Photo by Hazem Abdul

Find hotels in South Main, Houston from $74

    price find illustration

    Upfront pricing

    Our total price for your stay includes taxes and fees
    deals illustration

    Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Discover 6,382 South Main hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Our top choices for South Main hotels

Wyndham Houston near NRG Park/Medical Center

3.5 star property
7.2 out of 10, Good, (1129)
"It was quiet and close to our event. It was very clean and staff was helpful "
$129 nightly
The price is $151
Aug 23 - Aug 24
Total with taxes and fees
Wyndham Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center

3.0 star property
6.6 out of 10, (930)
"Great location, rooms were hot/warm. Needs a huge make over."
$109 nightly
The price is $128
Aug 23 - Aug 24
Total with taxes and fees
Wingate Houston near NRG Park/Medical Center

Quality Inn & Suites NRG Park - Medical Center

2.5 star property
6.4 out of 10, (1002)
"Wonderful experience absolutely love my stay"
$69 nightly
The price is $80
Sep 21 - Sep 22
Total with taxes and fees
Quality Inn & Suites NRG Park - Medical Center

Candlewood Suites Houston Medical Center by IHG

2.5 star property
7.4 out of 10, Good, (789)
"Will definitely be back again!"
$74 nightly
The price is $87
Sep 21 - Sep 22
Total with taxes and fees
Candlewood Suites Houston Medical Center by IHG

Hyatt Regency Houston/Galleria

4.0 star property
9.0 out of 10, Wonderful, (1002)
"Great stay!"
$128 nightly
The price is $149
Sep 1 - Sep 2
Total with taxes and fees
Hyatt Regency Houston/Galleria

Hyatt Place Houston Medical Center

3.0 star property
9.2 out of 10, Wonderful, (1908)
"Nice place to stay."
$119 nightly
The price is $139
Aug 28 - Aug 29
Total with taxes and fees
Hyatt Place Houston Medical Center

Omni Houston Hotel

4.0 star property
9.0 out of 10, Wonderful, (1002)
"Great place to stay Very relaxing out-of-the-way Great feel with a great swimming pool"
$153 nightly
The price is $180
Sep 4 - Sep 5
Total with taxes and fees
Omni Houston Hotel

The Whitehall Houston

4.0 star property
8.6 out of 10, Excellent, (1683)
"Great location and very friendly staff "
$143 nightly
The price is $167
Aug 29 - Aug 30
Total with taxes and fees
The Whitehall Houston

Hyatt Regency Houston West

3.5 star property
8.6 out of 10, Excellent, (1150)
"Nice rooms, plenty of food choices."
$105 nightly
The price is $123
Aug 28 - Aug 29
Total with taxes and fees
Hyatt Regency Houston West

Blossom Hotel Houston

4.0 star property
9.0 out of 10, Wonderful, (3468)
"The hotel is wonderful and I loved it "
$114 nightly
The price is $134
Sep 21 - Sep 22
Total with taxes and fees
Blossom Hotel Houston

The Lancaster Hotel

4.0 star property
9.8 out of 10, Exceptional, (1001)
"Beautiful hotel with Ana amazing room! Really enjoyed our stay and the staff was excellent!"
$241 nightly
The price is $282
Sep 5 - Sep 6
Total with taxes and fees
The Lancaster Hotel

Holiday Inn Express & Suites Houston – Downtown North by IHG

2.5 star property
9.2 out of 10, Wonderful, (557)
"Very clean with good breakfast! "
$103 nightly
The price is $121
Sep 1 - Sep 2
Total with taxes and fees
Holiday Inn Express & Suites Houston – Downtown North by IHG

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4.0 star property
8.2 out of 10, Very Good, (2419)
"We had a great stay, staff is very friendly and the location is great!!"
$105 nightly
The price is $122
Sep 21 - Sep 22
Total with taxes and fees
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

Hyatt House Houston Medical Center

3.0 star property
9.2 out of 10, Wonderful, (1083)
"We loved our stay. Great room, staff, and service."
$125 nightly
The price is $146
Aug 27 - Aug 28
Total with taxes and fees
Hyatt House Houston Medical Center

Haven Inn & Suites Downtown Houston

2.5 star property
9.4 out of 10, Exceptional, (1004)
"enjoyed stay "
$72 nightly
The price is $84
Aug 24 - Aug 25
Total with taxes and fees
Haven Inn & Suites Downtown Houston

La Quinta Inn & Suites by Wyndham Houston Southwest

3.0 star property
6.8 out of 10, (1001)
"The stay here was amazing me and my kids are currently homeless and going from hotel to hotel and this was the perfect stay for us "
$65 nightly
The price is $77
Sep 8 - Sep 9
Total with taxes and fees
La Quinta Inn & Suites by Wyndham Houston Southwest

Heights House Hotel - Houston Heights Downtown, Ascend Hotel Collection

3.0 star property
7.8 out of 10, Good, (1001)
"What a great place to stay. Super clean rooms, super kind staff. "
$115 nightly
The price is $134
Aug 25 - Aug 26
Total with taxes and fees
Heights House Hotel - Houston Heights Downtown, Ascend Hotel Collection

The Royal Sonesta Houston Galleria

4.0 star property
8.4 out of 10, Very Good, (1197)
"Overall decent hotel with a great location, lots of restaurants and attractions near the hotel"
$132 nightly
The price is $154
Aug 28 - Aug 29
Total with taxes and fees
The Royal Sonesta Houston Galleria

Club Quarters Hotel Downtown, Houston

4.0 star property
8.4 out of 10, Very Good, (3622)
"Very nice place to stay and a great staff!"
$105 nightly
The price is $123
Aug 24 - Aug 25
Total with taxes and fees
Club Quarters Hotel Downtown, Houston

Sonesta ES Suites Houston Galleria

3.0 star property
8.2 out of 10, Very Good, (1084)
"We enjoyed our stay. The room was spacious and clean and breakfast was amazing. We highly recommend to stay in this hotel if you are visiting Houston. "
$109 nightly
The price is $128
Aug 24 - Aug 25
Total with taxes and fees
Sonesta ES Suites Houston Galleria
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.

Downtown Houston

3 out of top 10 points of interest in this area

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Gerald D. Hines Waterwall Park.

Texas Medical Center

1 out of top 10 points of interest in this area

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Houston Heights

You'll enjoy the coffeehouses and live music in Houston Heights. You might want to make time for a stop at The Heights Theater or Artcar Museum.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Westheimer Rd while you're exploring the area.

Top South Main Hotel Reviews

Find out more about South Main

Find out more about South Main

Top reasons to visit South Main

  • Diverse Activities: South Main offers a mix of cultural experiences, wellness treatments, and thrilling sports events, catering to various interests.
  • Historic Charm: Explore historic colleges, art museums, and beautiful churches, perfect for families and culture enthusiasts.
  • Vibrant Main Street: Stroll down South Main Street to immerse yourself in local culture and unique attractions.
  • Great Dining Options: Discover a wide range of dining experiences in the bustling neighborhoods nearby.
  • Variety of Accommodations: Choose from budget-friendly to luxurious hotels, ensuring a comfortable stay for everyone.

Find great hotels near South Main

South Main in Houston boasts a diverse selection of hotels catering to all preferences and budgets, from cozy 1-star stays to luxurious 5-star accommodations. Visitors can choose from a variety of lodging types, including hotels and aparthotels, with many offering business-focused amenities. Whether you're seeking pet-friendly options or LGBTQIA welcoming environments, South Main has something for everyone, making it an ideal destination for your next getaway.

  • Club Quarters Hotel Downtown, Houston: Club Quarters Hotel Downtown, Houston is a stylish 4-star hotel located 7 miles from South Main, perfect for business travelers seeking a modern and efficient environment. This hotel features a range of business amenities, including a 24-hour business center and multiple meeting rooms, ensuring you have all the tools you need to stay productive. The property is also pet-friendly, allowing pets on-site with amenities tailored for furry companions. Situated in a bustling shopping district, you'll find plenty of retail options nearby, making it ideal for those looking to blend work with leisure.
  • DoubleTree by Hilton Hotel & Suites Houston by the Galleria: Located 5 miles from South Main, the DoubleTree by Hilton Hotel & Suites Houston by the Galleria is a welcoming 4-star hotel that caters to families. With special amenities for children, including cribs and window guards, this hotel ensures a safe and comfortable stay for younger guests. The property is pet-friendly, allowing pets and providing a warm environment for the entire family. Nestled in a vibrant shopping district, this hotel offers the perfect blend of comfort and convenience for family vacations.
  • The Royal Sonesta Houston Galleria: The Royal Sonesta Houston Galleria is a luxurious 4-star hotel situated 5 miles from South Main, ideal for business and leisure travelers alike. This hotel features extensive business facilities, including a conference center and multiple meeting rooms, catering to your professional needs. The Royal Sonesta is also pet-friendly, accommodating your furry friends with specific policies in place. Located in a thriving shopping district, this hotel combines upscale amenities with easy access to retail experiences, making it an excellent choice for a well-rounded trip.

Where to stay near South Main

South Main in Houston offers a vibrant blend of sports, business, and cultural experiences. With its bustling main street just a short walk away, you'll find an array of art galleries, family-friendly attractions, and urban parks. Explore the nearby neighborhoods for a taste of local charm and great dining options. Whether you're here for business or leisure, South Main's great location makes it the perfect base for your adventures in the heart of Houston.

  • Houston: As a vibrant metropolis, Houston offers a dynamic mix of culture, business, and leisure. Located in the heart of Texas, South Main is a key part of this sprawling city. Visitors can enjoy year-round attractions, with peak travel months in March, July, and October. Explore an array of shopping malls, catch a live music concert, or take in the local sights like sports stadiums and serene lakes. Houston’s diverse neighborhoods are filled with culinary delights, art galleries, and exciting nightlife, making it an ideal destination for families and business travelers alike.
  • Downtown Houston: Just 7 miles from South Main, Downtown Houston pulses with energy and excitement. This urban neighborhood sees a surge of visitors in April and during the summer months. It's a hotspot for family outings, business meetings, and sports events. Enjoy world-class shopping, attend thrilling concerts, or experience the vibrant atmosphere surrounding local stadiums and event venues. Downtown is a blend of modern skyscrapers and historic sites, offering a unique backdrop for any traveler seeking both adventure and relaxation.
  • Texas Medical Center: Located a mere 2 miles from South Main, Texas Medical Center is not only a hub for healthcare but also a vibrant neighborhood in its own right. With peak visitor numbers in April, July, and September, this area attracts those interested in business, sports, and educational opportunities. Here, you can explore cutting-edge research facilities and modern universities, while also indulging in shopping and dining options. The proximity to sports venues adds to the excitement, making it an excellent stop for those exploring Houston.

Things to do near South Main

South Main offers a diverse range of activities for tourists, from engaging cultural experiences to exciting sports events. Visitors can enjoy wellness treatments, explore nearby shopping malls and centers, and partake in unique party content. For those seeking adventure, snow skiing opportunities are also available in the area. Whether you're in town for business or leisure, South Main provides a vibrant atmosphere to make your vacation memorable.

Shopping

For a great shopping experience in South Main, visit Meyerland Plaza Shopping Center, just 3 miles away, offering a family-friendly vibe. The Galleria and River Oaks District, both 5 miles away, provide a mix of entertainment and city flair, perfect for finding unique gifts and souvenirs.

Recreation

Experience the energetic atmosphere at NRG Stadium, where you can catch a game and soak in the excitement. For a unique musical vibe, visit House of Blues Houston for live performances. Enjoy wellness and relaxation at Houston Sports Park, perfect for leisurely walks and outdoor activities.

Adventure

Experience the thrill of indoor skydiving at iFLY Indoor Skydiving, located 10 miles from South Main. For family-friendly adventure, visit Chancellors Family Center and the Homer Ford Tennis Center, both 5 miles away, offering exciting activities in a vibrant atmosphere.

Nightlife

Experience the vibrant nightlife in South Main by catching a show at the Hobby Center for the Performing Arts, or dance the night away at Bayou Place nightclub. For family fun, visit Zuma Fun Center South Houston for arcade games and adventures.

Booking tips and Expedia advantages for South Main

To save money on your trip to South Main, Houston, consider visiting during the cheaper months of August and December to January, with Sundays being the least expensive days to stay. Use Expedia to customize your hotel search and sort by price for the best deals. Look for package deals that combine flights and accommodations for further savings. Joining Expedia's One Key membership can provide exclusive discounts and allow you to earn OneKeyCash for future bookings. Take advantage of free activities in the area to enhance your visit without breaking the bank.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around South Main are August and December to January, where the prices are slightly lower. This is in comparison to March to May, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around South Main is Sunday. The most expensive day to stay around South Main is Saturday.
  • Find cheap hotels on Expedia: Utilize Expedia's search tool to customize your preferences, such as your budget, desired location, and type of hotel you'd like to stay in. To find the best prices and deals, simply arrange the price filter from lowest to highest.
  • Consider bundling your trip: You can potentially save money by combining your hotel stay in South Main with your flights and activities through an Expedia package deal.
  • Become a One Key member: Join Expedia's One Key membership program for exclusive discounts and deals on hotel bookings. You can also earn OneKeyCash to use on future selected hotels.

Find the best attractions near South Main

South Main in Houston, Texas, offers a delightful blend of sports, business, and cultural experiences. Visitors can explore historic colleges, art museums, and beautiful churches, making it perfect for families and those seeking a vibrant city atmosphere. Don't miss a stroll down South Main Street, where you can immerse yourself in the local culture and enjoy the unique attractions this area has to offer.

  • Rice University: Located 3 miles from South Main, Rice University offers a stunning blend of modern architecture and beautiful green spaces. Explore its tranquil campus, which features impressive sculptures and gardens, making it a perfect spot for a leisurely stroll or a picnic.
  • NRG Park: Just 1 mile away, NRG Park is a vibrant hub for culture and sports. Home to major events like the Houston Livestock Show and Rodeo, this historic stadium buzzes with energy, offering visitors a chance to experience exciting sports games and concerts.
  • University of Houston: Situated 6 miles from South Main, the University of Houston boasts a rich history and diverse cultural offerings. Visit its art galleries and performance venues, or enjoy the lively atmosphere of its student activities and events.

Best time to go to South Main

The best time to visit South Main is dependant on what kind of holiday you are seeking. August is its hottest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain.

calendar iconCalendar Monthtemperature iconTemperaturerain iconPrecipitationmostly cloudy iconCloudinessoccupation rate iconOccupancyprice iconPricing
January54.1°F (12.3°C)Light RainMostly SunnyAverageSlightly Low
February57.0°F (13.9°C)Light RainMostly CloudyAverageAverage
March63.9°F (17.7°C)Light RainMostly SunnyAverageSlightly High
April69.6°F (20.9°C)Light RainMostly SunnyModerately HighSlightly High
May76.6°F (24.8°C)Light RainMostly SunnyAverageSlightly High
June82.8°F (28.2°C)Light RainMostly SunnyModerately HighAverage
July84.2°F (29.0°C)Light RainMostly SunnyModerately HighAverage
August84.9°F (29.4°C)Light RainMostly SunnyAverageSlightly Low
September80.6°F (27.0°C)Light RainMostly SunnyAverageAverage
October72.7°F (22.6°C)Light RainMostly SunnyModerately LowAverage
November62.8°F (17.1°C)Light RainMostly SunnyModerately LowAverage
December57.4°F (14.1°C)Light RainMostly SunnyModerately LowSlightly Low

The nearest major airports for your trip to South Main

When visiting South Main, Houston, you can fly into its major airports, including George Bush Intercontinental Airport (IAH), located 22 miles away. Nearby hotels include the 4-star Sonesta Hotel, 5 miles from IAH, offering free airport transportation, and the DoubleTree by Hilton, just 3 miles away. William P. Hobby Airport (HOU) is 9 miles from South Main, with luxurious options like the 5-star JW Marriott and Four Seasons, both located nearby. Ellington Field (EFD), situated 16 miles away, has the Doubletree by Hilton, 7 miles from EFD, providing accessible transportation services. Each airport offers convenient access to quality accommodations for a comfortable stay.

Frequently asked questions

What are the best hotels in South Main that travelers recommend?
Wyndham Houston near NRG Park/Medical Center is a solid choice for travelers seeking comfort and convenience, earning a customer review rating of 7.2. This hotel features an inviting outdoor pool, superb for unwinding after a day of exploration, along with kitchenettes in the rooms—ideal for families wanting to prepare snacks or meals. The combination of free WiFi and a 24-hour business center makes it suitable for both leisure and business travelers, ensuring a straightforward stay.

For families, Wingate Houston near NRG Park/Medical Center is another great option. With a complimentary continental breakfast to fuel your adventures and a refreshing outdoor pool, it caters superbly to parents and kids alike. The accessible fitness center allows for some family fun, while the hotel's pet-friendly policies make it a fantastic choice for those traveling with furry companions. With a focus on convenience and value, this hotel provides excellent amenities while keeping everyone comfortable.
What are the best family hotels in South Main?
When it comes to family-friendly hotels in South Main, the Comfort Suites near Texas Medical Center - NRG Stadium shines brightly with a solid traveler review rating of 8.6. This hotel offers daily housekeeping to ensure your family's stay is comfortable and straightforward.

Another excellent option is the Candlewood Suites Houston Medical Center by IHG, which boasts a family-friendly atmosphere with its free cribs, connecting rooms, and a sofa bed, making it great for families needing extra space. Guests appreciate the convenience of in-room kitchen amenities like a microwave and dishwasher, allowing for easy meal prep during your stay. It has a review score of 7.6, reflecting its appeal to families on the go.

For those seeking a place with a pool, the Quality Inn & Suites NRG Park - Medical Center is a great choice. With its inviting pool area, free meals for children, and options for rollaway beds at no extra charge, families can enjoy a splash-filled vacation while also benefiting from daily housekeeping and snack options.

Lastly, the Wyndham Houston near NRG Park/Medical Center features child-friendly window designs and connecting rooms, catering specifically to families' needs. The presence of kitchenettes adds to the convenience, allowing families to prepare snacks or meals together. This property has a traveler rating of 7.2, making it a reliable choice for family stays.

These hotels exemplify quality and convenience, ensuring that your family's adventure in South Main is both enjoyable and comfortable.
What hotels in South Main offer free breakfast?
Comfort Suites near Texas Medical Center - NRG Stadium is a fantastic option for travelers seeking comfort and convenience in South Main. With a traveler review rating of 8.6, this hotel offers a delightful free full breakfast to start your day right. Families will appreciate the seasonal outdoor pool, superb for a refreshing dip after a day of exploring. Additionally, the property features complimentary WiFi and self-parking, making it easy to stay connected and save on travel expenses.

Another great choice is Quality Inn & Suites NRG Park - Medical Center, which also provides a free breakfast, including options for those on the go. This family-friendly hotel offers spacious suites with balconies and patios, allowing families to unwind outdoors. The outdoor pool invites guests to relax and enjoy the Texas sunshine, while the complimentary area shuttle makes it simple to explore the attractions nearby.

For those traveling without children, the Wingate Houston near NRG Park/Medical Center presents a delightful blend of comfort and accessibility. With an outdoor pool and fitness center, it caters to adults looking for a rejuvenating getaway. The hotel's continental breakfast is another perk that guarantees a satisfying start to your morning adventures.
What are the best budget hotels in South Main?
Comfort Suites near Texas Medical Center - NRG Stadium is a fantastic budget-friendly option for travelers seeking convenience and quality in South Main. With an excellent review score of 8.6, this hotel offers a range of family-friendly amenities, including a seasonal outdoor pool, free breakfast, and complimentary WiFi. Families will appreciate the spacious rooms and the convenience of free self-parking, making it easy to explore the area together.

For another appealing choice, Candlewood Suites Houston Medical Center by IHG stands out with a review score of 7.6. This property is superb for families, as it features kitchenettes in the rooms, allowing for meal preparation and snacks on the go. Kids can also enjoy the complimentary cribs and sofa beds, making it a comfortable stay for everyone. Additionally, the hotel offers a free area shuttle, which is great for exploring local attractions without the hassle of driving.

If you're traveling with your partner or friends, the Wyndham Houston near NRG Park/Medical Center offers a more relaxed atmosphere with a lower review score of 7.2. This hotel features outdoor pool access and convenient amenities, including a kitchenette in some rooms, which can appeal to those looking for a home-like experience while away.

No matter your travel group, these options in South Main cater to various needs while ensuring a comfortable and enjoyable stay.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in South Main.
How can I save on a South Main hotel booking with Expedia?
With Expedia, you earn OneKeyCash™* on eligible South Main hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a South Main hotel?
Hotel prices in South Main often vary, but you can find a great deal from $74 on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.