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Our top choices for Melrose hotels

1. Drury Inn & Suites Gainesville

Drury Inn & Suites Gainesville
3.0 star property
Gainesville
9.6 out of 10, Exceptional, (1,686 reviews)
"Great stay though I did miss the Celtics Magic game."
United States
andrew
3 days ago
$105 nightly
The price is $118
Nov 26 - Nov 27
Total with taxes and fees
Drury Inn & Suites Gainesville

2. Country Inn & Suites by Radisson, Gainesville, FL

Country Inn & Suites by Radisson, Gainesville, FL
3.0 star property
Gainesville
9.2 out of 10, Wonderful, (2,041 reviews)
"The staff was absolutely excellent friendly. The hotel is in a great location."
United States
Daniel
2 days ago
$88 nightly
The price is $99
Nov 17 - Nov 18
Total with taxes and fees
Country Inn & Suites by Radisson, Gainesville, FL

3. Hotel Indigo Gainesville-Celebration Pointe by IHG

Hotel Indigo Gainesville-Celebration Pointe by IHG
3.5 star property
Gainesville
9.2 out of 10, Wonderful, (1,066 reviews)
"Staff was friendly. Rooms were clean. Hotel was a perfect spot for the weekend."
United States
Jeanne
2 days ago
$102 nightly
The price is $115
Nov 15 - Nov 16
Total with taxes and fees
Hotel Indigo Gainesville-Celebration Pointe by IHG

4. Sleep Inn & Suites University/Shands

Sleep Inn & Suites University/Shands
2.5 star property
Gainesville
8.8 out of 10, Excellent, (1,332 reviews)
"Older property but very nice, the room was large for the price."
United States
Christopher
4 days ago
$81 nightly
The price is $91
Dec 4 - Dec 5
Total with taxes and fees
Sleep Inn & Suites University/Shands

5. Comfort Suites Gainesville near University

Comfort Suites Gainesville near University
2.5 star property
Gainesville
9.2 out of 10, Wonderful, (1,564 reviews)
"Front desk staff were very accommodating."
United States
Jorge
12 days ago
$84 nightly
The price is $94
Nov 22 - Nov 23
Total with taxes and fees
Comfort Suites Gainesville near University

6. Hotel Eleo at the University of Florida

Hotel Eleo at the University of Florida
3.0 star property
Gainesville
9.4 out of 10, Exceptional, (1,316 reviews)
"Good property to stay in Gainesville."
United States
Pedro
7 days ago
$170 nightly
The price is $191
Nov 24 - Nov 25
Total with taxes and fees
Hotel Eleo at the University of Florida

7. Hyatt Place Gainesville Downtown

Hyatt Place Gainesville Downtown
3.0 star property
Downtown Gainesville
9.2 out of 10, Wonderful, (1,249 reviews)
"Close to everything, great service, everything is clean."
United States
Desiree
4 days ago
$104 nightly
The price is $116
Nov 16 - Nov 17
Total with taxes and fees
Hyatt Place Gainesville Downtown

8. La Quinta by Wyndham Gainesville

La Quinta by Wyndham Gainesville
3.0 star property
Gainesville
9.2 out of 10, Wonderful, (1,395 reviews)
"My room was clean. Exceptional hot water for my shower."
United States
David
7 days ago
$97 nightly
The price is $109
Nov 15 - Nov 16
Total with taxes and fees
La Quinta by Wyndham Gainesville

9. HOM Hotel Gainesville, SureStay Collection by Best Western

HOM Hotel Gainesville, SureStay Collection by Best Western
2.5 star property
Gainesville
8.6 out of 10, Excellent, (2,168 reviews)
"Breakfast was ok. It was pretty good. The room did need more lighting."
United States
Benjamin
22 hours ago
$72 nightly
The price is $82
Nov 17 - Nov 18
Total with taxes and fees
HOM Hotel Gainesville, SureStay Collection by Best Western

10. Best Western Gateway Grand

Best Western Gateway Grand
3.0 star property
Gainesville
8.6 out of 10, Excellent, (1,534 reviews)
"The room we stayed in was really nice."
United States
Linda
5 days ago
$85 nightly
The price is $95
Nov 17 - Nov 18
Total with taxes and fees
Best Western Gateway Grand

11. Hilton University of Florida Conference Center Gainesville

Hilton University of Florida Conference Center Gainesville
3.5 star property
Gainesville
8.4 out of 10, Very good, (1,001 reviews)
"Nice location , clean and friendly."
United States
Yuleivy
22 days ago
$106 nightly
The price is $119
Nov 17 - Nov 18
Total with taxes and fees
Hilton University of Florida Conference Center Gainesville

12. Holiday Inn Gainesville - University Center by IHG

Holiday Inn Gainesville - University Center by IHG
3.0 star property
University Heights
8.2 out of 10, Very good, (1,006 reviews)
"Hotel was updated and clean with very helpful staff."
United States
Laila
4 days ago
$97 nightly
The price is $109
Nov 29 - Nov 30
Total with taxes and fees
Holiday Inn Gainesville - University Center by IHG

13. DoubleTree by Hilton Gainesville

DoubleTree by Hilton Gainesville
4.0 star property
Gainesville
8.0 out of 10, Very good, (1,007 reviews)
"Nice cozy hotel. Love the cookies!"
United States
Monica
1 day ago
$84 nightly
The price is $95
Nov 29 - Nov 30
Total with taxes and fees
DoubleTree by Hilton Gainesville

14. Comfort Inn Gainesville - University Area

Comfort Inn Gainesville - University Area
2.5 star property
Gainesville
8.2 out of 10, Very good, (1,089 reviews)
"Very helpful personel. Enjoyed closeness to shopping."
United States
ROMULO
8 days ago
$84 nightly
The price is $94
Nov 29 - Nov 30
Total with taxes and fees
Comfort Inn Gainesville - University Area

15. Sweetwater Branch Inn

Sweetwater Branch Inn
3.5 star property
Gainesville
9.8 out of 10, Exceptional, (1,000 reviews)
"We had a wonderful stay. Breakfast was top notch!"
United States
Bianca
17 days ago
$160 nightly
The price is $181
Nov 11 - Nov 12
Total with taxes and fees
Sweetwater Branch Inn

16. Days Inn by Wyndham Gainesville Hospital/University Area

Days Inn by Wyndham Gainesville Hospital/University Area
2.5 star property
Gainesville
7.8 out of 10, Good, (330 reviews)
"Close enoght to enjoy the city. This property is ok a little away from everything."
United States
Marco
14 days ago
$51 nightly
The price is $58
Nov 17 - Nov 18
Total with taxes and fees
Days Inn by Wyndham Gainesville Hospital/University Area

17. Super 8 by Wyndham Gainesville I-75 Hospital University Area

Super 8 by Wyndham Gainesville I-75 Hospital University Area
2.0 star property
Gainesville
7.6 out of 10, Good, (1,069 reviews)
"Good location, easy access from highway."
United States
Neal
6 days ago
$50 nightly
The price is $56
Nov 15 - Nov 16
Total with taxes and fees
Super 8 by Wyndham Gainesville I-75 Hospital University Area

18. Red Roof Inn PLUS+ Gainesville

Red Roof Inn PLUS+ Gainesville
2.5 star property
Gainesville
7.4 out of 10, Good, (1,332 reviews)
"The room was clean. The beds were comfortable. The water pressure was good."
United States
Stacy Watson
October 11th, 2026
$58 nightly
The price is $66
Dec 1 - Dec 2
Total with taxes and fees
Red Roof Inn PLUS+ Gainesville

19. Hampton Inn & Suites Gainesville Downtown University

Hampton Inn & Suites Gainesville Downtown University
3.0 star property
Downtown Gainesville
8.6 out of 10, Excellent, (1,003 reviews)
"Room was fine, 25. 00 parking fee."
United States
David W
October 8th, 2026
$95 nightly
The price is $107
Nov 26 - Nov 27
Total with taxes and fees
Hampton Inn & Suites Gainesville Downtown University

20. Hampton Inn Gainesville

Hampton Inn Gainesville
2.5 star property
Gainesville
8.8 out of 10, Excellent, (1,004 reviews)
"Great location just off the interstate and lots of restaurants near."
United States
William
11 days ago
$89 nightly
The price is $100
Nov 29 - Nov 30
Total with taxes and fees
Hampton Inn Gainesville
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Where to stay in and around Melrose

Explore the Melrose area for a perfect blend of outdoor adventure and charming scenery. Discover the heart of Melrose with its friendly atmosphere, or take a short trip to nearby Palm Springs for a romantic getaway. Enjoy the historic preservation along Duval Street for a unique travel experience.

Earleton

Discover Earleton, a charming destination perfect for families and nature lovers who will appreciate its serene environment and outdoor adventures. Just a short distance from Melrose, this lovely city offers access to beautiful spots like Santa Fe Lake and Gold Head Branch State Park, where visitors can enjoy recreational activities and breathtaking scenery. With a welcoming community and a variety of attractions nearby, Earleton is an excellent choice for travelers seeking memorable experiences in Florida.

Grandin

Experience the charm of Grandin, a delightful destination for families and nature lovers seeking a budget-friendly getaway. Nestled in Melrose, Grandin offers easy access to scenic spots like Flamingo Lake and Gold Head Branch State Park, perfect for outdoor adventures. Visitors can also enjoy the local Interlachen Branch Library for a relaxing afternoon. With its tranquil atmosphere and beautiful surroundings, Grandin is a smart choice for your next vacation stay.

Keystone Heights

Outdoor enthusiasts will love Keystone Heights, known for its stunning natural scenery and family-friendly atmosphere. This charming city offers easy access to beautiful spots like Santa Fe Lake and Gold Head Branch State Park, perfect for a day of adventure and relaxation. With its nearby recreational areas and unique attractions, including the Camp Blanding Museum and Memorial Park, Keystone Heights provides a delightful escape. Located about 5 miles from Melrose, it’s an excellent choice for your vacation stay.

Lake Geneva

Ideally situated for families and nature lovers, Lake Geneva offers a perfect weekend getaway filled with scenic beauty and outdoor activities. Visitors can enjoy the tranquility of Santa Fe Lake, explore the lush trails at Gold Head Branch State Park, or unwind at Dowda Park. With its proximity to Melrose, about 5 miles away, Lake Geneva is an excellent choice for those looking to immerse themselves in nature while experiencing the charm of a quaint village. It's a smart hotel booking choice for your next vacation.

Orange Heights

Travelers seeking a blend of family-friendly activities and natural beauty will find Orange Heights to be the ideal base for their vacation. This charming village offers easy access to outdoor adventures, with nearby attractions like the scenic Santa Fe Lake and the historic University of Florida. Visitors can enjoy exciting events at the Ben Hill Griffin Stadium, making it a vibrant spot for both relaxation and entertainment. With its close proximity of about 5 miles from Melrose, Orange Heights is a smart choice for your getaway.

Stay near popular attractions around Melrose

Escape to Melrose, Florida, where outdoor adventures and stunning scenery await. With charming lakes, serene parks, and romantic spots, this hidden gem is perfect for couples and nature lovers alike. Discover the beauty of the great outdoors and create unforgettable memories in this picturesque destination.

Learn more about Melrose

Nestled along Lake Santa Fe, this charming town offers peaceful kayaking and fishing at Melrose Bay Park. Art lovers can browse local galleries and studios, then enjoy fresh farm-to-table dining at the weekend farmers' market.

A deer standing behind a wire fence in a wooded area with trees and underbrush.

Top Melrose Hotel Reviews

More cheap stays in Melrose

Hotels in Melrose with star-rating

Find out more about Melrose

Top reasons to visit Melrose

  • Outdoor Adventures: Melrose is ideal for exploring beautiful lakes, national and state parks, and urban parks, perfect for nature enthusiasts.
  • Charming Atmosphere: The friendly vibe and inviting main streets make Melrose a great destination for romantic getaways or family fun.
  • Unique Experiences: Don't miss whale watching, which offers a memorable touch to your vacation in this quaint town.
  • Variety of Accommodations: Choose from cozy motels to inviting hotels, catering to diverse vacation needs.
  • Accessible Location: Just a short drive from Gainesville and Palatka, Melrose is conveniently located for easy exploration.

Find great hotels near Melrose

Discover a range of hotel accommodations in Melrose, Florida, perfect for your vacation needs. Whether you're seeking a pet-friendly stay, a comfortable spot for business travel, or an adventure-filled experience, Melrose offers a variety of options. From cozy motels to inviting hotels, you'll find the perfect room to make your visit enjoyable and memorable.

  • Hotel Eleo at the University of Florida: A 3.5-star hotel with an impressive guest rating of 9.4, Hotel Eleo at the University of Florida is a charming retreat located 18 miles from Melrose. This property stands out for its pet-friendly atmosphere, making it an excellent choice for travelers who wish to bring their furry companions along. With a variety of pet amenities, including a fee-waived service animal policy, guests can feel at home while enjoying the university's vibrant surroundings. The hotel offers a stylish blend of modern comfort and Southern hospitality, creating an inviting space for both relaxation and exploration.
  • Hyatt Place Gainesville Downtown: A 3-star hotel with a notable guest rating of 9.2, Hyatt Place Gainesville Downtown is situated 17 miles from Melrose and caters to families and business travelers alike. This property features a unique hot spring theme, with nearby access to natural hot springs for a rejuvenating experience. Amenities for children, such as free cribs and pool toys, ensure that families can enjoy their stay without compromising comfort. The hotel's modern design and welcoming atmosphere make it an ideal base for exploring the vibrant downtown area while enjoying quality time with loved ones.
  • Hampton Inn & Suites Gainesville-Downtown: A budget-friendly option with a guest rating of 8.6, Hampton Inn & Suites Gainesville-Downtown is located 17 miles from Melrose. This hotel is perfect for travelers seeking a pet-friendly environment while balancing business and leisure. It has a pet policy that accommodates various sizes, with fees waived for service animals. Guests will appreciate the comfortable rooms, complimentary breakfast, and convenient access to downtown, making it a practical choice for those looking to stay connected while enjoying the local attractions.

Where to stay in and around Melrose

Melrose, Florida, offers a charming escape with its friendly atmosphere and outdoor allure, perfect for romantic getaways or family adventures. Just a short drive from nearby cities like Gainesville and Palatka, you'll find local amenities and inviting main streets to explore. Enjoy scenic views and summer staycations that highlight the beauty of this hidden gem, making it an ideal destination for relaxation and discovery.

  • Earleton: Nestled just 3 miles from Melrose, Earleton is a charming city that offers a delightful outdoor experience, making it a popular choice for those seeking scenic views and romantic getaways. Visitors can explore its beautiful recreational areas, indulge in adventure activities, and even dive into underwater sports. The proximity to stunning lakes, rivers, and a national state park enhances its appeal, providing ample opportunities for nature lovers to immerse themselves in the great outdoors. The best time to visit is during the peak months of March, August, and November, when the weather is ideal for outdoor adventures.
  • Grandin: Located close to Melrose, Grandin is a quaint village known for its picturesque scenery and romantic atmosphere. Travelers flock here for its serene charm, with the local lakes serving as perfect spots for relaxation and reflection. The village provides a peaceful escape from the hustle and bustle, making it an ideal destination for couples and outdoor enthusiasts alike. Similar to Earleton, Grandin experiences peak visitor numbers in March, August, and November, making these months perfect for a visit to enjoy its natural beauty.
  • Keystone Heights: A mere 5 miles from Melrose, Keystone Heights is a unique city characterized by its island-like features. This vibrant locale is a haven for outdoor enthusiasts, offering various recreational areas and adventure activities, including underwater sports. Visitors are drawn to its breathtaking lakes, rivers, and the nearby national state park, which provide stunning backdrops for exploration and relaxation. Keystone Heights sees peak travel seasons in February to March and December, making it an excellent choice for tourists looking to connect with nature and enjoy a romantic getaway.

Things to do near Melrose

Melrose, Florida, is perfect for outdoor adventures and romantic getaways. Visitors can enjoy a range of activities, including exploring the beautiful recreational areas, indulging in educational experiences, and hitting the golf courses. While shopping opportunities abound, don't miss the chance for unique experiences like whale watching, which adds a memorable touch to your vacation in this charming town.

Shopping

In Melrose, enjoy local shops offering unique gifts and souvenirs. If you're up for a drive, visit the Gainesville Mall, about 15 miles away, which features a variety of national retailers and dining options for a more extensive shopping experience.

Recreation

Haile Plantation Golf and Country Club offers a luxurious golfing experience just 25 miles from Melrose, featuring pristine greens and upscale amenities. Similarly, Magnolia Point Golf and Country Club, located 29 miles away, provides an elegant atmosphere perfect for relaxation and recreation amidst beautiful landscapes.

Adventure

Explore the serene waters of Lake Santa Fe for kayaking and fishing, or hike the scenic trails at the nearby San Felasco Hammock Preserve State Park for a chance to spot local wildlife. For a thrilling experience, try horseback riding at local stables for a fun adventure.

Nightlife

Explore the vibrant nightlife in Melrose by visiting The Melrose Community Center for local events and gatherings. For a laid-back evening, check out the Melrose Pub, where you can enjoy a cold drink and mingle with friendly locals in a cozy atmosphere.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Melrose

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Melrose are July and December to January, where the prices are slightly lower. This is in comparison to May and September to October, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Melrose is Tuesday. The most expensive day to stay in Melrose is Saturday.
  • Find cheap hotels on Expedia: Utilize Expedia’s search tool to customize your travel preferences, such as your budget, desired location, and preferred hotel type. For instance, selecting the Eco-certified option will showcase sustainable and environmentally friendly hotels currently available. To find the best prices and deals, simply sort the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your hotel stay in Melrose with your flights and activities through an Expedia package deal.

Find the best attractions near Melrose

Melrose, Florida, is perfect for outdoor enthusiasts and romantic getaways, offering stunning scenery and a variety of attractions. Visitors can explore beautiful lakes, venture into nearby national and state parks, or relax in urban parks. For those seeking a beach experience or vibrant outdoor activities, Melrose provides a delightful escape into nature, making it an ideal destination for travelers looking to enjoy the great outdoors.

  • Santa Fe Lake: Located 3 miles from Melrose, Santa Fe Lake offers a serene escape with its picturesque scenery and sandy beach vibes. It's perfect for a romantic day or a family outing, providing opportunities for swimming, picnicking, and enjoying nature's beauty.
  • Gold Head Branch State Park: Situated 11 miles away, this state park is a haven for adventure lovers. Explore its scenic trails, discover diverse wildlife, and enjoy outdoor activities like hiking, biking, and camping amidst lush landscapes.
  • Lake Como United Methodist Church: About 15 miles from Melrose, this church invites visitors to experience its rich cultural heritage. Attend a service or enjoy the community events that highlight the local traditions and values.

Best time to go to Melrose

The best time to visit Melrose is dependent on what kind of holiday you are seeking. July and August are its hottest month on average. At the time of August, visitor numbers are average and weather is mostly sunny. January is its coolest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January55.8°F (13.2°C)Light RainMostly SunnyAverageSlightly Low
February60.1°F (15.6°C)Light RainMostly SunnyAverageAverage
March64.2°F (17.9°C)Light RainMostly SunnyAverageAverage
April70.2°F (21.2°C)Light RainMostly SunnySlightly HighAverage
May75.6°F (24.2°C)Light RainMostly SunnyAverageSlightly High
June80.1°F (26.7°C)Light RainMostly SunnyAverageAverage
July81.5°F (27.5°C)Light RainMostly SunnySlightly HighSlightly Low
August81.5°F (27.5°C)Light RainMostly SunnyAverageAverage
September78.6°F (25.9°C)Light RainMostly SunnySlightly HighSlightly High
October72.0°F (22.2°C)Light RainMostly SunnySlightly LowSlightly High
November63.9°F (17.7°C)Light RainMostly SunnySlightly LowAverage
December59.9°F (15.5°C)Light RainMostly SunnySlightly LowSlightly Low

The nearest major airports for your trip to Melrose

Traveling to Melrose, Florida, is convenient with three major airports nearby. Jacksonville International Airport (JAX) is 58 miles away, with hotels like the DoubleTree by Hilton Hotel Jacksonville Airport, just 0.3 miles from the airport, and the Hyatt Regency Jacksonville, located 12 miles away. Daytona Beach International Airport (DAB), situated 70 miles from Melrose, offers nearby accommodations such as The Shores Resort & Spa and Daytona Grande Oceanfront Resort, both 4 miles away. Gainesville Regional Airport (GNV) is the closest at 14 miles, featuring hotels like DoubleTree by Hilton Gainesville, 8 miles away, and Hotel Eleo at the University of Florida, just 5 miles from the airport.

Frequently asked questions

What is the best area to stay in Melrose?
The best area to stay in Melrose is directly within the town center, particularly around the intersection of SR 21 and SR 26, as this is where you'll find the most convenient access to local amenities and the lake.

Melrose itself is a small, quiet town centered around Melrose Bay on Lake Santa Fe, one of Florida's largest and cleanest lakes. The main activity revolves around the lake, with opportunities for boating, fishing, and enjoying the water. The town center offers a few local eateries and shops, providing a pleasant base for a relaxed stay.

Couples looking for a tranquil getaway will find Melrose an excellent fit. The area provides a peaceful setting away from city noise, superb for enjoying nature and quality time together.
When is the best time to go to Melrose?
The best time to visit Melrose, Florida, is during the spring (March to May) and fall (September to November) when the weather is most pleasant.

During these seasons, you'll experience mild temperatures and lower humidity, making it ideal for enjoying outdoor activities like exploring the local lakes and nature trails. The spring brings blooming wildflowers, while the fall offers comfortable conditions for fishing, kayaking, or simply relaxing by the water.

Melrose is particularly appealing to those looking for a laid-back getaway, away from more crowded tourist destinations.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Melrose.
How much is the nightly rate at a Melrose hotel?
Prices for hotels in Melrose often vary, but you can find a great deal from $66 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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