Find hotels in Southeast Jacksonville, FL from $53

  • Upfront pricing

    Our total price for your stay includes taxes and fees
  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Southeast Jacksonville hotels

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
Jacksonville
8.8 out of 10, Excellent, (1,003 reviews)
"Great stay!"
United States
Satavia
$99 nightly
The price is $113
May 3 - May 4
Total with taxes and fees
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Wingate by Wyndham Jacksonville FL

Wingate by Wyndham Jacksonville FL
3.0 star property
Southside
7.4 out of 10, Good, (1,000 reviews)
"The staff at this hotel were very friendly and accommodating. The room was comfortable and very clean, though the curtain was short and allowed a lot of sunlight in at sunup."
United States
Josie
$74 nightly
The price is $84
May 6 - May 7
Total with taxes and fees
Wingate by Wyndham Jacksonville FL

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
Isle of Palms
9.4 out of 10, Exceptional, (489 reviews)
"Location was very perfect for an appointment at The Mayo Clinic. Staff could not have been nicer."
United States
Jill
$139 nightly
The price is $157
May 2 - May 3
Total with taxes and fees
Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Hyatt Studios Jacksonville/St Johns Town Center

Hyatt Studios Jacksonville/St Johns Town Center
2.5 star property
Southside
10.0 out of 10, Exceptional, (3 reviews)
"Clean room, friendly staff"
United States
Despina
$127 nightly
The price is $144
Apr 28 - Apr 29
Total with taxes and fees
Hyatt Studios Jacksonville/St Johns Town Center

Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic
4.5 star property
Jacksonville
9.4 out of 10, Exceptional, (212 reviews)
"It was a very nice hotel , would recommend for any one 👌 "
United States
Michael
$163 nightly
The price is $185
May 8 - May 9
Total with taxes and fees
Hilton Jacksonville At Mayo Clinic

Tru by Hilton Jacksonville South Mandarin

Tru by Hilton Jacksonville South Mandarin
2.5 star property
Jacksonville
9.2 out of 10, Wonderful, (1,002 reviews)
"Definitely would stay again!!"
United States
Nyasia
$96 nightly
The price is $109
May 10 - May 11
Total with taxes and fees
Tru by Hilton Jacksonville South Mandarin

Hampton Inn & Suites Jacksonville South - Bartram Park

Hampton Inn & Suites Jacksonville South - Bartram Park
3.0 star property
Jacksonville
9.0 out of 10, Wonderful, (1,005 reviews)
"Clean room, friendly staff, great breakfast"
United States
Jared
$99 nightly
The price is $113
May 10 - May 11
Total with taxes and fees
Hampton Inn & Suites Jacksonville South - Bartram Park

TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
3.0 star property
Golden Glades - The Woods
9.2 out of 10, Wonderful, (606 reviews)
"Always nice, clean amd convenient to Mayo Clinic."
United States
DARON or CHARLON
$110 nightly
The price is $125
May 10 - May 11
Total with taxes and fees
TownePlace Suites by Marriott Jacksonville East

Holiday Inn Jacksonville E 295 Baymeadows by IHG

Holiday Inn Jacksonville E 295 Baymeadows by IHG
3.0 star property
Deerwood
8.6 out of 10, Excellent, (1,003 reviews)
"My family and I stayed here for a week"
United States
Alana
$105 nightly
The price is $119
May 3 - May 4
Total with taxes and fees
Holiday Inn Jacksonville E 295 Baymeadows by IHG

Sheraton Jacksonville Hotel

Sheraton Jacksonville Hotel
4.0 star property
Southside
9.2 out of 10, Wonderful, (1,007 reviews)
"Nice stay, soft beds"
United States
Charles
$134 nightly
The price is $152
May 2 - May 3
Total with taxes and fees
Sheraton Jacksonville Hotel

Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG
2.5 star property
Southside
9.6 out of 10, Exceptional, (1,001 reviews)
"Great place to stay"
United States
Clyde
$124 nightly
The price is $141
May 17 - May 18
Total with taxes and fees
Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Four Points by Sheraton Jacksonville Baymeadows

Four Points by Sheraton Jacksonville Baymeadows
3.0 star property
Jacksonville
9.0 out of 10, Wonderful, (1,005 reviews)
"Nice staff, cookies upon arrival, easy breakfast, comfortable beds. Easy stay! Would recommend."
United States
John
$93 nightly
The price is $106
May 9 - May 10
Total with taxes and fees
Four Points by Sheraton Jacksonville Baymeadows

Wyndham Garden Jacksonville

Wyndham Garden Jacksonville
3.0 star property
Southside
7.8 out of 10, Good, (1,871 reviews)
"Clean room, kind staff "
United States
Jacob
$77 nightly
The price is $87
May 6 - May 7
Total with taxes and fees
Wyndham Garden Jacksonville

Hampton Inn Jacksonville South/I-95 at JTB

Hampton Inn Jacksonville South/I-95 at JTB
2.5 star property
Southside
8.8 out of 10, Excellent, (1,002 reviews)
"Clean hotel. Clean room and bathrooms. Hampton inn breakfast did not disappoint. "
United States
Janice
$110 nightly
The price is $124
May 9 - May 10
Total with taxes and fees
Hampton Inn Jacksonville South/I-95 at JTB

Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center
3.0 star property
Southside
9.2 out of 10, Wonderful, (1,014 reviews)
"Nice place to stay "
United States
Rashad
$143 nightly
The price is $162
May 25 - May 26
Total with taxes and fees
Hyatt Place Jacksonville / St. Johns Town Center

Fairfield Inn & Suites by Marriott Jacksonville Butler Blvd

Fairfield Inn & Suites by Marriott Jacksonville Butler Blvd
3.0 star property
Southside
8.8 out of 10, Excellent, (1,003 reviews)
"Property was clean and staff was friendly "
United States
William
$107 nightly
The price is $122
May 3 - May 4
Total with taxes and fees
Fairfield Inn & Suites by Marriott Jacksonville Butler Blvd

Hampton Inn Jacksonville-I-295 East/Baymeadows

Hampton Inn Jacksonville-I-295 East/Baymeadows
2.5 star property
Southside
8.4 out of 10, Very Good, (1,003 reviews)
"Clean room, friendly staff and great breakfast."
United States
Elizabeth
$89 nightly
The price is $101
May 10 - May 11
Total with taxes and fees
Hampton Inn Jacksonville-I-295 East/Baymeadows

Baymont by Wyndham Jacksonville/Butler Blvd

Baymont by Wyndham Jacksonville/Butler Blvd
2.5 star property
Southside
8.2 out of 10, Very Good, (1,386 reviews)
"Nice easy stay"
United States
jamieson p
$69 nightly
The price is $78
May 18 - May 19
Total with taxes and fees
Baymont by Wyndham Jacksonville/Butler Blvd

La Quinta Inn & Suites by Wyndham Jacksonville Mandarin

La Quinta Inn & Suites by Wyndham Jacksonville Mandarin
3.0 star property
Jacksonville
7.6 out of 10, Good, (455 reviews)
"The property was very clean and the staff was very nice. Breakfast was delicious "
United States
Jose
$73 nightly
The price is $83
May 3 - May 4
Total with taxes and fees
La Quinta Inn & Suites by Wyndham Jacksonville Mandarin

AC Hotel Jacksonville St Johns Town Center

AC Hotel Jacksonville St Johns Town Center
2.5 star property
Southside
9.4 out of 10, Exceptional, (190 reviews)
"A bit dirty. Floor wasn’t clean. Bed sheets had hair, and pillow cases some dark stains. Blood stains on the shower. It’s a nice hotel, nice location, I wish they did a better job with cleaning. And it would be nice if the breakfast was included."
United States
Oleksandr
$209 nightly
The price is $237
May 28 - May 29
Total with taxes and fees
AC Hotel Jacksonville St Johns Town Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Northern Florida attractions

Learn more about Southeast Jacksonville

Explore the family-friendly area of Southeast Jacksonville—live music, shopping, and popular sights like St. Johns Town Center.

Photo by Nancy
Open Photo by Nancy

Top Southeast Jacksonville Hotel Reviews

More cheap stays in Southeast Jacksonville

Hotels in Southeast Jacksonville with star-rating

Explore a world of travel with Expedia