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Our top choices for Defiance 2-star hotels

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Days Inn and Suites by Wyndham St. Louis/Westport Plaza
2.5 star property
Maryland Heights
4.6 out of 10, (1,005 reviews)
"Everything was good "
United States
Timothy
$65 nightly
The price is $75
Mar 10 - Mar 11
Total with taxes and fees
Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Best Western Plus St. Louis West-Westport

Best Western Plus St. Louis West-Westport
2.5 star property
Maryland Heights
8.0 out of 10, Very Good, (1,054 reviews)
"This place is always good. Been there +10 times."
United States
Federico Gavuzzo
$79 nightly
The price is $92
Apr 5 - Apr 6
Total with taxes and fees
Best Western Plus St. Louis West-Westport

Relax Inn Saint Charles

Relax Inn Saint Charles
2.0 star property
St. Charles
6.8 out of 10, (1,004 reviews)
"Clean room very nice staff it’s nice"
United States
Mercedez
$61 nightly
The price is $71
Mar 8 - Mar 9
Total with taxes and fees
Relax Inn Saint Charles

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
St. Charles
8.0 out of 10, Very Good, (1,003 reviews)
"Great location and friendly staff "
United States
Heather
$102 nightly
The price is $117
Apr 5 - Apr 6
Total with taxes and fees
Hampton Inn St. Charles St. Peters

Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District
2.5 star property
St. Charles Historic District
9.4 out of 10, Exceptional, (1,012 reviews)
"Wonderful place staff awesome "
United States
Chad
$114 nightly
The price is $131
Apr 5 - Apr 6
Total with taxes and fees
Country Inn & Suites by Radisson, St. Charles Historic District

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
St. Charles
8.4 out of 10, Very Good, (1,004 reviews)
"Great hotel for the money"
United States
Jere
$87 nightly
The price is $100
Mar 15 - Mar 16
Total with taxes and fees
Comfort Suites St Charles - St Louis

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,009 reviews)
"Friendly staff, clean room, comfy bed, excellent breakfast buffet."
United States
Kathy
$79 nightly
The price is $93
Mar 11 - Mar 12
Total with taxes and fees
Sleep Inn & Suites O'Fallon MO - Technology Drive

Sonesta Simply Suites St Louis Earth City

Sonesta Simply Suites St Louis Earth City
2.0 star property
Earth City
8.8 out of 10, Excellent, (843 reviews)
"The rooms were spotless and the staff was great would definitley recommend "
United States
Trish
$93 nightly
The price is $107
Mar 29 - Mar 30
Total with taxes and fees
Sonesta Simply Suites St Louis Earth City

Extended Stay America Suites St Louis St Peters

Extended Stay America Suites St Louis St Peters
2.5 star property
St. Peters
7.0 out of 10, Good, (624 reviews)
"Location was perfect"
United States
Tara
$91 nightly
The price is $105
Mar 29 - Mar 30
Total with taxes and fees
Extended Stay America Suites St Louis St Peters

Americas Best Value Inn & Suites St. Louis, St. Charles Inn

Americas Best Value Inn & Suites St. Louis, St. Charles Inn
2.5 star property
St. Charles
5.8 out of 10, (1,004 reviews)
"Great place"
United States
Christina
$90 nightly
The price is $104
Mar 8 - Mar 9
Total with taxes and fees
Americas Best Value Inn & Suites St. Louis, St. Charles Inn

Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very Good, (947 reviews)
"Clean rooms, pleasant staff."
United States
Karen
$61 nightly
The price is $69
Mar 22 - Mar 23
Total with taxes and fees
Quality Inn Foristell

Extended Stay America Suites - St Louis - Fenton

Extended Stay America Suites - St Louis - Fenton
2.5 star property
Fenton
5.8 out of 10, (246 reviews)
"Very friendly "
United States
Brad
$70 nightly
The price is $81
Mar 15 - Mar 16
Total with taxes and fees
Extended Stay America Suites - St Louis - Fenton

Hampton Inn St. Louis Wentzville

Hampton Inn St. Louis Wentzville
2.5 star property
Wentzville
9.0 out of 10, Wonderful, (666 reviews)
"Prompt service, quick check in. "
United States
Emily
$119 nightly
The price is $136
Mar 15 - Mar 16
Total with taxes and fees
Hampton Inn St. Louis Wentzville

Comfort Inn & Suites St. Louis - O'Fallon

Comfort Inn & Suites St. Louis - O'Fallon
2.5 star property
O'Fallon
7.6 out of 10, Good, (1,003 reviews)
"Nice room, good front desk help"
United States
jeffrey
$87 nightly
The price is $103
Mar 31 - Apr 1
Total with taxes and fees
Comfort Inn & Suites St. Louis - O'Fallon

Candlewood Suites St Louis St Charles by IHG

Candlewood Suites St Louis St Charles by IHG
2.5 star property
St. Charles
7.6 out of 10, Good, (784 reviews)
"The staff was very professional and the room was clean. I will definitely book here again"
United States
Ngozi
$84 nightly
The price is $97
Mar 29 - Mar 30
Total with taxes and fees
Candlewood Suites St Louis St Charles by IHG

Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.4 out of 10, Good, (1,002 reviews)
"Nice place and nice people "
United States
Columbus
$74 nightly
The price is $85
Mar 8 - Mar 9
Total with taxes and fees
Baymont by Wyndham Warrenton

Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
O'Fallon
8.6 out of 10, Excellent, (876 reviews)
"Service, cleanliness and breakfast were all very agreeable "
United States
James
$87 nightly
The price is $103
Mar 22 - Mar 23
Total with taxes and fees
Holiday Inn Express St. Louis West - O'Fallon by IHG

Hampton Inn & Suites St. Charles Old Town Area

Hampton Inn & Suites St. Charles Old Town Area
2.5 star property
St. Charles
9.0 out of 10, Wonderful, (660 reviews)
"Pleasant staff and clean room"
United States
Michele
$114 nightly
The price is $137
Apr 5 - Apr 6
Total with taxes and fees
Hampton Inn & Suites St. Charles Old Town Area

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
2.5 star property
Chesterfield
9.0 out of 10, Wonderful, (1,002 reviews)
"Great hotel!"
United States
Lorelei
$122 nightly
The price is $142
Mar 8 - Mar 9
Total with taxes and fees
Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Best Western Plus Fenton

Best Western Plus Fenton
2.5 star property
Fenton
9.2 out of 10, Wonderful, (222 reviews)
"Stay was great, and the pool was perfect for my daughter and her friend. Wonderful spot for an easy "stay cation" with the girls. "
United States
Melissa
$91 nightly
The price is $105
Mar 8 - Mar 9
Total with taxes and fees
Best Western Plus Fenton
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Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

Find out more about Defiance

Defiance Motel Guide

Planning a getaway with only a few bucks to spare? Expedia can help! With the inexpensive rates at the top motels in Defiance, St. Louis you can put together the vacation of your dreams without spending every penny of your yearly travel budget.

These smaller places are ideal if you need a home base that lets you easily explore the local sights; many of the best motels in Defiance are located near major freeways and public transportation. Plus, when you book a cheap deal on a motel in Defiance, you’ll find quiet rooms, complimentary toiletries, and comfortable sleeping areas, so you can unwind after a long day.

No matter which motel you choose, don't forget to use the travel tools at Expedia to search for local discounts, compare rates on the hottest motels, and plan your next vacation. You won't believe how budget-friendly an amazing getaway can be.

Also, feel free to check out the motels near me page to find the cheapest deals on motels near your current location.

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