$273 Cheap Flights from Monroe (MLU) to Des Moines (DSM)

View $273 flight on Mon, Oct 6, 2025Opens in a new window

Popular airlines from Monroe, LA (MLU-Monroe Regional) to Des Moines International Airport (DSM)

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Cheap Flights from Monroe to Des Moines (MLU-DSM)

Prices were available within the past 7 days and start at $273 for one-way flights and $333 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Jul 29 - Thu, Aug 7
MLU
Monroe
DSM
Des Moines
$333 Roundtrip, found 5 days ago
$333
Roundtrip
found 5 days ago
Select Delta flight, departing Tue, Jul 29 from Monroe to Des Moines, returning Thu, Aug 7, priced at $333 found 5 days ago
Delta
Mon, Aug 4 - Tue, Aug 12
MLU
Monroe
DSM
Des Moines
$358 Roundtrip, found 5 days ago
$358
Roundtrip
found 5 days ago
Select Delta flight, departing Mon, Aug 4 from Monroe to Des Moines, returning Tue, Aug 12, priced at $358 found 5 days ago
Delta
Tue, Jul 22 - Thu, Jul 31
MLU
Monroe
DSM
Des Moines
$388 Roundtrip, found 4 days ago
$388
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Jul 22 from Monroe to Des Moines, returning Thu, Jul 31, priced at $388 found 4 days ago
American Airlines
Fri, Jul 25 - Mon, Jul 28
MLU
Monroe
DSM
Des Moines
$388 Roundtrip, found 4 days ago
$388
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Jul 25 from Monroe to Des Moines, returning Mon, Jul 28, priced at $388 found 4 days ago
American Airlines
Thu, Aug 7 - Sun, Aug 10
MLU
Monroe
DSM
Des Moines
$393 Roundtrip, found 5 days ago
$393
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Aug 7 from Monroe to Des Moines, returning Sun, Aug 10, priced at $393 found 5 days ago
American Airlines
Tue, Jul 29 - Sun, Aug 3
MLU
Monroe
DSM
Des Moines
$398 Roundtrip, found 5 days ago
$398
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Jul 29 from Monroe to Des Moines, returning Sun, Aug 3, priced at $398 found 5 days ago
American Airlines
Fri, Aug 8 - Sat, Aug 9
MLU
Monroe
DSM
Des Moines
$413 Roundtrip, found 5 days ago
$413
Roundtrip
found 5 days ago
Select American Airlines flight, departing Fri, Aug 8 from Monroe to Des Moines, returning Sat, Aug 9, priced at $413 found 5 days ago
American Airlines
Fri, Jul 25 - Wed, Aug 6
MLU
Monroe
DSM
Des Moines
$418 Roundtrip, found 5 days ago
$418
Roundtrip
found 5 days ago
Select American Airlines flight, departing Fri, Jul 25 from Monroe to Des Moines, returning Wed, Aug 6, priced at $418 found 5 days ago
Delta
Wed, Aug 6 - Tue, Aug 12
MLU
Monroe
DSM
Des Moines
$423 Roundtrip, found 5 days ago
$423
Roundtrip
found 5 days ago
Select Delta flight, departing Wed, Aug 6 from Monroe to Des Moines, returning Tue, Aug 12, priced at $423 found 5 days ago
American Airlines
Fri, Jul 25 - Tue, Aug 5
MLU
Monroe
DSM
Des Moines
$428 Roundtrip, found 4 days ago
$428
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Jul 25 from Monroe to Des Moines, returning Tue, Aug 5, priced at $428 found 4 days ago
Flights from Monroe (MLU) to Des Moines (DSM)
Origin airport
Monroe Regional
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta
Roundtrip price
$333
Distance
629 mi

Monroe to Des Moines Flights

The cheapest times to fly from Monroe to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Monroe to Des Moines are during the month of July. You can find some of the cheapest flights from Monroe to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Monroe to Des Moines

Sunday is one of the best days to book for cheap flights from Monroe to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Monroe to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Monroe to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $273 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Monroe to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Monroe to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Monroe Regional Airport (MLU) to Des Moines Intl. Airport (DSM) cost?
Discover the latest flight deals from MLU to DSM by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from MLU to DSM?
The cheapest flights from MLU to DSM are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from MLU to DSM?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from MLU to DSM. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Monroe Regional Airport (MLU) to Des Moines Intl. Airport (DSM)?
There aren't any daily direct flights departing from Monroe Regional Airport (MLU) to Des Moines Intl. Airport (DSM). But you can book flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be cruising above the clouds before you know it.
What day of the week has the most flights from MLU to DSM?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Remember that flight schedules can change depending on various factors, including the airline and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Monroe Regional Airport (MLU) to Des Moines Intl. Airport (DSM)?
To arrive at Des Moines Intl. Airport (DSM) on schedule, choose a flight that leaves from Monroe Regional Airport (MLU) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Monroe Regional Airport (MLU) to Des Moines Intl. Airport (DSM) last-minute?
Booking your plane ticket from MLU to DSM shortly before your trip is usually more expensive. However, if there's some wiggle room with your schedule, you could grab a cheap last-minute fare.
Is it cheaper to book a MLU to DSM flight and hotel package?
Booking a MLU to DSM flight and hotel package is generally cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your trip in one place. Choose from our impressive range of accommodations and then add activities, car rentals and flights to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Monroe Regional Airport (MLU) to Des Moines Intl. Airport (DSM)?
It's usually possible to cancel or reschedule your MLU to DSM flight. However, if it's been more than 24 hours since booking, additional charges may apply. Refer to your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find more details on our Customer Service portal.

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*Available to One Key members.