Title: Islip to Knoxville cheap flights from $148 (ISP to TYS) - Expedia.com ![Skyline of downtown Knoxville, Tennessee, USA](https://images.trvl-media.com/place/602977/e5dfacc8-29fe-4ae7-93f0-6aa1cd8e604b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/602977/e5dfacc8-29fe-4ae7-93f0-6aa1cd8e604b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # $148 Cheap Flights from Islip (ISP) to Knoxville (TYS) [View $148 flight on Tue, Jun 30, 2026](https://expedia.com/Flights-Search?trip=oneway&leg1=from:ISP,to:TYS,departure:6/30/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:147.20&airProductToken=AQpfCi0I15wBEgM5MjEYyHwgwUUoz46RAzCaj5EDOEFAAFgBagNXR0FyB0FCQVZOMkYKLgjXnAESAzQ0MxjBRSCTlgEo55CRAzDLkZEDOEFAAVgBagNXR0FyB0FCQVZOMkYSCggBEAEYASoCV04YASIECAEQASgCKAMoBDAB) ## Popular airlines from MacArthur Airport (ISP) to McGhee Tyson Airport (TYS) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_WN.svg) Southwest Airlines [](https://www.expedia.com/Flights-Search?leg1=from:ISP,to:TYS,departure:4/18/2026TANYT&leg2=from:TYS,to:ISP,departure:4/25/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"WN"}}]) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 30% on select hotels after you book a flight\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our OneKeyCash [Learn about One Key](https://www.expedia.com/welcome-one-key) ## Cheap Flights from Islip to Knoxville (ISP-TYS) Prices were available within the past 7 days and start at $148 for one-way flights and $303 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Roundtrip ![Southwest Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/wn.gif) Sat, May 30 - Tue, Jun 2 ISP Islip TYS Knoxville $303 Roundtrip found 21 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ISP,to:TYS,departure:5/30/2026TANYT&leg2=from:TYS,to:ISP,departure:6/2/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:302.40&airProductToken=AQpgCi0I15wBEgM5OTMYyHwgwUUooK-OAzDwr44DOEZAAFgBagNXR0FyB0ZaQVZOMkYKLwjXnAESBDE0MTQYwUUgk5YBKKywjgMwkLGOAzhGQAFYAWoDV0dBcgdGWkFWTjJGCmEKLwjXnAESBDM1NTAYk5YBIMxwKNLSjgMwu9OOAzhBQABYAWoDV0dBcgdBQkFWTjJGCi4I15wBEgQyNzk2GMxwIMh8KIDWjgMwoNeOAzhBQAFYAWoDV0dBcgdBQkFWTjJGEgoIARABGAEqAldOGAEiBAgBEAEoAigDKAQwAQ) ![Southwest Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/wn.gif) Thu, May 7 - Tue, May 12 ISP Islip TYS Knoxville $308 Roundtrip found 11 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ISP,to:TYS,departure:5/7/2026TANYT&leg2=from:TYS,to:ISP,departure:5/12/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:307.70&airProductToken=AQqRAQouCNecARIEMjE2MBjIfCDBRSj4qowDMMirjAM4RkAAWAFqA1dHQXIHRlpBVk4yRgouCNecARIEMTA1MRjBRSChAyjUrIwDMMytjAM4RkABWAFqA1dHQXIHRlpBVk4yRgovCNecARIEMTE1MhihAyCTlgEomLGMAzDUsYwDOEZAAVgBagNXR0FyB0ZaQVZOMkYKYQovCNecARIENDYwMRiTlgEgwUUon-SMAzCI5YwDOEFAAFgBagNXR0FyB0FCQVZOMkYKLgjXnAESBDIzNTcYwUUgyHwou-iMAzCG6YwDOEFAAVgBagNXR0FyB0FCQVZOMkYSCggBEAEYASoCV04YASIECAEQASgCKAMoBDAB) ![Southwest Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/wn.gif) Wed, Apr 29 - Tue, May 5 ISP Islip TYS Knoxville $311 Roundtrip found 5 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ISP,to:TYS,departure:4/29/2026TANYT&leg2=from:TYS,to:ISP,departure:5/5/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:310.40&airProductToken=AQpgCi0I15wBEgM5OTMYyHwgwUUo2tWLAzCq1osDOEZAAFgBagNXR0FyB0ZaQVZOMkYKLwjXnAESBDE0MTQYwUUgk5YBKInXiwMw8teLAzhGQAFYAWoDV0dBcgdGWkFWTjJGCmEKLwjXnAESBDQ2MDEYk5YBIMFFKL-VjAMwqJaMAzhGQABYAWoDV0dBcgdGWkFWTjJGCi4I15wBEgQxMjY2GMFFIMh8KMiXjAMwjpiMAzhGQAFYAWoDV0dBcgdGWkFWTjJGEgoIARABGAEqAldOGAEiBAgBEAEoAigDKAQwAQ) ![Southwest Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/wn.gif) Thu, May 7 - Tue, May 12 ISP Islip TYS Knoxville $313 Roundtrip found 11 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ISP,to:TYS,departure:5/7/2026TANYT&leg2=from:TYS,to:ISP,departure:5/12/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:313.00&airProductToken=AQqRAQouCNecARIEMjE2MBjIfCDBRSj4qowDMMirjAM4RkAAWAFqA1dHQXIHRlpBVk4yRgouCNecARIEMTA5NRjBRSChAyiJrIwDMPStjAM4RkABWAFqA1dHQXIHRlpBVk4yRgovCNecARIEMTE1MhihAyCTlgEomLGMAzDUsYwDOEZAAVgBagNXR0FyB0ZaQVZOMkYKYQovCNecARIENDYwMRiTlgEgwUUon-SMAzCI5YwDOEFAAFgBagNXR0FyB0FCQVZOMkYKLgjXnAESBDEyNjYYwUUgyHwoqOaMAzDu5owDOEFAAVgBagNXR0FyB0FCQVZOMkYSCggBEAEYASoCV04YASIECAEQASgCKAMoBDAB) ![Southwest Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/wn.gif) Wed, May 13 - Sat, May 16 ISP Islip TYS Knoxville $331 Roundtrip found 3 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ISP,to:TYS,departure:5/13/2026TANYT&leg2=from:TYS,to:ISP,departure:5/16/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:330.71&airProductToken=AQphCi4I15wBEgQyNDk4GMh8IMxwKO_ujAMwj_CMAzhBQABYAWoDV0dBcgdBQkFWTjJGCi8I15wBEgQyNzE4GMxwIJOWASjt8owDMNbzjAM4QUABWAFqA1dHQXIHQUJBVk4yRgqQAQovCNecARIENDYwMBiTlgEgoQMowJCNAzCBkY0DOEVAAFgBagNXR0FyB0VMQVdWMkYKLQjXnAESAzU0OBihAyDBRSjvkY0DMN2SjQM4RUABWAFqA1dHQXIHRUxBV1YyRgouCNecARIEMjM1NxjBRSDIfCiqlI0DMPCUjQM4RUABWAFqA1dHQXIHRUxBV1YyRhIMCAEQARgBKgJXTjIAGAEiBAgBEAEoAigDKAQwAQ) ![Southwest Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/wn.gif) Thu, May 28 - Mon, Jun 1 ISP Islip TYS Knoxville $334 Roundtrip found 2 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ISP,to:TYS,departure:5/28/2026TANYT&leg2=from:TYS,to:ISP,departure:6/1/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:333.40&airProductToken=AQphCi4I15wBEgQxMjU3GMh8IMFFKI6cjgMw3pyOAzhGQABYAWoDV0dBcgdGWkFWTjJGCi8I15wBEgQxNDE0GMFFIJOWASjCnY4DMKuejgM4RkABWAFqA1dHQXIHRlpBVk4yRgphCi8I15wBEgQzNTUwGJOWASDMcCiPx44DMPPHjgM4RUAAWAFqA1dHQXIHRUxBV1YyRgouCNecARIEMjc5NhjMcCDIfCjWyo4DMPbLjgM4RUABWAFqA1dHQXIHRUxBV1YyRhIMCAEQARgBKgJXTjIAGAEiBAgBEAEoAigDKAQwAQ) ![Southwest Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/wn.gif) Sat, May 2 - Tue, May 5 ISP Islip TYS Knoxville $335 Roundtrip found 5 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ISP,to:TYS,departure:5/2/2026TANYT&leg2=from:TYS,to:ISP,departure:5/5/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:334.72&airProductToken=AQphCi4I15wBEgQyMTYwGMh8IMFFKNjyiwMwqPOLAzhFQABYAWoDV0dBcgdFTEFXVjJGCi8I15wBEgQxNDE0GMFFIJOWASis9YsDMJD2iwM4RUABWAFqA1dHQXIHRUxBV1YyRgphCi8I15wBEgQ0NjAxGJOWASDBRSi_lYwDMKiWjAM4RkAAWAFqA1dHQXIHRlpBVk4yRgouCNecARIEMjM1NxjBRSDIfCjbmYwDMKaajAM4RkABWAFqA1dHQXIHRlpBVk4yRhIKCAEQARgBKgJXThgBIgQIARABKAIoAygEMAE) ![Southwest Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/wn.gif) Wed, May 13 - Sat, May 16 ISP Islip TYS Knoxville $337 Roundtrip found 3 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ISP,to:TYS,departure:5/13/2026TANYT&leg2=from:TYS,to:ISP,departure:5/16/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:336.01&airProductToken=AQphCi4I15wBEgQyNDk4GMh8IMxwKO_ujAMwj_CMAzhBQABYAWoDV0dBcgdBQkFWTjJGCi8I15wBEgQyNzE4GMxwIJOWASjt8owDMNbzjAM4QUABWAFqA1dHQXIHQUJBVk4yRgqRAQovCNecARIENDYwMBiTlgEgoQMowJCNAzCBkY0DOEVAAFgBagNXR0FyB0VMQVdWMkYKLgjXnAESBDE3NDUYoQMg8wMo-ZGNAzDiko0DOEVAAVgBagNXR0FyB0VMQVdWMkYKLgjXnAESBDMxNjEY8wMgyHwopJaNAzComI0DOEVAAVgBagNXR0FyB0VMQVdWMkYSDAgBEAEYASoCV04yABgBIgQIARABKAIoAygEMAE) ![Southwest Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/wn.gif) Mon, May 18 - Fri, May 22 ISP Islip TYS Knoxville $339 Roundtrip found 2 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ISP,to:TYS,departure:5/18/2026TANYT&leg2=from:TYS,to:ISP,departure:5/22/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:338.70&airProductToken=AQphCi4I15wBEgQyNDk4GMh8IMxwKIqnjQMwqqiNAzhGQABYAWoDV0dBcgdGWkFWTjJGCi8I15wBEgQyNzE4GMxwIJOWASjJq40DMLKsjQM4RkABWAFqA1dHQXIHRlpBVk4yRgqQAQovCNecARIENDYwMBiTlgEgoQMo-9ONAzC81I0DOEVAAFgBagNXR0FyB0VMQVdWMkYKLQjXnAESAzU0ORihAyDBRSi9140DMKvYjQM4RUABWAFqA1dHQXIHRUxBV1YyRgouCNecARIEMzE2MRjBRSDIfCis240DMPLbjQM4RUABWAFqA1dHQXIHRUxBV1YyRhIMCAEQARgBKgJXTjIAGAEiBAgBEAEoAigDKAQwAQ) ![Southwest Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/wn.gif) Wed, May 13 - Sat, May 16 ISP Islip TYS Knoxville $341 Roundtrip found 3 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ISP,to:TYS,departure:5/13/2026TANYT&leg2=from:TYS,to:ISP,departure:5/16/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:340.70&airProductToken=AQphCi4I15wBEgQyNDk4GMh8IMxwKO_ujAMwj_CMAzhBQABYAWoDV0dBcgdBQkFWTjJGCi8I15wBEgQyNzE4GMxwIJOWASjt8owDMNbzjAM4QUABWAFqA1dHQXIHQUJBVk4yRgqRAQovCNecARIEMjcxOBiTlgEgoQMo1JWNAzCVlo0DOEdAAFgBagNXR0FyB0dMQVdQMkYKLgjXnAESBDM3NjkYoQMgwUUox5aNAzC1l40DOEdAAVgBagNXR0FyB0dMQVdQMkYKLgjXnAESBDMxNjEYwUUgyHwo3ZeNAzComI0DOEdAAVgBagNXR0FyB0dMQVdQMkYSDAgBEAEYASoCV04yABgBIgQIARABKAIoAygEMAE) ## Frequently asked questions ### How much does a flight from Islip, NY (ISP-MacArthur) to Knoxville, TN (TYS-McGhee Tyson) cost? ### What is the cheapest month to fly from Islip, NY (ISP-MacArthur) to Knoxville, TN (TYS-McGhee Tyson)? ### Which airlines fly direct from Islip, NY (ISP-MacArthur) to Knoxville, TN (TYS-McGhee Tyson)? ### How do I find cheap flights from Islip, NY (ISP-MacArthur) to Knoxville, TN (TYS-McGhee Tyson)? ### What is the best time to fly from Islip, NY (ISP-MacArthur) to Knoxville, TN (TYS-McGhee Tyson)? ### What is the earliest flight from Islip, NY (ISP-MacArthur) to Knoxville, TN (TYS-McGhee Tyson)? ### What are the most popular departure times for flights from Islip, NY (ISP-MacArthur) to Knoxville, TN (TYS-McGhee Tyson)? ### How long does it take to fly from Islip, NY (ISP-MacArthur) to Knoxville, TN (TYS-McGhee Tyson)? ### Can you fly business or first class from Islip, NY (ISP-MacArthur) to Knoxville, TN (TYS-McGhee Tyson)? ### How do I earn miles on a Islip, NY (ISP-MacArthur) to Knoxville, TN (TYS-McGhee Tyson) flight with Expedia? ### What airports do you fly into for Knoxville from MacArthur (ISP)? ### Is it cheaper to buy a plane ticket from Islip, NY (ISP-MacArthur) to Knoxville, TN (TYS-McGhee Tyson) at the last minute? ### Is it cheaper to book a Islip, NY (ISP-MacArthur) to Knoxville, TN (TYS-McGhee Tyson) flight and hotel package? ### Can I cancel or change the date of my flight from Islip, NY (ISP-MacArthur) to Knoxville, TN (TYS-McGhee Tyson)? ## Travel information | Origin airport | MacArthur | | ------------------- | ------------------ | | Destination airport | McGhee Tyson | | Airlines serving | Southwest Airlines | | Roundtrip price | $302 | | Distance | 682 mi | ## Book with confidence # Islip to Knoxville Flights The cheapest times to fly from Islip to Knoxville On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Islip to Knoxville are during the month of May. You can find some of the cheapest flights from Islip to Knoxville with Expedia's search tool and vast selection of airlines. The best time to book a flight from Islip to Knoxville Sunday is one of the best days to book for cheap flights from Islip to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance. How to find cheap round-trip tickets from Islip to Knoxville Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Islip to Knoxville in 2026\. You can also book with separate airlines for your outbound and return journeys, from $148 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference\*. This is available for a small fee, and is free to One Key Gold and Platinum tier members. Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Islip to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps. You could also save big by booking one of Expedia's [vacation packages](https://www.expedia.com/package-deals). Bundling together your Islip to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures. \*Terms apply. Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023\. The percentages you see are averages. \*Flight schedules are subject to change. \*Available to One Key members. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - Other - [Alcoa Hotels ](https://www.expedia.com/Alcoa-Hotels.d5985.Travel-Guide-Hotels) - [Cheap Hotels in Alcoa ](https://www.expedia.com/Alcoa-Hotels-Cheap-Hotels.0-0-d5985-tCheapHotels.Travel-Guide-Filter-Hotels) - [Cabin Rentals in Alcoa ](https://www.expedia.com/Alcoa-Cabins.d5985-aaCabins.Travel-Guide-Accommodation) - [Hotels with Hot Tubs in Alcoa ](https://www.expedia.com/Alcoa-Hotels-Hotels-With-Hot-Tubs.0-0-d5985-tHotelsWithHotTubs.Travel-Guide-Filter-Hotels) - [Hotels with an Indoor Pool in Alcoa ](https://www.expedia.com/Alcoa-Hotels-Hotels-With-Indoor-Pool.0-0-d5985-tHotelswithIndoorPool.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Alcoa ](https://www.expedia.com/Alcoa-Hotels-Pet-Friendly-Hotel.0-0-d5985-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Hotels with smoking rooms in Alcoa ](https://www.expedia.com/Alcoa-Hotels-Hotels-With-Smoking-Rooms.0-0-d5985-tHotelswithsmokingrooms.Travel-Guide-Filter-Hotels) - 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