Mesilla Vacations from $296

Book a Hotel + Flight or Car together to unlock savings

Photo by Lane

Your Mesilla Vacation

With a vacation package to Mesilla, say goodbye to endless planning and hello to hassle-free adventure. Every detail of your journey has been taken care of before you go, so you can spend more time experiencing this exciting city. You'll want to sightsee during your trip to Mesilla. Carve out some time for top attractions such as New Mexico State University, Mesilla Valley Mall and New Mexico Farm and Ranch Heritage Museum. Expedia is here to help you escape your routine. Tailor your vacation to Mesilla to suit your style of travel, whatever that may be!

The Latest Mesilla vacation packages

Price found within the past 48 hours. Click for updated prices.
Holiday Inn El Paso West - Sunland Park by IHG
Stanton House
Radisson Hotel El Paso Airport
Holiday Inn El Paso Airport by IHG
Holiday Inn Express And Suites El Paso East by IHG
Don't see what you're looking for?
See all available trips from Columbus to Mesilla
View all trips

Discover the most popular places to visit in Mesilla

Mesilla Hotel Deals

Casita Azul, Mesilla Plaza Only Steps Away

Casita Azul, Mesilla Plaza Only Steps Away

Mesilla
10/10 Exceptional! (164 reviews)
"Very beautiful little casita! Nice and quiet, felt safe, and Mesilla is lovely. The hosts are very gracious."

Reviewed on Aug 17, 2025

Casita Azul, Mesilla Plaza Only Steps Away
Josefina's King Suite in Historic Old Mesilla Plaza.

Josefina's King Suite in Historic Old Mesilla Plaza.

2 out of 5
Mesilla
$155 nightly
The price is $167 total per night from Aug 22 to Aug 23
$167 total
Aug 22 - Aug 23
Total includes taxes and fees
9.8/10 Exceptional! (15 reviews)
Historic luxury
"Beautiful property in an historic building. Private and beautiful greenhouse surrounds room entry. Walking distance to all shops and many restaurants."

Reviewed on Aug 6, 2025

Josefina's King Suite in Historic Old Mesilla Plaza.
Hotel Encanto de Las Cruces

Hotel Encanto de Las Cruces

3.5 out of 5
705 S Telshor Blvd, Las Cruces, NM
Fully refundableReserve now, pay when you stay
$138 nightly
The price is $159 total per night from Sep 14 to Sep 15
$159 total
Sep 14 - Sep 15
Total includes taxes and fees
9/10 Wonderful! (1,444 reviews)
"Encanto is one of my favorite places to stay in Las Cruces. It’s close to NMSU, restaurants, and shops. The lobby is beautiful. The rooms are comfortable and well decorated. Front desk staff was very kind and friendly."

Reviewed on Aug 18, 2025

Hotel Encanto de Las Cruces
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More vacations you might like

Frequently asked questions

How much does a Mesilla vacation package cost?
Offering excellent value package deals from $296 on Expedia, you'll be pleasantly surprised at how much a vacation to Mesilla costs! Expedia's packages make travel planning easier and save you more.
What are the cheapest months to go to Mesilla?
You can typically find reduced prices and greater availability in September, October and December. Explore our cheap Mesilla vacation packages and you could score some great off-season deals.
How many days is enough for Mesilla?
With a well-organized travel plan, you can easily tick off the most popular Mesilla attractions in a few days. But if you'd like to discover hidden spots or go on day trips, think about booking your Mesilla vacation for longer.
Is it worth booking a vacation package to Mesilla?
It's no wonder a Mesilla vacation is on the must-do list of many travelers. Well-known attractions like Mesillia Plaza are just the start of things to see and do here.
How to find the best Mesilla package deals?
Use Expedia's filter tool to help you find some of the best Mesilla package deals. When you begin your search, simply set your maximum budget and then sort the results by "Price: low to high." If you want to save, plan your break for midweek, or look for Mesilla package deals in the off-season. Switch up your travel dates and you may land even bigger discounts. As a rule of thumb, it's usually best to lock in your vacation package well in advance.
Is it cheaper to book a Mesilla vacation as a package?
Expedia vacation packages are designed to help you keep more cash in your pocket. Bundle your car rental, flight and hotel into one great-value price and enjoy significant savings. You'll generally score a better deal than booking each component individually. And you'll still enjoy the freedom to create a customized Mesilla vacation by choosing your favorite type of stay, airline and car class.
When to book a vacation package to Mesilla?
Secure amazing discounts by booking your flights early with Expedia. If being spontaneous is more your thing, snap up one of our last-minute deals for an impromptu Mesilla getaway.
Does Expedia offer Book Now, Pay Later Mesilla vacation packages?
Set off on your perfect trip to Mesilla with our Book Now, Pay Later vacations. No need to save like crazy or hold off until payday — we've joined forces with online lender Affirm to give you financial flexibility. Our vacation packages with payment plans let you spread the cost over 3, 6 or 12 months. With no hidden or late payment fees, it's a breeze to budget for your trip and snap up travel deals before they sell out.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.