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Featured San Francisco Independent Hotels

See all 526 Hotels in San Francisco
Hotel Whitcomb

Hotel Whitcomb

1231 Market St, San Francisco
3.5 out of 5.0
3.1 out of 5 (3,218 reviews)
A Historic Hotel In A Less Than Historic Area Overall, I like this hotel. It's beautiful, having been built in the early 1900s, so the rooms are … - 

$149

$149
Hotel Zoe San Francisco

Hotel Zoe San Francisco

425 North Point, San Francisco
4.0 out of 5.0
4.2 out of 5 (2,381 reviews)
Newly renovated hotel on Fisherman's Wharf I've stayed at this hotel when it was Tuscan Inn. Now taken over, and totally renovated. it is mode … - 

$209

$209
Hotel Nikko San Francisco

Hotel Nikko San Francisco

222 Mason St, San Francisco
4.0 out of 5.0
4.3 out of 5 (2,779 reviews)
Good location near Union Square, restaurants, shopping. Comfortable clean Hotel - 

$232

$232
Serrano Hotel

Serrano Hotel

405 Taylor St, San Francisco
3.9 out of 5 (1,636 reviews)
Neighborhood A block away is the sketchy Tenderloin area.. needles and trash left on the sidewalk - 

$178

$178
Hotel Zephyr

Hotel Zephyr

250 Beach Street, San Francisco
3.5 out of 5.0
4.1 out of 5 (912 reviews)
Close to restaurants Clean and nice Hotel. The game room is awesome.. except the pillows.. looks fluffy but it stays fla … - 

$169

$169
Pier 2620 Hotel Fisherman's Wharf

Pier 2620 Hotel Fisherman's Wharf

2620 Jones Street, San Francisco
3.5 out of 5.0
4.2 out of 5 (1,959 reviews)
Very good location The location of this hotel is awesome. Its a walk away from everything you need. Breakfast was very … - 

$178

$178
The Westin St. Francis San Francisco on Union Square

The Westin St. Francis San Francisco on Union Square

335 Powell Street, San Francisco
4.0 out of 5.0
4.1 out of 5 (1,838 reviews)
Actually only unpleasing thing was the super noisy AC. It was impossible to rest or watch TV, talk … - 

$259

$259
Grand Hyatt San Francisco Union Square

Grand Hyatt San Francisco Union Square

345 Stockton St, San Francisco
4.0 out of 5.0
4.3 out of 5 (1,386 reviews)
Very nice hotel. Great location too. Check-in was very quick. Front desk person was able to find a nice room facing Union Square for us … - 

$209

$209
Palace Hotel, a Luxury Collection Hotel, San Francisco

Palace Hotel, a Luxury Collection Hotel, San Francisco

2 New Montgomery St, San Francisco
5.0 out of 5.0
4.5 out of 5 (1,545 reviews)
Close to everything! The lobby was very elegant and fancy and the amenities in the room are almost complete (no tootbrus … - 

$235

$235
Handlery Union Square Hotel

Handlery Union Square Hotel

351 Geary St, San Francisco
3.5 out of 5.0
3.9 out of 5 (1,603 reviews)
Very nice hotel close to everything the Handlery is a family owned hotel, and it has just enough of everything to please a traveller. T … - 

$179

$179
San Francisco Marriott Marquis

San Francisco Marriott Marquis

780 Mission Street, San Francisco
4.0 out of 5.0
4.4 out of 5 (1,660 reviews)
Comfortable Stay The hotel was great. In a great location which would explain why they do not have a real restaurant … - 

$246

$246
Argonaut Hotel - a Noble House Hotel

Argonaut Hotel - a Noble House Hotel

495 Jefferson St, San Francisco
4.5 out of 5.0
4.6 out of 5 (2,969 reviews)
Great location. Newly renovated. Rooms a bit on smaller side, but nice and clean. Parking expensive … - 

$255

$255
Hyatt Regency San Francisco Airport

Hyatt Regency San Francisco Airport

1333 Bayshore Hwy, Burlingame
4.0 out of 5.0
4.0 out of 5 (1,279 reviews)
Good hotel Pool could be better as lack of towels and sun cream - 

$149

$149
Fairmont San Francisco

Fairmont San Francisco

950 Mason Street Atop Nob Hill, San Francisco
5.0 out of 5.0
4.4 out of 5 (2,069 reviews)
Timeless Class! The Fairmont San Francisco has such a storied past yet has all the modern amenities you need. I sta … - 

$254

$254
Hotel Focus SFO

Hotel Focus SFO

111 Mitchell Ave, South San Francisco
3.0 out of 5.0
3.3 out of 5 (77 reviews)
Exterior of hotel was not great. Our room had brand new beds. Everything was very clean. The vanity … - 

$107

$107
Sheraton Fisherman's Wharf Hotel

Sheraton Fisherman's Wharf Hotel

2500 Mason St, San Francisco
4.0 out of 5.0
3.9 out of 5 (2,454 reviews)
Great Hotel close to all sightseeing highlights. Fantastic stay, loved sitting by fire pits with a glass of wine after a long day sightseeing. - 

$189

$189
La Quinta Inn San Francisco Airport North

La Quinta Inn San Francisco Airport North

20 Airport Blvd, South San Francisco
2.5 out of 5.0
3.4 out of 5 (946 reviews)
Under Construction and a Bit Scary Couldn't find the lobby, it was in a converted hotel room. Construction everywhere and the location … - 

$95

$95
Monarch Hotel

Monarch Hotel

1015 Geary St, San Francisco
2.0 out of 5.0
3.0 out of 5 (1,070 reviews)
Perfect location to visit the Masonic We stayed here so we could easily walk to the Masonic for a concert. This was easily achievable. Th … - 

$101

$101
San Francisco Marriott Union Square

San Francisco Marriott Union Square

480 Sutter Street, San Francisco
4.3 out of 5 (772 reviews)
Great hotel. Will return! Awesome staff and room was great. Very comfy!! My room was spacious and comfortable. Room service w … - 

$199

$199
Holiday Inn San Francisco-Fisherman's Wharf

Holiday Inn San Francisco-Fisherman's Wharf

1300 Columbus Ave, San Francisco
3.5 out of 5.0
3.9 out of 5 (1,856 reviews)
Great Location First off this hotel has 2 locations a block apart. I was not made aware of which hotel we were sta … - 

$160

$160
Map

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Independent San Francisco Hotel Guide

Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in San Francisco, California. Known for well-appointed rooms and friendly, personalized service, each of the top Independent San Francisco hotels guarantees an unparalleled level of comfort and quality.

You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some San Francisco Independent locations may even offer extra little benefits and discounts for frequent travelers.