Resorts & Hotels with Spas in Panama from $97
Upfront pricing
Our total price for your stay includes taxes and fees
Treat yourself
Save 10% or more on over 100,000 hotels worldwide with Member Prices
Be picky
Search almost a million properties worldwide
Check availability on Panama Resorts & Hotels with Spas
Pick from 275 Panama Resorts & Hotels with Spas with updated room rates, reviews, and availability. Most hotels are fully refundable.
Our top choices for Panama hotels with a spa

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
8.8 out of 10, Excellent, (988)
$150 nightly
The price is $165
Sep 18 - Sep 19
Total with taxes and fees

Crowne Plaza Panama Airport by IHG
Crowne Plaza Panama Airport by IHG
8.4 out of 10, Very Good, (2228)
$116 nightly
The price is $128
Sep 20 - Sep 21
Total with taxes and fees

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
9.6 out of 10, Exceptional, (607)
$216 nightly
The price is $238
Oct 3 - Oct 4
Total with taxes and fees

Marriott Panama Hotel
Marriott Panama Hotel
9.0 out of 10, Wonderful, (1002)
$127 nightly
The price is $139
Sep 21 - Sep 22
Total with taxes and fees

Bristol Panama, a Registry Collection Hotel
Bristol Panama, a Registry Collection Hotel
9.2 out of 10, Wonderful, (1006)
$176 nightly
The price is $194
Oct 18 - Oct 19
Total with taxes and fees

W Panama
W Panama
9.0 out of 10, Wonderful, (1005)
$179 nightly
The price is $197
Oct 17 - Oct 18
Total with taxes and fees

Radisson Colon 2,000 Hotel & Casino
Radisson Colon 2,000 Hotel & Casino
8.2 out of 10, Very Good, (783)
$88 nightly
The price is $97
Oct 3 - Oct 4
Total with taxes and fees

Sofitel Legend Casco Viejo, Panama City
Sofitel Legend Casco Viejo, Panama City
9.8 out of 10, Exceptional, (508)
$293 nightly
The price is $322
Oct 1 - Oct 2
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Top Panama Hotel Reviews

Dreams Playa Bonita Panama - All Inclusive
10/10 Excellent