Florida Keys Spa Vacations

Book a Spa Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Top Spa vacation packages in Florida Keys

Price found within the past 48 hours. Click for updated prices.
Hawks Cay Resort
Cheeca Lodge & Spa
Baker's Cay Resort Key Largo, Curio Collection by Hilton
Southernmost Beach Resort and Guesthouses
Casa Marina Key West, Curio Collection by Hilton
Don't see what you're looking for?
See all available trips from Columbus to Florida Keys
View all trips

5* Spa vacations in Florida Keys

Price found within the past 48 hours. Click for updated prices.
Cheeca Lodge & Spa
Don't see what you're looking for?
See all available trips from Columbus to Florida Keys
View all trips

3 Night Spa vacations in Florida Keys

Price found within the past 48 hours. Click for updated prices.
Hawks Cay Resort
Cheeca Lodge & Spa
Baker's Cay Resort Key Largo, Curio Collection by Hilton
Don't see what you're looking for?
See all available trips from Columbus to Florida Keys
View all trips

4 Night Spa vacations in Florida Keys

Price found within the past 48 hours. Click for updated prices.
Hawks Cay Resort
Southernmost Beach Resort and Guesthouses
Cheeca Lodge & Spa
Don't see what you're looking for?
See all available trips from Columbus to Florida Keys
View all trips

Top Spa Florida Keys Hotels

Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street Key West FL
  • 11 min walk from Duval Street
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.6/10 Excellent! (3,047 reviews)

Travelers like: full-service spa, massage, facials, couples spa treatments

Travelers say...
Always our favorite spot. Staff is wonderful. Can’t beat the views and amenities.

Reviewed on Feb 1, 2026

Southernmost Beach Resort and Guesthouses
Parrot Key Hotel & Villas

Parrot Key Hotel & Villas

4 out of 5
2801 N Roosevelt Blvd Key West FL
  • 5 min drive from Duval Street
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 4 outdoor pools, and breakfast (surcharge). Our guests praise the pool and the bar in our reviews. ...
9/10 Wonderful! (1,261 reviews)
Room was clean, lots of staff.

Reviewed on Feb 2, 2026

Parrot Key Hotel & Villas
Ibis Bay Beach Resort

Ibis Bay Beach Resort

2.5 out of 5
3101 N. Roosevelt Blvd Key West FL
  • 5 min drive from Duval Street
Book a stay at this beach hotel in Key West. Enjoy free breakfast, free WiFi, and a private beach. Our guests praise the breakfast and the pool in our reviews. ...
8/10 Very Good! (2,071 reviews)
Great ppl that work there!

Reviewed on Feb 5, 2026

Ibis Bay Beach Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More vacations you might like

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.