Find spa resorts & hotels in Central West End, St. Louis from $153

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Top Central West End Resorts & Hotels with Spas

Ameristar Casino Resort and Spa

4.5 star property
St. Charles
8.4 out of 10, Very Good, (1000)
"Clean room, wonderful helpful pleasant staff, amenities, everything was great love staying here!"
United States
Robyn
$166 nightly
The price is $194
Dec 7 - Dec 8
Total with taxes and fees
Ameristar Casino Resort and Spa

21C Museum Hotel St Louis

4.5 star property
Downtown West
9.0 out of 10, Wonderful, (1481)
"Staff is wonderful. We checked in late after a long journey and they could not have been nicer to us at check in also in the restaurant and bar. We loved the vibe and the location. I’d return again if ever in the area. "
United States
Jenifer
$131 nightly
The price is $153
Dec 28 - Dec 29
Total with taxes and fees
21C Museum Hotel St Louis

Four Seasons Hotel St Louis

5.0 star property
Downtown St. Louis
9.4 out of 10, Exceptional, (1001)
"The staff was amazing. The bed was so comfortable. "
United States
Mary
$415 nightly
The price is $485
Jan 1 - Jan 2, 2026
Total with taxes and fees
Four Seasons Hotel St Louis

The Ritz-Carlton, St. Louis

5.0 star property
Clayton
9.2 out of 10, Wonderful, (553)
"Service is exceptional!!!"
United States
Jorge
$499 nightly
The price is $583
Dec 21 - Dec 22
Total with taxes and fees
The Ritz-Carlton, St. Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Central West End

Top Central West End attractions for a relaxing vacation

In the heart of the Central West End, travelers will find a delightful blend of relaxation and adventure at hotels with top spa facilities. Begin your journey with a visit to the Saint Louis Art Museum, where you can immerse yourself in world-class art collections before unwinding with a massage back at your hotel. The Missouri Botanical Garden offers a serene escape with its lush landscapes, perfect for a peaceful stroll or a meditative moment. For an interactive experience, check out the City Museum, an eclectic mix of playground and art installation, which is sure to delight both kids and adults alike. Foodies will appreciate the vibrant local dining scene, with restaurants like Niche Food Group offering farm-to-table options that cater to both health and indulgence. After exploring, retreat to your hotel’s spa, where you'll be treated to luxurious therapies designed to rejuvenate your body and mind, ensuring an experience that’s both pampering and restorative. With attentive service and a focus on quality, your stay in the Central West End promises not only comfort but also a chance to create lasting memories.

Find the best hotels & resorts with spas in Central West End

For travelers seeking relaxation and rejuvenation in the Central West End of St. Louis, these top hotels offer luxurious spa amenities and tranquil environments to unwind.

The Royal Sonesta Chase Park Plaza St. Louis

  • Why it's great for tailored spa getaway: The Royal Sonesta Chase Park Plaza St. Louis is a premier choice for guests looking to indulge in a spa experience while enjoying luxurious accommodations. With a strong guest review rating of 8.8, this hotel features exclusive treatment rooms that provide a serene setting for relaxation and pampering. The elegant stay combined with high-end amenities ensures a tranquil getaway for spa enthusiasts.
  • Other amenities: In addition to its spa offerings, the hotel boasts a health club and fitness facilities to help guests maintain their wellness routines. Guests can enjoy a refreshing drink at the poolside bar or relax on their private balcony. The hotel also provides designer toiletries and premium bedding for a touch of luxury. Conveniences such as valet parking, concierge services, and complimentary breakfast enhance the overall guest experience, making it an ideal choice for a restful retreat.
  • Neighborhood: Central West End
  • Nearby attractions: Forest Park - 0.0 miles

Top Central West End Hotel Reviews

Frequently asked questions

Looking for a spa hotel in Central West End?
Treat yourself to some pampering and book a hotel with a spa. Travelers highly recommend the restaurants in Central West End. Take in the culture at the cathedral and museums during your stay. Hotels with spas are a great way to take a break from your routine and add a layer of luxury to your vacation.
What's there to see and do in Central West End?
Enjoy all that Central West End has to offer and visit World Chess Hall of Fame, St. Louis Union Station, and Gateway Arch. If you have extra time while you're in the area, you might want to stop by St. Louis Science Center and The Muny Theater.
What is a Central West End spa hotel?
Spa hotels in Central West End provide lodging and have a full on-site spa offering services such as therapies as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.

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