallory Square to make the most of what's on offer in the area.
Florida Keys National Marine Sanctuary Tours
Visit Florida Keys National Marine Sanctuary
Plan a trip to see Florida Keys National Marine Sanctuary
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Hyatt Vacation Club at Beach House, Key West
Save 100% on your flight
Price was $843, price is now $545 per person
$545
per person
Nov 16 - Nov 19
found 1 day ago
Roundtrip non-stop flight included
Cleveland (CLE) to Key West (EYW)
9.4/10 Exceptional! (1,008 reviews)
Very nice property for the price
Reviewed on Aug 19, 2025
Hyatt Vacation Club at Windward Pointe, Key West
Save 100% on your flight
Price was $945, price is now $566 per person
$566
per person
Oct 19 - Oct 22
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Key West (EYW)
9.6/10 Exceptional! (1,008 reviews)
Hotel was very spacious. Enjoyed the view of the beach. The concierge was very friendly and helpful.
Reviewed on Aug 18, 2025
Lighthouse Hotel - Key West Historic Inns
Old Town Key West
Save 100% on your flight
Price was $1,035, price is now $658 per person
$658
per person
Sep 26 - Sep 29
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Key West (EYW)
9/10 Wonderful! (775 reviews)
The property is cute with its own unique vibe. Our room did smell a bit musty, but it’s damp south Florida…so I took that with a grain of salt. There was some mold in our bathroom grout also, but I wasn’t in the mood to complain about something so petty. One thing I will rave about was Jefferson, he was working at the pool bar and not only was he a joy to talk to, he made a great drink!
Reviewed on Aug 19, 2025
Browse tours and tickets to explore Florida Keys National Marine Sanctuary
Tours & day trips
See all 157 activities
Day trip to Paradise from Miami: Key West Tour with Snorkeling, Open bar
Activity duration is 16 hours and 30 minutes
7.8 out of 10 with 15 reviews
History & culture
See all 52 activities
Key West Day Trip & Glass Bottom-Boat Tour from Miami
Activity duration is 12 hours
5.0 out of 10 with 27 reviews
Free cancellation available
Wildlife & nature
See all 48 activities
Key West Morning Snorkel Adventure with Bottomless Mimosas & Breakfast
Activity duration is 3 hours
9.2 out of 10 with 129 reviews
Free cancellation available
Private & custom tours
See all 34 activities
Dry Tortugas National Park Day Trip by Luxury Boat: Axopar 37 XC
Activity duration is 8 hours
Free cancellation available
Adventure & outdoor
See all 17 activities
Key West Half-Day Fishing Charter
Activity duration is 5 hours
9.2 out of 10 with 14 reviews
Free cancellation available
Popular places to visit
Florida Keys Eco - Discovery Center
Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.
Fort Zachary Taylor Historic State Park
The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.
Truman Beach
Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.
Jackson Square
You can learn about the history of Key West with a stop at Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.
Harry S. Truman Little White House
Visit the winter home of President Harry S. Truman to see where some of America’s most important post-war decisions were made.
Key West Lighthouse and Keeper's Quarters Museum
Climb to the top of this historic lighthouse for unparalleled photo opportunities and then visit the former home of Key West’s lighthouse keepers.
Best Lodging Options Near Florida Keys National Marine Sanctuary
Check availability on hotels close to Florida Keys National Marine Sanctuary
Southernmost Beach Resort and Guesthouses
1319 Duval Street, Key West, FL
Hyatt Centric Key West Resort and Spa
601 Front St, Key West, FL
Pier House Resort & Spa
1 Duval St, Key West, FL
The Southernmost Inn - Adults Only
525 United Street, Key West, FL
La Concha Key West, Autograph Collection
430 Duval St, Key West, FL
Casa Marina Key West, Curio Collection by Hilton
1500 Reynolds Street, Key West, FL
Opal Key Resort & Marina, Key West
245 Front Street, Key West, FL
Lighthouse Hotel - Key West Historic Inns
902 Whitehead St, Key West, FL
The Reach Key West, Curio Collection by Hilton
1435 Simonton Street, Key West, FL
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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- Ernest Hemingway Home and Museum
- Fort Zachary Taylor Historic State Park
- Duval Street
- Florida Keys Eco - Discovery Center
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- Harry S. Truman Little White House
- Jackson Square
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- San Carlos Institute - Casa Cuba
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- Tennessee Williams Key West Exhibit
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- Roy John-Karl Gallery
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