Find 2 Star Hotels in Defiance, MO from $66

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Our top choices for Defiance 2-star hotels

Relax Inn Saint Charles

Relax Inn Saint Charles
2.0 star property
St. Charles
6.6 out of 10, (1,002 reviews)
"Great place to stay "
United States
Askar
$60 nightly
The price is $70
Jan 21 - Jan 22
Total with taxes and fees
Relax Inn Saint Charles

Americas Best Value Inn & Suites St. Louis, St. Charles Inn

Americas Best Value Inn & Suites St. Louis, St. Charles Inn
2.5 star property
St. Charles
5.8 out of 10, (1,004 reviews)
"The best thing is the wonderful beds and pillows totally comfortable comfortable. Also television preferences is great for people that want to relax."
United States
Kathy
$59 nightly
The price is $69
Jan 18 - Jan 19
Total with taxes and fees
Americas Best Value Inn & Suites St. Louis, St. Charles Inn

Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District
2.5 star property
St. Charles Historic District
9.4 out of 10, Exceptional, (1,000 reviews)
"We had a great stay in a beautiful area. The staff were friendly, and Kay at the front desk was so kind and welcoming!"
United States
Audrey
$112 nightly
The price is $128
Jan 25 - Jan 26
Total with taxes and fees
Country Inn & Suites by Radisson, St. Charles Historic District

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
St. Charles
8.0 out of 10, Very Good, (1,000 reviews)
"Great location and friendly staff "
United States
Heather
$89 nightly
The price is $103
Feb 5 - Feb 6
Total with taxes and fees
Hampton Inn St. Charles St. Peters

Baymont by Wyndham St. Charles

Baymont by Wyndham St. Charles
2.5 star property
St. Charles
8.0 out of 10, Very Good, (1,000 reviews)
"Friendly staff, great breakfast and clean"
United States
Darin
Baymont by Wyndham St. Charles

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
St. Charles
8.4 out of 10, Very Good, (1,003 reviews)
"Great hotel for the money"
United States
Jere
$76 nightly
The price is $87
Jan 25 - Jan 26
Total with taxes and fees
Comfort Suites St Charles - St Louis

Best Western Plus St. Louis West-Westport

Best Western Plus St. Louis West-Westport
2.5 star property
Maryland Heights
8.0 out of 10, Very Good, (1,030 reviews)
"The room was great and the bed was very comfortable "
United States
Joyce
$76 nightly
The price is $88
Jan 19 - Jan 20
Total with taxes and fees
Best Western Plus St. Louis West-Westport

Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
O'Fallon
8.6 out of 10, Excellent, (858 reviews)
"A very nice stay with very pleasant staff"
United States
Clifford
$95 nightly
The price is $112
Jan 18 - Jan 19
Total with taxes and fees
Holiday Inn Express St. Louis West - O'Fallon by IHG

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,001 reviews)
"Very good place to stay"
United States
Jasur
$79 nightly
The price is $93
Jan 20 - Jan 21
Total with taxes and fees
Sleep Inn & Suites O'Fallon MO - Technology Drive

Economy Inn Wentzville

Economy Inn Wentzville
2.0 star property
Wentzville
6.4 out of 10, (513 reviews)
"The room was dirty so dirty we left didn't spend the night there, and the smell in the building weed or something else not sure which, it was ridiculous so we went to Hannibal and stayed at the Days inn "
United States
paul
$60 nightly
The price is $68
Jan 16 - Jan 17
Total with taxes and fees
Economy Inn Wentzville

Country Inn & Suites by Radisson, St. Peters, MO

Country Inn & Suites by Radisson, St. Peters, MO
2.5 star property
St. Charles
8.2 out of 10, Very Good, (1,000 reviews)
"Convenient spot for stopping through. Hallways smell a bit like cigarettes, room smelled a bit like body odor."
United States
James
$86 nightly
The price is $98
Jan 25 - Jan 26
Total with taxes and fees
Country Inn & Suites by Radisson, St. Peters, MO

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
2.5 star property
Chesterfield
9.0 out of 10, Wonderful, (1,000 reviews)
"Great hotel!"
United States
Lorelei
$108 nightly
The price is $126
Feb 2 - Feb 3
Total with taxes and fees
Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Comfort Inn & Suites St. Louis - O'Fallon

Comfort Inn & Suites St. Louis - O'Fallon
2.5 star property
O'Fallon
7.6 out of 10, Good, (1,007 reviews)
"Nice room, good front desk help"
United States
jeffrey
$68 nightly
The price is $81
Jan 23 - Jan 24
Total with taxes and fees
Comfort Inn & Suites St. Louis - O'Fallon

Hampton Inn & Suites St. Charles Old Town Area

Hampton Inn & Suites St. Charles Old Town Area
2.5 star property
St. Charles
9.2 out of 10, Wonderful, (643 reviews)
"The breakfast was delicious and contained a wide variety. The staff friendly and the rooms very clean. "
United States
Kim
$111 nightly
The price is $134
Feb 1 - Feb 2
Total with taxes and fees
Hampton Inn & Suites St. Charles Old Town Area

Red Roof Inn St Louis - Westport/ Maryland Heights

Red Roof Inn St Louis - Westport/ Maryland Heights
2.0 star property
Maryland Heights
5.4 out of 10, (1,000 reviews)
"Pretty spotless for the most part "
United States
David
$63 nightly
The price is $73
Jan 19 - Jan 20
Total with taxes and fees
Red Roof Inn St Louis - Westport/ Maryland Heights

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Days Inn and Suites by Wyndham St. Louis/Westport Plaza
2.5 star property
Maryland Heights
4.6 out of 10, (1,002 reviews)
"Everything was good "
United States
Timothy
$63 nightly
The price is $73
Jan 25 - Jan 26
Total with taxes and fees
Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Best Western Plus Fenton

Best Western Plus Fenton
2.5 star property
Fenton
9.2 out of 10, Wonderful, (190 reviews)
"Stay was great, and the pool was perfect for my daughter and her friend. Wonderful spot for an easy "stay cation" with the girls. "
United States
Melissa
$101 nightly
The price is $117
Jan 18 - Jan 19
Total with taxes and fees
Best Western Plus Fenton

Super 8 by Wyndham St Charles

Super 8 by Wyndham St Charles
2.0 star property
St. Charles
8.0 out of 10, Very Good, (1,000 reviews)
"Great place to stay for the $$$"
United States
Kale
$76 nightly
The price is $87
Jan 21 - Jan 22
Total with taxes and fees
Super 8 by Wyndham St Charles

Super 8 by Wyndham Eureka/Six Flags Nearby

Super 8 by Wyndham Eureka/Six Flags Nearby
2.0 star property
Eureka
7.0 out of 10, Good, (1,008 reviews)
"Chris was a great night host. He was kind, friendly, and very accommodating. "
United States
Kristi
$64 nightly
The price is $74
Feb 1 - Feb 2
Total with taxes and fees
Super 8 by Wyndham Eureka/Six Flags Nearby

Days Inn by Wyndham St Peters/St Charles

Days Inn by Wyndham St Peters/St Charles
2.0 star property
St. Peters
6.2 out of 10, (1,000 reviews)
"Room was excellent and clean"
United States
catherine
$58 nightly
The price is $66
Jan 18 - Jan 19
Total with taxes and fees
Days Inn by Wyndham St Peters/St Charles
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Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

Find out more about Defiance

Defiance Motel Guide

Planning a getaway with only a few bucks to spare? Expedia can help! With the inexpensive rates at the top motels in Defiance, St. Louis you can put together the vacation of your dreams without spending every penny of your yearly travel budget.

These smaller places are ideal if you need a home base that lets you easily explore the local sights; many of the best motels in Defiance are located near major freeways and public transportation. Plus, when you book a cheap deal on a motel in Defiance, you’ll find quiet rooms, complimentary toiletries, and comfortable sleeping areas, so you can unwind after a long day.

No matter which motel you choose, don't forget to use the travel tools at Expedia to search for local discounts, compare rates on the hottest motels, and plan your next vacation. You won't believe how budget-friendly an amazing getaway can be.

Also, feel free to check out the motels near me page to find the cheapest deals on motels near your current location.

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