The best area to stay in Bluffton is the Historic District, which is the heart of Old Town Bluffton, or the refined May River Forest within Palmetto Bluff for a more secluded, upscale experience.The Historic District of Old Town Bluffton is centered around Calhoun Street and the May River. This area is known for its moss-draped oak trees, historic homes, art galleries, and local eateries. It's a walkable area where you can explore unique shops and enjoy views of the May River. Couples often find this area appealing due to its relaxed pace and picturesque setting, superb for strolls and waterfront dining.For those seeking a luxurious and private retreat, May River Forest, located within Palmetto Bluff, is an excellent choice. This area offers spacious rooms, access to high-end fitness equipment, and a championship golf course.