A modern building with a glass dome, surrounded by lush gardens and a clear blue sky with clouds.

$243 Cheap Flights from Melbourne (MLB) to Des Moines (DSM)

View $243 flight on Fri, Oct 30, 2026Opens in a new window

Popular airlines from Melbourne Orlando Intl. Airport (MLB) to Des Moines International Airport (DSM)

  • Be in the know

    Get alerts if flight prices drop or rise*

  • Book smarter

    Save up to 30% on select hotels after you book a flight*

  • Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from Melbourne to Des Moines (MLB-DSM)

Prices were available within the past 7 days and start at $243 for one-way flights and $529 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Thu, Oct 8 - Sun, Oct 11
MLB
Melbourne
DSM
Des Moines
$529 Roundtrip, found 3 days ago
$529
Roundtrip
found 3 days ago
Select Delta flight, departing Thu, Oct 8 from Melbourne to Des Moines, returning Sun, Oct 11, priced at $529 found 3 days ago
Delta
Thu, Oct 8 - Sun, Oct 11
MLB
Melbourne
DSM
Des Moines
$531 Roundtrip, found 3 days ago
$531
Roundtrip
found 3 days ago
Select Delta flight, departing Thu, Oct 8 from Melbourne to Des Moines, returning Sun, Oct 11, priced at $531 found 3 days ago
Delta
Thu, Oct 8 - Sun, Oct 11
MLB
Melbourne
DSM
Des Moines
$574 Roundtrip, found 3 days ago
$574
Roundtrip
found 3 days ago
Select Delta flight, departing Thu, Oct 8 from Melbourne to Des Moines, returning Sun, Oct 11, priced at $574 found 3 days ago
Delta
Thu, Oct 8 - Sun, Oct 11
MLB
Melbourne
DSM
Des Moines
$576 Roundtrip, found 3 days ago
$576
Roundtrip
found 3 days ago
Select Delta flight, departing Thu, Oct 8 from Melbourne to Des Moines, returning Sun, Oct 11, priced at $576 found 3 days ago
American Airlines
Fri, Sep 18 - Mon, Sep 21
MLB
Melbourne
DSM
Des Moines
$577 Roundtrip, found 7 hours ago
$577
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Fri, Sep 18 from Melbourne to Des Moines, returning Mon, Sep 21, priced at $577 found 7 hours ago
Delta
Thu, Oct 8 - Sun, Oct 11
MLB
Melbourne
DSM
Des Moines
$594 Roundtrip, found 3 days ago
$594
Roundtrip
found 3 days ago
Select Delta flight, departing Thu, Oct 8 from Melbourne to Des Moines, returning Sun, Oct 11, priced at $594 found 3 days ago
American Airlines
Thu, Oct 8 - Sun, Oct 11
MLB
Melbourne
DSM
Des Moines
$610 Roundtrip, found 3 days ago
$610
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Oct 8 from Melbourne to Des Moines, returning Sun, Oct 11, priced at $610 found 3 days ago
Delta
Thu, Oct 8 - Sun, Oct 11
MLB
Melbourne
DSM
Des Moines
$619 Roundtrip, found 3 days ago
$619
Roundtrip
found 3 days ago
Select Delta flight, departing Thu, Oct 8 from Melbourne to Des Moines, returning Sun, Oct 11, priced at $619 found 3 days ago
Delta
Thu, Oct 8 - Sun, Oct 11
MLB
Melbourne
DSM
Des Moines
$621 Roundtrip, found 3 days ago
$621
Roundtrip
found 3 days ago
Select Delta flight, departing Thu, Oct 8 from Melbourne to Des Moines, returning Sun, Oct 11, priced at $621 found 3 days ago
Delta
Thu, Oct 8 - Sun, Oct 11
MLB
Melbourne
DSM
Des Moines
$623 Roundtrip, found 3 days ago
$623
Roundtrip
found 3 days ago
Select Delta flight, departing Thu, Oct 8 from Melbourne to Des Moines, returning Sun, Oct 11, priced at $623 found 3 days ago

What you need to know for your flight from Orlando Melbourne Intl. to Des Moines Intl.

Melbourne (MLB) to Des Moines (DSM) at a glance

Travel from Melbourne (MLB) to Des Moines (DSM) with a selection of airlines on this domestic short-haul route. Explore various options for Melbourne to Des Moines flights, comparing full-service carriers to find the best airfares for your budget and schedule. As you plan your visit to Des Moines, known for its notable attractions and vibrant neighborhoods, gather essential information about flights from Orlando Melbourne International Airport (MLB) to Des Moines International Airport (DSM).

  • Fastest flight duration: around 4 hours in-flight, plus roughly 2 hours layover with one stop
  • Route distance: roughly 1,200 miles (1,930 km)
  • Flights per week: around 7 departures on average
  • Typical fares (one-way): economy tickets often range from $165–$480, depending on seasonality and how far ahead you book

Flights from Orlando Melbourne International Airport (MLB) to Des Moines International Airport (DSM)

Based on the latest traveler bookings, here are the top airlines preferred for flights from Melbourne to Des Moines. These options typically include one-stop services, with popular layovers at Hartsfield-Jackson Atlanta International Airport (ATL) for about 1 hour and 45 minutes and Charlotte-Douglas International Airport (CLT) for roughly 2 hours and 15 minutes. This variety allows you to balance price, total travel time, and cabin class to create the perfect itinerary.

  • Delta: As a comprehensive airline, Delta provides one-stop service, representing around 58% of departures on this route. One-way ticket prices generally fall between $165 and $470, with an in-flight duration of 4 hours and a total travel time of approximately 5 hours and 45 minutes, including layover time.
  • American Airlines: This full-service airline offers one-stop flights and comprises about 38% of departures along this route. Typical one-way fares range from $180 to $480, with an in-flight experience of 4 hours and an overall journey lasting roughly 5 hours and 45 minutes, factoring in the layover.

Alternative routes from Melbourne (MLB) to Des Moines (DSM)

  • Fort Pierce to Des Moines (FPR-DSM): Located approximately 45 miles from Orlando Melbourne International Airport (MLB), Saint Lucie County International Airport (FPR) serves as a convenient departure point for this route.
  • Melbourne to Fort Dodge (MLB-FOD): Fort Dodge Regional Airport (FOD), situated around 76 miles from Des Moines International Airport (DSM), offers travelers easy access to the region.

How to find the best prices for flights from Melbourne (MLB) to Des Moines (DSM)

Getting some of the best deals on flights from Melbourne to Des Moines is all about timing and flexibility. Here are some key tips to help you save:

  1. Best times to book and fly: cheaper fares are usually available when booking within two weeks, although most travelers tend to book between two to eight weeks in advance. Morning departures, from 5 a.m. to 12 p.m., generally offer lower prices and are the most popular flight times, while flying on Sunday provides both affordable rates and is the busiest travel day.
  2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
  3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.*
  4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
  5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
  6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at Des Moines International Airport from Orlando Melbourne International Airport

Des Moines welcomes travelers from Melbourne with a range of transport options based on price, convenience, and proximity. Here's how to reach Des Moines efficiently:

  • Hotel transfer: Transfers offer a convenient way to reach your hotel in Des Moines, with private rides that can be arranged in advance.
  • Car rental: Renting a car from Des Moines International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Des Moines International Airport on Expedia.
  • Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.

Frequently asked questions

How much does a flight from Melbourne, FL (MLB-Orlando Melbourne Intl.) to Des Moines, IA (DSM-Des Moines Intl.) cost?
You can find cheap one-way flights from $243 and cheap return flights from $529 Melbourne, FL (MLB-Orlando Melbourne Intl.) to Des Moines, IA (DSM-Des Moines Intl.) with Expedia. One-way flights generally range between $266 and $880, and roundtrip flights usually range from $412 to $1386. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Melbourne, FL (MLB-Orlando Melbourne Intl.) to Des Moines, IA (DSM-Des Moines Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Melbourne, FL (MLB-Orlando Melbourne Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
The cheapest month to fly from MLB to DSM is October when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Melbourne, FL (MLB-Orlando Melbourne Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
Enter MLB to DSM and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Melbourne, FL (MLB-Orlando Melbourne Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
American Airlines is one of the cheapest airlines offering connecting flights from Melbourne, FL (MLB) to Des Moines, IA (DSM) starting from around $368 for a round-trip ticket. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Melbourne, FL (MLB-Orlando Melbourne Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
To find a cheap flight from Melbourne, FL (MLB-Orlando Melbourne Intl.) to Des Moines, IA (DSM-Des Moines Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Melbourne, FL (MLB-Orlando Melbourne Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Melbourne, FL (MLB-Orlando Melbourne Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
The earliest flight from Orlando Melbourne International Airport (MLB) to Des Moines International Airport (DSM) usually leaves at around 5:45 AM. This flight is operated by Delta and is part of a seasonal service active in July, allowing you to start your day early and make the most of your time in Des Moines. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Melbourne, FL (MLB-Orlando Melbourne Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
The most popular departure times for flights from Orlando Melbourne Intl. (MLB) to Des Moines Intl. (DSM) are in the early morning, from 3am to 6am. About 37% of passengers prefer this time window. Delta Airlines and United Airlines provide flights during this period. This timing works well because it allows you to arrive in Des Moines early, giving you a full day ahead.
How long does it take to fly from Melbourne, FL (MLB-Orlando Melbourne Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
Flights from MLB to DSM with one stop typically take around 5 hours, covering approximately 1,183 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Melbourne, FL (MLB-Orlando Melbourne Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
First class seats are offered on the MLB to DSM route with Delta Air Lines and American Airlines.
How do I earn miles on a Melbourne, FL (MLB-Orlando Melbourne Intl.) to Des Moines, IA (DSM-Des Moines Intl.) flight with Expedia?
It's easy to earn miles on a Melbourne, FL (MLB-Orlando Melbourne Intl.) to Des Moines, IA (DSM-Des Moines Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Des Moines from Orlando Melbourne Intl. (MLB)?
If you're planning to travel to Des Moines from Orlando Melbourne Intl. (MLB), you can fly into Des Moines Intl. (DSM) Some flights may connect through major hubs like Hartsfield-Jackson Atlanta Intl. (ATL), Charlotte-Douglas Intl. (CLT) before reaching Des Moines. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Melbourne, FL (MLB-Orlando Melbourne Intl.) to Des Moines, IA (DSM-Des Moines Intl.) at the last minute?
Typically, booking a last minute flight from Melbourne, FL (MLB-Orlando Melbourne Intl.) to Des Moines, IA (DSM-Des Moines Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Melbourne, FL (MLB-Orlando Melbourne Intl.) to Des Moines, IA (DSM-Des Moines Intl.) flight and hotel package?
Securing a Melbourne, FL (MLB-Orlando Melbourne Intl.) to Des Moines, IA (DSM-Des Moines Intl.) Des Moines Vacation Packages is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Melbourne, FL (MLB-Orlando Melbourne Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
If you booked your Melbourne, FL (MLB-Orlando Melbourne Intl.) to Des Moines, IA (DSM-Des Moines Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Orlando Melbourne Intl.
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta
Roundtrip price
$528
Distance
1183 mi

Book with confidence

Melbourne to Des Moines Flights

The cheapest times to fly from Melbourne to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Melbourne to Des Moines are during the month of October. You can find some of the cheapest flights from Melbourne to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Melbourne to Des Moines

Sunday is one of the best days to book for cheap flights from Melbourne to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Melbourne to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Melbourne to Des Moines in 2026. You can also book with separate airlines for your outbound and return journeys, from $243 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Melbourne to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Melbourne to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Melbourne to Des Moines Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

Explore a world of travel with Expedia