St. Charles Vacation Rentals

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Our top choices for St. Charles vacation rentals

Prime Loft of Main Street

Prime Loft of Main Street
St. Charles Historic District
9.8 out of 10, Exceptional, (104 reviews)
"The loft was very nice, very clean, well appointed, and in a perfect location. I highly recommend this property!"
United States
Mary ann S.
$219 nightly
The price is $234
Feb 9 - Feb 10
Total with taxes and fees
Prime Loft of Main Street

Historic 4‑BR Farmhouse • Steps to Main Street

Historic 4‑BR Farmhouse • Steps to Main Street
St. Charles Historic District
10.0 out of 10, Exceptional, (22 reviews)
"The house was perfect for our stay. "
United States
Susan F.
$526 nightly
The price is $586
Mar 10 - Mar 11
Total with taxes and fees
Historic 4‑BR Farmhouse • Steps to Main Street

The Below Deck Suite

The Below Deck Suite
Saint Charles
9.0 out of 10, Wonderful, (2 reviews)
"Overall good place for a family. The neighborhood is quiet and there is a good amount of space. Easy to find and to get places. You will hear the people upstairs and one bed was very squeaky. It was very clean and the couches are very comfy. "
United States
Amy B.
$217 nightly
The price is $217
Feb 9 - Feb 10
Total with taxes and fees
The Below Deck Suite

Main Street Living! 2 Bedroom Unit right On Main!

Main Street Living! 2 Bedroom Unit right On Main!
St. Charles Historic District
9.6 out of 10, Exceptional, (35 reviews)
"Great Stay and great location! "
United States
Angela
$310 nightly
The price is $342
Feb 9 - Feb 10
Total with taxes and fees
Main Street Living! 2 Bedroom Unit right On Main!

The Lofts of North Main Street

The Lofts of North Main Street
St. Charles Historic District
9.6 out of 10, Exceptional, (160 reviews)
"Very nice place near all the action. "
United States
Weston G.
$208 nightly
The price is $222
Feb 9 - Feb 10
Total with taxes and fees
The Lofts of North Main Street

6th street 101 - Walk to Main St

6th street 101 - Walk to Main St
St. Charles Historic District
10.0 out of 10, Exceptional, (1 review)
$242 nightly
The price is $272
Feb 9 - Feb 10
Total with taxes and fees
6th street 101 - Walk to Main St

Spacious Cottage on Main st- Near Downtown

Spacious Cottage on Main st- Near Downtown
St. Charles Historic District
10.0 out of 10, Exceptional, (7 reviews)
"The house was perfect. Clean, organized and portrayed exactly as in the pictures. We loved our stay here. The host was punctual and attentive to all questions. We would definitely stay again. "
United States
Theresa P.
$210 nightly
The price is $210
Feb 9 - Feb 10
Total with taxes and fees
Spacious Cottage on Main st- Near Downtown

Cozy Unit on Historic Main Street

Cozy Unit on Historic Main Street
St. Charles Historic District
10.0 out of 10, Exceptional, (11 reviews)
"Wonderful host and accomodations !"
United States
Matthew K.
$218 nightly
The price is $218
Feb 9 - Feb 10
Total with taxes and fees
Cozy Unit on Historic Main Street

Casa de Saint Charles

Casa de Saint Charles
Saint Charles
9.2 out of 10, Wonderful, (17 reviews)
"The home was perfect for our multi-family gathering. There was lots of room for everyone and the location was great for our needs."
United States
Karla Z.
$304 nightly
The price is $304
Feb 9 - Feb 10
Total with taxes and fees
Casa de Saint Charles

St. Charles 1860's Gem - Sleeps 6!

St. Charles 1860's Gem - Sleeps 6!
St. Charles Historic District
9.8 out of 10, Exceptional, (137 reviews)
"Very comfortable house, beds are very comfy as well which is rare in a lot of VRBOs. Would definitely recommend! "
United States
Phillip R.
$233 nightly
The price is $233
Feb 9 - Feb 10
Total with taxes and fees
St. Charles 1860's Gem - Sleeps 6!

5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1

5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1
St. Charles Historic District
9.4 out of 10, Exceptional, (13 reviews)
"House was beautiful. Very nice quiet stay"
United States
Amy S.
$209 nightly
The price is $235
Feb 9 - Feb 10
Total with taxes and fees
5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1

Amazing Renovated Historic Loft on Main Street

Amazing Renovated Historic Loft on Main Street
St. Charles Historic District
10.0 out of 10, Exceptional, (58 reviews)
"Great place and location. Owners were easy to work with."
United States
Cory M.
$236 nightly
The price is $252
Feb 9 - Feb 10
Total with taxes and fees
Amazing Renovated Historic Loft on Main Street

The Cul-de-Sac Retreat

The Cul-de-Sac Retreat
Saint Charles
8.4 out of 10, Very Good, (9 reviews)
"Great house, great location - close to the St. Charles convention center"
United States
Joe H.
$251 nightly
The price is $251
Feb 9 - Feb 10
Total with taxes and fees
The Cul-de-Sac Retreat

Madison House 1 -Walk to Main St

Madison House 1 -Walk to Main St
St. Charles Historic District
8.6 out of 10, Excellent, (17 reviews)
"The house was clean and well stocked, location was great, and plenty of street parking. "
United States
Brad K.
$209 nightly
The price is $235
Feb 9 - Feb 10
Total with taxes and fees
Madison House 1 -Walk to Main St

1st Capitol Mansion - Suite 401

1st Capitol Mansion - Suite 401
St. Charles Historic District
7.6 out of 10, Good, (8 reviews)
"Nice property and a great location to all the shops and restaurants that St. Charles has to offer. The place was clean and nicely updated. Will definitely stay here again!"
United States
Emily L.
$209 nightly
The price is $235
Feb 9 - Feb 10
Total with taxes and fees
1st Capitol Mansion - Suite 401

The Historic Bricks on Main

The Historic Bricks on Main
St. Charles Historic District
8.8 out of 10, Excellent, (15 reviews)
"Host was very welcoming and helpful when we have any questions no matter what time of day. The place was very quaint and comfy. We would highly recommend. "
United States
Chelsea L.
$187 nightly
The price is $206
Feb 9 - Feb 10
Total with taxes and fees
The Historic Bricks on Main

Duplex Hideaway in St. Charles, MO

Duplex Hideaway in St. Charles, MO
St. Charles Historic District
10.0 out of 10, Exceptional, (5 reviews)
"I will stay here again. It was a great location for my visit. Lots of room and amenities. Highly recommend this location if you are visiting the St Louis area. Barely a mile to get to Hwy 70, so easy access to St Louis, St Peter's, Wentzville etc. Maybe two blocks from Historic St Charles and Ameristar Casino."
United States
Karen M.
$202 nightly
The price is $223
Feb 9 - Feb 10
Total with taxes and fees
Duplex Hideaway in St. Charles, MO

Spacious 2 bed Townhome by StayLage

Spacious 2 bed Townhome by StayLage
Saint Charles
9.0 out of 10, Wonderful, (9 reviews)
"Great location, clean, and management was informative and reacted to any needs quickly. Would recommend to anyone."
United States
Nathan D.
$255 nightly
The price is $281
Feb 9 - Feb 10
Total with taxes and fees
Spacious 2 bed Townhome by StayLage

Charming Duplex on Main

Charming Duplex on Main
St. Charles Historic District
10.0 out of 10, Exceptional, (16 reviews)
"We had an AMAZING time here and you can't beat the close walking distance to main st!! Absolutely loved our stay. "
United States
Wendy K.
$211 nightly
The price is $233
Feb 9 - Feb 10
Total with taxes and fees
Charming Duplex on Main

The Original Custom House!

The Original Custom House!
St. Charles Historic District
9.8 out of 10, Exceptional, (36 reviews)
"The location is excellent. "
United States
McRay H.
$310 nightly
The price is $342
Feb 9 - Feb 10
Total with taxes and fees
The Original Custom House!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top St. Charles Hotel Reviews

Find out more about St. Charles

Everything you need to know about St. Charles vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the St. Charles vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect St. Charles vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

St. Charles vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in St. Charles. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit St. Charles in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $153 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on St. Charles rentals

At Expedia, we put the best St. Charles vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top St. Charles rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream St. Charles vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around St. Charles. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Can I find vacation rentals in St. Charles?

Yes, you can find vacation rentals near popular attractions in St. Charles, or you can choose a secluded option if you're looking for relaxation. Tourists like the array of shops and top-notch restaurants in St. Charles. The live music and theater scene are some other things you might like to check out during your trip.

What are some of the best vacation rentals that St. Charles has to offer?

The St. Charles Guest House, lovely historic home, fun for families and groups: This St. Charles vacation home rental is located on a river and has a fireplace, a selection of games, and air-conditioning to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Some other top choices in St. Charles are 🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟 and Stunning 1890's Home - Sleeps 8! .

How many vacation rentals are there in St. Charles?

Expedia has 89 vacation rentals for your stay in St. Charles.

What can I see and do in St. Charles?

Katy Trail and Mississippi River are a couple of scenic spots to enjoy the outdoors, whereas Missouri Artists on Main is one of the cultural attractions. Other places in town to visit include Historic Main Street and Lewis & Clark Boathouse and Nature Center.

What are vacation rentals like in St. Charles?

Vacation rentals are privately owned accommodations you can book for several days or more in St. Charles. Vacation rentals provide amenities such as laundry facilities and kitchens to help you enjoy your stay. If you're concerned about a clean environment, vacation rentals can offer a sense of privacy away from shared hotel elevators and lobbies packed with people while still allowing you the enjoyment of travel. You'll also have more space in a vacation rental than in a hotel, which makes a vacation rental an attractive option for a family getaway.