Title: Panama Resorts & Hotels with Spas from $120 - Fully Refundable Options - Expedia.com [Panama Travel Guide](https://expedia.com/Panama.dx142)[Panama Hotels](https://expedia.com/Destinations-In-Panama.d142.Hotel-Destinations)[Vacation Rentals in Panama](https://expedia.com/Destinations-In-Panama.d142.Vacation-Rental-Destinations)[Panama Flights](https://expedia.com/Destinations-In-Panama.d142.Flight-Destinations)[Car Rentals in Panama](https://expedia.com/Destinations-In-Panama.d142.Car-Rental-Destinations)[Panama Vacations](https://expedia.com/Panama.d142.Destination-Travel-Guides) ![](https://images.trvl-media.com/place/142/329febe6-4cd6-48f7-a9e8-71ea862bef81.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by PhotoJoy ![](https://images.trvl-media.com/place/142/329febe6-4cd6-48f7-a9e8-71ea862bef81.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ## Top Cities in Panama ![default](https://images.trvl-media.com/place/2897/9a0fe9cb-10b8-4a85-b416-4677f1455ea0.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Panama City [](https://expedia.com/Panama-City-Hotels-Spa-Hotel.0-0-d2897-tSpaHotel.Travel-Guide-Filter-Hotels) ![ISLA COLON BOCAS DEL TORO](https://images.trvl-media.com/place/6023445/f17b18cc-4a72-405d-ab41-dfd48c15b97d.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Bocas del Toro [](https://expedia.com/Bocas-Del-Toro-Hotels-Spa-Hotel.0-0-d6023445-tSpaHotel.Travel-Guide-Filter-Hotels) ![Idyllic Sunset at Playa Blanca, Panama](https://images.trvl-media.com/place/6246042/058a4e01-e481-4197-9791-26c53b4ee917.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Rio Hato [](https://expedia.com/Rio-Hato-Hotels-Spa-Hotel.0-0-d6246042-tSpaHotel.Travel-Guide-Filter-Hotels) ![Sunrise with a view at Volcán Barú in Panama](https://images.trvl-media.com/place/500194/a9fdba1c-ad36-4683-90ac-2cdb584e103b.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Boquete [](https://expedia.com/Boquete-Hotels-Spa-Hotel.0-0-d500194-tSpaHotel.Travel-Guide-Filter-Hotels) ![Protected nature surrounding Gatun Lake, a freshwater artificial lake to the south of Colón, Panama. It forms a major part of the Panama Canal](https://images.trvl-media.com/place/601867/0f4b2986-19e2-41b5-93da-ec0bc70c4cc2.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Colon [](https://expedia.com/Colon-Hotels-Spa-Hotel.0-0-d601867-tSpaHotel.Travel-Guide-Filter-Hotels) ![Panoramic view of El Valle de Anton town surrounded by mountains in Panama](https://images.trvl-media.com/place/6053180/c16502d5-7d2c-4d59-91a1-745c940461bf.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### El Valle de Anton [](https://expedia.com/El-Valle-De-Anton-Hotels-Spa-Hotel.0-0-d6053180-tSpaHotel.Travel-Guide-Filter-Hotels) ## Check availability on Panama Resorts & Hotels with Spas Tonight [Apr 4 - Apr 5](https://www.expedia.com/Hotel-Search?regionId=142&startDate=2026-04-04&endDate=2026-04-05&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Apr 5 - Apr 6](https://www.expedia.com/Hotel-Search?regionId=142&startDate=2026-04-05&endDate=2026-04-06&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Apr 10 - Apr 12](https://www.expedia.com/Hotel-Search?regionId=142&startDate=2026-04-10&endDate=2026-04-12&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Apr 17 - Apr 19](https://www.expedia.com/Hotel-Search?regionId=142&startDate=2026-04-17&endDate=2026-04-19&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Panama hotels with a spa ![Steam room, body treatments, body wraps, body scrubs, facials](https://images.trvl-media.com/lodging/9000000/8790000/8785100/8785045/9e776b0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/9000000/8790000/8785100/8785045/ab95ae6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/9000000/8790000/8785100/8785045/86e96c74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/9000000/8790000/8785100/8785045/486951c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sortis Hotel, Spa & Casino, Autograph Collection by Marriott [](https://www.expedia.com/Panama-City-Hotels-Sortis-Hotel.h8785045.Hotel-Information) Bella Vista 8.8/10 Excellent (1,000 reviews) - Luxurious spa retreat in the heart of Panama with 10 treatment rooms and pampering Ayurvedic services for a complete wellness journey. $145 nightly $160 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Panama-City-Hotels-Sortis-Hotel.h8785045.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/9000000/8840000/8836200/8836117/757e8465.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, soundproofing](https://images.trvl-media.com/lodging/9000000/8840000/8836200/8836117/5f648ea5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/9000000/8840000/8836200/8836117/2f37bae5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/9000000/8840000/8836200/8836117/8103ef2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Crowne Plaza Panama Airport by IHG [](https://www.expedia.com/Tocumen-Hotels-Crowne-Plaza-Panama-Airport.h8836117.Hotel-Information) Tocumen 8.6/10 Excellent (2,491 reviews) $133 nightly $146 total Apr 28 - Apr 29 Total with taxes and fees [](https://www.expedia.com/Tocumen-Hotels-Crowne-Plaza-Panama-Airport.h8836117.Hotel-Information) ![Couples treatment rooms, steam room, Turkish bath, body treatments](https://images.trvl-media.com/lodging/21000000/20960000/20958600/20958573/0b681c03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/21000000/20960000/20958600/20958573/3972c3df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/21000000/20960000/20958600/20958573/db85bc00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch served; local and international cuisine](https://images.trvl-media.com/lodging/21000000/20960000/20958600/20958573/ea9ff933.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City [](https://www.expedia.com/Panama-City-Hotels-The-Santa-Maria.h20958573.Hotel-Information) Juan Diaz 9.6/10 Exceptional (683 reviews) - Discover tranquility at this luxury spa oasis with 5 treatment rooms and a garden retreat for the ultimate wellness escape. $245 nightly $270 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Panama-City-Hotels-The-Santa-Maria.h20958573.Hotel-Information) ![Outdoor pool, open 7:00 AM to 8:00 PM, pool umbrellas](https://images.trvl-media.com/lodging/7000000/6100000/6099300/6099287/d26cb29b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/7000000/6100000/6099300/6099287/c617be5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/7000000/6100000/6099300/6099287/b61be540.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/7000000/6100000/6099300/6099287/7bb8f38a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Marriott Panama Hotel [](https://www.expedia.com/Panama-City-Hotels-Marriott-Panama-Hotel.h6099287.Hotel-Information) Panama City 9.0/10 Wonderful (1,002 reviews) $152 nightly $167 total Apr 25 - Apr 26 Total with taxes and fees [](https://www.expedia.com/Panama-City-Hotels-Marriott-Panama-Hotel.h6099287.Hotel-Information) ![Couples treatment rooms, sauna, steam room, body treatments](https://images.trvl-media.com/lodging/1000000/70000/69700/69638/80d0e2a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment rooms, sauna, steam room, body treatments](https://images.trvl-media.com/lodging/1000000/70000/69700/69638/1700edf5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/70000/69700/69638/8e0cdd04.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; international cuisine ](https://images.trvl-media.com/lodging/1000000/70000/69700/69638/620cc150.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Bristol Panama, a Registry Collection Hotel [](https://www.expedia.com/Panama-City-Hotels-Bristol-Panama.h69638.Hotel-Information) Bella Vista 9.4/10 Exceptional (1,002 reviews) - Immerse in luxurious tranquility at this Art Deco hotel with 6 treatment rooms and an outdoor pool for a rejuvenating retreat. $194 nightly $213 total May 1 - May 2 Total with taxes and fees [](https://www.expedia.com/Panama-City-Hotels-Bristol-Panama.h69638.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/22000000/21320000/21314100/21314035/79004c32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, local cuisine](https://images.trvl-media.com/lodging/22000000/21320000/21314100/21314035/5dc0b3d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/22000000/21320000/21314100/21314035/8f2104c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/22000000/21320000/21314100/21314035/1175365b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### W Panama [](https://www.expedia.com/Panama-City-Hotels-W-Panama.h21314035.Hotel-Information) Bella Vista 9.0/10 Wonderful (1,004 reviews) - Revitalize at this luxury hotel with three hot tubs, yoga classes, and rejuvenating massage services in a serene garden setting. $269 nightly $296 total May 2 - May 3 Total with taxes and fees [](https://www.expedia.com/Panama-City-Hotels-W-Panama.h21314035.Hotel-Information) ![Couples treatment rooms, Turkish bath, body treatments](https://images.trvl-media.com/lodging/3000000/2150000/2147400/2147349/46a37de3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2150000/2147400/2147349/53f67005.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Beach/ocean view](https://images.trvl-media.com/lodging/3000000/2150000/2147400/2147349/665077af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Gym](https://images.trvl-media.com/lodging/3000000/2150000/2147400/2147349/1a303895.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Radisson Colon 2,000 Hotel & Casino [](https://www.expedia.com/Colon-Hotels-Radisson-Colon-2.h2147349.Hotel-Information) Barrio Sur 8.2/10 Very Good (892 reviews) - Rejuvenate at this waterfront hotel featuring couples spa treatments, an outdoor pool, and hot stone massages for a serene escape. $109 nightly $120 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Colon-Hotels-Radisson-Colon-2.h2147349.Hotel-Information) ![Couples treatment rooms, body treatments, aromatherapy](https://images.trvl-media.com/lodging/73000000/72990000/72981200/72981169/8d3d5a59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges, swim-up bar, poolside bar](https://images.trvl-media.com/lodging/73000000/72990000/72981200/72981169/83d16a00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/73000000/72990000/72981200/72981169/c28c4592.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Balcony, Oceanfront (Magnifique) | Premium bedding, down comforters, pillowtop beds, minibar](https://images.trvl-media.com/lodging/73000000/72990000/72981200/72981169/ccd122a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sofitel Legend Casco Viejo, Panama City [](https://www.expedia.com/Panama-City-Hotels-Sofitel-Legend-Casco-Viejo.h72981169.Hotel-Information) Casco Viejo 9.8/10 Exceptional (630 reviews) - Indulge in a waterfront spa retreat with outdoor treatment areas and hot stone massages at this beautifully restored Colonial hotel. $347 nightly $381 total Apr 27 - Apr 28 Total with taxes and fees [](https://www.expedia.com/Panama-City-Hotels-Sofitel-Legend-Casco-Viejo.h72981169.Hotel-Information) ![Couples treatment rooms, sauna, hot tub, Turkish bath, body treatments](https://images.trvl-media.com/lodging/1000000/10000/1200/1161/f95b4a50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/1200/1161/22409c1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily buffet breakfast (PAB 21 per person)](https://images.trvl-media.com/lodging/1000000/10000/1200/1161/4e948961.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/1200/1161/c780324d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sheraton Grand Panama [](https://www.expedia.com/Panama-City-Hotels-Sheraton-Grand-Panama.h1161.Hotel-Information) San Francisco 8.6/10 Excellent (1,006 reviews) - Immerse in tranquility at this Art Deco resort with two treatment rooms for couples and a Turkish bath, where expert spa therapists await. $134 nightly $148 total May 1 - May 2 Total with taxes and fees [](https://www.expedia.com/Panama-City-Hotels-Sheraton-Grand-Panama.h1161.Hotel-Information) ![Sports facility](https://images.trvl-media.com/lodging/6000000/5940000/5938200/5938139/124fc0d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 restaurants, breakfast, lunch served; American cuisine](https://images.trvl-media.com/lodging/6000000/5940000/5938200/5938139/17d1dc17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 restaurants, breakfast, lunch served; American cuisine](https://images.trvl-media.com/lodging/6000000/5940000/5938200/5938139/eb1560c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sports facility](https://images.trvl-media.com/lodging/6000000/5940000/5938200/5938139/99beffbc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Panama [](https://www.expedia.com/Panama-City-Hotels-Hilton-Panama.h5938139.Hotel-Information) Bella Vista 8.8/10 Excellent (1,000 reviews) - Indulge in blissful wellness at this Panama hotel with a full-service spa, casino, and outdoor pool to restore and rejuvenate. $227 nightly $250 total May 1 - May 2 Total with taxes and fees [](https://www.expedia.com/Panama-City-Hotels-Hilton-Panama.h5938139.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-18&endDate=2026-04-19®ionId=142&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Panama-Spa-Hotel.0-0-d142-tSpaHotel.Hotel-Filter-Destinations)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Panama-Spa-Hotel.0-0-d142-tSpaHotel.Hotel-Filter-Destinations) ## Top Panama Hotel Reviews ![W Panama](https://images.trvl-media.com/lodging/22000000/21320000/21314100/21314035/5dc0b3d1_y.jpg) ### W Panama 10/10 Excellent "Clean room " [](https://expedia.com/Panama-City-Hotels-W-Panama.h21314035.Hotel-Information) ![Crowne Plaza Panama Airport by IHG](https://images.trvl-media.com/lodging/9000000/8840000/8836200/8836117/877d081d_y.jpg) ### Crowne Plaza Panama Airport by IHG 8/10 Good "Poor at 6am" [](https://expedia.com/Tocumen-Hotels-Crowne-Plaza-Panama-Airport.h8836117.Hotel-Information) ![Courtyard by Marriott Panama Multiplaza Mall](https://images.trvl-media.com/lodging/2000000/1150000/1145700/1145666/7dd302e1_y.jpg) ### Courtyard by Marriott Panama Multiplaza Mall 10/10 Excellent "Very clean room, excellent staff, breakfast wonderful and amazing shopping. " [](https://expedia.com/Panama-City-Hotels-Courtyard-By-Marriott-Panama-Multiplaza-Mall.h1145666.Hotel-Information) ![JW Marriott Panama](https://images.trvl-media.com/lodging/5000000/4110000/4109200/4109123/fb42dbf6_y.jpg) ### JW Marriott Panama 8/10 Good "The room was clean an spacious. I loved my ocean view. The food at both Masi and Azul was delicious. Overall, I thoroughly enjoyed my time here and would definitely stay again." [](https://expedia.com/Panama-City-Hotels-JW-Marriott-Panama.h4109123.Hotel-Information) ![The Executive Hotel](https://images.trvl-media.com/lodging/1000000/530000/522100/522086/e3ee3bd7_y.jpg) ### The Executive Hotel 8/10 Good "The location of the property is great for getting around Panama especially by the bus or metro. Staff is very friendly and helpful even with a language barrier - I don't know much Spanish. Clean rooms with good amenities. Good buffet breakfast." [](https://expedia.com/Panama-City-Hotels-The-Executive-Hotel.h522086.Hotel-Information) ![Hotel El Panama by Faranda Grand, a member of Radisson Individuals](https://images.trvl-media.com/lodging/1000000/10000/7200/7164/cfc3400a_y.jpg) ### Hotel El Panama by Faranda Grand, a member of Radisson Individuals 10/10 Excellent "Was excellent all the staff " [](https://expedia.com/Panama-City-Hotels-Hotel-El-Panama-By-Faranda-Grand.h7164.Hotel-Information) ![Principe Hotel and Suites](https://images.trvl-media.com/lodging/8000000/7460000/7451800/7451703/2baee2b4_y.jpg) ### Principe Hotel and Suites 8/10 Good "Good " [](https://expedia.com/Panama-City-Hotels-Principe-Hotel-And-Suites.h7451703.Hotel-Information) ![Hotel Riu Plaza Panama](https://images.trvl-media.com/lodging/4000000/3910000/3900400/3900395/6f5f0f4f_y.jpg) ### Hotel Riu Plaza Panama 10/10 Excellent "The staff was very nice and helpful the room was beautiful " [](https://expedia.com/Panama-City-Hotels-Hotel-Riu-Plaza-Panama.h3900395.Hotel-Information) ![Waymore Hotel Spa & Casino](https://images.trvl-media.com/lodging/97000000/96830000/96825200/96825193/a1c4d702_y.jpg) ### Waymore Hotel Spa & Casino 6/10 Okay "We chose to stay at the Waymore for our honeymoon to Panama. The best thing about this hotel is the location. There were a lot of food options and souvenir shops within walking distance of the hotel. I was sad to find out that the pool was closed for remodeling-they did not inform us of this prior to our stay. Hotel staff did offer the option to go to a nearby hotel 15 minutes away and use their pool and even offered a complimentary shuttle service to get there. Breakfast was only okay. They offered the same thing every single day. The hotel advertised a chef to prepare eggs on the spot- I never found this. The hot lamps didn't keep the food hot, instead it tasted soggy and slightly warm. When we first checked into the room, the soap dispenser on the wall was practically empty and this was NEVER refilled during our 8 night stay. The water pressure in the shower was very spotty sometimes would barely drip out. The water wasn't wasn't always hot and we found ourselves showering with cold water at times. I think one of the biggest complaints of our stay is that there was a maintenance worker on a scaffold right outside of our window and mind you we were staying on like the 12th floor. The maintenance worker was outside our window at like 10 AM when our curtains were wide open and I had just gotten out of the shower and was trying to get dressed. The hotel room had 1 singular light in the ceiling which barely provided any lighting- so we had to close the shades. " [](https://expedia.com/Panama-City-Hotels-Waymore-Hotel-Spa-Casino.h96825193.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Packages - Cars - [Hotels near Sante Fe National Park ](https://www.expedia.com/Sante-Fe-National-Park-Hotels.0-l553248635976022317-0.Travel-Guide-Filter-Hotels) - [Sante Fe National Park ](https://www.expedia.com/Sante-Fe-National-Park-Panama.d553248635976022317.Vacation-Attraction) - [Car rentals near Sante Fe National Park ](https://www.expedia.com/Car-Rentals-In-Sante-Fe-National-Park.d553248635976022317.Car-Rental-Guide)