Find 4 Star Hotels in Grand Center, MO from $117
Upfront pricing
Our total price for your stay includes taxes and fees
Treat yourself
Save 10% or more on over 100,000 hotels worldwide with Member Prices
Be picky
Search almost a million properties worldwide
Check availability on Grand Center 4 Star Hotels
Compare Grand Center 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Renaissance St. Louis Airport Hotel
Renaissance St. Louis Airport Hotel
8.4 out of 10, Very Good, (1023)
$118 nightly
The price is $138
Oct 31 - Nov 1
Total with taxes and fees

Hyatt Regency St. Louis at The Arch
Hyatt Regency St. Louis at The Arch
8.6 out of 10, Excellent, (3974)
$125 nightly
The price is $147
Oct 2 - Oct 3
Total with taxes and fees

21C Museum Hotel St Louis
21C Museum Hotel St Louis
9.0 out of 10, Wonderful, (1393)
$165 nightly
The price is $193
Oct 31 - Nov 1
Total with taxes and fees

St. Louis Union Station Hotel, Curio Collection by Hilton
St. Louis Union Station Hotel, Curio Collection by Hilton
8.4 out of 10, Very Good, (1027)
$173 nightly
The price is $205
Oct 9 - Oct 10
Total with taxes and fees

Marriott St. Louis Grand
Marriott St. Louis Grand
8.2 out of 10, Very Good, (1050)
$135 nightly
The price is $161
Oct 12 - Oct 13
Total with taxes and fees

DoubleTree by Hilton St. Louis Airport
DoubleTree by Hilton St. Louis Airport
7.8 out of 10, Good, (823)
$114 nightly
The price is $134
Oct 5 - Oct 6
Total with taxes and fees

River City Casino & Hotel
River City Casino & Hotel
9.0 out of 10, Wonderful, (1402)
$100 nightly
The price is $117
Oct 19 - Oct 20
Total with taxes and fees

Live by Loews - St.Louis
Live by Loews - St.Louis
9.2 out of 10, Wonderful, (1062)
$169 nightly
The price is $201
Oct 5 - Oct 6
Total with taxes and fees
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 5-star hotels
Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Grand Center.

Four Seasons Hotel St Louis
999 North Second Street, St. Louis, MO
$425 nightly
The price is $497 total per night from Oct 26 to Oct 27
$497 total
Oct 26 - Oct 27
Total with taxes and fees
9.4/10 Exceptional! (1,000 reviews)
Still don't see what you're looking for?
See all properties in Grand Center.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Grand Center Hotel Reviews

River City Casino & Hotel
10/10 Excellent
Frequently asked questions
Explore a world of travel with Expedia
Explore a world of travel with Expedia
- St. Louis Hotels
- Cheap Hotels in St. Louis
- Hotels near Fox Theater
- Hotels near Grandel Theater
- Hotels near Powell Hall
- Hotels near Powell Symphony Hall
- Hotels near St. Louis Symphony Orchestra
- Hotels near Downtown St. Louis
- Hotels near Sheldon Concert Hall
- Hotels near Pulitzer Foundation for the Arts
- Hotels near St. Alphonsus Liguori Catholic Church
- Hotels near Contemporary Art Museum St. Louis
- Hotels near St. Louis University
- Hotels near Chaifetz Arena
- Hotels near Busch Stadium
- Hotels near St. Teresa of Avila Catholic Church
- 5 Star Hotels in St. Louis
- Hotels with Free Airport Shuttle in St. Louis
- 4 Star Hotels in Central West End
- 3 Star Hotels in Central West End
- 4 Star Hotels in St. Louis
- Hotels near Washington Avenue Historic District
- Hotels near Enterprise Center
- 3 Star Hotels in St. Louis
- Hotels with an Indoor Pool in St. Louis
- Pet-friendly Hotels in St. Louis
- Casino Hotels in St. Louis
- Hotels near Cathedral Basilica of St. Louis
- Hotels near Central West End
- Hotels near St. Louis Union Station
- Motels in St. Louis
- Extended Stay Hotels in St. Louis
- Hotels near Griot Museum of Black History
- Hotels with Waterslides in St. Louis
- Cabin Rentals in St. Louis
- Romantic Hotels in St. Louis
- Hotels with Hot Tubs in St. Louis
- Resorts & Hotels with Spas in St. Louis
- Waterpark Hotels in St. Louis
- Hotels with smoking rooms in St. Louis
- Hotels with Balconies in St. Louis
- Family Hotels in St. Louis
- Cheap Hotels in Central West End
- Pet-friendly Hotels in Central West End
- Resorts & Hotels with Spas in Central West End
- Hyatt Hotels in Central West End
- Hotels with Balconies in Central West End
- Historic Hotels in Central West End
- Luxury Hotels in Central West End
- Hotel Wedding Venues Hotels in Central West End
- Hotels with a Pool in Central West End
- Hotels with Connecting Rooms in Central West End
- Boutique Hotels in Central West End
- Hotels with Bars in Central West End
- Family Hotels in Central West End
- Hotels with Free Parking in Central West End
- Casino Hotels in Central West End
- Extended Stay Hotels in Central West End
- Green Hotels in Central West End
- Hotels with Laundry Facilities in Central West End
- Romantic Hotels in Central West End
- Drury Inn & Suites Hotels in Central West End
- Hotels with an Outdoor Pool in Central West End
- Business Hotels in Central West End
- Golf Hotels in Central West End
- Non-Smoking Hotels in Central West End
- Hotels with an Indoor Pool in Central West End
- Hotels & Resorts for Couples in Central West End
- Hilton Hotels in Central West End
- Marriott Hotels & Resorts in St. Louis
- Grandel Theater
- Powell Hall
- St. Louis Symphony Orchestra
- Fox Theater
- Pulitzer Foundation for the Arts
- Sheldon Concert Hall
- Bruno David Gallery
- St. Alphonsus Liguori Catholic Church
- Contemporary Art Museum St. Louis
- St. Louis University
- Chaifetz Arena
- Scott Joplin House State Historic Site
- Washington Avenue Historic District
- Cathedral Basilica of St. Louis
- St. Louis Vacations
- Visit St. Louis
- Visit Central West End
- Central West End Vacations
- Car rentals near St. Louis
- Car rentals near Ellen Clark Sculpture Park
- Car rentals near St. Louis University
- Mini Car Rentals near St. Louis University
- Car rentals near Cathedral Basilica of St. Louis
- Car rentals near Central West End
- Avis Rental Cars in Central West End
- Hertz Rental Cars in Central West End