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Find 4 Star Hotels in Medical Center District, TX from $191

Compare Medical Center District 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Riverwalk Plaza
4.0 star property
8.2 out of 10, Very Good, 3,658 reviews
"I thought the staff was super nice and very helpful anytime i had a question or a problem. And, if i get the chance i would return to this hotel again"
The price is $119
$141 total
includes taxes & fees
Jun 9 - Jun 10
Riverwalk Plaza
Canopy by Hilton San Antonio Riverwalk
4.0 star property
9.4 out of 10, Exceptional, 1,325 reviews
"Ice machine was broke the whole time. Paying to park at A place staying maybe 20 bucks ok not 55."
The price is $191
$230 total
includes taxes & fees
Jun 16 - Jun 17
Canopy by Hilton San Antonio Riverwalk
JW Marriott San Antonio Hill Country Resort & Spa
4.5 star property
8.8 out of 10, Excellent, 1,019 reviews
"Great place to stay. Went in June and not too busy Sunday through Tuesday. Kids had a lot of fun. "
The price is $356
$472 total
includes taxes & fees
Jul 4 - Jul 5
JW Marriott San Antonio Hill Country Resort & Spa
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Hotel Contessa
4.0 star property
8.8 out of 10, Excellent, 2,777 reviews
"Great location and beautiful hotel. In walking distance to La Villita Historic Village and even the mall (and I’m pregnant)! Great breakfast and bar food in the hotel and in walking distance to some of the best restaurants in the city. "
The price is $190
$239 total
includes taxes & fees
Jun 17 - Jun 18
Hotel Contessa
Hyatt Regency San Antonio Riverwalk
4.0 star property
8.8 out of 10, Excellent, 1,631 reviews
"Hotel room was very clean and lovely. Location is ideal and very walkable to many attractions. Staff was responsive. Housekeeping could have been somewhat better but otherwise a good stay and would recommend. Currently city of San Antonio is doing construction in their lower area so the noise level was annoying during the day. "
The price is $195
$233 total
includes taxes & fees
Jun 15 - Jun 16
Hyatt Regency San Antonio Riverwalk
Hotel Gibbs Downtown Riverwalk
4.5 star property
9.0 out of 10, Wonderful, 2,912 reviews
"Be prepared to spend $47 for one night of parking, that was a surprise. Downtown San Antonio is pretty dodgy, I don’t think it is somewhere I would take my daughter again for a getaway girls weekend. Beds were comfortable and clean though."
The price is $116
$136 total
includes taxes & fees
Jun 13 - Jun 14
Hotel Gibbs Downtown Riverwalk
Omni La Mansion del Rio
4.0 star property
9.2 out of 10, Wonderful, 2,182 reviews
"To get free basic WiFi, the hotel requires you to create a free membership account. I would check with the hotel to ensure basic WiFi is not an additional fee."
The price is $197
$236 total
includes taxes & fees
Jun 23 - Jun 24
Omni La Mansion del Rio
Hotel Valencia Riverwalk
4.0 star property
9.2 out of 10, Wonderful, 1,758 reviews
"Great place. "
The price is $159
$193 total
includes taxes & fees
Jun 16 - Jun 17
Hotel Valencia Riverwalk
Grand Hyatt San Antonio River Walk
4.0 star property
8.8 out of 10, Excellent, 1,094 reviews
"Clean"
The price is $189
$227 total
includes taxes & fees
Jun 15 - Jun 16
Grand Hyatt San Antonio River Walk
The St. Anthony, A Luxury Collection Hotel, San Antonio
4.5 star property
9.0 out of 10, Wonderful, 1,009 reviews
"We love the staff and especially the pool! Great spot for a staycation:)"
The price is $183
$217 total
includes taxes & fees
Jun 9 - Jun 10
The St. Anthony, A Luxury Collection Hotel, San Antonio
The Westin San Antonio North
4.0 star property
8.4 out of 10, Very Good, 1,011 reviews
"Tons of food options around "
The price is $111
$131 total
includes taxes & fees
Jul 1 - Jul 2
The Westin San Antonio North
La Cantera Resort & Spa
4.0 star property
8.8 out of 10, Excellent, 1,070 reviews
"La Cantera Resort is a must for anyone traveling through San Antonio. I had a wonderful time! The food was excellent and the service phenomenal. "
The price is $333
$435 total
includes taxes & fees
Jul 1 - Jul 2
La Cantera Resort & Spa
Element San Antonio Riverwalk
4.0 star property
8.8 out of 10, Excellent, 275 reviews
"Excellent "
The price is $122
$144 total
includes taxes & fees
Jun 16 - Jun 17
Element San Antonio Riverwalk
AC Hotel by Marriott San Antonio Riverwalk
4.0 star property
8.4 out of 10, Very Good, 263 reviews
"nice "
The price is $118
$140 total
includes taxes & fees
Jun 16 - Jun 17
AC Hotel by Marriott San Antonio Riverwalk
Plaza San Antonio Hotel & Spa, Autograph Collection
4.0 star property
9.2 out of 10, Wonderful, 95 reviews
"Such a great location with a super friendly staff! Bar and restaurant in the hotel were both great and again, staff super friendly. You can walk anywhere from this location and not be in a noisy area at night."
The price is $167
$200 total
includes taxes & fees
Jul 7 - Jul 8
Plaza San Antonio Hotel & Spa, Autograph Collection
The Westin Riverwalk, San Antonio
4.0 star property
8.6 out of 10, Excellent, 1,049 reviews
"The staff was very polite, professional, helpful & kind. "
The price is $175
$208 total
includes taxes & fees
Jun 30 - Jul 1
The Westin Riverwalk, San Antonio
Hyatt Regency Hill Country Resort & Spa
4.0 star property
8.8 out of 10, Excellent, 1,006 reviews
"The "
The price is $224
$313 total
includes taxes & fees
Jun 24 - Jun 25
Hyatt Regency Hill Country Resort & Spa
Hilton Palacio Del Rio
4.0 star property
8.8 out of 10, Excellent, 1,583 reviews
"Experience was okay, clean. Older hotel. We were put in a room that had terrace and that night they had an event on the terrace. Was very loud till 2am. Food was okay. "
The price is $165
$195 total
includes taxes & fees
Jun 23 - Jun 24
Hilton Palacio Del Rio
Marriott San Antonio Airport
4.0 star property
8.2 out of 10, Very Good, 1,004 reviews
"Nice hotel area not great "
The price is $118
$139 total
includes taxes & fees
Jul 5 - Jul 6
Marriott San Antonio Airport
Hilton San Antonio Hill Country
4.0 star property
8.0 out of 10, Very Good, 1,103 reviews
"Wonderful customer service! "
The price is $135
$160 total
includes taxes & fees
Jun 16 - Jun 17
Hilton San Antonio Hill Country

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the best 4-star hotels in Medical Center District?
The Westin San Antonio North is highly praised by Expedia guests. This 4-star hotel located around Medical Center District guarantees a warm and inviting atmosphere and plenty of handy amenities.
How much does it cost to stay in a 4-star hotel in Medical Center District?
To book a 4-star hotel in Medical Center District that’s within your budget, make use of Expedia’s filters. Take a look at the availability during your travel dates and use our pricing filter to set your maximum rate. You can also list your results by the most budget-friendly retreat first.

  • Search for the lowest price from $191

What's the difference between 5-star and 4-star hotels in Medical Center District?
Treat yourself to refined living during your Medical Center District vacation by checking in to a 4-star hotel. As well as featuring upscale accommodations, these properties are typically packed with amenities like large beds, complimentary bathrobes and more. A 5-star hotel will go the extra mile to make your stay an even more indulgent and unforgettable one. 24-hour front desk, on-site spas and gourmet dining are a few of the exclusive services and conveniences you’ll likely have access to.
Does Medical Center District have any 4-star all-inclusive resorts?
Finding your dream hotel in Medical Center District is as simple as entering your travel dates and selecting our “All inclusive” filter. Stay and play where almost everything is already taken care of like your meals, room, entertainment and activities, or go for a standard 4-star resort in or around this sought-after destination.
Are there any 4-star casino hotels in Medical Center District?
Shuffle between your room and the craps table with ease by using our filter tool to find 4-star casino hotels in and around Medical Center District. Celebrating with someone special? Refine your search further by choosing amenities with a wow-factor, like a view or pool.

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