
Find 2 Star Hotels in Defiance, MO from $65
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Our top choices for Defiance 2-star hotels

1. Days Inn and Suites by Wyndham St. Louis/Westport Plaza
Days Inn and Suites by Wyndham St. Louis/Westport Plaza
2. Hampton Inn St. Charles St. Peters
Hampton Inn St. Charles St. Peters
3. Country Inn & Suites by Radisson, St. Charles Historic District
Country Inn & Suites by Radisson, St. Charles Historic District
4. Relax Inn Saint Charles
Relax Inn Saint Charles
5. Comfort Suites St Charles - St Louis
Comfort Suites St Charles - St Louis
6. Sleep Inn & Suites O'Fallon MO - Technology Drive
Sleep Inn & Suites O'Fallon MO - Technology Drive
7. Studio 6 Extended Stay - St Louis, MO - Westport/Craig Road
Studio 6 Extended Stay - St Louis, MO - Westport/Craig Road
8. WoodSpring Suites St Peters-OFallon
WoodSpring Suites St Peters-OFallon
9. Extended Stay America Select Suites St Louis Earth City
Extended Stay America Select Suites St Louis Earth City
10. Quality Inn Foristell
Quality Inn Foristell
11. The Lodge Hotel and Banquets
The Lodge Hotel and Banquets
12. Best Western Plus St. Louis West-Westport
Best Western Plus St. Louis West-Westport
13. Americas Best Value Inn & Suites St. Louis, St. Charles Inn
Americas Best Value Inn & Suites St. Louis, St. Charles Inn
14. Country Inn & Suites by Radisson, St. Peters, MO
Country Inn & Suites by Radisson, St. Peters, MO
15. Motel 6 Maryland Heights, MO
Motel 6 Maryland Heights, MO
16. Super 8 by Wyndham St Charles
Super 8 by Wyndham St Charles
17. Red Roof Inn St Louis - Westport/ Maryland Heights
Red Roof Inn St Louis - Westport/ Maryland Heights
18. Holiday Inn Express Warrenton by IHG
Holiday Inn Express Warrenton by IHG
19. Best Western Plus Fenton
Best Western Plus Fenton
20. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
Holiday Inn Express & Suites St. Louis - Chesterfield by IHGExplore similar 3-star hotels

Hollywood Casino & Hotel St. Louis
Learn more about Defiance
Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

Top Defiance Hotel Reviews
Find out more about Defiance
Defiance Motel Guide
Planning a getaway with only a few bucks to spare? Expedia can help! With the inexpensive rates at the top motels in Defiance, St. Louis you can put together the vacation of your dreams without spending every penny of your yearly travel budget.
These smaller places are ideal if you need a home base that lets you easily explore the local sights; many of the best motels in Defiance are located near major freeways and public transportation. Plus, when you book a cheap deal on a motel in Defiance, you’ll find quiet rooms, complimentary toiletries, and comfortable sleeping areas, so you can unwind after a long day.
No matter which motel you choose, don't forget to use the travel tools at Expedia to search for local discounts, compare rates on the hottest motels, and plan your next vacation. You won't believe how budget-friendly an amazing getaway can be.
Also, feel free to check out the motels near me page to find the cheapest deals on motels near your current location.
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