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Our top choices for Defiance 2-star hotels

Best Western Plus St. Louis West-Westport

Best Western Plus St. Louis West-Westport
2.5 star property
Maryland Heights
8.0 out of 10, Very Good, (1,056 reviews)
"Great poperty!"
United States
Sarah
$99 nightly
The price is $115
Apr 5 - Apr 6
Total with taxes and fees
Best Western Plus St. Louis West-Westport

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Days Inn and Suites by Wyndham St. Louis/Westport Plaza
2.5 star property
Maryland Heights
4.6 out of 10, (1,004 reviews)
"Easy parking. Difficulty getting an accessible room. Breakfast was not great."
United States
Stephany
$65 nightly
The price is $75
Mar 22 - Mar 23
Total with taxes and fees
Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
St. Charles
8.4 out of 10, Very Good, (1,005 reviews)
"Over all our stay was good. The room was a good size, we are thankful there was an ironing board and iron in the room. Good options at breakfast and the staff we encountered we are very pleasant. "
United States
Elizabeth
$84 nightly
The price is $97
Apr 5 - Apr 6
Total with taxes and fees
Comfort Suites St Charles - St Louis

Relax Inn Saint Charles

Relax Inn Saint Charles
2.0 star property
St. Charles
6.8 out of 10, (1,000 reviews)
"Nice place and good price for the night "
United States
David
$61 nightly
The price is $71
Mar 18 - Mar 19
Total with taxes and fees
Relax Inn Saint Charles

Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District
2.5 star property
St. Charles Historic District
9.4 out of 10, Exceptional, (1,007 reviews)
"Great location, great breakfast, reasonable prices. "
United States
Jean
$127 nightly
The price is $146
Mar 22 - Mar 23
Total with taxes and fees
Country Inn & Suites by Radisson, St. Charles Historic District

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,008 reviews)
"Wonderful staff,very clean rooms!! Great breakfast and atmosphere. "
United States
Sherri
$79 nightly
The price is $93
Mar 22 - Mar 23
Total with taxes and fees
Sleep Inn & Suites O'Fallon MO - Technology Drive

Best Western Plus Fenton

Best Western Plus Fenton
2.5 star property
Fenton
9.2 out of 10, Wonderful, (230 reviews)
"Friendly staff, clean room, quiet, nice amenities."
United States
Catherine
$99 nightly
The price is $115
Mar 22 - Mar 23
Total with taxes and fees
Best Western Plus Fenton

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
St. Charles
8.0 out of 10, Very Good, (1,005 reviews)
"Great location and friendly staff "
United States
Heather
$101 nightly
The price is $116
Apr 5 - Apr 6
Total with taxes and fees
Hampton Inn St. Charles St. Peters

Motel 6 Maryland Heights, MO

Motel 6 Maryland Heights, MO
2.0 star property
Maryland Heights
6.0 out of 10, (1,001 reviews)
"Whole place was dirty"
United States
Xavier
$61 nightly
The price is $71
Mar 27 - Mar 28
Total with taxes and fees
Motel 6 Maryland Heights, MO

Extended Stay America Suites - St Louis - Fenton

Extended Stay America Suites - St Louis - Fenton
2.5 star property
Fenton
5.8 out of 10, (251 reviews)
"It was a nice room"
United States
Damon
$70 nightly
The price is $81
Mar 24 - Mar 25
Total with taxes and fees
Extended Stay America Suites - St Louis - Fenton

Americas Best Value Inn & Suites St. Louis, St. Charles Inn

Americas Best Value Inn & Suites St. Louis, St. Charles Inn
2.5 star property
St. Charles
5.8 out of 10, (1,005 reviews)
"Great place"
United States
Christina
$90 nightly
The price is $104
Mar 18 - Mar 19
Total with taxes and fees
Americas Best Value Inn & Suites St. Louis, St. Charles Inn

Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very Good, (951 reviews)
"Clean rooms, pleasant staff."
United States
Karen
$72 nightly
The price is $82
Mar 23 - Mar 24
Total with taxes and fees
Quality Inn Foristell

Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
O'Fallon
8.6 out of 10, Excellent, (882 reviews)
"It was a wonderful stay for my girls and her birthday. She had a blast and the room was Lovely 😍🌹"
United States
Amanda
$93 nightly
The price is $110
Mar 22 - Mar 23
Total with taxes and fees
Holiday Inn Express St. Louis West - O'Fallon by IHG

Comfort Inn & Suites St. Louis - O'Fallon

Comfort Inn & Suites St. Louis - O'Fallon
2.5 star property
O'Fallon
7.6 out of 10, Good, (1,002 reviews)
"Good spot and great location to visit with family "
United States
Ernest
$83 nightly
The price is $97
Apr 5 - Apr 6
Total with taxes and fees
Comfort Inn & Suites St. Louis - O'Fallon

Hampton Inn & Suites St. Charles Old Town Area

Hampton Inn & Suites St. Charles Old Town Area
2.5 star property
St. Charles
9.0 out of 10, Wonderful, (665 reviews)
"Everything went smooth . 2nd time staying here. Recommended "
United States
Adela
$130 nightly
The price is $156
Apr 5 - Apr 6
Total with taxes and fees
Hampton Inn & Suites St. Charles Old Town Area

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
2.5 star property
Chesterfield
9.0 out of 10, Wonderful, (1,002 reviews)
"This property is currently under some remodeling, but it is being updated nicely! The staff is very accommodating and friendly. And there is so much to do in this area! We really enjoyed our stay."
United States
Julie
$126 nightly
The price is $147
Apr 5 - Apr 6
Total with taxes and fees
Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
9.0 out of 10, Wonderful, (53 reviews)
"Newly open and no complaints, staff is accommodating and nice. Rooms are very clean, first time I ever put my clothing items in a drawer and unpacked. Right off the highway and close to everything "
United States
Cassie
$91 nightly
The price is $105
Mar 18 - Mar 19
Total with taxes and fees
WoodSpring Suites St Peters-OFallon

Extended Stay America Suites St Louis St Peters

Extended Stay America Suites St Louis St Peters
2.5 star property
St. Peters
7.0 out of 10, Good, (628 reviews)
"Location was perfect"
United States
Tara
$91 nightly
The price is $105
Mar 29 - Mar 30
Total with taxes and fees
Extended Stay America Suites St Louis St Peters

Candlewood Suites St Louis St Charles by IHG

Candlewood Suites St Louis St Charles by IHG
2.5 star property
St. Charles
7.6 out of 10, Good, (786 reviews)
"The best"
United States
Mernurvia
$84 nightly
The price is $97
Mar 29 - Mar 30
Total with taxes and fees
Candlewood Suites St Louis St Charles by IHG

Country Inn & Suites by Radisson, St. Peters, MO

Country Inn & Suites by Radisson, St. Peters, MO
2.5 star property
St. Charles
8.0 out of 10, Very Good, (1,005 reviews)
"Parking was safe and easy to reach. The staff was great and kind. Wasn't the cleanest, but overall a great stay."
United States
Hector
$86 nightly
The price is $98
Apr 7 - Apr 8
Total with taxes and fees
Country Inn & Suites by Radisson, St. Peters, MO
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Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

Find out more about Defiance

Defiance Motel Guide

Planning a getaway with only a few bucks to spare? Expedia can help! With the inexpensive rates at the top motels in Defiance, St. Louis you can put together the vacation of your dreams without spending every penny of your yearly travel budget.

These smaller places are ideal if you need a home base that lets you easily explore the local sights; many of the best motels in Defiance are located near major freeways and public transportation. Plus, when you book a cheap deal on a motel in Defiance, you’ll find quiet rooms, complimentary toiletries, and comfortable sleeping areas, so you can unwind after a long day.

No matter which motel you choose, don't forget to use the travel tools at Expedia to search for local discounts, compare rates on the hottest motels, and plan your next vacation. You won't believe how budget-friendly an amazing getaway can be.

Also, feel free to check out the motels near me page to find the cheapest deals on motels near your current location.

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