Title: Visit Melrose: 2026 Travel Guide for Melrose, Florida | Expedia.com

[Hotels in Melrose](https://expedia.com/Melrose-Hotels.d3000431362.Travel-Guide-Hotels)[Vacation Rentals in Melrose](https://expedia.com/Melrose-Vacation-Rentals.d3000431362.Travel-Guide-VacationRentals)[Flights to Melrose](https://expedia.com/Cheap-Flights-To-Melrose.d3000431362.Travel-Guide-Flights)[Car Rentals in Melrose](https://expedia.com/Car-Rentals-In-Melrose.d3000431362.Car-Rental-Guide)[Melrose Vacation Packages](https://expedia.com/Melrose.d3000431362.Destination-Travel-Guides)

# Melrose, FL

## Travel Guide

![Melrose, FL
Lake Santa Fe 
](https://images.trvl-media.com/place/3000431362/0b90ed1d-67eb-4497-a9f6-f9ac696978e8.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh)

## Visit Melrose

Things to do

- Melrose Hotel Deals
- Vacation Rentals in Melrose

![3 Bedroom House on Private Scenic Lake Mable](https://images.trvl-media.com/lodging/94000000/93160000/93156100/93156079/w906h683x59y0-4020ce62_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

3 Bedroom House on Private Scenic Lake Mable

 Melrose FL

Stay at this vacation home in Melrose. Enjoy free WiFi, a garden, and laundry facilities. Popular attraction Santa Fe Lake is located nearby.

9.8/10 Exceptional! (13 reviews)

Amenities were fine.

Reviewed on Feb 25, 2026

[Get rates](https://expedia.com/Hotel-Search?startDate=4%2F8%2F2026&endDate=4%2F9%2F2026&selected=93156079&PinnedHotelID=93156079&HadPinnedHotel=true&regionId=3000431362)

[](https://expedia.com/Hotel-Search?startDate=4%2F8%2F2026&endDate=4%2F9%2F2026&selected=93156079&PinnedHotelID=93156079&HadPinnedHotel=true&regionId=3000431362)

![HOM Hotel Gainesville, SureStay Collection by Best Western](https://images.trvl-media.com/lodging/1000000/210000/200800/200755/8a6fa57c_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

HOM Hotel Gainesville, SureStay Collection by Best Western

3905 Sw 43Rd St Gainesville FL

$77 nightly

$87 total

Apr 5 - Apr 6

Total with taxes and fees

Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...

8.4/10 Very Good! (1,856 reviews)

I have stayed at HOM since they opened, years ago. It had become a tad tired, last time I stayed there, but they have renovated and the entire place looks great. The rooms were very reasonable - especially as it was spring break - clean, super comfortable beds. The sheets were actually a bottom fitted ...

Reviewed on Mar 23, 2026

[](https://expedia.com/Hotel-Search?startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&selected=200755&PinnedHotelID=200755&HadPinnedHotel=true&regionId=3000431362)

![Country Inn & Suites by Radisson, Gainesville, FL](https://images.trvl-media.com/lodging/2000000/1290000/1289100/1289043/e387508a_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Country Inn & Suites by Radisson, Gainesville, FL

4015 Sw 43rd St Gainesville FL

$88 nightly

$99 total

Apr 5 - Apr 6

Total with taxes and fees

Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...

9.2/10 Wonderful! (1,731 reviews)

This visit was our second one as a large group of friends. During the day and later at night, we gathered in the area used for the breakfast. The staff was always so kind to us, never complaining about us being in the area. We were not loud nor did we leave a mess. We felt welcome and will return ...

Reviewed on Mar 24, 2026

[](https://expedia.com/Hotel-Search?startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&selected=1289043&PinnedHotelID=1289043&HadPinnedHotel=true&regionId=3000431362)

[See all 857 properties in Melrose](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=3%2F26%2F2026&endDate=3%2F27%2F2026&regionId=3000431362)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

![House in Melrose on Lake Sante Fe](https://images.trvl-media.com/lodging/101000000/100030000/100023700/100023634/e28101ba_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

House in Melrose on Lake Sante Fe

 Melrose FL

Stay at this vacation home in Melrose. Enjoy a garden, laundry facilities, and patios. Popular attraction Santa Fe Lake is located nearby.

10/10 Exceptional! (13 reviews)

Beautiful quiet property on the lake and great for families.

Reviewed on Mar 10, 2026

[](https://expedia.com/Melrose-Hotels-House-In-Melrose-On-Lake-Sante-Fe.h100023634.Hotel-Information)

![Rustic Fishing Cabin on Lake Swan, Melrose](https://images.trvl-media.com/lodging/77000000/76550000/76548500/76548421/53f94235_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Rustic Fishing Cabin on Lake Swan, Melrose

 Melrose FL

Stay at this cabin in Melrose. Enjoy free WiFi, laundry facilities, and an in-room coffeemaker. Popular attraction Santa Fe Lake is located nearby.

[](https://expedia.com/Melrose-Hotels-Rustic-Fishing-Cabin-On-Lake-Swan.h76548421.Hotel-Information)

![3 Bedroom House on Private Scenic Lake Mable](https://images.trvl-media.com/lodging/94000000/93160000/93156100/93156079/w906h683x59y0-4020ce62_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

3 Bedroom House on Private Scenic Lake Mable

 Melrose FL

Stay at this vacation home in Melrose. Enjoy free WiFi, a garden, and laundry facilities. Popular attraction Santa Fe Lake is located nearby.

9.8/10 Exceptional! (13 reviews)

Amenities were fine.

Reviewed on Feb 25, 2026

[](https://expedia.com/Melrose-Hotels-3-Bedroom-House-On-Private-Scenic-Lake-Mable.h93156079.Hotel-Information)

[See all properties in Melrose](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&regionId=3000431362&sort=VACATION_RENTAL)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Check Melrose hotel availability

[Tonight

](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=3000431362&startDate=2026-03-25&endDate=2026-03-26)[Mar 25 - Mar 26](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=3000431362&startDate=2026-03-25&endDate=2026-03-26)

[Tomorrow night

](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=3000431362&startDate=2026-03-26&endDate=2026-03-27)[Mar 26 - Mar 27](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=3000431362&startDate=2026-03-26&endDate=2026-03-27)

[This weekend

](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=3000431362&startDate=3%2F27%2F2026&endDate=3%2F29%2F2026)[Mar 27 - Mar 29](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=3000431362&startDate=3%2F27%2F2026&endDate=3%2F29%2F2026)

[Next weekend

](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=3000431362&startDate=4%2F3%2F2026&endDate=4%2F5%2F2026)[Apr 3 - Apr 5](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=3000431362&startDate=4%2F3%2F2026&endDate=4%2F5%2F2026)

### Popular places to visit

#### Single Vision Inc.

See the exotic and native animals who call Single Vision Inc. home during your trip to Melrose. While you're in the area, wander around the parks. 

[](https://expedia.com/Single-Vision-Inc-Melrose.d553248621532654075.Vacation-Attraction)

## Cities near Melrose

![Little Devil's Spring on the Santa Fe River, Gilchrist County, Florida](https://images.trvl-media.com/place/7113/c94b2830-c3dc-4b8e-85ae-2ef81bf5b73f.jpg?impolicy=fcrop&w=512&h=288&q=medium)

### Starke

![Early Winter Morning at Ginnie Springs on the Santa Fe River, Florida	
](https://images.trvl-media.com/place/6094592/37b6770f-7d44-4947-893a-9c78f4da8098.jpg?impolicy=fcrop&w=512&h=288&q=medium)

### Waldo

![Aerial View of Florida Lakes](https://images.trvl-media.com/place/6351663/3b2bf0e0-b7c8-4f5f-a972-a77a1a6bdb0c.jpg?impolicy=fcrop&w=512&h=288&q=medium)

### Keystone Heights

![Interlachen featuring a church or cathedral](https://images.trvl-media.com/place/6355346/421736d5-6ed7-4872-9786-4ded67f1dafb.jpg?impolicy=fcrop&w=512&h=288&q=medium)

### Interlachen

## Explore a world of travel with Expedia

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- Cities near Melrose
- Places of interest

[Starke](https://expedia.com/Starke.dx7113)[Waldo](https://expedia.com/Waldo.dx6094592)[Hawthorne](https://expedia.com/Hawthorne.dx6351661)[Keystone Heights](https://expedia.com/Keystone-Heights.dx6351663)[Interlachen](https://expedia.com/Interlachen.dx6355346)[Earleton](https://expedia.com/Earleton.dx3000345210)[Florahome](https://expedia.com/Florahome.dx3000345223)

- [University of Florida ](https://expedia.com/University-Of-Florida-Gainesville.d6068631.Vacation-Attraction)
- [Shands at the University of Florida ](https://expedia.com/Shands-At-The-University-Of-Florida-Gainesville.d6187967.Vacation-Attraction)
- [Ben Hill Griffin Stadium ](https://expedia.com/Ben-Hill-Griffin-Stadium-Gainesville.d6068633.Vacation-Attraction)
- [Ocala National Forest ](https://expedia.com/Ocala-National-Forest-Florida.d6091129.Vacation-Attraction)
- [Gainesville Raceway ](https://expedia.com/Gainesville-Raceway-Gainesville.d6128074.Vacation-Attraction)
- [Paynes Prairie Preserve State Park ](https://expedia.com/Paynes-Prairie-Preserve-State-Park-Florida.d6068627.Vacation-Attraction)
- [Oaks Mall ](https://expedia.com/Oaks-Mall-Gainesville.d6128062.Vacation-Attraction)
- [North Florida Regional Medical Center ](https://expedia.com/North-Florida-Regional-Medical-Center-Gainesville.d6187962.Vacation-Attraction)
- [Santa Fe River ](https://expedia.com/Santa-Fe-River-Florida.d684510373599707136.Vacation-Attraction)
- [Camp Blanding Museum and Memorial Park ](https://expedia.com/Camp-Blanding-Museum-And-Memorial-Park-Starke.d6184475.Vacation-Attraction)
- [Florida Museum of Natural History ](https://expedia.com/Florida-Museum-Of-Natural-History-Gainesville.d6068619.Vacation-Attraction)
- [Devil's Milhopper Geological State Park ](https://expedia.com/Devils-Milhopper-Geological-State-Park-Gainesville.d6224724.Vacation-Attraction)
- [University of Florida Bat Houses ](https://expedia.com/University-Of-Florida-Bat-Houses-Gainesville.d553248621532654132.Vacation-Attraction)
- [Marjorie Kinnan Rawlings State Park ](https://expedia.com/Marjorie-Kinnan-Rawlings-State-Park-Hawthorne.d6068625.Vacation-Attraction)
- [San Felasco Hammock Preserve State Park ](https://expedia.com/San-Felasco-Hammock-Preserve-State-Park-Florida.d6128058.Vacation-Attraction)
- [Rodman Reservoir ](https://expedia.com/Rodman-Reservoir-Florida.d906277736304234496.Vacation-Attraction)
- [Thomas Center ](https://expedia.com/Thomas-Center-Duckpond.d6187991.Vacation-Attraction)
- [Ravine Gardens State Park ](https://expedia.com/Ravine-Gardens-State-Park-Palatka.d553248621532654079.Vacation-Attraction)
- [Palatka Welcome Center ](https://expedia.com/Palatka-Welcome-Center-Palatka.d553248621560669151.Vacation-Attraction)
- [Curtis M. Phillips Center ](https://expedia.com/Curtis-M-Phillips-Center-Gainesville.d6188013.Vacation-Attraction)
- [Waldo Motorsports ](https://expedia.com/Waldo-Motorsports-Waldo.d6128078.Vacation-Attraction)
- [Gold Head Branch State Park ](https://expedia.com/Gold-Head-Branch-State-Park-Keystone-Heights.d6184480.Vacation-Attraction)
- [Micanopy Historical Society Museum ](https://expedia.com/Micanopy-Historical-Society-Museum-Micanopy.d6209527.Vacation-Attraction)
- [Regal Royal Park ](https://expedia.com/Regal-Royal-Park-Gainesville.d553248621563220056.Vacation-Attraction)
- [Turkey Creek Golf Course ](https://expedia.com/Turkey-Creek-Golf-Course-Alachua.d553248621532654065.Vacation-Attraction)

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