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St. Charles Vacation Rentals

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Our top choices for St. Charles vacation rentals

1. Historic Main Street Studio | Dog-Friendly

Historic Main Street Studio | Dog-Friendly
St. Charles Historic District
9.2 out of 10, 38, (38 reviews)
"Had a wonderful stay. It was a Monday night so parking was very easy and the room was clean and comfortable. I would recommend this place 100% "
United States
Sarah C.
$182 nightly
The price is $200
Sep 17 - Sep 18
Total with taxes and fees
Historic Main Street Studio | Dog-Friendly

2. St. Charles 1860's Gem - Sleeps 6!

St. Charles 1860's Gem - Sleeps 6!
St. Charles Historic District
9.8 out of 10, 163, (163 reviews)
"Very nice very clean property. Very much enjoyed our stay"
United States
Joe R.
$249 nightly
The price is $267
Sep 16 - Sep 17
Total with taxes and fees
St. Charles 1860's Gem - Sleeps 6!

3. 6th street 101 - Walk to Main St

6th street 101 - Walk to Main St
St. Charles Historic District
10.0 out of 10, 3, (3 reviews)
"Excellent"
United States
Scott N.
$244 nightly
The price is $274
Sep 15 - Sep 16
Total with taxes and fees
6th street 101 - Walk to Main St

4. The Lofts of North Main Street

The Lofts of North Main Street
St. Charles Historic District
9.6 out of 10, 190, (190 reviews)
"It was great! Clean and great communication with host."
United States
Natalie H.
$229 nightly
The price is $245
Sep 15 - Sep 16
Total with taxes and fees
The Lofts of North Main Street

5. Prime Loft of Main Street

Prime Loft of Main Street
St. Charles Historic District
9.8 out of 10, 117, (117 reviews)
"Host was great. The cutest place in the perfect spot! "
United States
Anonymous traveler
$213 nightly
The price is $228
Sep 15 - Sep 16
Total with taxes and fees
Prime Loft of Main Street

6. Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!

Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!
St. Charles Historic District
9.6 out of 10, 86, (86 reviews)
"Quaint and quiet, with easy access to downtown St Charles."
United States
Jeffrey E.
$245 nightly
The price is $262
Sep 15 - Sep 16
Total with taxes and fees
Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!

7. Amazing Renovated Historic Loft on Main Street

Amazing Renovated Historic Loft on Main Street
St. Charles Historic District
10.0 out of 10, 68, (68 reviews)
"Lovely accommodations, very clean, well equipped, great location. "
United States
Emily B.
$259 nightly
The price is $277
Sep 20 - Sep 21
Total with taxes and fees
Amazing Renovated Historic Loft on Main Street

8. Historic Main St 2BR | Steps to Shops

Historic Main St 2BR | Steps to Shops
St. Charles Historic District
9.4 out of 10, 42, (42 reviews)
"This property has a nice renovation while keeping a lot of its original character. Very clean and comfortable beds as well. The location couldn’t be better! We really enjoyed our stay."
United States
William O.
$359 nightly
The price is $398
Sep 20 - Sep 21
Total with taxes and fees
Historic Main St 2BR | Steps to Shops

9. 5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1

5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1
St. Charles Historic District
8.8 out of 10, 16, (16 reviews)
"House was beautiful. Very nice quiet stay"
United States
Amy S.
$225 nightly
The price is $253
Sep 20 - Sep 21
Total with taxes and fees
5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1

10. Walk to Main | Pet-Friendly Yard & Workspace

Walk to Main | Pet-Friendly Yard & Workspace
St. Charles Historic District
10.0 out of 10, 11, (11 reviews)
"Very close to downtown St. Charles and the Kati Trail. The home is cute and bed is comfortable. Easy check in process and fenced in back yard was nice to have."
United States
Jessica S.
$251 nightly
The price is $276
Sep 20 - Sep 21
Total with taxes and fees
Walk to Main | Pet-Friendly Yard & Workspace

11. Historic Main St. Customs House Upstairs Apartment

Historic Main St. Customs House Upstairs Apartment
St. Charles Historic District
9.6 out of 10, 39, (39 reviews)
"Lovely place to stay!"
United States
Margaret A.
$341 nightly
The price is $376
Sep 28 - Sep 29
Total with taxes and fees
Historic Main St. Customs House Upstairs Apartment

12. Near Streets of St Charles | 2 King Beds

Near Streets of St Charles | 2 King Beds
Saint Charles
9.0 out of 10, 12, (12 reviews)
"We really enjoyed our stay. The house was clean, spacious, and very accommodating. We stayed for a dance competition and the proximity to the convention center was unbeatable. "
United States
Chloe
$281 nightly
The price is $310
Sep 17 - Sep 18
Total with taxes and fees
Near Streets of St Charles | 2 King Beds

13. HotTub-2br2b-near Historic Main Street

HotTub-2br2b-near Historic Main Street
St. Charles Historic District
10.0 out of 10, 21, (21 reviews)
"Comfy beds, great location!"
United States
Jessie W.
$271 nightly
The price is $290
Sep 21 - Sep 22
Total with taxes and fees
HotTub-2br2b-near Historic Main Street

14. Cottage on Main st- Low Cleaning Fee

Cottage on Main st- Low Cleaning Fee
St. Charles Historic District
10.0 out of 10, 10, (10 reviews)
"Good location. Decorated very nicely. "
United States
Debbie A.
$286 nightly
The price is $306
Sep 20 - Sep 21
Total with taxes and fees
Cottage on Main st- Low Cleaning Fee

15. Pet-Friendly Duplex | Historic Main

Pet-Friendly Duplex | Historic Main
St. Charles Historic District
10.0 out of 10, 25, (25 reviews)
"Great location"
United States
todd p.
$262 nightly
The price is $288
Sep 24 - Sep 25
Total with taxes and fees
Pet-Friendly Duplex | Historic Main

16. Dog-Friendly 2BR | Walk to Main Street

Dog-Friendly 2BR | Walk to Main Street
Saint Charles
8.0 out of 10, 5, (5 reviews)
"The best price-value ratio. Quiet neighborhood, close to the city center."
United States
Tamas P.
$256 nightly
The price is $282
Sep 17 - Sep 18
Total with taxes and fees
Dog-Friendly 2BR | Walk to Main Street

17. Historic 1908 Frenchtown Home

Historic 1908 Frenchtown Home
St. Charles Historic District
8.8 out of 10, 26, (26 reviews)
"Great property in historic neighborhood. Listing was accurate. Neighbors were friendly and helpful. I stayed there by myself and felt very safe and comfortable in the neighborhood. I had a last-minute change in travel plans and needed to add on a night. The host was very responsive and accommodating to my request. Will definitely stay here again!"
United States
Kim V.
$302 nightly
The price is $332
Sep 17 - Sep 18
Total with taxes and fees
Historic 1908 Frenchtown Home

18. Driftwood Den | Boho 2BR | Dog-Friendly

Driftwood Den | Boho 2BR | Dog-Friendly
St. Charles Historic District
9.2 out of 10, 7, (7 reviews)
"Loved our stay here. Clean, comfortable, convenient. Couldn’t have been easier, in all aspects. Already plan to stay there again!!!"
United States
Kourtney S.
$305 nightly
The price is $336
Sep 17 - Sep 18
Total with taxes and fees
Driftwood Den | Boho 2BR | Dog-Friendly

19. 1st Capitol Mansion - Suite 401

1st Capitol Mansion - Suite 401
St. Charles Historic District
7.4 out of 10, 9, (9 reviews)
"Nice property and a great location to all the shops and restaurants that St. Charles has to offer. The place was clean and nicely updated. Will definitely stay here again!"
United States
Emily L.
$215 nightly
The price is $241
Sep 15 - Sep 16
Total with taxes and fees
1st Capitol Mansion - Suite 401

20. Historic Main St 1BR | Walk to Dining & Nightlife

Historic Main St 1BR | Walk to Dining & Nightlife
St. Charles Historic District
9.2 out of 10, 24, (24 reviews)
"Great place, very fun. I’d stay again for sure. "
United States
Michael C.
$245 nightly
The price is $269
Sep 17 - Sep 18
Total with taxes and fees
Historic Main St 1BR | Walk to Dining & Nightlife
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top St. Charles Hotel Reviews

Find out more about St. Charles

Everything you need to know about St. Charles vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the St. Charles vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect St. Charles vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

St. Charles vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in St. Charles. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit St. Charles in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $68 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on St. Charles rentals

At Expedia, we put the best St. Charles vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top St. Charles rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream St. Charles vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around St. Charles. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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Frequently asked questions

Can I find vacation rentals in St. Charles?

Yes, you can find vacation rentals near popular attractions in St. Charles, or you can choose a secluded option if you're looking for relaxation. Tourists like the array of shops and top-notch restaurants in St. Charles. The live music and theater scene are some other things you might like to check out during your trip.

What are some of the best vacation rentals that St. Charles has to offer?

The St. Charles Guest House, lovely historic home, fun for families and groups: This St. Charles vacation home rental is located on a river and has a fireplace, a selection of games, and air-conditioning to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Some other top choices in St. Charles are St. Charles 1860's Gem - Sleeps 6! and Honky Tonk Hideaway | 2BR Near Historic Main St.

How many vacation rentals are there in St. Charles?

Expedia has 92 vacation rentals for your stay in St. Charles.

What can I see and do in St. Charles?

Katy Trail and Mississippi River are a couple of scenic spots to enjoy the outdoors, whereas Missouri Artists on Main is one of the cultural attractions. Other places in town to visit include Historic Main Street and Lewis & Clark Boathouse and Nature Center.

What are vacation rentals like in St. Charles?

Vacation rentals are privately owned accommodations you can book for several days or more in St. Charles. Vacation rentals provide amenities such as laundry facilities and kitchens to help you enjoy your stay. If you're concerned about a clean environment, vacation rentals can offer a sense of privacy away from shared hotel elevators and lobbies packed with people while still allowing you the enjoyment of travel. You'll also have more space in a vacation rental than in a hotel, which makes a vacation rental an attractive option for a family getaway.