$173 Cheap Flights from Knoxville (TYS) to Charleston (CHS)

View $173 flight on Thu, Nov 27, 2025Opens in a new window

Popular airlines from McGhee Tyson Airport (TYS) to Charleston Intl. Airport (CHS)

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Cheap Flights from Knoxville to Charleston (TYS-CHS)

Prices were available within the past 7 days and start at $173 for one-way flights and $287 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Sep 23 - Tue, Sep 30
TYS
Knoxville
CHS
Charleston
$287 Roundtrip, found 3 hours ago
$287
Roundtrip
found 3 hours ago
Select Delta flight, departing Tue, Sep 23 from Knoxville to Charleston, returning Tue, Sep 30, priced at $287 found 3 hours ago
Delta
Fri, Sep 19 - Tue, Sep 30
TYS
Knoxville
CHS
Charleston
$297 Roundtrip, found 3 hours ago
$297
Roundtrip
found 3 hours ago
Select Delta flight, departing Fri, Sep 19 from Knoxville to Charleston, returning Tue, Sep 30, priced at $297 found 3 hours ago
American Airlines
Wed, Sep 17 - Sat, Sep 20
TYS
Knoxville
CHS
Charleston
$297 Roundtrip, found 5 hours ago
$297
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Wed, Sep 17 from Knoxville to Charleston, returning Sat, Sep 20, priced at $297 found 5 hours ago
Delta
Sat, Aug 23 - Tue, Sep 9
TYS
Knoxville
CHS
Charleston
$307 Roundtrip, found 4 hours ago
$307
Roundtrip
found 4 hours ago
Select Delta flight, departing Sat, Aug 23 from Knoxville to Charleston, returning Tue, Sep 9, priced at $307 found 4 hours ago
Delta
Sat, Aug 23 - Sat, Sep 13
TYS
Knoxville
CHS
Charleston
$317 Roundtrip, found 4 hours ago
$317
Roundtrip
found 4 hours ago
Select Delta flight, departing Sat, Aug 23 from Knoxville to Charleston, returning Sat, Sep 13, priced at $317 found 4 hours ago
American Airlines
Wed, Aug 20 - Sat, Aug 23
TYS
Knoxville
CHS
Charleston
$322 Roundtrip, found 5 days ago
$322
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Aug 20 from Knoxville to Charleston, returning Sat, Aug 23, priced at $322 found 5 days ago
Delta
Sat, Aug 23 - Tue, Aug 26
TYS
Knoxville
CHS
Charleston
$327 Roundtrip, found 4 hours ago
$327
Roundtrip
found 4 hours ago
Select Delta flight, departing Sat, Aug 23 from Knoxville to Charleston, returning Tue, Aug 26, priced at $327 found 4 hours ago
American Airlines
Wed, Sep 17 - Sat, Sep 20
TYS
Knoxville
CHS
Charleston
$332 Roundtrip, found 5 hours ago
$332
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Wed, Sep 17 from Knoxville to Charleston, returning Sat, Sep 20, priced at $332 found 5 hours ago
Delta
Sun, Oct 19 - Tue, Oct 28
TYS
Knoxville
CHS
Charleston
$333 Roundtrip, found 9 hours ago
$333
Roundtrip
found 9 hours ago
Select Delta flight, departing Sun, Oct 19 from Knoxville to Charleston, returning Tue, Oct 28, priced at $333 found 9 hours ago
United
Sat, Nov 8 - Sat, Nov 15
TYS
Knoxville
CHS
Charleston
$486 Roundtrip, found 13 hours ago
$486
Roundtrip
found 13 hours ago
Select United flight, departing Sat, Nov 8 from Knoxville to Charleston, returning Sat, Nov 15, priced at $486 found 13 hours ago

Find the cheapest month to fly from Knoxville (TYS) to Charleston (CHS)

May is typically the cheapest month to fly

From $286 - $516 per traveler.

Graph displaying average flight prices per month

Alternative airports near Charleston

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Charleston Intl. CHS. Cheapest and Closest option available. Average driving time to city center is 16 minutes. Flights from $327
CHS
Charleston Intl.
CheapestClosest
Average driving time to city center16 min
Flights from $327
Flights from Knoxville (TYS) to Charleston (CHS)
Origin airport
McGhee Tyson
Destination airport
Charleston Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$286
Distance
302 mi

Knoxville to Charleston Flights

The cheapest times to fly from Knoxville to Charleston

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to Charleston are during the month of September. You can find some of the cheapest flights from Knoxville to Charleston with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Knoxville to Charleston

Sunday is one of the best days to book for cheap flights from Knoxville to Charleston: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Knoxville to Charleston

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to Charleston in 2025. You can also book with separate airlines for your outbound and return journeys, from $173 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to Charleston flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to Charleston airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from McGhee Tyson Airport (TYS) to Charleston Intl. Airport (CHS) cost?
Discover the latest flight deals from TYS to CHS by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from TYS to CHS?
The cheapest flights from TYS to CHS are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from TYS to CHS?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from TYS to CHS. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from McGhee Tyson Airport (TYS) to Charleston Intl. Airport (CHS)?
There are no daily direct flights from McGhee Tyson Airport (TYS) to Charleston Intl. Airport (CHS). But you can book flights with layovers. Filter your search results on Expedia to include one or more stops, and you'll be on your way in no time at all.
What day of the week has the most flights from TYS to CHS?
Friday is typically the busiest day for flights, while Tuesday is often the quietest.* Remember that flight schedules can vary based on a number of factors, such as the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from McGhee Tyson Airport (TYS) to Charleston Intl. Airport (CHS)?
To reach Charleston Intl. Airport (CHS) without delays, select a flight that leaves from McGhee Tyson Airport (TYS) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from McGhee Tyson Airport (TYS) to Charleston Intl. Airport (CHS) last-minute?
Last-minute fares from TYS to CHS are generally more expensive. To secure the cheapest rates, start looking for flights well ahead of time. That said, if you can play around with your travel dates, it's possible to score a cheap fare right before your trip.
Is it cheaper to book a TYS to CHS flight and hotel package?
Opting for a TYS to CHS flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your trip in one place. Choose from our impressive range of stays and then add activities, flights and car rentals to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from McGhee Tyson Airport (TYS) to Charleston Intl. Airport (CHS)?
In most cases, you can reschedule or cancel your TYS to CHS flight. However, there may be additional fees, especially if you booked more than 24 hours ago. Check your itinerary for the airline's rules and fees on flight changes, or if you'd like more details, head to our Customer Service portal.

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*Available to One Key members.