Title: Top Independent in Mesilla, NM from $54 - Expedia.com [Mesilla Travel Guide](https://expedia.com/Mesilla.dx132684)[Hotels in Mesilla](https://expedia.com/Mesilla-Hotels.d132684.Travel-Guide-Hotels)[Vacation Rentals in Mesilla](https://expedia.com/Mesilla-Vacation-Rentals.d132684.Travel-Guide-VacationRentals)[Flights to Mesilla](https://expedia.com/Cheap-Flights-To-Mesilla.d132684.Travel-Guide-Flights)[Car Rentals in Mesilla](https://expedia.com/Car-Rentals-In-Mesilla.d132684.Car-Rental-Guide)[Mesilla Vacation Packages](https://expedia.com/Mesilla.d132684.Destination-Travel-Guides) ![Red chile doorway Mesilla NM](https://images.trvl-media.com/place/132684/621c4b20-e7ee-452c-9495-0ec62a9d9908.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/132684/621c4b20-e7ee-452c-9495-0ec62a9d9908.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Feb 14 - Feb 15](https://www.expedia.com/Hotel-Search?regionId=132684&startDate=2026-02-14&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Feb 15 - Feb 16](https://www.expedia.com/Hotel-Search?regionId=132684&startDate=2026-02-15&endDate=2026-02-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Feb 20 - Feb 22](https://www.expedia.com/Hotel-Search?regionId=132684&startDate=2026-02-20&endDate=2026-02-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Feb 27 - Mar 1](https://www.expedia.com/Hotel-Search?regionId=132684&startDate=2026-02-27&endDate=2026-03-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Mesilla Independent ![Outdoor pool, open 8:00 AM to 10:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/30000/21300/21267/5b5c1a96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21300/21267/0464c626.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/21300/21267/67719f59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/30000/21300/21267/0b5e48d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Encanto de Las Cruces [](https://www.expedia.com/Las-Cruces-Hotels-Hotel-Encanto-De-Las-Cruces.h21267.Hotel-Information) Las Cruces 9.0/10 Wonderful (1,638 reviews) "Always a wonderful place to stay, even just for an overnighter" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jeremy $143 nightly $165 total Feb 21 - Feb 22 Total with taxes and fees [](https://www.expedia.com/Las-Cruces-Hotels-Hotel-Encanto-De-Las-Cruces.h21267.Hotel-Information) ![Full-size fridge, microwave, toaster, cookware/dishes/utensils](https://images.trvl-media.com/lodging/60000000/59870000/59861000/59860905/508a0752.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite | Private kitchen | Full-size fridge, microwave, toaster, cookware/dishes/utensils](https://images.trvl-media.com/lodging/60000000/59870000/59861000/59860905/18caa7c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/60000000/59870000/59861000/59860905/e146d19f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/60000000/59870000/59861000/59860905/b46c0d63.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 9 Las Cruces [](https://www.expedia.com/Las-Cruces-Hotels-Motel-9-Las-Cruces.h59860905.Hotel-Information) Las Cruces 6.4/10 (255 reviews) "Was clean and front desk lady was awesome and beautiful! Real nice I loved the coffee " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Minerva $45 nightly $54 total Feb 16 - Feb 17 Total with taxes and fees [](https://www.expedia.com/Las-Cruces-Hotels-Motel-9-Las-Cruces.h59860905.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/93000000/92190000/92186700/92186674/0ee34930.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/93000000/92190000/92186700/92186674/84d1ed9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/93000000/92190000/92186700/92186674/d73b3e11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/93000000/92190000/92186700/92186674/352afc71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Big Chile Inn & Suites [](https://www.expedia.com/Las-Cruces-Hotels-Big-Chile-Inn-Suites.h92186674.Hotel-Information) Las Cruces 6.8/10 (56 reviews) "Clean, affordable and felt safe " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stephanie $58 nightly $69 total Feb 24 - Feb 25 Total with taxes and fees [](https://www.expedia.com/Las-Cruces-Hotels-Big-Chile-Inn-Suites.h92186674.Hotel-Information) ![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/114000000/113810000/113801900/113801868/e49a0ed4_edited_6fe0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/114000000/113810000/113801900/113801868/79a24f19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/114000000/113810000/113801900/113801868/d1e7b649.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/114000000/113810000/113801900/113801868/f2b9f370.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Relaxing 3-Bdrs, 2-Baths Spacious Backyard – Family-Friendly & Fully Equipped! [](https://www.expedia.com/Las-Cruces-Hotels-Relaxing-3-Bdrs.h113801868.Hotel-Information) Las Cruces 10/10 Exceptional (10 reviews) "Very cozy home and the hosts were fantastic and very responsive to messages. We will definitely come back! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Melissa J. [](https://www.expedia.com/Las-Cruces-Hotels-Relaxing-3-Bdrs.h113801868.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/120000000/119460000/119453800/119453789/2e3e8863.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/120000000/119460000/119453800/119453789/533d2cda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/120000000/119460000/119453800/119453789/93854e6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/120000000/119460000/119453800/119453789/52479f84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Las Cruces - Modern 3BR Near Downtown, Mesilla, White Sands + Backyard Oasis [](https://www.expedia.com/Las-Cruces-Hotels-Las-Cruces-Modern-3BR-Near-Downtown.h119453789.Hotel-Information) Las Cruces 9.4/10 Exceptional (13 reviews) "Great location, comfortable set up. I’d stay here again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Clay C. $191 nightly $207 total Mar 4 - Mar 5 Total with taxes and fees [](https://www.expedia.com/Las-Cruces-Hotels-Las-Cruces-Modern-3BR-Near-Downtown.h119453789.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/18000000/17520000/17517100/17517011/1be7158a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/18000000/17520000/17517100/17517011/9f91d875.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, rollaway beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/18000000/17520000/17517100/17517011/347fddf0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/18000000/17520000/17517100/17517011/cdc70de0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Century 21 Motel [](https://www.expedia.com/Las-Cruces-Hotels-Century-21-Motel.h17517011.Hotel-Information) Las Cruces 6.8/10 (171 reviews) "Loved my stay!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ramon $72 nightly $84 total Feb 17 - Feb 18 Total with taxes and fees [](https://www.expedia.com/Las-Cruces-Hotels-Century-21-Motel.h17517011.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/88000000/87800000/87796300/87796251/d537f667.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/88000000/87800000/87796300/87796251/9523e9e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/88000000/87800000/87796300/87796251/47bb0497.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, computer monitors](https://images.trvl-media.com/lodging/88000000/87800000/87796300/87796251/490d7bf1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Yucca House | Views, Jetted Bath, Central Retreat [](https://www.expedia.com/Las-Cruces-Hotels-Yucca-House-Views.h87796251.Hotel-Information) Las Cruces 9.8/10 Exceptional (36 reviews) "We had a great stay!! Perfect home!! SUPER CLEAN!!! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Bobby L. $279 nightly $318 total Mar 2 - Mar 3 Total with taxes and fees [](https://www.expedia.com/Las-Cruces-Hotels-Yucca-House-Views.h87796251.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/113000000/112300000/112293600/112293584/498ea670.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/113000000/112300000/112293600/112293584/1f6cf098.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/113000000/112300000/112293600/112293584/9e12b514.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books](https://images.trvl-media.com/lodging/113000000/112300000/112293600/112293584/3f402121.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Desert Whisper 3-bedroom home with Xfinity Cable and WiFi, AC, EV charger [](https://www.expedia.com/Las-Cruces-Hotels-Desert-Whisper-3-Bedroom-Home-With-WiFi.h112293584.Hotel-Information) Las Cruces 10/10 Exceptional (12 reviews) "Wonderful home! Great neighborhood and very quiet! So clean and relaxing!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Allison K. [](https://www.expedia.com/Las-Cruces-Hotels-Desert-Whisper-3-Bedroom-Home-With-WiFi.h112293584.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/108000000/107490000/107488900/107488849/122cbe77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/108000000/107490000/107488900/107488849/dca76153.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/108000000/107490000/107488900/107488849/d45d0acb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/108000000/107490000/107488900/107488849/9fe70933.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Josefina's King Suite in Historic Old Mesilla Plaza. [](https://www.expedia.com/Mesilla-Hotels-Josefinas-King-Suite-In-Historic-Old-Mesilla-Plaza.h107488849.Hotel-Information) Mesilla 10/10 Exceptional (24 reviews) "Excellent location near the square!!! Such a cute cozy place! Loved the fireplace! Highly recommend!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Amy [](https://www.expedia.com/Mesilla-Hotels-Josefinas-King-Suite-In-Historic-Old-Mesilla-Plaza.h107488849.Hotel-Information) ![Smart TV, video games, books](https://images.trvl-media.com/lodging/80000000/79720000/79712800/79712757/711f264f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/80000000/79720000/79712800/79712757/bcbd9e9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/80000000/79720000/79712800/79712757/9463ff8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/80000000/79720000/79712800/79712757/29c3838a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### "Casa de Maíz" centrally located - close to NMSU [](https://www.expedia.com/Las-Cruces-Hotels-Casa-De-Maiz-Centrally-Located-Close-To-NMSU.h79712757.Hotel-Information) Las Cruces 10/10 Exceptional (47 reviews) "Excellent place for a family to stay without being cramped in a hotel!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Daniel [](https://www.expedia.com/Las-Cruces-Hotels-Casa-De-Maiz-Centrally-Located-Close-To-NMSU.h79712757.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-02-28&endDate=2026-03-01®ionId=132684&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FMesilla-Hotels-Independent.0-0-d132684--bIndependent.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FMesilla-Hotels-Independent.0-0-d132684--bIndependent.Travel-Guide-Filter-Hotels) ## Top Mesilla Hotel Reviews ![Best Western Mission Inn](https://images.trvl-media.com/lodging/1000000/30000/20600/20506/90d9a325_y.jpg) ### Best Western Mission Inn 10/10 Excellent "Clean, warm and cozy! " [](https://expedia.com/Las-Cruces-Hotels-Best-Western-Mission-Inn.h20506.Hotel-Information) ![Drury Inn & Suites Las Cruces](https://images.trvl-media.com/lodging/2000000/1730000/1723300/1723204/0bffe062_y.jpg) ### Drury Inn & Suites Las Cruces 10/10 Excellent "great place, friendly staff, great accommodation, breakfast, dinner lunch, pet friendly" [](https://expedia.com/Las-Cruces-Hotels-Drury-Inn-Suites-Las-Cruces.h1723204.Hotel-Information) ![Home2 Suites by Hilton Las Cruces](https://images.trvl-media.com/lodging/18000000/17400000/17394300/17394207/fc66f953_y.jpg) ### Home2 Suites by Hilton Las Cruces 10/10 Excellent "Yes" [](https://expedia.com/Las-Cruces-Hotels-Home2-Suites-By-Hilton-Las-Cruces.h17394207.Hotel-Information) ![Comfort Suites Las Cruces I-25 North](https://images.trvl-media.com/lodging/11000000/10330000/10320300/10320201/c5bb6ea5_y.jpg) ### Comfort Suites Las Cruces I-25 North 10/10 Excellent "Location, room cleanliness, check in to out process - (including bkfast)" [](https://expedia.com/Las-Cruces-Hotels-Comfort-Suites-Las-Cruces-I-25-North.h10320201.Hotel-Information) ![Hotel Encanto de Las Cruces](https://images.trvl-media.com/lodging/1000000/30000/21300/21267/5b5c1a96_y.jpg) ### Hotel Encanto de Las Cruces 10/10 Excellent "Always a wonderful place to stay, even just for an overnighter" [](https://expedia.com/Las-Cruces-Hotels-Hotel-Encanto-De-Las-Cruces.h21267.Hotel-Information) ![Hampton Inn & Suites Las Cruces I-10](https://images.trvl-media.com/lodging/13000000/12820000/12817800/12817768/a6b6426a_y.jpg) ### Hampton Inn & Suites Las Cruces I-10 10/10 Excellent "Comfortable and quiet room. Great staff. And the free breakfast in the morning is a great way to start the day." [](https://expedia.com/Las-Cruces-Hotels-Hampton-Inn-Suites-Las-Cruces-I-10.h12817768.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain](https://images.trvl-media.com/lodging/1000000/80000/75400/75365/62ae9c45_y.jpg) ### La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain 10/10 Excellent "The staff was very courteous. The room was clean and functional." [](https://expedia.com/Las-Cruces-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Las-Cruces-Organ-Mountain.h75365.Hotel-Information) ![Hampton Inn & Suites Las Cruces I-25](https://images.trvl-media.com/lodging/2000000/1670000/1665200/1665185/b0473335_y.jpg) ### Hampton Inn & Suites Las Cruces I-25 10/10 Excellent "The staff was friendly, the breakfast was really good, the rooms were clean. " [](https://expedia.com/Las-Cruces-Hotels-Hampton-Inn-Suites-Las-Cruces-I-25.h1665185.Hotel-Information) ![Days Inn by Wyndham Las Cruces](https://images.trvl-media.com/lodging/1000000/20000/15100/15035/4e26c2df_y.jpg) ### Days Inn by Wyndham Las Cruces 10/10 Excellent "Clean room, nice staff, all good!" [](https://expedia.com/Las-Cruces-Hotels-Days-Inn-By-Wyndham-Las-Cruces.h15035.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - Other - [Hotels near Mesillia Plaza ](https://www.expedia.com/Mesillia-Plaza-Hotels.0-l656813499404554240-0.Travel-Guide-Filter-Hotels) - [Hotels near Fountain Theatre ](https://www.expedia.com/Fountain-Theatre-Hotels.0-l553248621532643092-0.Travel-Guide-Filter-Hotels) - [Hotels near Fountain Theater ](https://www.expedia.com/Fountain-Theater-Hotels.0-l553248621532643091-0.Travel-Guide-Filter-Hotels) - [Hotels near Rio Grande Vineyards and Winery ](https://www.expedia.com/Rio-Grande-Vineyards-And-Winery-Hotels.0-l553248621532643097-0.Travel-Guide-Filter-Hotels) - [Las Cruces Hotels ](https://www.expedia.com/Las-Cruces-Hotels.d2137.Travel-Guide-Hotels) - [Best Western Hotels in Las Cruces ](https://www.expedia.com/Las-Cruces-Hotels-Best-Western.0-0-d2137--bBestWestern.Travel-Guide-Filter-Hotels) - 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