Title: Visit Pamplico: 2026 Travel Guide for Pamplico, South Carolina | Expedia.com

[Hotels in Pamplico](https://expedia.com/Pamplico-Hotels.d3000353197.Travel-Guide-Hotels)[Vacation Rentals in Pamplico](https://expedia.com/Pamplico-Vacation-Rentals.d3000353197.Travel-Guide-VacationRentals)[Flights to Pamplico](https://expedia.com/Cheap-Flights-To-Pamplico.d3000353197.Travel-Guide-Flights)[Things to do in Pamplico](https://expedia.com/Things-To-Do-In-Pamplico.d3000353197.Travel-Guide-Activities)[Car Rentals in Pamplico](https://expedia.com/Car-Rentals-In-Pamplico.d3000353197.Car-Rental-Guide)[Pamplico Vacation Packages](https://expedia.com/Pamplico.d3000353197.Destination-Travel-Guides)

# Pamplico, SC

## Travel Guide

## Visit Pamplico

![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh)

## 

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.

[Book now](https://expedia.com/deals?rfrr=DX_SPRING_PROMO_3000353197)

- Pamplico Hotel Deals
- Vacation Rentals in Pamplico

![Comfort Inn & Suites Florence Center Area](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/64840011_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Comfort Inn & Suites Florence Center Area

527 Woody Jones Blvd Florence SC

$101 nightly

$113 total

Mar 29 - Mar 30

Total with taxes and fees

Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...

9.2/10 Wonderful! (1,245 reviews)

At 8am breakfast was missing many items. Oatmeal low and no sugar or cinnamon etc. no yogurt. Granted it was a full hotel but planning for capacity seemed amiss.

Reviewed on Mar 8, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F29%2F2026&endDate=3%2F30%2F2026&selected=38336321&PinnedHotelID=38336321&HadPinnedHotel=true&regionId=3000353197)

![Park Inn by Radisson Florence, SC](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/e4f3361f_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Park Inn by Radisson Florence, SC

1729 Mandeville Road Florence SC

$86 nightly

$96 total

Mar 15 - Mar 16

Total with taxes and fees

Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...

9/10 Wonderful! (2,254 reviews)

Room was comfortable and nice

Reviewed on Mar 8, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F15%2F2026&endDate=3%2F16%2F2026&selected=47086732&PinnedHotelID=47086732&HadPinnedHotel=true&regionId=3000353197)

![Howard Johnson by Wyndham Florence](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Howard Johnson by Wyndham Florence

2038 W Lucas Street Florence SC

$67 nightly

$75 total

Apr 1 - Apr 2

Total with taxes and fees

Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

8.6/10 Excellent! (2,568 reviews)

A great basic hotel. I appreciate the space for parking, especially with a trailer and can drive in a circle around the parking lot and not have to back up.

Reviewed on Mar 10, 2026

[](https://expedia.com/Hotel-Search?startDate=4%2F1%2F2026&endDate=4%2F2%2F2026&selected=11037&PinnedHotelID=11037&HadPinnedHotel=true&regionId=3000353197)

[See all 166 properties in Pamplico](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=3%2F12%2F2026&endDate=3%2F13%2F2026&regionId=3000353197)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

![Charming Cottage with easy access to local attractions-pet and kid friendly](https://images.trvl-media.com/lodging/96000000/95030000/95026900/95026870/e767c5d7_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Charming Cottage with easy access to local attractions-pet and kid friendly

 Sellers SC

Stay at this cottage in Sellers. Enjoy free WiFi, laundry facilities, and patios.

9.6/10 Exceptional! (23 reviews)

The cottage was clean and comfortable. After the original VRBO was cancelled (four days before we traveled), the hostess made us and our dogs feel very welcomed. The overall experience was very good.

Reviewed on Feb 23, 2026

[](https://expedia.com/Sellers-Hotels-Charming-Cottage-With-Easy-Access-To-Local-Attractions-Pet-And-Kid-Friendly.h95026870.Hotel-Information)

![Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/e85ce030_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's

 Florence SC

Stay at this vacation home in Florence. Enjoy a garden, laundry facilities, and patios. Popular attractions Regal Swamp Fox and Florence Veterans Park are located ...

10/10 Exceptional! (47 reviews)

The house is always super clean and welcoming perfect setup for our family when we visit our son at FMU. Comfy beds, plenty of linens, and great living space to relax. Love being able to cook meals and spend time together!

Reviewed on Feb 25, 2026

[](https://expedia.com/Florence-Hotels-Take-A-Rest-In-Florence-Ideal-For-I95-Traveler-And-Florence-Center-And-Buc-Ees.h103861731.Hotel-Information)

![Secret SC Cabin on 100 acres Hot Tub Large Pond](https://images.trvl-media.com/lodging/34000000/33750000/33743000/33742964/8b91a232_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Secret SC Cabin on 100 acres Hot Tub Large Pond

 Marion SC

Stay at this cabin in Marion. Enjoy laundry facilities, patios, and cable/satellite TV service.

9.6/10 Exceptional! (182 reviews)

We thoroughly enjoyed our stay at this beautiful and serene cabin. The pictures do not do it justice. The charm and coziness of this lovely place that is tucked away in your own little escape to nature will make you never want to leave. From the beautiful back deck with a hot tub, the screened in ...

Reviewed on Mar 9, 2026

[](https://expedia.com/Marion-Hotels-Secret-SC-Cabin-On-100-Acres-Hot-Tub-Large-Pond.h33742964.Hotel-Information)

[See all properties in Pamplico](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&regionId=3000353197&sort=VACATION_RENTAL)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Check Pamplico hotel availability

[Tonight

](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=3000353197&startDate=2026-03-11&endDate=2026-03-12)[Mar 11 - Mar 12](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=3000353197&startDate=2026-03-11&endDate=2026-03-12)

[Tomorrow night

](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=3000353197&startDate=2026-03-12&endDate=2026-03-13)[Mar 12 - Mar 13](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=3000353197&startDate=2026-03-12&endDate=2026-03-13)

[This weekend

](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=3000353197&startDate=3%2F13%2F2026&endDate=3%2F15%2F2026)[Mar 13 - Mar 15](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=3000353197&startDate=3%2F13%2F2026&endDate=3%2F15%2F2026)

[Next weekend

](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=3000353197&startDate=3%2F20%2F2026&endDate=3%2F22%2F2026)[Mar 20 - Mar 22](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=3000353197&startDate=3%2F20%2F2026&endDate=3%2F22%2F2026)

## Cities near Pamplico

![Wyche Pavilion Greenville South Carolina ](https://images.trvl-media.com/place/1221/22638cec-95e4-4f53-af15-3963f8a47f19.jpg?impolicy=fcrop&w=512&h=288&q=medium)

### Florence

![a stunning aerial panoramic shot of the blue waters of Lake Hartwell surrounded by vast miles of lush green trees and grass with powerful clouds at sunset in Fair Play South Carolina USA](https://images.trvl-media.com/place/8506/47c9f422-933e-4135-8743-774b754f1db4.jpg?impolicy=fcrop&w=512&h=288&q=medium)

### Lake City

![Charleston skyline from drone, South Carolina](https://images.trvl-media.com/place/8689/320786f2-8a2d-4940-b390-6aca1b71d230.jpg?impolicy=fcrop&w=512&h=288&q=medium)

### Marion

![The tree canopy walk is cool.  If you don't like high places might not be for you and the bridges do bounce when you walk across to the next platform. It is beautiful with the river under you.](https://images.trvl-media.com/place/3000353109/1ba541e6-959a-412b-af08-d95ad3aaedb8.jpg?impolicy=fcrop&w=512&h=288&q=medium)

### Coward

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- Cities near Pamplico
- Places of interest

[Florence](https://expedia.com/Florence.dx1221)[Lake City](https://expedia.com/Lake-City.dx8506)[Marion](https://expedia.com/Marion.dx8689)[Coward](https://expedia.com/Coward.dx3000353109)[Gresham](https://expedia.com/Gresham.dx3000455952)[Scranton](https://expedia.com/Scranton.dx3000456074)

- [Florence Civic Center ](https://expedia.com/Florence-Civic-Center-Florence.d6165605.Vacation-Attraction)
- [Mcleod Regional Medical Center ](https://expedia.com/Mcleod-Regional-Medical-Center-Florence.d6162127.Vacation-Attraction)
- [Magnolia Mall ](https://expedia.com/Magnolia-Mall-Florence.d6165602.Vacation-Attraction)
- [Francis Marion University ](https://expedia.com/Francis-Marion-University-Florence.d6162133.Vacation-Attraction)
- [Eastern Carolina Agricultural Fairgrounds ](https://expedia.com/Eastern-Carolina-Agricultural-Fairgrounds-Florence.d6162140.Vacation-Attraction)
- [Florence Museum ](https://expedia.com/Florence-Museum-Florence.d6162137.Vacation-Attraction)
- [Florence Motor Speedway ](https://expedia.com/Florence-Motor-Speedway-Timmonsville.d6215468.Vacation-Attraction)
- [Palmetto Shores Lake ](https://expedia.com/Palmetto-Shores-Lake-Florence.d553248635976195800.Vacation-Attraction)
- [Florence National Cemetery ](https://expedia.com/Florence-National-Cemetery-Florence.d553248621532657341.Vacation-Attraction)
- [Oakdale Country Club ](https://expedia.com/Oakdale-Country-Club-Florence.d553248621532657334.Vacation-Attraction)
- [Lions Park ](https://expedia.com/Lions-Park-Lake-City.d553248621560871592.Vacation-Attraction)
- [Columns Plantation ](https://expedia.com/Columns-Plantation-Florence.d553248621532657342.Vacation-Attraction)
- [Florence Veterans Park ](https://expedia.com/Florence-Veterans-Park-Florence.d619470572411232256.Vacation-Attraction)
- [The Country Club at Lake City ](https://expedia.com/The-Country-Club-At-Lake-City-Lake-City.d553248621560871593.Vacation-Attraction)
- [Woods Bay State Park ](https://expedia.com/Woods-Bay-State-Park-South-Carolina.d553248621532657294.Vacation-Attraction)
- [The Bean Market ](https://expedia.com/The-Bean-Market-Lake-City.d553248621560871591.Vacation-Attraction)
- [Ronald E. McNair Life History Center ](https://expedia.com/Ronald-E-McNair-Life-History-Center-Lake-City.d553248621560871590.Vacation-Attraction)

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