Title: Top Mississippi County Hotels: 2026 Best Hotels in Mississippi County - Expedia.com [Vacation Rentals in Mississippi County](https://expedia.com/Destinations-In-Mississippi-County.d553248635976432543.Vacation-Rental-Destinations)[Mississippi County Flights](https://expedia.com/Destinations-In-Mississippi-County.d553248635976432543.Flight-Destinations)[Car Rentals in Mississippi County](https://expedia.com/Destinations-In-Mississippi-County.d553248635976432543.Car-Rental-Destinations)[Mississippi County Vacations](https://expedia.com/Mississippi-County.d553248635976432543.Destination-Travel-Guides) ![Hernando de Soto Bridge over the Mississippi River Memphis. It separates Tennessee from Arkansas, United States of America.](https://images.trvl-media.com/place/553248635976432543/a415ea8a-3196-45f9-80cd-79b265986557.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/553248635976432543/a415ea8a-3196-45f9-80cd-79b265986557.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Top Cities in Mississippi County ![Really neat architecture! ](https://mediaim.expedia.com/destination/2/3218b9e72b04a13e39c05a76ec0bf6d9.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Blytheville [](https://expedia.com/Blytheville-Hotels.d6058418.Travel-Guide-Hotels) ![](https://mediaim.expedia.com/destination/1/20c58da39cb45f31906f2ff20fd71d38.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Dyess [](https://expedia.com/Dyess-Hotels.d553248635458706086.Travel-Guide-Hotels) ## Check prices for these dates Tonight [Feb 6 - Feb 7](https://www.expedia.com/Hotel-Search?regionId=553248635976432543&startDate=2026-02-06&endDate=2026-02-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Feb 7 - Feb 8](https://www.expedia.com/Hotel-Search?regionId=553248635976432543&startDate=2026-02-07&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Feb 6 - Feb 8](https://www.expedia.com/Hotel-Search?regionId=553248635976432543&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Feb 13 - Feb 15](https://www.expedia.com/Hotel-Search?regionId=553248635976432543&startDate=2026-02-13&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Mississippi County hotels ![Breakfast area](https://images.trvl-media.com/lodging/3000000/2040000/2032200/2032178/9e3a6143.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2040000/2032200/2032178/1f2bbf62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2040000/2032200/2032178/54184826.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/3000000/2040000/2032200/2032178/45f575e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Blytheville [](https://www.expedia.com/Blytheville-Hotels-Comfort-Inn-Suites.h2032178.Hotel-Information) Blytheville 8.6/10 Excellent (701 reviews) "This was a nice place to stay. Would recommend it to all." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tina $93 nightly $105 total Feb 22 - Feb 23 Total with taxes and fees [](https://www.expedia.com/Blytheville-Hotels-Comfort-Inn-Suites.h2032178.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/50000/41800/41712/05343fb1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41800/41712/00922bdc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/41800/41712/b4d3f15c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/50000/41800/41712/d69e7fe5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Blytheville [](https://www.expedia.com/Blytheville-Hotels-Hampton-Inn-Blytheville.h41712.Hotel-Information) Blytheville 9.2/10 Wonderful (900 reviews) "Clean room friendly staff good breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John $107 nightly $121 total Feb 12 - Feb 13 Total with taxes and fees [](https://www.expedia.com/Blytheville-Hotels-Hampton-Inn-Blytheville.h41712.Hotel-Information) ![Indoor pool, seasonal outdoor pool, open 7 AM to 10 PM, pool umbrellas](https://images.trvl-media.com/lodging/1000000/10000/3400/3357/77afceed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/3400/3357/c70c96e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cocktail bar](https://images.trvl-media.com/lodging/1000000/10000/3400/3357/ccab0c81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/3400/3357/a8aa83eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Blytheville by IHG [](https://www.expedia.com/Blytheville-Hotels-Holiday-Inn-Blytheville.h3357.Hotel-Information) Blytheville 8.4/10 Very Good (666 reviews) "Spotless, great shower, comfy beds" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sandi $112 nightly $127 total Feb 13 - Feb 14 Total with taxes and fees [](https://www.expedia.com/Blytheville-Hotels-Holiday-Inn-Blytheville.h3357.Hotel-Information) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/115000000/114390000/114380100/114380079/89abfba4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room](https://images.trvl-media.com/lodging/115000000/114390000/114380100/114380079/33099aea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/115000000/114390000/114380100/114380079/2274ab65.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/115000000/114390000/114380100/114380079/w3840h2158x0y0-52160e0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Osceola by IHG [](https://www.expedia.com/Osceola-Hotels-Holiday-Inn-Osceola-By-Ihg.h114380079.Hotel-Information) Osceola 8.8/10 Excellent (20 reviews) "Staff was courteous. Clean rooms. Restaurant was great." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Adrian $118 nightly $136 total Feb 20 - Feb 21 Total with taxes and fees [](https://www.expedia.com/Osceola-Hotels-Holiday-Inn-Osceola-By-Ihg.h114380079.Hotel-Information) ![Louis 3 Bedroom Cottage A | Private kitchen | Mini-fridge, coffee/tea maker](https://images.trvl-media.com/lodging/94000000/93830000/93829900/93829832/4161dd61.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Golf](https://images.trvl-media.com/lodging/94000000/93830000/93829900/93829832/3e2d6625.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/94000000/93830000/93829900/93829832/a7d05be5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/94000000/93830000/93829900/93829832/2473875f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Louis Hotel [](https://www.expedia.com/Wilson-Hotels-The-Louis-Hotel.h93829832.Hotel-Information) Wilson 9.6/10 Exceptional (54 reviews) "The staff was extremely courteous and the room was so beautiful and clean. I would LOVE to stay there again! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alexa $191 nightly $214 total Feb 9 - Feb 10 Total with taxes and fees [](https://www.expedia.com/Wilson-Hotels-The-Louis-Hotel.h93829832.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1230000/1226700/1226644/c16d0cb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1230000/1226700/1226644/1c261b0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/2000000/1230000/1226700/1226644/79155d53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-size fridge, microwave, coffee/tea maker](https://images.trvl-media.com/lodging/2000000/1230000/1226700/1226644/c1c85af2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### America's Best Value Inn & Suites Blytheville by Sonesta [](https://www.expedia.com/Blytheville-Hotels-Americas-Best-Value-Inn-Blytheville.h1226644.Hotel-Information) Blytheville 6.8/10 (426 reviews) "Nice staff helpful, clean rooms." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Deepak $59 nightly $67 total Feb 14 - Feb 15 Total with taxes and fees [](https://www.expedia.com/Blytheville-Hotels-Americas-Best-Value-Inn-Blytheville.h1226644.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41700/41676/6e8f6961.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, free cribs/infant beds, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/1000000/50000/41700/41676/927574bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/50000/41700/41676/d5c1715d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/1000000/50000/41700/41676/2481e426.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn & Suites by Wyndham Osceola AR [](https://www.expedia.com/Blytheville-Hotels-Days-Inn-Suites-By-Wyndham-Osceola-AR.h41676.Hotel-Information) Osceola 6.4/10 (370 reviews) "One of the worst motels I have stayed at in years" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gary $64 nightly $74 total Feb 8 - Feb 9 Total with taxes and fees [](https://www.expedia.com/Blytheville-Hotels-Days-Inn-Suites-By-Wyndham-Osceola-AR.h41676.Hotel-Information) ![Single Room | Blackout drapes, soundproofing, free WiFi, bed sheets](https://images.trvl-media.com/lodging/122000000/121070000/121062600/121062570/ba85d102.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/122000000/121070000/121062600/121062570/e5685d98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave](https://images.trvl-media.com/lodging/122000000/121070000/121062600/121062570/2391c860.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/122000000/121070000/121062600/121062570/8cd0affc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairview Suites [](https://www.expedia.com/Blytheville-Hotels-Fairview-Suites.h121062570.Hotel-Information) Blytheville 7.8/10 Good (12 reviews) "Good place to stay for blue collar workers " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Scott $57 nightly $65 total Mar 9 - Mar 10 Total with taxes and fees [](https://www.expedia.com/Blytheville-Hotels-Fairview-Suites.h121062570.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/9800/9746/beb06494.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Individually decorated, individually furnished, desk, iron/ironing board](https://images.trvl-media.com/lodging/1000000/10000/9800/9746/db885cf0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9800/9746/5ebfc8a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, Accessible, Refrigerator | Bathroom | Combined shower/tub, eco-friendly toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/1000000/10000/9800/9746/1b27c316.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Blytheville [](https://www.expedia.com/Blytheville-Hotels-Super-8-By-Wyndham-Blytheville.h9746.Hotel-Information) Blytheville 6.0/10 (527 reviews) "I really enjoyed my stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sara $50 nightly $56 total Feb 9 - Feb 10 Total with taxes and fees [](https://www.expedia.com/Blytheville-Hotels-Super-8-By-Wyndham-Blytheville.h9746.Hotel-Information) ![Room, 2 Double Beds, Smoking | Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/88000000/87920000/87916900/87916825/dddaf316.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/88000000/87920000/87916900/87916825/6b6b4e27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/88000000/87920000/87916900/87916825/1fa5848b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/88000000/87920000/87916900/87916825/36ff656a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Deerfield Inn By Capital O Blytheville AR I55 [](https://www.expedia.com/Blytheville-Hotels-Deerfield-Inn-By-Capital-O-Blytheville-AR-I55.h87916825.Hotel-Information) Blytheville 7.4/10 Good (59 reviews) "Room is clean, sheets have been changed, staff people are nice and attentive " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tina $65 nightly $73 total Mar 1 - Mar 2 Total with taxes and fees [](https://www.expedia.com/Blytheville-Hotels-Deerfield-Inn-By-Capital-O-Blytheville-AR-I55.h87916825.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/77000000/76940000/76930100/76930021/c6c2c410.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bathtub, hair dryer, towels](https://images.trvl-media.com/lodging/77000000/76940000/76930100/76930021/9b00666e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/77000000/76940000/76930100/76930021/825e07c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Single Room | Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/77000000/76940000/76930100/76930021/26684060.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Roadside Inn [](https://www.expedia.com/Osceola-Hotels-Roadside-Inn.h76930021.Hotel-Information) Osceola 7.4/10 Good (23 reviews) "Room temperature was great even when we first walked in. Very clean, comfortable and nice. Staff was very friendly and polite. Sure wish they had a coffee pot in the room. Other than that everything was great!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Vicky $53 nightly $61 total Feb 12 - Feb 13 Total with taxes and fees [](https://www.expedia.com/Osceola-Hotels-Roadside-Inn.h76930021.Hotel-Information) ![Business center](https://images.trvl-media.com/lodging/1000000/30000/20200/20128/ce00ef2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/30000/20200/20128/aff9a978.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, down comforters](https://images.trvl-media.com/lodging/1000000/30000/20200/20128/0fd71e28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception hall](https://images.trvl-media.com/lodging/1000000/30000/20200/20128/1ece02d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Blytheville [](https://www.expedia.com/Blytheville-Hotels-Days-Inn-By-Wyndham-Blytheville.h20128.Hotel-Information) Blytheville 5.8/10 (383 reviews) "Nastiest place ive ever spent the night. Slept with my clothes on afraid of the sheets" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carl $55 nightly $63 total Feb 8 - Feb 9 Total with taxes and fees [](https://www.expedia.com/Blytheville-Hotels-Days-Inn-By-Wyndham-Blytheville.h20128.Hotel-Information) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/20000/15700/15679/4746c4b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business center](https://images.trvl-media.com/lodging/1000000/20000/15700/15679/347725ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lunch and dinner served](https://images.trvl-media.com/lodging/1000000/20000/15700/15679/6034c339.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15700/15679/22d67d8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Blytheville [](https://www.expedia.com/Blytheville-Hotels-Quality-Inn-Blytheville-I-55.h15679.Hotel-Information) Blytheville 6.6/10 (116 reviews) "Everything was good and the staff was friendly and courteous " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mike [](https://www.expedia.com/Blytheville-Hotels-Quality-Inn-Blytheville-I-55.h15679.Hotel-Information) ![Private kitchen](https://images.trvl-media.com/lodging/123000000/122920000/122917200/122917109/8eb6cdab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hair dryer, towels, soap, toilet paper](https://images.trvl-media.com/lodging/123000000/122920000/122917200/122917109/226e521f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/123000000/122920000/122917200/122917109/2826de7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/123000000/122920000/122917200/122917109/34d0f520.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tranquil 2-bedroom house with AC in charming Blytheville [](https://www.expedia.com/Blytheville-Hotels-Tranquil-2-Bedroom-House-With-AC-In-Charming-Blytheville.h122917109.Hotel-Information) Blytheville 6.0/10 (3 reviews) "All the pipes were frozen" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Wendy H. $227 nightly $256 total Feb 22 - Feb 23 Total with taxes and fees [](https://www.expedia.com/Blytheville-Hotels-Tranquil-2-Bedroom-House-With-AC-In-Charming-Blytheville.h122917109.Hotel-Information) ![Dishwasher, toaster](https://images.trvl-media.com/lodging/112000000/111760000/111753600/111753521/54e5e6b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/112000000/111760000/111753600/111753521/29ebd25f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/112000000/111760000/111753600/111753521/da4a91cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hair dryer, towels, soap, toilet paper](https://images.trvl-media.com/lodging/112000000/111760000/111753600/111753521/d3fcb24b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Delta House - CHARMING 3 BED. HOUSE W/DECK & GRILL, VERY CLEAN! [](https://www.expedia.com/Blytheville-Hotels-The-Delta-House-CHARMING-3-BED-HOUSE-WDECK-GRILL.h111753521.Hotel-Information) Blytheville 9.4/10 Exceptional (3 reviews) "Excellent host, very accommodating, and clean. Have stayed at multiple properties this host owns and would definitely stay again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael F. [](https://www.expedia.com/Blytheville-Hotels-The-Delta-House-CHARMING-3-BED-HOUSE-WDECK-GRILL.h111753521.Hotel-Information) ![Premium Room, 2 Double Beds, Kitchenette | Room amenity](https://images.trvl-media.com/lodging/24000000/23400000/23397300/23397288/98d458b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Room, 1 King Bed, Kitchenette | Private kitchenette | Microwave, coffee/tea maker](https://images.trvl-media.com/lodging/24000000/23400000/23397300/23397288/dc1779cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Room, 2 Double Beds, Kitchenette | Private kitchenette | Microwave, coffee/tea maker](https://images.trvl-media.com/lodging/24000000/23400000/23397300/23397288/61bc760e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Room, 2 Double Beds, Kitchenette | Private kitchen | Microwave, coffee/tea maker](https://images.trvl-media.com/lodging/24000000/23400000/23397300/23397288/d45c4f5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### OYO Hotel Blytheville AR I-55 [](https://www.expedia.com/Blytheville-Hotels-OYO-Hotel-Blytheville-AR-Hwy-61.h23397288.Hotel-Information) Blytheville 3.8/10 (130 reviews) "Cleanliness, staff & service, property conditions & facilities, room comfort, everything is excellent. Loved and enjoyed the stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mark [](https://www.expedia.com/Blytheville-Hotels-OYO-Hotel-Blytheville-AR-Hwy-61.h23397288.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/112000000/111540000/111531500/111531448/5b8972f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/112000000/111540000/111531500/111531448/f88a4262.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/112000000/111540000/111531500/111531448/eac776b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/112000000/111540000/111531500/111531448/6f99b3ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Mahase Guest House at The Refuge [](https://www.expedia.com/Mahase-Guest-House-At-The-Refuge.h111531448.Hotel-Information) Osceola 10/10 Exceptional (2 reviews) "Great place to stay! Quiet place and not too far from restaurants and market. Enjoyed the comfortable bed and the nice size kiitchen. I would definitely stay again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alex b. [](https://www.expedia.com/Mahase-Guest-House-At-The-Refuge.h111531448.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/98000000/97160000/97150600/97150528/d34a5a6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/98000000/97160000/97150600/97150528/9cf1d3e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/98000000/97160000/97150600/97150528/fa0f0e89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/98000000/97160000/97150600/97150528/7c6132b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 3 bedrooms, 2 full bath, dining room, great room, den, beautiful outdoor patio. [](https://www.expedia.com/Blytheville-Hotels-3-Bedrooms.h97150528.Hotel-Information) Blytheville 10/10 Exceptional (15 reviews) "Great place to stay, much better thana hotel. Enjoyed the backyard, the place was really clean and comfortable." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dan H. [](https://www.expedia.com/Blytheville-Hotels-3-Bedrooms.h97150528.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/121000000/120550000/120547600/120547558/096dfdd8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/121000000/120550000/120547600/120547558/7b08b617.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Double Room | Bathroom | Bathtub, towels, soap, shampoo](https://images.trvl-media.com/lodging/121000000/120550000/120547600/120547558/4a3b3bb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free WiFi](https://images.trvl-media.com/lodging/121000000/120550000/120547600/120547558/da5c1fc9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sands Hotel [](https://www.expedia.com/Blytheville-Hotels-Sands-Hotel.h120547558.Hotel-Information) Blytheville $50 nightly $57 total Feb 7 - Feb 8 Total with taxes and fees [](https://www.expedia.com/Blytheville-Hotels-Sands-Hotel.h120547558.Hotel-Information) ![Smart TV, fireplace](https://images.trvl-media.com/lodging/111000000/110690000/110689300/110689242/0aefcbea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/111000000/110690000/110689300/110689242/d399db35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/111000000/110690000/110689300/110689242/9fc28f51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/111000000/110690000/110689300/110689242/b635afc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### "Misty Blue"-Newly Renovated home in Blytheville [](https://www.expedia.com/Blytheville-Hotels-Misty-Blue-Newly-Renovated-Home-In-Blytheville.h110689242.Hotel-Information) Blytheville 9.8/10 Exceptional (6 reviews) "We came for a duck hunting trip. Accommodations were perfect! Very clean and we had everything we needed. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Abby W. [](https://www.expedia.com/Blytheville-Hotels-Misty-Blue-Newly-Renovated-Home-In-Blytheville.h110689242.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-02-20&endDate=2026-02-21®ionId=553248635976432543&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Mississippi-County.d553248635976432543.Hotel-Destinations)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Mississippi-County.d553248635976432543.Hotel-Destinations) ## Top Mississippi County Hotel Reviews ![La Quinta Inn & Suites by Wyndham West Memphis](https://images.trvl-media.com/lodging/35000000/34580000/34578000/34577952/b94559ee_y.jpg) ### La Quinta Inn & Suites by Wyndham West Memphis 10/10 Excellent "Breakfast Bar" [](https://expedia.com/West-Memphis-Hotels-La-Quinta-Inn-Suites-By-Wyndham-West-Memphis.h34577952.Hotel-Information) ![Southland Casino Hotel](https://images.trvl-media.com/lodging/83000000/82950000/82940100/82940076/d23864be_y.jpg) ### Southland Casino Hotel 10/10 Excellent "Security and check in were organized and time efficient . Good food choices with a quiet and clean environment. Always a good stay here. " [](https://expedia.com/Memphis-Hotels-Southland-Casino-Racing.h82940076.Hotel-Information) ![The Westin Memphis Beale Street](https://images.trvl-media.com/lodging/2000000/1620000/1619600/1619507/f2a08eff_y.jpg) ### The Westin Memphis Beale Street 10/10 Excellent "Very nice room, close to arena and the staff was very friendly and helpful." [](https://expedia.com/Memphis-Hotels-The-Westin-Memphis-Beale-Street.h1619507.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Memphis Downtown](https://images.trvl-media.com/lodging/19000000/18110000/18110000/18109970/358319c6_y.jpg) ### La Quinta Inn & Suites by Wyndham Memphis Downtown 10/10 Excellent "Great place to stay!" [](https://expedia.com/Memphis-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Memphis-Downtown.h18109970.Hotel-Information) ![Comfort Inn Memphis Downtown](https://images.trvl-media.com/lodging/1000000/20000/12700/12659/f07ebe17_y.jpg) ### Comfort Inn Memphis Downtown 10/10 Excellent "It was a very decent place to stay for a couple of days. Really enjoy the view that we had! And breakfast was great as well. " [](https://expedia.com/Memphis-Hotels-Comfort-Inn-Memphis-Downtown.h12659.Hotel-Information) ![Hu. Hotel](https://images.trvl-media.com/lodging/1000000/810000/807600/807514/240adf57_y.jpg) ### Hu. Hotel 10/10 Excellent "The staff was amazing " [](https://expedia.com/Memphis-Hotels-Hu-Hotel.h807514.Hotel-Information) ![Big Cypress Lodge](https://images.trvl-media.com/lodging/13000000/13000000/12993400/12993388/d7eafe81_y.jpg) ### Big Cypress Lodge 10/10 Excellent "Loved the Lodge feel, staff was very nice. Amenities were nice!!" [](https://expedia.com/Memphis-Hotels-Big-Cypress-Lodge.h12993388.Hotel-Information) ![The Stallion](https://images.trvl-media.com/lodging/111000000/110410000/110403300/110403215/ae37187f_edited_d887_y.jpg) ### The Stallion 10/10 Excellent "Clean room , great amenities, and an over all good experience. " [](https://expedia.com/Memphis-Hotels-The-Stallion.h110403215.Hotel-Information) ![Hyatt Centric Beale Street Memphis](https://images.trvl-media.com/lodging/63000000/63000000/62999300/62999249/a29c606e_y.jpg) ### Hyatt Centric Beale Street Memphis 10/10 Excellent "Room was fantastic. Service staff and restaurants and bars were superb. " [](https://expedia.com/Memphis-Hotels-Hyatt-Centric-Beale-Street-Memphis.h62999249.Hotel-Information) ## Explore a world of travel with Expedia - Explore a world of travel with Expedia ### Top cities in Mississippi County - [Blytheville Hotels ](https://expedia.com/Blytheville-Hotels.d6058418.Travel-Guide-Hotels) - [Osceola Hotels ](https://expedia.com/Osceola-Hotels.d9048.Travel-Guide-Hotels) - [Wilson Hotels ](https://expedia.com/Wilson-Hotels.d553248635458701109.Travel-Guide-Hotels) - [Manila Hotels ](https://expedia.com/Manila-Hotels.d553248634999080581.Travel-Guide-Hotels) - [Leachville Hotels ](https://expedia.com/Leachville-Hotels.d3000343188.Travel-Guide-Hotels) - [Joiner Hotels ](https://expedia.com/Joiner-Hotels.d553248634999254953.Travel-Guide-Hotels) - [Dyess Hotels ](https://expedia.com/Dyess-Hotels.d553248635458706086.Travel-Guide-Hotels) - [Dell Hotels ](https://expedia.com/Dell-Hotels.d553248635975876297.Travel-Guide-Hotels) - [Luxora Hotels ](https://expedia.com/Luxora-Hotels.d553248635975867783.Travel-Guide-Hotels) - [Burdette Hotels ](https://expedia.com/Burdette-Hotels.d553248635975868572.Travel-Guide-Hotels) - [Etowah Hotels ](https://expedia.com/Etowah-Hotels.d6341249.Travel-Guide-Hotels) ### Hotels near popular Attractions - [Hotels near Johnny Cash House ](https://expedia.com/Johnny-Cash-House-Hotels.0-l553248621532648013-0.Travel-Guide-Filter-Hotels) - [Hotels near Lights of the Delta ](https://expedia.com/Lights-Of-The-Delta-Hotels.0-l6274731-0.Travel-Guide-Filter-Hotels) - [Hotels near Arkansas Aeroplex ](https://expedia.com/Arkansas-Aeroplex-Hotels.0-l6274726-0.Travel-Guide-Filter-Hotels) - [Hotels near Delta Gateway Museum ](https://expedia.com/Delta-Gateway-Museum-Hotels.0-l553248634328751079-0.Travel-Guide-Filter-Hotels) - [Hotels near Arkansas Northeastern College ](https://expedia.com/Arkansas-Northeastern-College-Hotels.0-l6239816-0.Travel-Guide-Filter-Hotels) - [Hotels near Walker Park ](https://expedia.com/Walker-Park-Hotels.0-l6239818-0.Travel-Guide-Filter-Hotels) - [Hotels near Thunder Bayou Golf Links ](https://expedia.com/Thunder-Bayou-Golf-Links-Hotels.0-l6239820-0.Travel-Guide-Filter-Hotels) ### More Accommodation Types in Mississippi County - [Vacation Homes in Mississippi County ](https://expedia.com/Mississippi-County-Private-Vacation-Homes.d553248635976432543-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [Apartments in Mississippi County ](https://expedia.com/Mississippi-County-Apartments.d553248635976432543-aaApartments.Travel-Guide-Accommodation) - [Motels in Mississippi County ](https://expedia.com/Mississippi-County-Motels.d553248635976432543-aaMotels.Travel-Guide-Accommodation) - [Condo Rentals in Mississippi County ](https://expedia.com/Mississippi-County-Condos.d553248635976432543-aaCondos.Travel-Guide-Accommodation) - [Cottages in Mississippi County ](https://expedia.com/Mississippi-County-Cottages.d553248635976432543-aaCottages.Travel-Guide-Accommodation) - [Farmstay in Mississippi County ](https://expedia.com/Mississippi-County-Agritourism.d553248635976432543-aaAgritourism.Travel-Guide-Accommodation) - [Villas in Mississippi County ](https://expedia.com/Mississippi-County-Villas.d553248635976432543-aaVillas.Travel-Guide-Accommodation) - [Aparthotels in Mississippi County ](https://expedia.com/Mississippi-County-Apart-Hotels.d553248635976432543-aaApartHotels.Travel-Guide-Accommodation) - [Guest Houses in Mississippi County ](https://expedia.com/Mississippi-County-Guest-Houses.d553248635976432543-aaGuestHouses.Travel-Guide-Accommodation) - [Cabin Rentals in Mississippi County ](https://expedia.com/Mississippi-County-Cabins.d553248635976432543-aaCabins.Travel-Guide-Accommodation) - [B&B in Mississippi County ](https://expedia.com/Mississippi-County-Bed-And-Breakfast.d553248635976432543-aaBedAndBreakfast.Travel-Guide-Accommodation) ### Hotels near Mississippi County Airports - [Memphis Intl. 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Hotel ](https://expedia.com/Memphis-Hotels-Hu-Hotel.h807514.Hotel-Information) - [Hyatt Centric Beale Street Memphis ](https://expedia.com/Memphis-Hotels-Hyatt-Centric-Beale-Street-Memphis.h62999249.Hotel-Information) - [Big Cypress Lodge ](https://expedia.com/Memphis-Hotels-Big-Cypress-Lodge.h12993388.Hotel-Information) - [Comfort Inn Memphis Downtown ](https://expedia.com/Memphis-Hotels-Comfort-Inn-Memphis-Downtown.h12659.Hotel-Information) - [Sheraton Memphis Downtown Hotel ](https://expedia.com/Memphis-Hotels-Sheraton-Memphis-Downtown-Hotel.h821.Hotel-Information) - [Southland Casino Hotel ](https://expedia.com/Memphis-Hotels-Southland-Casino-Racing.h82940076.Hotel-Information) - [ARRIVE Memphis ](https://expedia.com/Memphis-Hotels-ARRIVE-Memphis.h38941518.Hotel-Information) - [Hotel Indigo Memphis Downtown by IHG ](https://expedia.com/Memphis-Hotels-Hotel-Indigo-Memphis-Downtown.h27363058.Hotel-Information) - [Hampton Inn & Suites Memphis-Beale Street ](https://expedia.com/Memphis-Hotels-Hampton-Inn-Suites-Memphis-Beale-Street.h456281.Hotel-Information) [See a list of all hotels in Mississippi County](https://expedia.com/All-Mississippi-County-Hotels.d553248635976432543.Travel-Guide-City-All-Hotels) ### Expedia's Latest Trends Hotels - 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[Thorncrown Chapel](https://expedia.com/Thorncrown-Chapel-Eureka-Springs.d6096452.Vacation-Attraction) - [Crater of Diamonds State Park](https://expedia.com/Crater-Of-Diamonds-State-Park-Murfreesboro.d6070777.Vacation-Attraction) - [Lake Catherine State Park](https://expedia.com/Lake-Catherine-State-Park-Hot-Springs.d553248621532647727.Vacation-Attraction) - [Hot Springs National Park](https://expedia.com/Hot-Springs-National-Park-Hot-Springs.d6070773.Vacation-Attraction) General - [Visit Lake Hamilton](https://expedia.com/Hot-Springs-Lake-Hamilton.dx6348050) - [Visit Eureka Springs Historic District](https://expedia.com/Eureka-Springs-Eureka-Springs-Historic-District.dx6340782) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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