Santa Cruz

Travel Guide

A colonial-style building with a bell tower, palm trees, and a paved walkway.
A brick building with arched windows and a spiral design on the facade.
A historic building with columns and flags, palm trees, and a clear blue sky.
A historic brick tower with a dome and bell, surrounded by lush green palm trees.
A historic church with two bell towers and a central facade.

Experience Bolivia as the locals see it in the country’s busiest city, where the museums, public squares and churches give you a glimpse into their everyday lives.

Although Santa Cruz de la Sierra, more commonly known as Santa Cruz, is the most populous city in Bolivia, it is still relatively unknown by tourists. Sample an authentic Bolivian lifestyle in this busy city. Visit Santa Cruz’s churches and museums for an insight into the region’s history or simply soak up the atmosphere over a drink with the friendly locals.

Explore a city that started out in a totally different location. Santa Cruz was founded in 1561, but had to move west after several decades of fending off attacks. Visit the historic heart of the city in Plaza 24 de SeptiembreOpens in a new window, which is more than 400 years old, to relax with the locals, who are known as “cruceños.”

The most distinctive attraction in the city is San Lorenzo CathedralOpens in a new window, which is immediately recognizable for its red-brick frontage featuring two clock towers standing on either side of a pediment. The cathedral hosts the Museum of Sacred Art, with exhibits that display religious icons and Jesuit relics. Climb to the top of the clock tower for panoramic views of the city.

Wander around the Parque Arenal, a green space in the middle of the city. The park has a boating lagoon and the Museo Etnofolklorico (Santa Cruz Ethnographic Museum). Other museums in the city include the Guarani Museum, which examines the culture of the indigenous Guarani people, and the National History Museum.

Take children to the Zoological Gardens, where they can meet animals from around Bolivia. The zoo’s llamas and sloths are always popular with younger visitors.

Fly into the busiest airport in Bolivia, Viru Viru International Airport. Flights arrive here from destinations in both Bolivia and cities in North and South America. Some operators even fly here from cities in Europe, such as Madrid.

Santa Cruz de la Sierra is located in the lowlands of Bolivia in the east of the country, which means that rainfall is high during the summer months around January. Come during the high season, between May and October, for more dependable weather but higher prices.

Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Learn more about Santa Cruz

Equipetrol

Though Equipetrol might not have many top sights, you can venture to the surrounding area to see attractions like Santa Cruz Zoo and Municipal Library.

Centro Histórico

If you're spending some time in Centro Histórico, Plaza 24 de Septiembre and La Recova Artisan Walk are top sights worth seeing.

Hamacas

While Hamacas isn't home to many top sights, Las Brisas Shopping Center and Santa Cruz Zoo are some notable places to visit nearby.

Zona Sur (South Zone)

Zona Sur (South Zone) might not have many top sights, but Ramon Tahuichi Aguilera Stadium and Plaza 24 de Septiembre are two attractions nearby that you can check out.

Urubó

While Urubó might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Guembe Biocenter and Ventura Mall.

Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
$34 nightly
The price is $34 total per night from Nov 22 to Nov 23
$34 total
Nov 22 - Nov 23
Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
Ibis Santa Cruz DE LA Sierra
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
$152 nightly
The price is $152 total per night from Nov 14 to Nov 15
$152 total
Nov 14 - Nov 15
Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
9/10 Wonderful! (425 reviews)
"Nice, good quality hotel with good service and ambiance. pool needs better maintenance. walk from room to lobby was outside the building so that when it rained, we got wet."

Reviewed on Nov 6, 2026

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

5 out of 5
4to Anillo Entre Radial 23 Santa Cruz Santa Cruz
$123 nightly
The price is $123 total per night from Nov 14 to Nov 15
$123 total
Nov 14 - Nov 15
Book a stay at this luxury hotel in Santa Cruz. Enjoy free parking, a full-service spa, and a rooftop terrace. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (261 reviews)
"Beautiful views and clean property. The food there is great, and it’s well located. However, the cleaning staff stole a $100 bill from my backpack and replaced it with a fake one. I would rather they just took the money, but replacing it with a fake note could’ve gotten me in serious trouble, and ..."

Reviewed on Oct 30, 2026

Marriott Santa Cruz de la Sierra Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz

3.5 out of 5
Calle Las Begonias Nro 45 Santa Cruz
Book a stay at this business-friendly apartment in Santa Cruz. Enjoy free WiFi, free parking, and room service. Popular attractions Patio Design LifeStyle Center ...
8.6/10 Excellent! (107 reviews)
"Book at the hotel and they will take you in to different place. Building entrance key doesn't work most of the time. Very hard to take transportation to and to the place. Male attendants were very friendly and helpful. And many more small details."

Reviewed on Oct 6, 2026

Apart Hotel Premium Suites Santa Cruz
Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol

3.5 out of 5
Calle Las Azucenas No. 127 Santa Cruz Santa Cruz
Book a stay at this business-friendly aparthotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Patio Design LifeStyle ...
Premium Suites Deluxe Aparthotel Equipetrol
AMERICA APARTMENTS

AMERICA APARTMENTS

3 out of 5
61 Carandí Santa Cruz Departamento de Santa Cruz
Stay at this apartment in Santa Cruz. Enjoy free WiFi, laundry facilities, and balconies or patios. Popular attractions Artecampo and Parque Ecológico are located ...
10/10 Exceptional! (3 reviews)
"Clean room, great staff"

Reviewed on Feb 10, 2026

AMERICA APARTMENTS
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Santa Cruz attractions

Things to do

Frequently asked questions

Is Santa Cruz worth visiting?
Santa Cruz is worth visiting for its standout attractions like Plaza 24 de Septiembre and Ventura Mall. Travelers can also enjoy a diverse food scene, with options for Latin American and Asian cuisine. The destination also offers practical train access, making it convenient to explore.
When is the best time to visit Santa Cruz?
The best time to visit Santa Cruz is from February through June, when the climate is generally pleasant. For fewer crowds and better value, the warmer months of October through November are a good option for travelers seeking a quieter experience.
What is Santa Cruz known for?
Santa Cruz is known for its central Plaza 24 de Septiembre, a prominent landmark, and for shopping at Ventura Mall. Travelers can also explore the Guembe Biocenter. This city on the Pirai River also offers a rich Latin American food culture for visitors to enjoy.
What is a good itinerary length for Santa Cruz?
A good itinerary length for Santa Cruz is two to three days to explore highlights like Plaza 24 de Septiembre, Ventura Mall, and Guembe Biocenter. An extended stay of four to five days allows for a Day Tour to Amboro National Park (north side), a Bolivian Wine Tasting, or the multi-day Kaa Iya Expedition. See Santa Cruz Activities.
How do you get around Santa Cruz?
Travelers in Santa Cruz can use train services, with Santa Cruz de la Sierra Station serving as the primary station. For more flexible local travel, rideshare services are also available throughout the area, offering convenient options to explore the city.
What are the top things to do in and around Santa Cruz?
Santa Cruz offers a blend of wildlife adventures, cultural tastes, and natural wonders:

  • Embark on a Kaa Iya Expedition to track jaguars.
  • Enjoy a Bolivian Wine Tasting with a Charcuterie Board.
  • Take a Day Tour of Amboro National Park (north side).
  • Explore El Fuerte and Samaipata on a day tour.
  • Visit the Guembe Biocenter.

How do I plan a trip to Santa Cruz?
To plan your trip to Santa Cruz, book flights, hotels, and popular activities like the Kaa Iya Expedition or a Day Tour to Amboro National Park in advance. For outdoor activities, plan for early morning or late afternoon. Explore the city using available train services or on foot, and consider a rental car for excursions beyond.
What cuisines can you find in Santa Cruz?
In Santa Cruz you can find Portuguese cuisine, with dishes like Bacalhau à Brás, Piri-piri chicken, and Pastel de Nata. Travelers can also enjoy Latin American options, including Mexican tacos and burritos, alongside Asian, Italian, and other European and North American flavors.
Can I book a refundable hotel in Santa Cruz?
Yes, Expedia offers many flexible booking options, and you can look for refundable hotels in Santa Cruz by entering your dates and using the refundable or fully refundable filter. Always check the hotel's cancellation policy before you book, since terms can vary by hotel, and visit Expedia help center for further details.
Why book a trip to Santa Cruz with Expedia?
Expedia makes it easier to plan your Santa Cruz trip with travel tools, flexible search options, and bookable trip components all in one place. You can organize your plans in one account and use Expedia to help build a trip that fits your budget and travel style. Find out more about how by visiting Expedia's Trip Planner page.
Should I stay in a hotel or vacation rental in Santa Cruz?
The best choice depends on your travel style. Hotels in Santa Cruz can be a good fit for convenience, on-site amenities, and shorter stays, while vacation rentals may offer more space, privacy, and home-style amenities for longer trips, families, or groups. With Expedia, you can compare both options side by side, read traveler reviews, and filter by amenities to find the right fit for your trip.
How can I manage my Santa Cruz trip on Expedia?
Once you've booked your Santa Cruz trip, you can manage it through your Expedia account or the Expedia app. You can view your itinerary, access booking details, make eligible changes, and check for updates in My Trips. The Expedia app can also help you stay organized while you travel.
What if I need help during my Santa Cruz trip?
Expedia offers customer support before, during, and after your Santa Cruz trip. If your plans change or something unexpected happens, you can review your booking in My Trips and use Expedia help center channels for help with eligible changes, cancellations, or travel issues.
How can Expedia help me plan my first trip to Santa Cruz?
If it's your first trip to Santa Cruz, Expedia can help you plan by bringing together stays, flights, activities, traveler reviews, and trip-planning tools in one place. With Expedia's Trip Planner you can compare options, read reviews from other travelers, and build an itinerary that matches your interests and budget.
How can I save on my Santa Cruz hotel booking with Expedia?
Join One Key™ for free to unlock instant discounts with Member Prices on select hotels. You can also earn and use OneKeyCash™* on eligible bookings on Expedia. Booking in advance is usually another great way to save on your Santa Cruz hotel.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.

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