Cheap Flights from Tupelo (TUP) to Des Moines (DSM)

Popular airlines from Tupelo, MS (TUP-Tupelo Regional) to Des Moines International Airport (DSM)

Cheap Flights from Tupelo to Des Moines (TUP-DSM)

Prices were available within the past 7 days and start at for one-way flights and $365 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Contour Airlines
Wed, Dec 31 - Sun, Jan 18
TUP
Tupelo
DSM
Des Moines
$365 Roundtrip, found 5 days ago
$365
Roundtrip
found 5 days ago
Select Contour Airlines flight, departing Wed, Dec 31 from Tupelo to Des Moines, returning Sun, Jan 18, priced at $365 found 5 days ago
Contour Airlines
Wed, Dec 31 - Sat, Jan 17
TUP
Tupelo
DSM
Des Moines
$374 Roundtrip, found 4 days ago
$374
Roundtrip
found 4 days ago
Select Contour Airlines flight, departing Wed, Dec 31 from Tupelo to Des Moines, returning Sat, Jan 17, priced at $374 found 4 days ago
Contour Airlines
Tue, Dec 30 - Sat, Jan 17
TUP
Tupelo
DSM
Des Moines
$383 Roundtrip, found 4 days ago
$383
Roundtrip
found 4 days ago
Select Contour Airlines flight, departing Tue, Dec 30 from Tupelo to Des Moines, returning Sat, Jan 17, priced at $383 found 4 days ago
Contour Airlines
Mon, Dec 8 - Fri, Dec 12
TUP
Tupelo
DSM
Des Moines
$393 Roundtrip, found 5 days ago
$393
Roundtrip
found 5 days ago
Select Contour Airlines flight, departing Mon, Dec 8 from Tupelo to Des Moines, returning Fri, Dec 12, priced at $393 found 5 days ago
Contour Airlines
Wed, Dec 31 - Thu, Jan 15
TUP
Tupelo
DSM
Des Moines
$408 Roundtrip, found 4 days ago
$408
Roundtrip
found 4 days ago
Select Contour Airlines flight, departing Wed, Dec 31 from Tupelo to Des Moines, returning Thu, Jan 15, priced at $408 found 4 days ago
Contour Airlines
Tue, Dec 30 - Thu, Jan 15
TUP
Tupelo
DSM
Des Moines
$417 Roundtrip, found 4 days ago
$417
Roundtrip
found 4 days ago
Select Contour Airlines flight, departing Tue, Dec 30 from Tupelo to Des Moines, returning Thu, Jan 15, priced at $417 found 4 days ago
Contour Airlines
Sat, Jan 17 - Sat, Jan 31
TUP
Tupelo
DSM
Des Moines
$426 Roundtrip, found 5 days ago
$426
Roundtrip
found 5 days ago
Select Contour Airlines flight, departing Sat, Jan 17 from Tupelo to Des Moines, returning Sat, Jan 31, priced at $426 found 5 days ago
Contour Airlines
Sat, Dec 6 - Wed, Dec 24
TUP
Tupelo
DSM
Des Moines
$427 Roundtrip, found 4 days ago
$427
Roundtrip
found 4 days ago
Select Contour Airlines flight, departing Sat, Dec 6 from Tupelo to Des Moines, returning Wed, Dec 24, priced at $427 found 4 days ago
Contour Airlines
Sat, Dec 13 - Wed, Dec 24
TUP
Tupelo
DSM
Des Moines
$432 Roundtrip, found 5 days ago
$432
Roundtrip
found 5 days ago
Select Contour Airlines flight, departing Sat, Dec 13 from Tupelo to Des Moines, returning Wed, Dec 24, priced at $432 found 5 days ago
Contour Airlines
Mon, Dec 8 - Fri, Dec 12
TUP
Tupelo
DSM
Des Moines
$435 Roundtrip, found 5 days ago
$435
Roundtrip
found 5 days ago
Select Contour Airlines flight, departing Mon, Dec 8 from Tupelo to Des Moines, returning Fri, Dec 12, priced at $435 found 5 days ago
Contour Airlines
Mon, Dec 8 - Fri, Dec 12
TUP
Tupelo
DSM
Des Moines
$436 Roundtrip, found 5 days ago
$436
Roundtrip
found 5 days ago
Select Contour Airlines flight, departing Mon, Dec 8 from Tupelo to Des Moines, returning Fri, Dec 12, priced at $436 found 5 days ago
Contour Airlines
Tue, Jan 27 - Sat, Feb 14
TUP
Tupelo
DSM
Des Moines
$437 Roundtrip, found 5 days ago
$437
Roundtrip
found 5 days ago
Select Contour Airlines flight, departing Tue, Jan 27 from Tupelo to Des Moines, returning Sat, Feb 14, priced at $437 found 5 days ago
Contour Airlines
Sun, Nov 23 - Mon, Dec 8
TUP
Tupelo
DSM
Des Moines
$443 Roundtrip, found 4 days ago
$443
Roundtrip
found 4 days ago
Select Contour Airlines flight, departing Sun, Nov 23 from Tupelo to Des Moines, returning Mon, Dec 8, priced at $443 found 4 days ago
Contour Airlines
Thu, Jan 29 - Sat, Feb 14
TUP
Tupelo
DSM
Des Moines
$446 Roundtrip, found 5 days ago
$446
Roundtrip
found 5 days ago
Select Contour Airlines flight, departing Thu, Jan 29 from Tupelo to Des Moines, returning Sat, Feb 14, priced at $446 found 5 days ago
Contour Airlines
Wed, Dec 3 - Mon, Dec 15
TUP
Tupelo
DSM
Des Moines
$451 Roundtrip, found 4 days ago
$451
Roundtrip
found 4 days ago
Select Contour Airlines flight, departing Wed, Dec 3 from Tupelo to Des Moines, returning Mon, Dec 15, priced at $451 found 4 days ago
Contour Airlines
Sun, Nov 23 - Sat, Dec 13
TUP
Tupelo
DSM
Des Moines
$452 Roundtrip, found 4 days ago
$452
Roundtrip
found 4 days ago
Select Contour Airlines flight, departing Sun, Nov 23 from Tupelo to Des Moines, returning Sat, Dec 13, priced at $452 found 4 days ago
Contour Airlines
Tue, Dec 2 - Mon, Dec 15
TUP
Tupelo
DSM
Des Moines
$460 Roundtrip, found 4 days ago
$460
Roundtrip
found 4 days ago
Select Contour Airlines flight, departing Tue, Dec 2 from Tupelo to Des Moines, returning Mon, Dec 15, priced at $460 found 4 days ago
Contour Airlines
Sun, Jan 4 - Sat, Jan 17
TUP
Tupelo
DSM
Des Moines
$461 Roundtrip, found 5 days ago
$461
Roundtrip
found 5 days ago
Select Contour Airlines flight, departing Sun, Jan 4 from Tupelo to Des Moines, returning Sat, Jan 17, priced at $461 found 5 days ago
Contour Airlines
Tue, Dec 16 - Wed, Dec 31
TUP
Tupelo
DSM
Des Moines
$462 Roundtrip, found 4 days ago
$462
Roundtrip
found 4 days ago
Select Contour Airlines flight, departing Tue, Dec 16 from Tupelo to Des Moines, returning Wed, Dec 31, priced at $462 found 4 days ago
Contour Airlines
Sat, Dec 13 - Wed, Dec 31
TUP
Tupelo
DSM
Des Moines
$467 Roundtrip, found 4 days ago
$467
Roundtrip
found 4 days ago
Select Contour Airlines flight, departing Sat, Dec 13 from Tupelo to Des Moines, returning Wed, Dec 31, priced at $467 found 4 days ago

Alternative airports near Des Moines

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Des Moines Intl. DSM. Cheapest and Closest option available. Average driving time to city center is 10 minutes. Flights from $525
DSM
Des Moines Intl.
CheapestClosest
Average driving time to city center10 min
Flights from $525

Frequently asked questions

How much does a flight from Tupelo Regional Airport (TUP) to Des Moines Intl. Airport (DSM) cost?
Secure a cheap one-way flight or cheap return flight from $365 from Tupelo Regional Airport (TUP) to Des Moines Intl. Airport (DSM) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Tupelo Regional Airport (TUP) to Des Moines Intl. Airport (DSM)?
The cheapest month to fly from TUP to DSM is December, when demand is low. Off-peak months are usually when you'll find lower airfares between these airports.
What is the cheapest airline that flies from Tupelo Regional Airport (TUP) to Des Moines Intl. Airport (DSM)?
Expedia's filter tool lets you easily compare different airlines, flight durations and fares all in one place. Choose your preferences, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest TUP to DSM flight.
How many flights per day from Tupelo Regional Airport (TUP) to Des Moines Intl. Airport (DSM)?
There are no daily nonstop flights available from Tupelo Regional Airport (TUP) to Des Moines Intl. Airport (DSM). But you can book flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be cruising above the clouds in no time.
What day of the week has the most flights from TUP to DSM?
Generally you'll find the greatest selection of flight options on a Friday. Tuesdays tend to be the quietest.* But this can vary depending on the airline, season and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Tupelo Regional Airport (TUP) to Des Moines Intl. Airport (DSM)?
To avoid potential delays on the Tupelo Regional Airport (TUP) to Des Moines Intl. Airport (DSM) route, travel before 3 PM. Later departures are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Tupelo Regional Airport (TUP) to Des Moines Intl. Airport (DSM) last-minute?
Holding off until right before your break to book a flight from TUP to DSM often results in higher prices. While it's possible to find some last-minute deals, there's no guarantee. Allow some flexibility in your schedule to boost your chances of scoring a bargain.
Is it cheaper to book a TUP to DSM flight and hotel package?
You'll typically save money by securing a TUP to DSM flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's simple to manage it all in one convenient place. Once you've selected your ideal flights and accommodations, consider other add-ons like tours, car rentals and activities.
Can I cancel or change the date of my flight from Tupelo Regional Airport (TUP) to Des Moines Intl. Airport (DSM)?
In most instances, you're able to cancel or reschedule your TUP to DSM flight. However, additional fees may apply, especially if your booking was made over 24 hours ago. Double-check your itinerary for the airline's rules and fees on flight changes, or if you'd like further information, go to our Customer Service portal.

Travel information

Origin airport
Tupelo Regional
Destination airport
Des Moines Intl.
Roundtrip price
$365
Distance
567 mi

Book with confidence

Tupelo to Des Moines Flights

The cheapest times to fly from Tupelo to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Tupelo to Des Moines are during the month of December. You can find some of the cheapest flights from Tupelo to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Tupelo to Des Moines

Sunday is one of the best days to book for cheap flights from Tupelo to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Tupelo to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Tupelo to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Tupelo to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Tupelo to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Tupelo to Des Moines Flights

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*Available to One Key members.