St. Charles Vacation Rentals

  • Bundle & Save

    Get more, spend less whenever you see Bundle & Save deals

  • OneKeyCash

    Earn OneKeyCash on all your eligible bookings

  • Upfront pricing

    We are not like the others - we include taxes and fees

Check prices for these dates

In two weeks
Feb 13 - Feb 15
In two months
Mar 27 - Mar 29
In three months
Apr 24 - Apr 26
In four months
May 22 - May 24

Our top choices for St. Charles vacation rentals

Interior

Condo in Saint Charles

The Great Room - fully cozy & private Townhome
10.0 out of 10, Exceptional, (1 review)
"The place was beautiful and decorated well. Our experience was great and i recommend this rental. Would be nice if they honored military discount as I am a veteran. "
United States
Rodney M.
$231 nightly
The price is $231
Jan 27 - Jan 28
Total with taxes and fees
The Great Room - fully cozy & private Townhome
3 bedrooms, iron/ironing board, WiFi, bed sheets

Vacation Home in Saint Charles

The Below Deck Suite
9.0 out of 10, Wonderful, (2 reviews)
"Overall good place for a family. The neighborhood is quiet and there is a good amount of space. Easy to find and to get places. You will hear the people upstairs and one bed was very squeaky. It was very clean and the couches are very comfy. "
United States
Amy B.
$241 nightly
The price is $241
Jan 27 - Jan 28
Total with taxes and fees
The Below Deck Suite
Smart TV, books

Vacation Home in Saint Charles

Casa de Saint Charles
9.2 out of 10, Wonderful, (17 reviews)
"We group of senior ladies thoroughly enjoyed our weekend at Casa de Saint Charles. The accommodations were perfect, inside and out. Our hosts were very accessible and made sure all our wants and needs were taken care of. What a wonderful home! "
United States
Rosalind W.
$311 nightly
The price is $311
Jan 27 - Jan 28
Total with taxes and fees
Casa de Saint Charles
Living area

Vacation Home in Saint Charles

Saint Charles White House
8.6 out of 10, Excellent, (4 reviews)
"It was great Needed towels but otherwise great"
United States
Jennifer R.
$316 nightly
The price is $316
Jan 27 - Jan 28
Total with taxes and fees
Saint Charles White House
Living area

Apartment in Saint Charles

The Cul-de-Sac Retreat
8.4 out of 10, Very Good, (9 reviews)
"Great house, great location - close to the St. Charles convention center"
United States
Joe H.
$273 nightly
The price is $273
Jan 27 - Jan 28
Total with taxes and fees
The Cul-de-Sac Retreat
TV

Apartment in St. Charles Historic District

6th street 101 - Walk to Main St
10.0 out of 10, Exceptional, (1 review)
$239 nightly
The price is $268
Jan 27 - Jan 28
Total with taxes and fees
6th street 101 - Walk to Main St
Interior

Apartment in Saint Charles

Luxurious 2-Bedroom Abode with Elevated Comforts Near Main Street
9.0 out of 10, Wonderful, (2 reviews)
"The overall vibe struck me as a college town apartment: the building was fine, but finishes were underwhelming. The unit itself was a little small, but workable. We had a scenario where the heater seemed to be acting up; the room actually got warmer after we shut the heat off. It was a pleasant enough stay, and served the purpose we had come for: visiting our adult children. It was a bit of a walk to get to the historic district."
United States
Greg L.
$233 nightly
The price is $257
Feb 8 - Feb 9
Total with taxes and fees
Luxurious 2-Bedroom Abode with Elevated Comforts Near Main Street
TV

Vacation Home in St. Charles Historic District

5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1
9.2 out of 10, Wonderful, (12 reviews)
"House was beautiful. Very nice quiet stay"
United States
Amy S.
$211 nightly
The price is $237
Jan 27 - Jan 28
Total with taxes and fees
5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1
Interior

Vacation Home in Saint Charles

The Olive House - Near Main Street- Fully rehabbed
8.8 out of 10, Excellent, (9 reviews)
"Great place to stay for the weekend. Only 1 bathroom can be a stretch if you’re used to having access to multiple. However, it’s a quick walk to Upshot or Lady Di’s for coffee or breakfast. "
United States
Rachel Y.
$313 nightly
The price is $352
Jan 27 - Jan 28
Total with taxes and fees
The Olive House - Near Main Street- Fully rehabbed
Interior

Vacation Home in St. Charles Historic District

Victorian Gem Steps from Main St - Sleeps 9 & Pets
9.8 out of 10, Exceptional, (22 reviews)
"A beautiful place with Victorian charm and modern amenities! This was the perfect place for our family."
United States
Kathleen D.
$490 nightly
The price is $546
Jan 28 - Jan 29
Total with taxes and fees
Victorian Gem Steps from Main St - Sleeps 9 & Pets
Smart TV, fireplace, computer monitors

Vacation Home in Saint Charles

Charming open 4bd and screen-in porch! Sleeps 10!
9.2 out of 10, Wonderful, (33 reviews)
"Stay here for 3 weeks. Place was just as described. Would recommend. Thank you "
United States
Eddy
$446 nightly
The price is $455
Jan 27 - Jan 28
Total with taxes and fees
Charming open 4bd and screen-in porch! Sleeps 10!
Interior

Vacation Home in Saint Charles

Spacious 2 Bedroom Townhome by StayLage
7.8 out of 10, Good, (12 reviews)
"Perfect size"
United States
Barbie D.
$253 nightly
The price is $278
Feb 8 - Feb 9
Total with taxes and fees
Spacious 2 Bedroom Townhome by StayLage
Fridge, microwave, oven, stovetop

Vacation Home in Saint Charles

Winter SALE,Cozy 2BR Chalet, Hot Tub 1.2 Acres!
8.8 out of 10, Excellent, (3 reviews)
"We loved the location for our travel needs and we had everything we needed for a family of two adults and two dogs. "
United States
Leslie R.
$497 nightly
The price is $592
Jan 27 - Jan 28
Total with taxes and fees
Winter SALE,Cozy 2BR Chalet, Hot Tub 1.2 Acres!
Interior

Vacation Home in Saint Charles

The Knotty Pine House
$262 nightly
The price is $262
Jan 27 - Jan 28
Total with taxes and fees
The Knotty Pine House
Interior

Apartment in St. Charles Historic District

Amazing Renovated Historic Loft on Main Street
10.0 out of 10, Exceptional, (58 reviews)
"Great place and location. Owners were easy to work with."
United States
Cory M.
$238 nightly
The price is $254
Jan 27 - Jan 28
Total with taxes and fees
Amazing Renovated Historic Loft on Main Street
TV, books

Vacation Home in St. Charles Historic District

St. Charles 1860's Gem - Sleeps 6!
9.8 out of 10, Exceptional, (136 reviews)
"Very comfortable house, beds are very comfy as well which is rare in a lot of VRBOs. Would definitely recommend! "
United States
Phillip R.
$247 nightly
The price is $247
Jan 28 - Jan 29
Total with taxes and fees
St. Charles 1860's Gem - Sleeps 6!
TV

Vacation Home in Saint Charles

Spacious 2 bed Townhome by StayLage
9.0 out of 10, Wonderful, (9 reviews)
"Great location, clean, and management was informative and reacted to any needs quickly. Would recommend to anyone."
United States
Nathan D.
$253 nightly
The price is $278
Jan 27 - Jan 28
Total with taxes and fees
Spacious 2 bed Townhome by StayLage
Fridge, microwave, stovetop, toaster

Apartment in St. Charles Historic District

Charming Duplex on Main
10.0 out of 10, Exceptional, (16 reviews)
"We had an AMAZING time here and you can't beat the close walking distance to main st!! Absolutely loved our stay. "
United States
Wendy K.
$206 nightly
The price is $228
Feb 1 - Feb 2
Total with taxes and fees
Charming Duplex on Main
Fridge, microwave, oven, stovetop

Vacation Home in St. Charles Historic District

Historic 4‑BR Farmhouse • Steps to Main Street
10.0 out of 10, Exceptional, (22 reviews)
"The house was perfect for our stay. "
United States
Susan F.
$478 nightly
The price is $533
Jan 29 - Jan 30
Total with taxes and fees
Historic 4‑BR Farmhouse • Steps to Main Street
Interior

Apartment in St. Charles Historic District

The Lofts of North Main Street
9.6 out of 10, Exceptional, (158 reviews)
"Very nice place near all the action. "
United States
Weston G.
$227 nightly
The price is $242
Jan 27 - Jan 28
Total with taxes and fees
The Lofts of North Main Street
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top St. Charles Hotel Reviews

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

10/10 Excellent
"Room comfortable and clean. Dtaff very polite, professional, and helpful."
LOUIS 2-night trip
Posted 17 hours ago
Clayton Plaza Hotel & Extended Stay

Find out more about St. Charles

Everything you need to know about St. Charles vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the St. Charles vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect St. Charles vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

St. Charles vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in St. Charles. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit St. Charles in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $151 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on St. Charles rentals

At Expedia, we put the best St. Charles vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top St. Charles rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream St. Charles vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around St. Charles. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Can I find vacation rentals in St. Charles?

Yes, you can find vacation rentals near popular attractions in St. Charles, or you can choose a secluded option if you're looking for relaxation. Tourists like the array of shops and top-notch restaurants in St. Charles. The live music and theater scene are some other things you might like to check out during your trip.

What are some of the best vacation rentals that St. Charles has to offer?

The St. Charles Guest House, lovely historic home, fun for families and groups: This St. Charles vacation home rental is located on a river and has a fireplace, a selection of games, and air-conditioning to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Some other top choices in St. Charles are 1870's Luxury Guest Cottage, Historic Downtown St. Charles, Mo. and 🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟.

How many vacation rentals are there in St. Charles?

Expedia has 87 vacation rentals for your stay in St. Charles.

What can I see and do in St. Charles?

Katy Trail and Mississippi River are a couple of scenic spots to enjoy the outdoors, whereas Missouri Artists on Main is one of the cultural attractions. Other places in town to visit include Historic Main Street and Lewis & Clark Boathouse and Nature Center.

What are vacation rentals like in St. Charles?

Vacation rentals are privately owned accommodations you can book for several days or more in St. Charles. Vacation rentals provide amenities such as laundry facilities and kitchens to help you enjoy your stay. If you're concerned about a clean environment, vacation rentals can offer a sense of privacy away from shared hotel elevators and lobbies packed with people while still allowing you the enjoyment of travel. You'll also have more space in a vacation rental than in a hotel, which makes a vacation rental an attractive option for a family getaway.