Title: 20 Best B&B in Sikeston, MO - Bed and Breakfast from $292 | Expedia.com [Sikeston Travel Guide](https://expedia.com/Sikeston.dx6058766)[Hotels in Sikeston](https://expedia.com/Sikeston-Hotels.d6058766.Travel-Guide-Hotels)[Vacation Rentals in Sikeston](https://expedia.com/Sikeston-Vacation-Rentals.d6058766.Travel-Guide-VacationRentals)[Flights to Sikeston](https://expedia.com/Cheap-Flights-To-Sikeston.d6058766.Travel-Guide-Flights)[Car Rentals in Sikeston](https://expedia.com/Car-Rentals-In-Sikeston.d6058766.Car-Rental-Guide)[Sikeston Vacation Packages](https://expedia.com/Sikeston.d6058766.Destination-Travel-Guides) ![Pre-teen girl walking through corn maze during fall](https://images.trvl-media.com/place/6058766/0353751e-5978-48d0-a913-84533caba2b0.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6058766/0353751e-5978-48d0-a913-84533caba2b0.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_bundle_and_save.svg) ### Bundle & Save Get more, spend less whenever you see Bundle & Save deals - ![](https://a.travel-assets.com/travel-assets-manager/pictograms-expedia/light__onekey.svg) ### OneKeyCash Earn OneKeyCash on all your eligible bookings - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_ftc.svg) ### Upfront pricing We are not like the others - we include taxes and fees ## Check prices for these dates Next weekend [Feb 27 - Mar 1](https://www.expedia.com/Hotel-Search?regionId=6058766&startDate=2026-02-27&endDate=2026-03-01&adults=2&lodging=BED_AND_BREAKFAST&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=6058766&startDate=2026-03-06&endDate=2026-03-08&adults=2&lodging=BED_AND_BREAKFAST&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In one month [Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=6058766&startDate=2026-03-20&endDate=2026-03-22&adults=2&lodging=BED_AND_BREAKFAST&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [Apr 17 - Apr 19](https://www.expedia.com/Hotel-Search?regionId=6058766&startDate=2026-04-17&endDate=2026-04-19&adults=2&lodging=BED_AND_BREAKFAST&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Sikeston bed & breakfast ![Front of property - evening/night](https://images.trvl-media.com/lodging/35000000/34530000/34529000/34528901/d6ab8f51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Romantic Cottage, 1 King Bed, Non Smoking (Indigo Cottage) | Living area](https://images.trvl-media.com/lodging/35000000/34530000/34529000/34528901/addd1b66.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/35000000/34530000/34529000/34528901/5b224348.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Cottage, Multiple Beds, Non Smoking (West End Cottage) | Living area](https://images.trvl-media.com/lodging/35000000/34530000/34529000/34528901/b59945fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Makanda Inn [](https://www.expedia.com/Carbondale-Hotels-Makanda-Inn-Cottages.h34528901.Hotel-Information) Makanda 10/10 Exceptional (35 reviews) "I had a great stay - wonderful hosts and yummy breakfast." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Julie $264 nightly $292 total Mar 1 - Mar 2 Total with taxes and fees [](https://www.expedia.com/Carbondale-Hotels-Makanda-Inn-Cottages.h34528901.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-08&endDate=2026-03-09®ionId=6058766&adults=2&lodging=BED_AND_BREAKFAST&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=AA_SPRING_PROMO_6058766) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSikeston-Bed-And-Breakfast.d6058766-aaBedAndBreakfast.Travel-Guide-Accommodation)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSikeston-Bed-And-Breakfast.d6058766-aaBedAndBreakfast.Travel-Guide-Accommodation) ## Top Sikeston Hotel Reviews ![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/f91b29ea_y.jpg) ### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) 10/10 Excellent "Very friendly and had an amazing stay so peaceful " [](https://expedia.com/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information) ![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89_y.jpg) ### Pear Tree Inn Cape Girardeau West 10/10 Excellent "Wonderful stay! Was in Cape Girardeau for Volleyball tournament. The check-in was easy, and a bit earlier than normal time. Very clean rooms with super comfortable beds and pillows & clean smell. Exceptional lighting and spacious bathroom. Popcorn and soda in the evening & an outstanding hot breakfast; Biscuits & Gravy, Sausage, Scrambled Eggs, Waffle Maker (2) Cereal, Muffins, Bagels, Yogurt, Fruit, Hot Coffee, Juices and Milk. Very clean and organized, with plenty of seating for large attendance!! Staff amazing. Checked out & realized I left my phone in the room. No worries they quickly provided me access to my room to retrieve my phone. Parking was very adequate & location was perfect with Sam's, Walmart, Target and restaurants, very near. Easy access from I 55\. A 10+ stay. " [](https://expedia.com/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![The Riverview](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg) ### The Riverview 10/10 Excellent "Wonderful stay at hotel and casino! The band, Next of Kin, was fantastic on Valentine’s Day night. Food was excellent too! Highly recommend!!! " [](https://expedia.com/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759_y.jpg) ### Hampton Inn Sikeston 10/10 Excellent "Very clean room and pleasant staff " [](https://expedia.com/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg) ### Drury Inn & Suites Sikeston, MO 10/10 Excellent "upgrade to a suite" [](https://expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg) ### Drury Plaza Hotel Cape Girardeau Conference Center 10/10 Excellent "Clean, great staff" [](https://expedia.com/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Best Western Plus Sikeston](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg) ### Best Western Plus Sikeston 10/10 Excellent "Thestaff at the front counter was awesome." [](https://expedia.com/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information) ![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/4b521966_y.jpg) ### Drury Inn & Suites Cape Girardeau 10/10 Excellent "Friendly staff, great amneties, spotless, relaxing. We always look for Drurys wherever we go. " [](https://expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information) ![Drury Inn & Suites Jackson MO](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d_y.jpg) ### Drury Inn & Suites Jackson MO 10/10 Excellent "Clean and spacious room. Staff was very friendly and helpful. " [](https://expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) ## Find out more about Sikeston ## Sikeston B&B information | Number of reviews | 35 | | ----------------- | ----- | | Accommodation | 5 B&B | | Lowest Price | $292 | | Highest Price | $292 | ## Frequently asked questions ### What is the nightly rate for a Bed and Breakfast in Sikeston? ### When is the best time to book a B&B in Sikeston? > April, in particular, is a delightful month to visit, offering a wonderful balance of comfortable weather and lively community events. With many festivals and outdoor gatherings taking place, it's an excellent opportunity to immerse yourself in the local culture while enjoying the pleasant spring climate. > > > For those seeking a more budget-friendly experience, consider traveling to Sikeston in November. While this month is quieter, it still offers charming sights and experiences, such as exploring the area's unique cuisine, including the famous Sikeston BBQ. ### What is the difference between a Sikeston Bed & Breakfast and a hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Hotels near Sikeston Depot Museum ](https://www.expedia.com/Sikeston-Depot-Museum-Hotels.0-l6305602-0.Travel-Guide-Filter-Hotels) - [Hotels near Central Park ](https://www.expedia.com/Central-Park-Hotels.0-l6305608-0.Travel-Guide-Filter-Hotels) - [Hotels near Sikeston Memorial Municipal ](https://www.expedia.com/Sikeston-Memorial-Municipal-Airport-Hotels.0-aSIK-0.Travel-Guide-Filter-Hotels) - [The Book Bug ](https://www.expedia.com/The-Book-Bug-Hotels.0-l553248621532655751-0.Travel-Guide-Filter-Hotels) - [Miner Hotels ](https://www.expedia.com/Miner-Hotels.d553248634983441802.Travel-Guide-Hotels) - [Motels in Bertrand ](https://www.expedia.com/Bertrand-Motels.d3000349285-aaMotels.Travel-Guide-Accommodation) - 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