Title: $254 Cheap flights from Ithaca to Des Moines (ITH to DSM) - Expedia.com ![Iowa State Capitol](https://images.trvl-media.com/place/601690/d6e0e2f2-7876-4d18-865a-ae2f68f4627c.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/601690/d6e0e2f2-7876-4d18-865a-ae2f68f4627c.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # $254 Cheap Flights from Ithaca (ITH) to Des Moines (DSM) [View $254 flight on Tue, Apr 14, 2026](https://expedia.com/Flights-Search?trip=oneway&leg1=from:ITH,to:DSM,departure:4/14/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:253.50&airProductToken=AQqlAQo1CMSYARIENTI2NRjoPCCpUSjwp4oDMMKoigM4RUAAWAFqCU1BSU5CQVNJQ3IIVUFWTkEwQlEKNQjEmAESBDIyMjcYqVEg4FwokKmKAzCzqooDOEVAAVgBaglNQUlOQkFTSUNyCFVBVk5BMEJRCjUIxJgBEgQyMDg2GOBcIMNkKK6rigMwr6yKAzhFQAFYAWoJTUFJTkJBU0lDcghVQVZOQTBCURIKCAEQARgBKgJETBgBIgQIARABKAIoAygEMAE) - [Roundtrip](?flightType=roundtrip) - [One-way](?flightType=oneway) - [Multi-city](?flightType=multicity) ### Travelers Adults ChildrenAges 2 to 17 InfantsYounger than 2 EconomyPremium economyBusiness classFirst class Leaving from Going to Departing Returning Add a place to stay Add a car Direct flights only ## Popular airlines from Ithaca, NY (ITH-Tompkins Regional) to Des Moines International Airport (DSM) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_DL.svg) Delta [](https://www.expedia.com/Flights-Search?leg1=from:ITH,to:DSM,departure:2/20/2026TANYT&leg2=from:DSM,to:ITH,departure:2/27/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"DL"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_UA.svg) United [](https://www.expedia.com/Flights-Search?leg1=from:ITH,to:DSM,departure:2/20/2026TANYT&leg2=from:DSM,to:ITH,departure:2/27/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"UA"}}]) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 30% on select hotels after you book a flight\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our OneKeyCash [Learn about One Key](https://www.expedia.com/welcome-one-key) ## Cheap Flights from Ithaca to Des Moines (ITH-DSM) Prices were available within the past 7 days and start at $254 for one-way flights and $279 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Roundtrip ![Delta](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/DL.gif) Wed, Apr 15 - Tue, May 5 ITH Ithaca DSM Des Moines $279 Roundtrip found 23 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ITH,to:DSM,departure:4/15/2026TANYT&leg2=from:DSM,to:ITH,departure:5/5/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:279.00&airProductToken=AQpmCiAIxJgBEgQ1MjY1GOg8IKlRKJCzigMw4rOKAzhFQABYAQogCMSYARIEMjIyNxipUSDgXCiwtIoDMNO1igM4RUABWAEKIAjEmAESBDIwODYY4Fwgw2QozraKAzDPt4oDOEVAAVgBCmYKIAjEmAESBDE3MDQYw2Qg4Fwo05eMAzDPmIwDOEVAAFgBCiAIxJgBEgQyMzc4GOBcIKlRKISajAMwnZuMAzhFQAFYAQogCMSYARIENTM5NBipUSDoPCj9m4wDMOKcjAM4RUABWAESCggBEAEYASoCREwYASIECAEQASgEMAE) ![United](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/UA.gif) Tue, Apr 14 - Sat, Apr 18 ITH Ithaca DSM Des Moines $310 Roundtrip found 2 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ITH,to:DSM,departure:4/14/2026TANYT&leg2=from:DSM,to:ITH,departure:4/18/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:310.00&airProductToken=AQqoAQo2CNWCARIENDkzORjoPCCIGCiYqIoDMOqoigM4TkAAWAFqCjFfYmFzaWNlY29yCEtGQTJBREJOCjYI1YIBEgQxNzc1GIgYIK4cKKSpigMwrqqKAzhOQABYAWoKMV9iYXNpY2Vjb3IIS0ZBMkFEQk4KNgjVggESBDM0NzgYrhwgw2Qo-KqKAzDZq4oDOE5AAFgBagoxX2Jhc2ljZWNvcghLRkEyQURCTgqoAQo2CNWCARIENDM5NRjDZCCuHCiZ2IoDMPfYigM4TkAAWAFqCjFfYmFzaWNlY29yCExGSzVQRkJOCjYI1YIBEgQyNDM3GK4cIIgYKMDaigMwu9uKAzhOQABYAWoKMV9iYXNpY2Vjb3IITEZLNVBGQk4KNgjVggESBDQ5NTAYiBgg6Dwo_9yKAzDP3YoDOE5AAFgBagoxX2Jhc2ljZWNvcghMRks1UEZCThIKCAEQARgBKgJVQRgBIgQIARABKAIoAygEMAs) ![Delta](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/DL.gif) Tue, Mar 10 - Tue, Mar 31 ITH Ithaca DSM Des Moines $314 Roundtrip found 23 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ITH,to:DSM,departure:3/10/2026TANYT&leg2=from:DSM,to:ITH,departure:3/31/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:314.00&airProductToken=AQpoCiAIxJgBEgQ1MzE1GOg8IKlRKP2hhwMw06KHAzhFQABYAQohCMSYARIEMjQ0MxipUSDjtAEon6OHAzCipIcDOEVAAVgBCiEIxJgBEgQ1MDg3GOO0ASDDZCj2pIcDMOmlhwM4RUABWAEKZgogCMSYARIEMTcwNBjDZCDgXCjhjYkDMNuOiQM4RUAAWAEKIAjEmAESBDIzOTgY4FwgqVEo4Y-JAzD4kIkDOEVAAVgBCiAIxJgBEgQ1Mzk0GKlRIOg8KLmSiQMwj5OJAzhFQAFYARIKCAEQARgBKgJETBgBIgQIARABKAQwAQ) ![Delta](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/DL.gif) Tue, Feb 10 - Tue, Mar 3 ITH Ithaca DSM Des Moines $329 Roundtrip found 23 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ITH,to:DSM,departure:2/10/2026TANYT&leg2=from:DSM,to:ITH,departure:3/3/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:329.00&airProductToken=AQpmCiAIxJgBEgQ1MjY1GOg8IKlRKNXjhAMwsOSEAzhFQABYAQogCMSYARIEMjIyNxipUSDgXCiK5YQDMLDmhAM4RUABWAEKIAjEmAESBDIwODYY4Fwgw2Qon-iEAzCk6YQDOEVAAVgBCmgKIQjEmAESBDU0MTQYw2Qg47QBKOPQhgMw09GGAzhFQABYAQohCMSYARIENTI4OBjjtAEgqVEohNKGAzD90oYDOEVAAVgBCiAIxJgBEgQ1MzE1GKlRIOg8KMPThgMwi9SGAzhFQAFYARIKCAEQARgBKgJETBgBIgQIARABKAQwAQ) ![Delta](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/DL.gif) Sat, Feb 7 - Tue, Feb 24 ITH Ithaca DSM Des Moines $334 Roundtrip found 23 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ITH,to:DSM,departure:2/7/2026TANYT&leg2=from:DSM,to:ITH,departure:2/24/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:334.00&airProductToken=AQpmCiAIxJgBEgQ1MzE1GOg8IKlRKJjGhAMw9caEAzhFQABYAQogCMSYARIEMjI5MxipUSDgXCiZx4QDMLvIhAM4RUABWAEKIAjEmAESBDIzMDYY4Fwgw2Qop8mEAzCtyoQDOEVAAVgBCmgKIQjEmAESBDU0MTQYw2Qg47QBKIOChgMw84KGAzhFQABYAQohCMSYARIENTI4OBjjtAEgqVEopIOGAzCdhIYDOEVAAVgBCiAIxJgBEgQ1MzE1GKlRIOg8KOOEhgMwq4WGAzhFQAFYARIKCAEQARgBKgJETBgBIgQIARABKAQwAQ) ![United](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/UA.gif) Tue, Mar 24 - Sat, Mar 28 ITH Ithaca DSM Des Moines $342 Roundtrip found 3 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ITH,to:DSM,departure:3/24/2026TANYT&leg2=from:DSM,to:ITH,departure:3/28/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:341.01&airProductToken=AQqoAQo2CNWCARIENDkzORjoPCCIGCj4u4gDMNW8iAM4TkAAWAFqCjFfYmFzaWNlY29yCExGSzVQRkJOCjYI1YIBEgQxNzc1GIgYIK4cKJC9iAMwmr6IAzhOQABYAWoKMV9iYXNpY2Vjb3IITEZLNVBGQk4KNgjVggESBDU1NTIYrhwgw2Qokr-IAzDvv4gDOE5AAFgBagoxX2Jhc2ljZWNvcghMRks1UEZCTgqoAQo2CNWCARIENTcxNRjDZCCuHCiY7YgDMPntiAM4TkAAWAFqCjFfYmFzaWNlY29yCExGSzVQRkJOCjYI1YIBEgQyMjEzGK4cIIgYKPXuiAMw5e-IAzhOQABYAWoKMV9iYXNpY2Vjb3IITEZLNVBGQk4KNgjVggESBDQ5NTAYiBgg6Dwo1vCIAzCe8YgDOE5AAFgBagoxX2Jhc2ljZWNvcghMRks1UEZCThIKCAEQARgBKgJVQRgBIgQIARABKAIoAygEMAs) ![United](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/UA.gif) Tue, Apr 14 - Mon, Apr 27 ITH Ithaca DSM Des Moines $349 Roundtrip found 23 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ITH,to:DSM,departure:4/14/2026TANYT&leg2=from:DSM,to:ITH,departure:4/27/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:349.00&airProductToken=AQpmCiAI1YIBEgQ0OTM5GOg8IIgYKJioigMw6qiKAzhLQABYAQogCNWCARIEMTc3NRiIGCCuHCikqYoDMK6qigM4S0ABWAEKIAjVggESBDM0NzgYrhwgw2Qo-KqKAzDZq4oDOEtAAVgBCmUKHwjVggESAzMxMhjDZCCuHCilv4sDMIHAiwM4S0AAWAEKIAjVggESBDIyMjMYrhwgiBgoxcCLAzDAwYsDOEtAAVgBCiAI1YIBEgQ0OTUwGIgYIOg8KJ_CiwMw78KLAzhLQAFYARIKCAEQARgBKgJVQRgBIgQIARABKAQwAQ) ![United](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/UA.gif) Wed, Feb 18 - Tue, Mar 10 ITH Ithaca DSM Des Moines $354 Roundtrip found 23 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ITH,to:DSM,departure:2/18/2026TANYT&leg2=from:DSM,to:ITH,departure:3/10/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:354.00&airProductToken=AQpmCiAI1YIBEgQ0OTM5GOg8IIgYKPS9hQMw0b6FAzhLQABYAQogCNWCARIEMTc3NRiIGCCuHCj7voUDMIbAhQM4S0ABWAEKIAjVggESBDE4MzAYrhwgw2Qo1MGFAzCrwoUDOEtAAVgBCmUKHwjVggESAzMxMhjDZCCuHCiso4cDMIykhwM4S0AAWAEKIAjVggESBDIyMTMYrhwgiBgotaSHAzClpYcDOEtAAVgBCiAI1YIBEgQ0OTUwGIgYIOg8KJamhwMw3qaHAzhLQAFYARIKCAEQARgBKgJVQRgBIgQIARABKAQwAQ) ![Delta](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/DL.gif) Sat, Feb 7 - Wed, Feb 25 ITH Ithaca DSM Des Moines $364 Roundtrip found 23 hours ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ITH,to:DSM,departure:2/7/2026TANYT&leg2=from:DSM,to:ITH,departure:2/25/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:364.00&airProductToken=AQpmCiAIxJgBEgQ1MzE1GOg8IKlRKJjGhAMw9caEAzhFQABYAQogCMSYARIEMjI5MxipUSDgXCiZx4QDMLvIhAM4RUABWAEKIAjEmAESBDIzMDYY4Fwgw2Qop8mEAzCtyoQDOEVAAVgBCmgKIQjEmAESBDU0MTQYw2Qg47QBKKONhgMwk46GAzhFQABYAQohCMSYARIENTI4OBjjtAEgqVEoxI6GAzC9j4YDOEVAAVgBCiAIxJgBEgQ1MzE1GKlRIOg8KIOQhgMwy5CGAzhFQAFYARIKCAEQARgBKgJETBgBIgQIARABKAQwAQ) ![United](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/UA.gif) Tue, Apr 14 - Sat, Apr 18 ITH Ithaca DSM Des Moines $367 Roundtrip found 2 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:ITH,to:DSM,departure:4/14/2026TANYT&leg2=from:DSM,to:ITH,departure:4/18/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:366.28&airProductToken=AQqoAQo2CNWCARIENDkzORjoPCCIGCiYqIoDMOqoigM4TkAAWAFqCjFfYmFzaWNlY29yCEtGQTJBREJOCjYI1YIBEgQxNzc1GIgYIK4cKKSpigMwrqqKAzhOQABYAWoKMV9iYXNpY2Vjb3IIS0ZBMkFEQk4KNgjVggESBDM0NzgYrhwgw2Qo-KqKAzDZq4oDOE5AAFgBagoxX2Jhc2ljZWNvcghLRkEyQURCTgqnAQo2CNWCARIEMjY2OBjDZCCuHCjQ1ooDMKzXigM4TkAAWAFqCjFfYmFzaWNlY29yCFRGQTJBRkJOCjUI1YIBEgMyOTMYrhwgiBgo-NiKAzDz2YoDOE5AAFgBagoxX2Jhc2ljZWNvcghURkEyQUZCTgo2CNWCARIENDk0NRiIGCDoPCjF2ooDMJnbigM4TkAAWAFqCjFfYmFzaWNlY29yCFRGQTJBRkJOEgoIARABGAEqAlVBGAEiBAgBEAEoAigDKAQwCw) ## Alternative airports near Des Moines Prices were available within the past 7 days. Prices and availability are subject to change. [](https://www.expedia.com/Flights-Search?leg1=from:ITH,to:DSM,departure:2/20/2026TANYT&leg2=from:DSM,to:ITH,departure:3/9/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&sortOrder=INCREASING&sortType=PRICE) DSM Des Moines Intl. CheapestClosest 10 min [Flights from $477 ](https://www.expedia.com/Flights-Search?leg1=from:ITH,to:DSM,departure:2/20/2026TANYT&leg2=from:DSM,to:ITH,departure:3/9/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&sortOrder=INCREASING&sortType=PRICE) __Flights from Ithaca (ITH) to Des Moines (DSM)__ | Origin airport | Tompkins Regional | | ------------------- | ----------------- | | Destination airport | Des Moines Intl. | | Airlines serving | Delta, United | | Roundtrip price | $279 | | Distance | 883 mi | ## Ithaca to Des Moines Flights The cheapest times to fly from Ithaca to Des Moines On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Ithaca to Des Moines are during the month of April. You can find some of the cheapest flights from Ithaca to Des Moines with Expedia's search tool and vast selection of airlines. The best time to book a flight from Ithaca to Des Moines Sunday is one of the best days to book for cheap flights from Ithaca to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance. How to find cheap round-trip tickets from Ithaca to Des Moines Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Ithaca to Des Moines in 2026\. You can also book with separate airlines for your outbound and return journeys, from $254 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference\*. This is available for a small fee, and is free to One Key Gold and Platinum tier members. Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Ithaca to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps. You could also save big by booking one of Expedia's [vacation packages](https://www.expedia.com/package-deals). Bundling together your Ithaca to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures. \*Terms apply. Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023\. The percentages you see are averages. ## Frequently asked questions ### How much does a flight from Tompkins Regional Airport (ITH) to Des Moines Intl. Airport (DSM) cost? ### What is the cheapest month to fly from Tompkins Regional Airport (ITH) to Des Moines Intl. Airport (DSM)? ### What is the cheapest airline that flies from Tompkins Regional Airport (ITH) to Des Moines Intl. Airport (DSM)? ### How many flights per day from Tompkins Regional Airport (ITH) to Des Moines Intl. Airport (DSM)? ### What day of the week has the most flights from ITH to DSM? ### What is the best time to fly from Tompkins Regional Airport (ITH) to Des Moines Intl. Airport (DSM)? ### Is it cheaper to buy a plane ticket from Tompkins Regional Airport (ITH) to Des Moines Intl. Airport (DSM) last-minute? ### Is it cheaper to book an ITH to DSM flight and hotel package? ### Can I cancel or change the date of my flight from Tompkins Regional Airport (ITH) to Des Moines Intl. 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