Top 10 Hotels in Cross Keys, MO (from $72) 2026 - Competitive Prices

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Our top choices for Cross Keys hotels

A snack kiosk with a variety of packaged foods and beverages, a cash register, and a sign reading 'The Shop.'

1. Hilton Garden Inn St. Louis Airport

Berkeley

Sorrell

$100 nightly

Nov 14 - Nov 15

Total with taxes and fees

A spacious lobby with modern seating, a reception desk, and large windows offering views of the parking area.

2. Pear Tree Inn St. Louis Airport

St. Ann

Rebecca

$90 nightly

Nov 16 - Nov 17

Total with taxes and fees

A modern living room with a built-in fireplace, a large flat-screen TV, a unique hexagonal pendant light, and a patterned rug.

3. Hyatt Select St. Louis Airport

Woodson Terrace

Thadora

$110 nightly

Nov 15 - Nov 16

Total with taxes and fees

A modern hotel room with a dining area, wooden cabinets, a checkered floor, and a flat-screen TV.

4. Wingate by Wyndham St. Louis Airport

St. Ann

Cindy

$96 nightly

Nov 19 - Nov 20

Total with taxes and fees

A multi-level hotel lobby with seating areas, a reception desk, and large windows offering views.

5. Drury Inn & Suites St. Louis Airport

Edmundson

Ethan

$115 nightly

Nov 16 - Nov 17

Total with taxes and fees

A hotel lobby with a tiled floor, white columns, a reception desk, and a view into the dining area.

6. Motel 6 Hazelwood, MO

Hazelwood

Rosemary

$59 nightly

Nov 15 - Nov 16

Total with taxes and fees

A buffet with fruits, pastries, and beverages.

7. Renaissance St. Louis Airport Hotel

Berkeley

Joy

$111 nightly

Nov 27 - Nov 28

Total with taxes and fees

A modern bar area with a central bar counter, seating, and decorative plants.

8. Hampton Inn By Hilton St Louis Airport

Woodson Terrace

Janet

$114 nightly

Nov 23 - Nov 24

Total with taxes and fees

A bar area with a long counter, multiple screens, and seating.

9. Hollywood Casino & Hotel St. Louis

Riverport

Shayla

$81 nightly

Dec 6 - Dec 7

Total with taxes and fees

A hotel entrance with a covered driveway and a parking area.

10. Best Western Plus Parkway Hotel

Alton

Jane

$98 nightly

Nov 12 - Nov 13

Total with taxes and fees

A snack and beverage section with shelves stocked with various snacks and drinks, and a wall with a geometric design and text.

11. Hampton Inn & Suites St. Louis/Alton

Alton

kimberley

$122 nightly

Nov 29 - Nov 30

Total with taxes and fees

A modern lobby with a fireplace, comfortable seating, and a large TV screen.

12. Best Western Plus St. Louis West-Westport

Westport

Herb

$84 nightly

Nov 12 - Nov 13

Total with taxes and fees

A breakfast bar with a coffee machine, a bowl of fruit, and a clock on the wall.

13. MainStay Suites St Louis Airport

Bridgeton

Marcus M

$90 nightly

Nov 12 - Nov 13

Total with taxes and fees

A hotel lobby with blue seating, a flat-screen TV, and a fireplace.

14. Comfort Inn Edwardsville - St. Louis

Edwardsville

Christina

$87 nightly

Nov 29 - Nov 30

Total with taxes and fees

A modern living room with a sofa set, two armchairs, a coffee table, and a wall art piece.

15. Comfort Inn St. Louis Airport

Bridgeton

Crystal

$86 nightly

Nov 15 - Nov 16

Total with taxes and fees

A modern lobby with a stone wall, seating area, and a fireplace.

16. The Great Rivers, an Ascend Collection Hotel

Alton

Jaclyn

$93 nightly

Nov 29 - Nov 30

Total with taxes and fees

A spacious lobby with a high ceiling, large windows, and a variety of seating options including sofas and chairs.

17. Drury Inn & Suites St. Louis Collinsville

Eastport

Amanda

$98 nightly

Nov 22 - Nov 23

Total with taxes and fees

A spacious bar area with a long wooden counter, multiple bar stools, and a variety of bar tools.

18. Holiday Inn St. Louis Arpt West-Earth City by IHG

Earth City

marilyn

$75 nightly

Nov 29 - Nov 30

Total with taxes and fees

A bar area with a long counter, multiple seating options, and a television screen displaying a program.

19. Hilton St. Louis Airport

Woodson Terrace

Julie

$119 nightly

Nov 20 - Nov 21

Total with taxes and fees

A hotel with a covered entrance, a tower with signage, and a landscaped area with planters.

20. La Quinta Inn & Suites by Wyndham St. Louis Westport

Westport

Thomas

$70 nightly

Nov 18 - Nov 19

Total with taxes and fees

View all properties

Hotels recommended for families in Cross Keys

Hilton Garden Inn St. Louis Airport

Berkeley

$100 nightly

Nov 14 - Nov 15

Total with taxes and fees

Top Cross Keys Hotel Reviews

Pear Tree Inn St. Louis Airport

St. Ann

10/10 Excellent

Jane

Hyatt Select St. Louis Airport

Woodson Terrace

10/10 Excellent

Chandis

Hilton Garden Inn St. Louis Airport

Berkeley

10/10 Excellent

Lisa

Drury Inn & Suites St. Louis Airport

Edmundson

10/10 Excellent

Veronica

Drury Inn & Suites St. Louis Collinsville

Eastport

10/10 Excellent

gary

Hampton Inn By Hilton St Louis Airport

Woodson Terrace

10/10 Excellent

Virginia

A restaurant with round tables and chairs, a bar area, and a patterned ceiling.

Drury Plaza Hotel St. Louis Brentwood

Brentwood

10/10 Excellent

Lisa

An indoor pool area with a hot tub, seating, and a stone wall.

Drury Plaza Hotel St. Louis Union Station

Downtown West

10/10 Excellent

In town for the NCAA Tournament with my son. Staff was friendly, and attentive. Breakfast was honesty the best hotel free breakfast I have had in 5 years if travel hockey. The parking garage is secured after dark to protect your cars and personal safety coming and going into the hotel. The area around the hotel is clean, well lit, and feels safe. It is downtown in a major city, so be smart. However there was no feeling of threats. Work out room was small, but clean with free weights,...

Anonymous traveler

A hot tub with a wooden deck, surrounded by a bamboo fence, and string lights.

The West End

Central West End

10/10 Excellent

Amy

A long bar with multiple tables and chairs, wooden floors, and ornate chandeliers.

River City Casino & Hotel

St. Louis

10/10 Excellent

David

Drury Inn & Suites St. Louis Forest Park

Clifton Heights

10/10 Excellent

This is a fantastic hotel, especially if you are traveling with kids. The rooms were clean and modern. The amenities were impressive: the free drinks for the adults, and the free breakfast and dinner for kids (and adults.) It’s close to Forest Park and felt very safe: lots of families and kids. Despite all of the kids, though, my room was super quiet. Andrew and Kevin at the front desk were super enthusiastic and helpful, and made check-in a breeze. For the price, this hotel is amazing and I...

Mitchell

A rooftop terrace with wicker furniture, offering a city view.

Drury Plaza Hotel St. Louis at the Arch

Downtown St. Louis

10/10 Excellent

Richard

A hotel lobby with a hot tub, a pool, and outdoor seating.

Drury Plaza Hotel St. Louis Creve Coeur

Creve Coeur

10/10 Excellent

Rachel

Frequently Asked Questions

What are some of the best vacation home rentals in Cross Keys?

Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!: This vacation home rental near Cross Keys is located in the city center and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. You and your friends and family can relax into your vacation with amenities like a selection of games. See all vacation rentals in Cross Keys.

If I need to cancel my hotel reservation in Cross Keys, will I receive a refund?

Yes! Most hotel reservations are fully refundable if cancelled prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you have a reservation that's non-refundable, you may still be able to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Cross Keys.

Where can I learn more about changing or cancelling my trip to Cross Keys?

For additional details about updating your trip to Cross Keys or cancelling it, head over to our customer service page.

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Lodging

Find hotels in Cross Keys, MO from $72

Upfront pricing

Treat yourself

Be picky

Go beyond your typical stay in Cross Keys

Check prices for these dates

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Star rating

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Our top choices for Cross Keys hotels

1. Hilton Garden Inn St. Louis Airport

2. Pear Tree Inn St. Louis Airport

3. Hyatt Select St. Louis Airport

4. Wingate by Wyndham St. Louis Airport

5. Drury Inn & Suites St. Louis Airport

6. Motel 6 Hazelwood, MO

7. Renaissance St. Louis Airport Hotel

8. Hampton Inn By Hilton St Louis Airport

9. Hollywood Casino & Hotel St. Louis

10. Best Western Plus Parkway Hotel

11. Hampton Inn & Suites St. Louis/Alton

12. Best Western Plus St. Louis West-Westport

13. MainStay Suites St Louis Airport

14. Comfort Inn Edwardsville - St. Louis

15. Comfort Inn St. Louis Airport

16. The Great Rivers, an Ascend Collection Hotel

17. Drury Inn & Suites St. Louis Collinsville

18. Holiday Inn St. Louis Arpt West-Earth City by IHG

19. Hilton St. Louis Airport

20. La Quinta Inn & Suites by Wyndham St. Louis Westport

Hotels recommended for families in Cross Keys

Hilton Garden Inn St. Louis Airport

Top Cross Keys Hotel Reviews

Pear Tree Inn St. Louis Airport

10/10 Excellent

Frequently Asked Questions

What are some of the best vacation home rentals in Cross Keys?

If I need to cancel my hotel reservation in Cross Keys, will I receive a refund?

Where can I learn more about changing or cancelling my trip to Cross Keys?

Explore a world of travel with Expedia