Top 10 Hotels in Lithium, MO (from $70) 2026 - Competitive Prices

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Our top choices for Lithium hotels

A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.

A spacious lobby with a checkered floor, two sofas with patterned cushions, a computer desk, and a reception area with a glass door.

A hotel lobby with two sofas, a coffee table, lamps, and a large window with a plant.

A hotel room with a kitchenette, a large mirror, a sofa, and a patterned carpet.

1. Super 8 by Wyndham Perryville

Perryville

Matthew

$68 nightly

$78 total

Nov 8 - Nov 9

Total with taxes and fees

A hotel lobby with a reception desk, seating area, and a patterned carpet.

A kitchen counter with a coffee machine, a kettle, and storage boxes.

A hotel room with a large bed, a nightstand, a lamp, a chair, and a mirror.

A reception area with a counter, vending machines, and a security camera.

2. Holiday Inn Express & Suites Perryville by IHG

Perryville

Perry

$95 nightly

$109 total

Nov 22 - Nov 23

Total with taxes and fees

A hotel room with a large bed, a bathroom with a bathtub, and a mirror reflecting the room.

A kitchen with wooden cabinets, a dining area with a table and chairs, and various kitchen appliances.

A swimming pool with a metal ladder, a Days Inn sign, and a blue water tower in the background.

A hotel hallway with a patterned carpet, blue walls, and a sign indicating an office.

3. Days Inn by Wyndham Perryville

Perryville

Jesse

$68 nightly

$77 total

Oct 26 - Oct 27

Total with taxes and fees

A hotel room with a bed, a desk with a chair, a small table, a sofa, a bathtub, and a window with curtains.

A modern bathroom with a large bathtub, a wooden floor, and a dark wall with a colorful abstract painting.

A gym with treadmills, a weight machine, and exercise balls.

A breakfast area with a counter, seating, and kitchen appliances.

4. Baymont by Wyndham Chester IL

Chester

Keng

$80 nightly

$89 total

Nov 22 - Nov 23

Total with taxes and fees

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

A fireplace with a decorative mantel, a framed sign, and a small table with plants.

A building with a sign that reads "The Atrium Boutique Hotel".

A building with a dark exterior, a large window, and a sign that reads "The Atrium."

5. The Atrium - A Boutique Hotel

Perryville

Brian

$98 nightly

$112 total

Oct 26 - Oct 27

Total with taxes and fees

A lobby with a TV, framed pictures, a plant, and patterned chairs.

A hotel room with a desk, a television, a coffee maker, a chair, and a window with curtains.

A breakfast bar with a toaster, coffee maker, and fruit juice dispenser.

A hotel room with a large bathtub, a bed with two pillows, a nightstand, and a wall-mounted lamp.

6. Quality Inn Perryville I-55

Perryville

Evelynmaryeka

$64 nightly

$73 total

Nov 15 - Nov 16

Total with taxes and fees

A row of single-story houses with attached garages, a paved driveway, and a clear sky.

A modern living room with a flat-screen TV, a desk with a computer, two armchairs, a coffee table, and large windows with a view.

A hotel dining area with tables and chairs, a kitchen area, and a flat-screen TV mounted on the wall.

A hotel room with two beds, a desk, a chair, and a window with curtains.

7. Microtel Inn & Suites by Wyndham Sainte Genevieve

Ste Genevieve

Samantha

$84 nightly

$98 total

Nov 15 - Nov 16

Total with taxes and fees

A rustic cabin-style lodging with a covered porch, picnic tables, and a fire pit.

A swimming pool with a small water slide, surrounded by lounge chairs and umbrellas.

A cabin interior with a kitchenette, a ceiling fan, a television, a sofa, and a window with blinds.

A lakeside RV resort with wooden cabins, a picnic area, and a reflection in the water.

8. Perryville RV Resort

Perryville

Kevin

$74 nightly

$84 total

Nov 1 - Nov 2

Total with taxes and fees

A parking lot with a sign for Triangle Inn.

A room with a wooden table, two patterned chairs, a framed artwork on the wall, and a window with brown curtains.

A compact kitchen with black cabinets, a black refrigerator, a microwave, and a sink.

9. Triangle Inn Motel

Ste Genevieve

Kimmy

$59 nightly

$70 total

Nov 8 - Nov 9

Total with taxes and fees

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.

A hallway with exposed brick walls, wooden flooring, and a white door.

A spacious living area with a large window, a ceiling fan, and a kitchen area with modern appliances.

10. Urban Lofts

Perryville

Grace

$295 nightly

$338 total

Oct 26 - Oct 27

Total with taxes and fees

A modern kitchen with stainless steel appliances, a large window, and a green cabinet.

A two-story building with a balcony, a front door with a wreath, and a sign indicating a restaurant.

A wooden interior with a dining area, staircase, and a television mounted on the wall.

A kitchen with a large black sink, a window with a view of trees, and a microwave on the counter.

11. The Mediterranean House 1858

Perryville

$743 nightly

$850 total

Oct 27 - Oct 28

Total with taxes and fees

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Hotels recommended for families in Lithium

Super 8 by Wyndham Perryville

Perryville

$68 nightly

$78 total

Nov 8 - Nov 9

Total with taxes and fees

Holiday Inn Express & Suites Perryville by IHG

Perryville

$95 nightly

$109 total

Nov 22 - Nov 23

Total with taxes and fees

Baymont by Wyndham Chester IL

Chester

$80 nightly

$89 total

Nov 22 - Nov 23

Total with taxes and fees

Days Inn by Wyndham Perryville

Perryville

$68 nightly

$77 total

Oct 26 - Oct 27

Total with taxes and fees

Microtel Inn & Suites by Wyndham Sainte Genevieve

Ste Genevieve

$84 nightly

$98 total

Nov 15 - Nov 16

Total with taxes and fees

Urban Lofts

Perryville

$295 nightly

$338 total

Oct 26 - Oct 27

Total with taxes and fees

A living room with a leather sofa, a coffee table, and a television on a wooden shelf.

A hot tub in front of a house with a wooden deck and a light fixture on the wall.

A kitchen with a framed artwork of a vintage truck, a modern Instant Pot, and a marble countertop.

A single-story yellow house with a front porch, a garage, and a well-maintained lawn.

Sleeps 8 | Private Hot Tub + Fenced Yard | Near Historic Ste. Genevieve

Saint Mary

$382 nightly

$417 total

Oct 27 - Oct 28

Total with taxes and fees

A white two-story house with a covered porch, a chimney, and a small garden area with chairs and a table.

A bay window with a view of green hills, white cabinetry, and a television on the right.

Two Adirondack chairs facing a pond with a view of a green field and hills in the background.

A bedroom with a bed, bedside table, and a window. There is a kitchenette with a sink, stove, and cabinets.

Beautiful Modern Loft In Wine Country!

Ste. Genevieve

$181 nightly

$202 total

Oct 28 - Oct 29

Total with taxes and fees

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Top Lithium Hotel Reviews

The Atrium - A Boutique Hotel

10/10 Excellent

"Walking into this property is like walking into another world. We were utterly charmed, and plan to use it as our personal romantic getaway going forward. The host is unbelievably responsive. We had a problem with a smoke detector in the unit at close to midnight. Maintenance assistance arrived in under 5 minutes. And when the problem could not be resolved, we were moved to a beautiful property nearby, which was worth far more than what we had paid. We are very much forward to staying here again."

Baymont by Wyndham Chester IL

10/10 Excellent

"Staff upgraded our room to the first floor and we appreciate that after a long day."