Default HTG hotel image

Depew Vacation Rentals

  • Bundle & Save

    Get more, spend less whenever you see Bundle & Save deals

  • OneKeyCash

    Earn OneKeyCash on all your eligible bookings

  • Upfront pricing

    We are not like the others - we include taxes and fees

Check prices for these dates

In two weeks
Oct 16 - Oct 18
In two months
Nov 27 - Nov 29
In three months
Dec 25 - Dec 27
In four months
Jan 22 - Jan 24

Our top choices for Depew vacation rentals

A spacious living room with a wooden dining table, a sofa, a coffee table, and a TV mounted on the wall.

1. Luxury Villa

Luxury Villa
Lancaster
10.0 out of 10, Exceptional, (25 reviews)
"Super convenient location and wonderful open layout! "
United States
Lisa K.
$168 nightly
The price is $188
Oct 5 - Oct 6
Total with taxes and fees
Luxury Villa
A living room with a dark brown sofa, a patterned rug, and a red patterned ottoman. There is a kitchen area in the background with a refrigerator and a bar counter.

2. Niagara Falls is only 30minutes away.Airport 4 min away. Family & pet friendly!

Niagara Falls is only 30minutes away.Airport 4 min away. Family & pet friendly!
Buffalo
9.8 out of 10, Exceptional, (44 reviews)
"Great location, pet friendly- would stay again."
United States
Jean C.
$181 nightly
The price is $208
Oct 5 - Oct 6
Total with taxes and fees
Niagara Falls is only 30minutes away.Airport 4 min away. Family & pet friendly!
A coffee station with a coffee maker, sugar, creamer, and coffee beans.

3. 11 min from BUF Airport, 19 min from Bills Stadium, 35 min from Niagara Falls!

11 min from BUF Airport, 19 min from Bills Stadium, 35 min from Niagara Falls!
Buffalo
9.8 out of 10, Exceptional, (12 reviews)
"A very clean, pleasant space with attention to detail!The furnishings were perfect for the space, especially loved the comfy recliners. It was a great place for the 2 of us, we only stayed one night as we were passing through town but we would have loved to stay a few more just to relax ."
United States
Sandra W.
$180 nightly
The price is $201
Oct 1 - Oct 2
Total with taxes and fees
11 min from BUF Airport, 19 min from Bills Stadium, 35 min from Niagara Falls!
A modern living room with a wooden wall, a flat-screen TV, a round coffee table, and a sofa with cushions.

4. *Central location*Clean*Parking*2BDRM*A/C

*Central location*Clean*Parking*2BDRM*A/C
Cheektowaga
10.0 out of 10, Exceptional, (2 reviews)
"Loved it"
United States
Mara R.
$262 nightly
The price is $267
Sep 30 - Oct 1
Total with taxes and fees
*Central location*Clean*Parking*2BDRM*A/C
A spacious kitchen with a granite countertop, white cabinetry, and a large island with a sink. There is a chandelier, a television, and a dining area visible.

5. *Perfect Vacation* Cozy Lancaster Village Bungalow

*Perfect Vacation* Cozy Lancaster Village Bungalow
Lancaster
10.0 out of 10, Exceptional, (1 review)
"No concerns. Everything as stated. "
United States
Ronald F.
$337 nightly
The price is $342
Sep 30 - Oct 1
Total with taxes and fees
*Perfect Vacation* Cozy Lancaster Village Bungalow
A modern living room with a sofa, a coffee table, a TV, and a potted plant.

6. Cozy 3-Bedroom Home Near Airport

Cozy 3-Bedroom Home Near Airport
Depew
$283 nightly
The price is $325
Sep 30 - Oct 1
Total with taxes and fees
Cozy 3-Bedroom Home Near Airport
A kitchen with a stove, oven, and a ladder leading to a loft area.

7. Tiny Spa Cottage Retreat

Tiny Spa Cottage Retreat
Alden
9.8 out of 10, Exceptional, (146 reviews)
"Me and my girlfriend wanted a place to stay for the Bryson tiller concert and we couldn’t have chose a better place, the communication between me and host was great and they were very welcoming!!"
United States
Daniel
$183 nightly
The price is $205
Sep 30 - Oct 1
Total with taxes and fees
Tiny Spa Cottage Retreat
A bedroom with a bed, dresser, and a television.

8. Peaceful one bedroom in university district

Peaceful one bedroom in university district
University Heights
8.8 out of 10, Excellent, (6 reviews)
"Very clean, basic studio apt. Excellent communication from owner. Good location"
United States
Ben
$145 nightly
The price is $166
Sep 30 - Oct 1
Total with taxes and fees
Peaceful one bedroom in university district
A dining room with a black table, blue upholstered chairs, and a matching bench.

9. 420 Friendly 3 bedroom upstairs apartment. Street parking only.

420 Friendly 3 bedroom upstairs apartment. Street parking only.
Seneca
9.4 out of 10, Exceptional, (75 reviews)
"great location, clean, spacious"
United States
MacKenzie G.
$196 nightly
The price is $199
Oct 1 - Oct 2
Total with taxes and fees
420 Friendly 3 bedroom upstairs apartment. Street parking only.
A residential house with a blue exterior, a front porch, and a driveway.

10. Nice big house with parking, fenced yard

Nice big house with parking, fenced yard
Buffalo
7.2 out of 10, Good, (7 reviews)
"Great place"
United States
JOSEPH Z.
$321 nightly
The price is $381
Sep 30 - Oct 1
Total with taxes and fees
Nice big house with parking, fenced yard
A covered outdoor patio with a fire feature, seating, and a table.

11. Spacious/Comfy/Private Home near Buffalo/Bills/Airport/Niagara Falls

Spacious/Comfy/Private Home near Buffalo/Bills/Airport/Niagara Falls
Depew
10.0 out of 10, Exceptional, (54 reviews)
"The rental was perfect for our family and the kids lived the pool!"
United States
Dawn S.
$562 nightly
The price is $645
Sep 30 - Oct 1
Total with taxes and fees
Spacious/Comfy/Private Home near Buffalo/Bills/Airport/Niagara Falls
A corner room with a curved wall, large windows, and a wooden floor.

12. Cozy 3-bedroom house in charming Buffalo with WiFi, AC

Cozy 3-bedroom house in charming Buffalo with WiFi, AC
Kaisertown
8.4 out of 10, Very good, (19 reviews)
"Great place to stay"
United States
Cristian
$221 nightly
The price is $253
Sep 30 - Oct 1
Total with taxes and fees
Cozy 3-bedroom house in charming Buffalo with WiFi, AC
A grassy backyard with a wooden structure, surrounded by trees and a fence.

13. Sweet home, King bed, fenced backyard, and parking

Sweet home, King bed, fenced backyard, and parking
Buffalo
$437 nightly
The price is $510
Oct 5 - Oct 6
Total with taxes and fees
Sweet home, King bed, fenced backyard, and parking
A modern living room with a sofa, a coffee table, and a TV stand.

14. Cozy 3BR • 4 beds • Parking - Buffalo Niagara Falls

Cozy 3BR • 4 beds • Parking - Buffalo Niagara Falls
Buffalo
7.6 out of 10, Good, (12 reviews)
"I will recommend for big families."
United States
israr
$330 nightly
The price is $379
Oct 21 - Oct 22
Total with taxes and fees
Cozy 3BR • 4 beds • Parking - Buffalo Niagara Falls
A living room with a fireplace, grey sofas, a TV, and a coffee table.

15. King bed fenced backyard and parking

King bed fenced backyard and parking
Buffalo
9.4 out of 10, Exceptional, (3 reviews)
"We were in town for our daughter’s college graduation and the house was perfect. Great landing place, clean, had the basics, enough space for all. "
United States
Deb G.
$377 nightly
The price is $449
Sep 30 - Oct 1
Total with taxes and fees
King bed fenced backyard and parking
A modern living room with a sofa, armchair, and coffee table. There is a flat-screen TV mounted on the wall.

16. Your Cozy Home Away From Home king bed, parking

Your Cozy Home Away From Home king bed, parking
West Seneca
8.0 out of 10, Very good, (3 reviews)
"We staying here for a concert at Highmark"
United States
Jay M.
$249 nightly
The price is $296
Sep 30 - Oct 1
Total with taxes and fees
Your Cozy Home Away From Home king bed, parking
A room with a blue sofa, a small round table, a white desk, and a radiator.

17. Sunlit One Bedroom In Allentown

Sunlit One Bedroom In Allentown
Downtown Buffalo
$172 nightly
The price is $193
Sep 30 - Oct 1
Total with taxes and fees
Sunlit One Bedroom In Allentown
A hotel room with a bed, a desk, a chair, a TV, and a window.

18. Studio 6 Buffalo|1 Queen Bed,Nsmk|Kitchen

Studio 6 Buffalo|1 Queen Bed,Nsmk|Kitchen
Buffalo NY
8.8 out of 10, Excellent, (52 reviews)
"Card never worked, had to be replaced numerous times throughout the week. Front desk assistance was always unavailable or took 15 minutes to answer the front desk bell."
United States
Dylan
$87 nightly
The price is $99
Oct 7 - Oct 8
Total with taxes and fees
Studio 6 Buffalo|1 Queen Bed,Nsmk|Kitchen
A residential house with a dark exterior, a front porch with a bench, and a driveway leading to a parked car.

19. Nice house with private parking, king bed fenced yard

Nice house with private parking, king bed fenced yard
West Seneca
8.8 out of 10, Excellent, (10 reviews)
"Yes suitable for pets. Kitchen had what we needed. We very much enjoyed our stay, immaculate condition. "
United States
Sean
$320 nightly
The price is $381
Oct 19 - Oct 20
Total with taxes and fees
Nice house with private parking, king bed fenced yard
A residential property with a large tree, a swing set, and a garage.

20. Como Lake Park Retreat | Hot Tub + Designer Home

Como Lake Park Retreat | Hot Tub + Designer Home
Lancaster
$445 nightly
The price is $449
Oct 2 - Oct 3
Total with taxes and fees
Como Lake Park Retreat | Hot Tub + Designer Home
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Depew Hotel Reviews

Garden Place Hotel

Garden Place Hotel

8/10 Good
"Need to update room"
Carter 2-night trip
Posted less than an hour ago
Garden Place Hotel

Find out more about Depew

Everything you need to know about Depew vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Depew vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Depew vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Depew vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Depew. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Depew in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Depew rentals

At Expedia, we put the best Depew vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Depew rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Depew vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Depew. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Can I find vacation rentals in Depew?

Yes, we have vacation rentals near well known sights in Depew, or you can choose a secluded option if you're looking for relaxation. Depew is known for its shopping and restaurants. Make sure you have time to check out the sporting events and waterfalls during your trip.

What are some of the best vacation home rentals in Depew?

HTR Niagara: Visitors like this Depew vacation home rental. It is on the riverwalk and equipped with air-conditioning and free WiFi to help you feel perfectly comfortable in your new surroundings. Amenities like a coffee maker and free parking are also available for your convenience.

How many vacation rentals will I find in Depew?

Choose from 5 Expedia vacation rentals in Depew for a memorable vacation.

What can I see and do in Depew?

While exploring the area, visit family-friendly sights like Buffalo Museum of Science, or get outside and enjoy nature at Glen Falls. Highmark Stadium and Walden Galleria Mall are a couple of places you'll find in the larger area.

What are vacation rentals like in Depew?

Vacation rentals are private accommodations you can reserve for several days or more in Depew. Vacation rentals feature extras like WiFi and washers and dryers so you'll have everything you want. If you're concerned about a sanitized environment, a vacation rental can provide a sense of safety away from shared hotel elevators and busy lobbies while still allowing you a great travel experience. You'll also find more space in a vacation rental than in a standard hotel, which makes a vacation rental a great option for a family trip.