Photo by Jessica Richter

Find all hotels by Independent in Southeast Missouri, MO from $52

Most hotels are fully refundable. Because flexibility matters.

Save 10% or more on over 100,000 hotels worldwide as a One Key member.

Search over 2.9 million properties and 550 airlines worldwide.

Compare rooms and suites by Independent in Southeast Missouri with rates, reviews, and availability. Most hotels are fully refundable.

Fridge, microwave, oven, stovetop
Unique cabins in the woods<br>Not friendly for Street Bikes. Beautifulin FALL!
10.0 out of 10, Exceptional, (68)
"I love staying here. It is so clean and comfortable. I loved waking up in the morning and having my coffee on the front porch soaking in the beautiful natural world. It far enough away from town to enjoy the quiet but close enough to grab delicious food for meals. I’ll always stay here when visiting Eminence."
Unique cabins in the woods<br>Not friendly for Street Bikes. Beautifulin FALL!
Property grounds
Secluded Ozarks Tiny House cabin in Eminence, MO
10.0 out of 10, Exceptional, (78)
"My husband, young children (6 and 4), and I enjoyed our stay. The cabin was cute and clean. Great place to stay."
Secluded Ozarks Tiny House cabin in Eminence, MO
Fridge, microwave, coffee/tea maker
Shepherd Mountain Inn
2.5 star property
9.2 out of 10, Wonderful, (211)
"Convenient "
The price is $115
$126 total
includes taxes & fees
May 27 - May 28
Shepherd Mountain Inn
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free
BBQ/picnic area
Auburn Place Hotel And Suites
2.5 star property
8.8 out of 10, Excellent, (1004)
"18 years ago, my wife and I stayed in the honeymoon suite and it was wonderful. This time, we had the opportunity to stay there with our son and it was wonderful. The staff was very friendly and immediately took care of getting us checked-in so that we could make in time for our niece’s graduation. I would recommend this hotel to anyone traveling to Cape Girardeau, MO. Blessings to you! Robert and Katherine M."
The price is $66
$75 total
includes taxes & fees
May 26 - May 27
Auburn Place Hotel And Suites
Reception
The Farmstead Hotel
2.5 star property
8.8 out of 10, Excellent, (190)
"What we liked about it was it was convenient to the casino. What we didn't like was it's in a run down area that's a little sketchy, making you feel unsafe."
The price is $105
$119 total
includes taxes & fees
May 19 - May 20
The Farmstead Hotel
Fountain
Bullwinkles Rustic Lodge
2.5 star property
8.8 out of 10, Excellent, (152)
"everything was perfect"
The price is $84
$95 total
includes taxes & fees
May 21 - May 22
Bullwinkles Rustic Lodge
Front of property
Honeysuckle Inn - Mountain View
3.0 star property
8.6 out of 10, Excellent, (190)
"Exterior of the building was a neat design. Interior of the room so what dated, but generally clean."
The price is $100
$109 total
includes taxes & fees
May 21 - May 22
Honeysuckle Inn - Mountain View
Hallway
Travel Inn & Suites
2.5 star property
8.4 out of 10, Very Good, (522)
"Rooms a little small. "
The price is $62
$71 total
includes taxes & fees
Jun 5 - Jun 6
Travel Inn & Suites
Premier Room, 1 Bedroom, Non Smoking | Desk, free WiFi, bed sheets
New Orleans Inn Portageville
2.5 star property
8.0 out of 10, Very Good, (424)
"It was excellent, the room was clean, staff (Nicole) was Friendly. "
The price is $52
$56 total
includes taxes & fees
May 19 - May 20
New Orleans Inn Portageville
Economy Single Room, 1 Queen Bed, Kitchenette | Free WiFi, bed sheets
Town House Inn
2.5 star property
8.0 out of 10, Very Good, (290)
"We were in town for a soccer tournament and was looking for a comfortable yet affordable weekend stay. Over all we were very satisified and will stay here again next year. Hotel was quit and clean. the full kitchen was a blessing to have for a family trip. easy access to ice and had coin oporated washer and dryer. (important for those muddy soccer weekends) We did not use it but was important for us to have access to. Only complaints we had was that the the microwave turntable didnt work and one...
The price is $74
$81 total
includes taxes & fees
May 19 - May 20
Town House Inn
Don't see what you're looking for?
See all available properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Independent Southeast Missouri Hotel Guide

Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in Southeast Missouri, Missouri. Known for well-appointed rooms and friendly, personalized service, each of the top Independent Southeast Missouri hotels guarantees an unparalleled level of comfort and quality.

You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some Southeast Missouri Independent locations may even offer extra little benefits and discounts for frequent travelers.

Recent reviews of Southeast Missouri hotels
Expedia verified reviews

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

5/5 Excellent
"This hotel is definitely not as bad as everyone says. Definitely the best food selection as for vending machines. The only bad thing would have to be the smell of the rooms. It’s an odd smell but not like dead animal odd smell"
A verified traveler stayed at Motel 6 Poplar Bluff, MO
Posted 2 days ago
Motel 6 Poplar Bluff, MO