An aerial view of a coastal landscape with a dam, farmland, and dense forests.

Santee Vacation Rentals

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Check prices for these dates

In two weeks
Oct 16 - Oct 18
In two months
Nov 27 - Nov 29
In three months
Dec 25 - Dec 27
In four months
Jan 22 - Jan 24

Our top choices for Santee vacation rentals

A covered patio with outdoor furniture, a view of a lake, and a sunset.

1. LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks

LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks
Santee
9.0 out of 10, Wonderful, (7 reviews)
"We had a wonderful stay. Couldn't have asked for better location. It was beautiful, close to everything and perfect for our family."
United States
Michelle H.
$440 nightly
The price is $489
Oct 3 - Oct 4
Total with taxes and fees
LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks
A spacious living room with a large sofa, two coffee tables, and a potted plant.

2. Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
Santee
10.0 out of 10, Exceptional, (46 reviews)
"This was our first long trip with our dog and she loved the place! Fenced in yard and home was cozy and dog friendly. Loved the farmhouse style and large bedrooms and baths. "
United States
Lori B.
$319 nightly
The price is $354
Oct 5 - Oct 6
Total with taxes and fees
Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
A wicker outdoor seating area with cushioned chairs and a matching ottoman on a porch.

3. Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!

Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!
Santee
10.0 out of 10, Exceptional, (16 reviews)
"Annual golf trip with old friends. Perfect accommodations & location. Hope to stay again"
United States
Greg M.
$457 nightly
The price is $507
Oct 11 - Oct 12
Total with taxes and fees
Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!
A modern kitchen with white cabinets, stainless steel appliances, a black countertop, and a tiled floor.

4. Lake Marion Condo, Boat Slip Included, Pet Friendly

Lake Marion Condo, Boat Slip Included, Pet Friendly
Santee
$296 nightly
The price is $329
Oct 11 - Oct 12
Total with taxes and fees
Lake Marion Condo, Boat Slip Included, Pet Friendly
A compact living space with a kitchen, dining area, and a small seating area.

5. Country living lake style near Santee

Country living lake style near Santee
Summerton
10.0 out of 10, Exceptional, (46 reviews)
"Very convenient to the lake."
United States
John P.
$193 nightly
The price is $214
Oct 3 - Oct 4
Total with taxes and fees
Country living lake style near Santee
A tent with a view of a lake and boats, a wooden chair, and a potted plant.

6. Bells Marina & Resort

Bells Marina & Resort
2.5 star property
Eutawville
8.6 out of 10, Excellent, (102 reviews)
"Love it"
United States
Mark
$72 nightly
The price is $79
Nov 1 - Nov 2
Total with taxes and fees
Bells Marina & Resort
A covered outdoor seating area with a view of a dock and boats, wooden furniture, and string lights.

7. Lakefront tiny cabin amazing view on Lake Marion! Pet friendly.

Lakefront tiny cabin amazing view on Lake Marion! Pet friendly.
Summerton
8.8 out of 10, Excellent, (37 reviews)
"Great place to stay on the lake! "
United States
Troy S.
$161 nightly
The price is $179
Nov 1 - Nov 2
Total with taxes and fees
Lakefront tiny cabin amazing view on Lake Marion! Pet friendly.
A wooden cabin with a porch, outdoor seating, and a large planter.

8. Relax and unwind near Lake Marion - 2-bedroom 1.5 bath cabin getaway.

Relax and unwind near Lake Marion - 2-bedroom 1.5 bath cabin getaway.
Summerton
10.0 out of 10, Exceptional, (2 reviews)
"This property is absolutely gorgeous! The pics don't do it justice. Very nice and quiet neighbor. Would recommend it anytime"
United States
Judy v.
$238 nightly
The price is $264
Oct 4 - Oct 5
Total with taxes and fees
Relax and unwind near Lake Marion - 2-bedroom 1.5 bath cabin getaway.
Living area

9. Private Farm Stay on 30-Acres with Fish Pond + Sleeps 8

Private Farm Stay on 30-Acres with Fish Pond + Sleeps 8
Summerton
10.0 out of 10, Exceptional, (1 review)
"A Perfect Family Getaway!Our stay at this beautiful Summerton cabin was everything we hoped for and more. It provided the perfect opportunity to step back into a simpler time, unplug, and truly focus on making memories together as a family.The host family is wonderful. We purchased some of their farm-fresh goodies ahead of time, and having them waiting for us at the cabin when we arrived was a fantastic touch. A major highlight of our trip was getting to see all of the farm animals and the farm...
United States
Max N.
$480 nightly
The price is $533
Oct 4 - Oct 5
Total with taxes and fees
Private Farm Stay on 30-Acres with Fish Pond + Sleeps 8
A kitchen with wooden cabinets, a built-in dishwasher, a sink, and a ceiling fan.

10. Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301

Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301
Bowman
9.8 out of 10, Exceptional, (36 reviews)
"The place was excellent. The bed was really nice and comfortable. I'd definitely stay again."
United States
Joseph
$147 nightly
The price is $163
Oct 4 - Oct 5
Total with taxes and fees
Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301
A wooden deck with a white sofa, a wooden serving tray with snacks, and a pitcher of lemonade.

11. Pet friendly country cottage with large fenced-in yard & horses on property

Pet friendly country cottage with large fenced-in yard & horses on property
Holly Hill
10.0 out of 10, Exceptional, (163 reviews)
"Had a great stay at this cute cottage, just what we needed to get away from the busy city!"
United States
Yevheniya R.
$187 nightly
The price is $207
Oct 7 - Oct 8
Total with taxes and fees
Pet friendly country cottage with large fenced-in yard & horses on property
A wooden cabin with a porch and picnic table in a wooded area.

12. Cozy Camping Cabin on Lake Marion near Congaree Nat Park

Cozy Camping Cabin on Lake Marion near Congaree Nat Park
Rimini
8.2 out of 10, Very good, (17 reviews)
"Great place to stay. "
United States
Scott J.
$121 nightly
The price is $134
Oct 2 - Oct 3
Total with taxes and fees
Cozy Camping Cabin on Lake Marion near Congaree Nat Park
A kitchen with dark blue cabinets, a granite countertop, stainless steel sink, and a microwave.

13. Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston

Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston
Holly Hill
10.0 out of 10, Exceptional, (15 reviews)
"Great stay!"
United States
Hayden S.
$145 nightly
The price is $161
Oct 4 - Oct 5
Total with taxes and fees
Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston
Beach

14. Country Resting Spot just off I95. 12 miles west on hwy 6.

Country Resting Spot just off I95. 12 miles west on hwy 6.
Elloree
9.4 out of 10, Exceptional, (24 reviews)
"Everyone was pleased and said they would stay here again."
United States
Tom B.
$161 nightly
The price is $179
Oct 4 - Oct 5
Total with taxes and fees
Country Resting Spot just off I95. 12 miles west on hwy 6.
A living room with a sofa, two armchairs, a coffee table, and a lamp.

15. Modern apartment overlooking historic downtown Elloree, SC.

Modern apartment overlooking historic downtown Elloree, SC.
Elloree
$176 nightly
The price is $195
Oct 2 - Oct 3
Total with taxes and fees
Modern apartment overlooking historic downtown Elloree, SC.
A neatly made bed with white linens and patterned pillows, a bedside table with a lamp, and a remote control.

16. Quiet 1-bedroom apartment in charming Elloree, SC

Quiet 1-bedroom apartment in charming Elloree, SC
Elloree
$164 nightly
The price is $182
Oct 2 - Oct 3
Total with taxes and fees
Quiet 1-bedroom apartment in charming Elloree, SC
A wooden cabin with a red garage, outdoor seating area, and a deck.

17. Sweet Marion - Dock + Boat Ramp + Hot Tub!

Sweet Marion - Dock + Boat Ramp + Hot Tub!
Summerton
8.8 out of 10, Excellent, (26 reviews)
"Nice comfortable place to stay"
United States
Dylan H.
$449 nightly
The price is $510
Oct 4 - Oct 5
Total with taxes and fees
Sweet Marion - Dock + Boat Ramp + Hot Tub!
A compact kitchen with wooden cabinets, a stainless steel refrigerator, and a gas stove.

18. Beautiful brick home w/ large porch and 3 bedrooms

Beautiful brick home w/ large porch and 3 bedrooms
Bowman
9.2 out of 10, Wonderful, (5 reviews)
"A great home and very peaceful!! The host is very friendly and very easy to work with. I recommend this home for a stay 100 percent!!We plan on staying there again when we are in the area, such a great value!!"
United States
Troy K.
$253 nightly
The price is $280
Oct 6 - Oct 7
Total with taxes and fees
Beautiful brick home w/ large porch and 3 bedrooms
A small cabin with a fire pit, outdoor seating, and string lights.

19. Cabin at the lake in Rimini, SC

Cabin at the lake in Rimini, SC
Rimini
7.4 out of 10, Good, (8 reviews)
"Great view, excellent communication with the owners, relaxing, peaceful. "
United States
Christie
$135 nightly
The price is $150
Oct 3 - Oct 4
Total with taxes and fees
Cabin at the lake in Rimini, SC
A bunk bed with white bedding, a window with blinds, and a wooden floor.

20. Lake Marion Escape for 10

Lake Marion Escape for 10
Manning
$338 nightly
The price is $375
Oct 4 - Oct 5
Total with taxes and fees
Lake Marion Escape for 10
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santee Hotel Reviews

Baymont by Wyndham Santee

Baymont by Wyndham Santee

8/10 Good
"The property was maintained pretty well, but there is no pool (filled in), the beverage machine was busted up and not working. For me personally, the bed was not comfortable, with little half pillows. The sheets pulled off every time you rolled over. But over all, the property looks like it was recently remodeled, the desk person was very friendly and accommodating. It was well lighted all around. And quiet. A good place to over night if you have a pet."
Sandra 1-night trip
Posted 15 hours ago
Baymont by Wyndham Santee

Find out more about Santee

Everything you need to know about Santee vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Santee vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santee vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Santee vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Santee. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Santee in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $79 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Santee rentals

At Expedia, we put the best Santee vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Santee rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santee vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santee. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Can I find vacation rentals in Santee?

Yes, we offer vacation rentals near the most popular points of interest in Santee, or you can select a more remote option if you'd like a relaxing place to stay. Tourists appreciate the top-notch restaurants and coffeehouses in Santee. Make sure you have time to check out the golf courses and lake views during your trip.

What are some of the best vacation home rentals in Santee?

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!: This highly rated vacation home rental in Santee is located on a lake and has a patio, a selection of games, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family.

How many vacation rentals are there in Santee?

Expedia has 9 vacation rentals for your stay in Santee.

What can I see and do in Santee?

While you're exploring the area, Lake Marion and Taw Caw Creek Park are a couple of picturesque spots to get outside and enjoy nature. Santee Cooper Country Club and Santee State Park are other places to visit while you're in town.

What are vacation rentals like in Santee?

Vacation rentals are private accommodations you can book for several days or more in Santee. Vacation rentals feature amenities like kitchens and laundry facilities so you'll feel just like you're at home. If you're concerned about a sanitized environment, a vacation rental can provide a sense of safety away from public hotel elevators and bustling concierge desks while still allowing you the experience of travel. You'll also get more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is a great choice for family gatherings.