Find 4 Star Hotels in Illinois Medical District, IL from $99

Start date: Check-in selected.
To Date
End date: Check-out

  • Upfront pricing

    Our total price for your stay includes taxes and fees

  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

Check availability on Illinois Medical District 4 Star Hotels

Our top choices for Illinois Medical District 4-star hotels

Lobby
Embassy Suites by Hilton Chicago Downtown River North

Embassy Suites by Hilton Chicago Downtown River North

Embassy Suites by Hilton Chicago Downtown River North
4.0 star property
Downtown Chicago
8.6 out of 10, Excellent, (5405)
"Spacious rooms , free drinks and great breakfast "
United States
Ebony
$96 nightly
The price is $113
Jan 6 - Jan 7, 2026
Total with taxes and fees
Embassy Suites by Hilton Chicago Downtown River North
Reception
Palmer House a Hilton Hotel

Palmer House a Hilton Hotel

Palmer House a Hilton Hotel
4.0 star property
Downtown Chicago
8.4 out of 10, Very Good, (2141)
"Loved and enjoyed our stay"
United States
Luis
$132 nightly
The price is $151
Dec 30 - Dec 31
Total with taxes and fees
Palmer House a Hilton Hotel
55-inch TV with cable channels, video-game console, pay movies
Hilton Chicago O'Hare Airport

Hilton Chicago O'Hare Airport

Hilton Chicago O'Hare Airport
4.0 star property
O'Hare
8.2 out of 10, Very Good, (2183)
"The family room we stayed has a wide airport view, which I’m so impressed with."
Canada
Naw Kanyaw
$196 nightly
The price is $230
Jan 16 - Jan 17, 2026
Total with taxes and fees
Hilton Chicago O'Hare Airport
Lounge
Pendry Chicago

Pendry Chicago

Pendry Chicago
4.5 star property
Downtown Chicago
9.4 out of 10, Exceptional, (1155)
"Rooms are lovely, bar / restaurant is top notch. Love staying at the pendry!"
United States
Lucia
$195 nightly
The price is $229
Jan 1 - Jan 2, 2026
Total with taxes and fees
Pendry Chicago
Property amenity
citizenM Chicago Downtown

citizenM Chicago Downtown

citizenM Chicago Downtown
4.0 star property
Downtown Chicago
9.4 out of 10, Exceptional, (4118)
"Great stay"
United States
Ericka
$103 nightly
The price is $121
Dec 21 - Dec 22
Total with taxes and fees
citizenM Chicago Downtown
Property amenity
The Wade

The Wade

The Wade
4.5 star property
Downtown Chicago
8.4 out of 10, Very Good, (1522)
"Great staff and great location. "
United States
Joe
$101 nightly
The price is $119
Dec 21 - Dec 22
Total with taxes and fees
The Wade
Indoor pool
InterContinental Chicago Magnificent Mile by IHG

InterContinental Chicago Magnificent Mile by IHG

InterContinental Chicago Magnificent Mile by IHG
4.5 star property
Downtown Chicago
9.0 out of 10, Wonderful, (2632)
"Great hotel, best location, nice and very helpful staff "
United States
Carlos
$179 nightly
The price is $205
Jan 13 - Jan 14, 2026
Total with taxes and fees
InterContinental Chicago Magnificent Mile by IHG
Exterior
Warwick Allerton - Chicago

Warwick Allerton - Chicago

Warwick Allerton - Chicago
4.0 star property
Downtown Chicago
8.4 out of 10, Very Good, (3017)
"Enjoyed this hotel stay. "
United States
Kimberly
$88 nightly
The price is $104
Dec 23 - Dec 24
Total with taxes and fees
Warwick Allerton - Chicago
Nightclub
Club Quarters Hotel, Central Loop, Chicago

Club Quarters Hotel, Central Loop, Chicago

Club Quarters Hotel, Central Loop, Chicago
4.0 star property
Downtown Chicago
8.8 out of 10, Excellent, (3317)
"Great location!"
Mexico
Jose
$87 nightly
The price is $102
Dec 22 - Dec 23
Total with taxes and fees
Club Quarters Hotel, Central Loop, Chicago
Front of property
Hotel Riu Plaza Chicago

Hotel Riu Plaza Chicago

Hotel Riu Plaza Chicago
4.0 star property
Downtown Chicago
9.4 out of 10, Exceptional, (2983)
"Excellent stay great location and great rooms"
United States
Joseph
$124 nightly
The price is $145
Dec 21 - Dec 22
Total with taxes and fees
Hotel Riu Plaza Chicago
Ballroom
The Royal Sonesta Chicago Downtown

The Royal Sonesta Chicago Downtown

The Royal Sonesta Chicago Downtown
4.0 star property
Downtown Chicago
9.4 out of 10, Exceptional, (3159)
"The location, hotel, and views are absolutely fantastic!"
United States
Frederick
$141 nightly
The price is $166
Jan 15 - Jan 16, 2026
Total with taxes and fees
The Royal Sonesta Chicago Downtown
Lobby
Hotel Felix River North/Magnificent Mile

Hotel Felix River North/Magnificent Mile

Hotel Felix River North/Magnificent Mile
4.0 star property
Downtown Chicago
8.2 out of 10, Very Good, (2443)
"Decent hotel in a great location with extremely helpful staff. "
United States
Aaron
$105 nightly
The price is $123
Dec 17 - Dec 18
Total with taxes and fees
Hotel Felix River North/Magnificent Mile
Indoor wedding
Swissotel - Chicago

Swissotel - Chicago

Swissotel - Chicago
4.5 star property
Downtown Chicago
9.0 out of 10, Wonderful, (3022)
"Very beautiful place to stay"
United States
FaithBrenda
$139 nightly
The price is $163
Jan 1 - Jan 2, 2026
Total with taxes and fees
Swissotel - Chicago
Exterior
Hilton Chicago

Hilton Chicago

Hilton Chicago
4.0 star property
Downtown Chicago
8.4 out of 10, Very Good, (2381)
"We had a great stay and will be back again."
United States
Amber
$114 nightly
The price is $134
Dec 22 - Dec 23
Total with taxes and fees
Hilton Chicago
Lobby
River Hotel

River Hotel

River Hotel
4.0 star property
Downtown Chicago
8.8 out of 10, Excellent, (4861)
"Great location, comfortable room, and nice staff."
United States
Claudia
$88 nightly
The price is $103
Dec 22 - Dec 23
Total with taxes and fees
River Hotel
Lobby
Hyatt Regency O'Hare Chicago

Hyatt Regency O'Hare Chicago

Hyatt Regency O'Hare Chicago
4.0 star property
Rosemont
8.8 out of 10, Excellent, (2212)
"Very nice place to stay "
United States
Ramon
$110 nightly
The price is $125
Dec 17 - Dec 18
Total with taxes and fees
Hyatt Regency O'Hare Chicago
2 restaurants, breakfast, lunch, dinner served; American cuisine
LondonHouse Chicago, Curio Collection by Hilton

LondonHouse Chicago, Curio Collection by Hilton

LondonHouse Chicago, Curio Collection by Hilton
4.5 star property
Downtown Chicago
9.4 out of 10, Exceptional, (3439)
"Loved the location and view!"
United States
Erica
$130 nightly
The price is $153
Jan 4 - Jan 5, 2026
Total with taxes and fees
LondonHouse Chicago, Curio Collection by Hilton
Exterior
DoubleTree by Hilton Hotel Chicago Wood Dale - Elk Grove

DoubleTree by Hilton Hotel Chicago Wood Dale - Elk Grove

DoubleTree by Hilton Hotel Chicago Wood Dale - Elk Grove
4.0 star property
Wood Dale
8.0 out of 10, Very Good, (1007)
"Nest room Good staff Free parking Good value for money "
United States
Shakeel
$89 nightly
The price is $99
Dec 22 - Dec 23
Total with taxes and fees
DoubleTree by Hilton Hotel Chicago Wood Dale - Elk Grove
2 bars/lounges
Hyatt Regency Chicago

Hyatt Regency Chicago

Hyatt Regency Chicago
4.0 star property
Downtown Chicago
9.4 out of 10, Exceptional, (3409)
"I always love staying at this place when I visit"
Canada
William
$161 nightly
The price is $189
Dec 29 - Dec 30
Total with taxes and fees
Hyatt Regency Chicago
Bar (on property)
Canopy by Hilton Chicago Central Loop

Canopy by Hilton Chicago Central Loop

Canopy by Hilton Chicago Central Loop
4.0 star property
Downtown Chicago
9.4 out of 10, Exceptional, (1445)
"Beautiful hotel. Great ambiance. "
United States
Joan
$130 nightly
The price is $153
Dec 28 - Dec 29
Total with taxes and fees
Canopy by Hilton Chicago Central Loop
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Illinois Medical District.
Four Seasons Hotel Chicago

Four Seasons Hotel Chicago

120 East Delaware Place Chicago IL
$420 nightly
The price is $493 total per night from Jan 11 to Jan 12
$493 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
9.2/10 Wonderful! (998 reviews)
Still don't see what you're looking for?
See all properties in Illinois Medical District.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Illinois Medical District Hotel Reviews

Palmer House a Hilton Hotel

Palmer House a Hilton Hotel

10/10 Excellent
"The staff was so friendly and helpful and the hotel was beautiful"
Julianne 2-night trip
Posted 5 hours ago
Palmer House a Hilton Hotel

Explore a world of travel with Expedia