An aerial view of a coastal landscape with a dam, farmland, and dense forests.

Santee Vacation Rentals

  • Bundle & Save

    Get more, spend less whenever you see Bundle & Save deals

  • OneKeyCash

    Earn OneKeyCash on all your eligible bookings

  • Upfront pricing

    We are not like the others - we include taxes and fees

Check prices for these dates

In two weeks
Nov 27 - Nov 29
In two months
Jan 8 - Jan 10
In three months
Feb 5 - Feb 7
In four months
Mar 5 - Mar 7

Our top choices for Santee vacation rentals

A spacious living room with a large sofa, two coffee tables, and a potted plant.

1. Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
Santee
10.0 out of 10, Exceptional, (47 reviews)
"Comfortable home with fenced in yard for dogs is a plus. The house had everything needed for a stay. Furniture was comfy. House is an hour drive from congaree NP. Many opportunities nearby to connect with nature."
United States
Jessica C.
$269 nightly
The price is $299
Nov 23 - Nov 24
Total with taxes and fees
Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
A lakeside park with picnic tables and a wooden bridge over the water.

2. Lake Marion Condo, Boat Slip Included, Pet Friendly

Lake Marion Condo, Boat Slip Included, Pet Friendly
Santee
10.0 out of 10, Exceptional, (1 review)
"My husband, son and I booked a relatively last-minute weekend trip. Gabriel was great, and fast about answering my questions. The unit was easy to find and gain entry to. It is very clean, quiet, and accessible to the water; a very short walk to the on-prem docks and the covered porch is very nice. We had an enjoyable stay and liked the area."
United States
Katie A.
$296 nightly
The price is $329
Nov 16 - Nov 17
Total with taxes and fees
Lake Marion Condo, Boat Slip Included, Pet Friendly
A covered patio with outdoor furniture, a view of a lake, and a sunset.

3. LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks

LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks
Santee
9.0 out of 10, Wonderful, (8 reviews)
"We had a wonderful stay. Couldn't have asked for better location. It was beautiful, close to everything and perfect for our family."
United States
Michelle H.
$440 nightly
The price is $488
Nov 22 - Nov 23
Total with taxes and fees
LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks
A wicker outdoor seating area with cushioned chairs and a matching ottoman on a porch.

4. Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!

Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!
Santee
10.0 out of 10, Exceptional, (16 reviews)
"Annual golf trip with old friends. Perfect accommodations & location. Hope to stay again"
United States
Greg M.
$436 nightly
The price is $484
Nov 22 - Nov 23
Total with taxes and fees
Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!
A tent with a view of a lake and boats, a wooden chair, and a potted plant.

5. Bells Marina & Resort

Bells Marina & Resort
2.5 star property
Eutawville
8.6 out of 10, Excellent, (103 reviews)
"Love it"
United States
Mark
$75 nightly
The price is $84
Nov 16 - Nov 17
Total with taxes and fees
Bells Marina & Resort
A kitchen with wooden cabinets, a built-in dishwasher, a sink, and a ceiling fan.

6. Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301

Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301
Bowman
9.8 out of 10, Exceptional, (38 reviews)
"The place was excellent. The bed was really nice and comfortable. I'd definitely stay again."
United States
Joseph
$139 nightly
The price is $154
Nov 16 - Nov 17
Total with taxes and fees
Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301
A covered outdoor seating area with a view of a dock and boats, wooden furniture, and string lights.

7. Lakefront tiny cabin amazing view on Lake Marion! Pet friendly.

Lakefront tiny cabin amazing view on Lake Marion! Pet friendly.
Summerton
8.8 out of 10, Excellent, (44 reviews)
"Great place to stay on the lake! "
United States
Troy S.
$133 nightly
The price is $148
Nov 16 - Nov 17
Total with taxes and fees
Lakefront tiny cabin amazing view on Lake Marion! Pet friendly.
A kitchen with dark blue cabinets, a granite countertop, stainless steel sink, and a microwave.

8. Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston

Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston
Holly Hill
10.0 out of 10, Exceptional, (18 reviews)
"Great stay!"
United States
Hayden S.
$137 nightly
The price is $152
Nov 17 - Nov 18
Total with taxes and fees
Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston
A wooden cabin with a porch and picnic table in a wooded area.

9. Cozy Camping Cabin on Lake Marion near Congaree Nat Park

Cozy Camping Cabin on Lake Marion near Congaree Nat Park
Rimini
8.2 out of 10, Very good, (17 reviews)
"Great place to stay. "
United States
Scott J.
$119 nightly
The price is $132
Nov 16 - Nov 17
Total with taxes and fees
Cozy Camping Cabin on Lake Marion near Congaree Nat Park
A small cabin with a fire pit, outdoor seating, and string lights.

10. Cabin at the lake in Rimini, SC

Cabin at the lake in Rimini, SC
Rimini
7.4 out of 10, Good, (8 reviews)
"Great view, excellent communication with the owners, relaxing, peaceful. "
United States
Christie
$115 nightly
The price is $128
Nov 16 - Nov 17
Total with taxes and fees
Cabin at the lake in Rimini, SC
A compact living space with a kitchen, dining area, and a small seating area.

11. Country living lake style near Santee

Country living lake style near Santee
Summerton
10.0 out of 10, Exceptional, (47 reviews)
"Very convenient to the lake."
United States
John P.
$199 nightly
The price is $221
Nov 18 - Nov 19
Total with taxes and fees
Country living lake style near Santee
A modern kitchen with stainless steel appliances, white cabinetry, and a wooden floor.

12. Quiet 1-bedroom apartment in charming Elloree, SC

Quiet 1-bedroom apartment in charming Elloree, SC
Elloree
$169 nightly
The price is $188
Nov 16 - Nov 17
Total with taxes and fees
Quiet 1-bedroom apartment in charming Elloree, SC
A living room with a sofa, two armchairs, a coffee table, and a lamp.

13. Modern apartment overlooking historic downtown Elloree, SC.

Modern apartment overlooking historic downtown Elloree, SC.
Elloree
$167 nightly
The price is $185
Nov 16 - Nov 17
Total with taxes and fees
Modern apartment overlooking historic downtown Elloree, SC.
Beach

14. Country Resting Spot just off I95. 12 miles west on hwy 6.

Country Resting Spot just off I95. 12 miles west on hwy 6.
Elloree
9.4 out of 10, Exceptional, (25 reviews)
"Everyone was pleased and said they would stay here again."
United States
Tom B.
$141 nightly
The price is $157
Dec 1 - Dec 2
Total with taxes and fees
Country Resting Spot just off I95. 12 miles west on hwy 6.
A wooden cabin with a porch, a bench, and a potted plant.

15. Relax and unwind near Lake Marion - 2-bedroom 1.5 bath cabin getaway.

Relax and unwind near Lake Marion - 2-bedroom 1.5 bath cabin getaway.
Summerton
10.0 out of 10, Exceptional, (4 reviews)
"This was first VRBO and it was exactly as planned and expected ! Thank you Ronald !"
United States
Jeff B.
$243 nightly
The price is $270
Nov 17 - Nov 18
Total with taxes and fees
Relax and unwind near Lake Marion - 2-bedroom 1.5 bath cabin getaway.
A wooden deck with a white sofa, a wooden serving tray with snacks, and a pitcher of lemonade.

16. Pet friendly country cottage with large fenced-in yard & horses on property

Pet friendly country cottage with large fenced-in yard & horses on property
Holly Hill
10.0 out of 10, Exceptional, (169 reviews)
"Great place to stay on our trip!"
United States
Thomas G.
$190 nightly
The price is $211
Nov 30 - Dec 1
Total with taxes and fees
Pet friendly country cottage with large fenced-in yard & horses on property
A compact kitchen with wooden cabinets, a stainless steel refrigerator, and a gas stove.

17. Beautiful brick home w/ large porch and 3 bedrooms

Beautiful brick home w/ large porch and 3 bedrooms
Bowman
9.2 out of 10, Wonderful, (5 reviews)
"A great home and very peaceful!! The host is very friendly and very easy to work with. I recommend this home for a stay 100 percent!!We plan on staying there again when we are in the area, such a great value!!"
United States
Troy K.
$243 nightly
The price is $269
Nov 16 - Nov 17
Total with taxes and fees
Beautiful brick home w/ large porch and 3 bedrooms
A living room with a beige sofa, a patterned armchair, a coffee table, and a blue door with a stained glass window.

18. Turtle Cove - Lake Living on Lake Marion

Turtle Cove - Lake Living on Lake Marion
Summerton
10.0 out of 10, Exceptional, (1 review)
"Great quiet and cozy home with a nice backyard and porch with the easy water access by dock. Really enjoyed our stay."
United States
Judith H.
$440 nightly
The price is $501
Nov 19 - Nov 20
Total with taxes and fees
Turtle Cove - Lake Living on Lake Marion
A wooden cabin with a red garage, outdoor seating area, and a deck.

19. Sweet Marion - Dock + Boat Ramp + Hot Tub!

Sweet Marion - Dock + Boat Ramp + Hot Tub!
Summerton
8.8 out of 10, Excellent, (26 reviews)
"Nice comfortable place to stay"
United States
Dylan H.
$494 nightly
The price is $562
Nov 16 - Nov 17
Total with taxes and fees
Sweet Marion - Dock + Boat Ramp + Hot Tub!
Living area

20. Private Farm Stay on 30-Acres with Fish Pond + Sleeps 8

Private Farm Stay on 30-Acres with Fish Pond + Sleeps 8
Summerton
10.0 out of 10, Exceptional, (2 reviews)
"Nice and private. Very quiet and relaxing. Nice to just sit on the front porch with the sunrise."
United States
Bryant T.
$456 nightly
The price is $506
Nov 30 - Dec 1
Total with taxes and fees
Private Farm Stay on 30-Acres with Fish Pond + Sleeps 8
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Santee Hotel Reviews

Super 8 by Wyndham, Orangeburg

Super 8 by Wyndham, Orangeburg

8/10 Good
"0"
Dwayne 4-night trip
Posted 7 hours ago
Super 8 by Wyndham, Orangeburg

Find out more about Santee

Everything you need to know about Santee vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Santee vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santee vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Santee vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Santee. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Santee in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $84 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Santee rentals

At Expedia, we put the best Santee vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Santee rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santee vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santee. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Can I find vacation rentals in Santee?

Yes, we offer vacation rentals near the most popular points of interest in Santee, or you can select a more remote option if you'd like a relaxing place to stay. Tourists appreciate the top-notch restaurants and coffeehouses in Santee. Make sure you have time to check out the golf courses and lake views during your trip.

What are some of the best vacation home rentals in Santee?

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!: This highly rated vacation home rental in Santee is located on a lake and has a patio, a selection of games, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family.

How many vacation rentals are there in Santee?

Expedia has 9 vacation rentals for your stay in Santee.

What can I see and do in Santee?

While you're exploring the area, Lake Marion and Taw Caw Creek Park are a couple of picturesque spots to get outside and enjoy nature. Santee Cooper Country Club and Santee State Park are other places to visit while you're in town.

What are vacation rentals like in Santee?

Vacation rentals are private accommodations you can book for several days or more in Santee. Vacation rentals feature amenities like kitchens and laundry facilities so you'll feel just like you're at home. If you're concerned about a sanitized environment, a vacation rental can provide a sense of safety away from public hotel elevators and bustling concierge desks while still allowing you the experience of travel. You'll also get more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is a great choice for family gatherings.