Title: Sikeston Vacation Packages 2026 from $355 | Expedia.com [Sikeston Travel Guide](https://expedia.com/Sikeston.dx6058766)[Hotels in Sikeston](https://expedia.com/Sikeston-Hotels.d6058766.Travel-Guide-Hotels)[Vacation Rentals in Sikeston](https://expedia.com/Sikeston-Vacation-Rentals.d6058766.Travel-Guide-VacationRentals)[Flights to Sikeston](https://expedia.com/Cheap-Flights-To-Sikeston.d6058766.Travel-Guide-Flights)[Car Rentals in Sikeston](https://expedia.com/Car-Rentals-In-Sikeston.d6058766.Car-Rental-Guide) ![](https://images.trvl-media.com/place/6058766/0353751e-5978-48d0-a913-84533caba2b0.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Sikeston Vacations from $355 ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to $1,045 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ## Your Sikeston Vacation There's tons to like about Sikeston, from its rich history to its rural countryside. When you're ready to say hi to this captivating city, our Sikeston vacation packages will be perfect for you. Fill your spare time with visits to [Sikeston Depot Museum](https://www.expedia.com/Sikeston-Depot-Museum-Sikeston.d6305602.Vacation-Attraction), [The Book Bug](https://www.expedia.com/The-Book-Bug-Sikeston.d553248621532655751.Vacation-Attraction) and [Central Park](https://www.expedia.com/Central-Park-Sikeston.d6305608.Vacation-Attraction), some of the top attractions you just have to see during your trip to Sikeston. That dream Sikeston vacation is clicks away. Browse hotels, flights and more on Expedia for a getaway that's tailored to suit your travel style. ## The Latest Sikeston vacation packages Price found within the past 48 hours. Click for updated prices. ![The Wildwood Hotel](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/035dee6c_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Wildwood Hotel $355 per person Apr 24 - Apr 27 found 1 day ago Roundtrip flight included Atlanta (ATL) to St. Louis (STL) 9.2/10 Wonderful! (1,626 reviews) Place was nice. Had handicap room. No living room type chair, just computer chair. Hot tub was like a four-seater and only two mild jets. Main pool half size of most and a nly went from 3 feet to 4 feet. Very small. Breakfast was excellent. Reviewed on Mar 11, 2026 ![Angad Arts Hotel St. Louis, Tapestry Collection by Hilton](https://images.trvl-media.com/lodging/28000000/27620000/27617000/27616925/25bc97a8_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Angad Arts Hotel St. Louis, Tapestry Collection by Hilton Grand Center Save 100% on your flight $442 per person Apr 24 - Apr 27 found 1 day ago Roundtrip flight included Atlanta (ATL) to St. Louis (STL) 8.8/10 Excellent! (1,060 reviews) The property was beautiful and unique. The food was a disappointment. Unfortunately it was just too greasy for us. Reviewed on Mar 6, 2026 ![Home2 Suites by Hilton St. Louis Downtown](https://images.trvl-media.com/lodging/77000000/76520000/76510800/76510729/104b5741_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Home2 Suites by Hilton St. Louis Downtown Downtown West Save 100% on your flight $471 per person Apr 21 - Apr 25 found 1 day ago Roundtrip flight included Denver (DEN) to St. Louis (STL) 8/10 Very Good! (690 reviews) We booked this hotel for the vicinity to the Dome and for the known chain name. There were several issues during our stay that i think were significant due to the fact the hotel was sold out for the weekend: Parking is only valet and there was only one person working valet, so, could take up to 45min to get the vehicle 3 elevators but only 1 was working We didnt have hot water the first morning we showered The handle on our bathroom drawer was broken, the piece put in the drawer, when we arrived There were dirty dishes from the previous guest in the dishwasher, which caused the room to smell bad Reviewed on Mar 9, 2026 ![Spacious 3-Bedroom with King Bed](https://images.trvl-media.com/lodging/110000000/109680000/109680000/109679988/f2203ae1_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Spacious 3-Bedroom with King Bed Central West End Save 100% on your flight $1,144 per person May 21 - May 26 found 1 day ago Roundtrip flight included Atlanta (ATL) to St. Louis (STL) 8.8/10 Excellent! (11 reviews) Clean room nice area Reviewed on Feb 1, 2026 ![Hotel Saint Louis, Autograph Collection](https://images.trvl-media.com/lodging/28000000/27480000/27478600/27478599/8a12cc18_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Saint Louis, Autograph Collection Downtown St. Louis Save 100% on your flight $687 per person Apr 21 - Apr 25 found 1 day ago Roundtrip flight included Denver (DEN) to St. Louis (STL) 8.8/10 Excellent! (476 reviews) Good location, sheets were dirty and bathroom shower was also covered in someone else’s hair. Reviewed on Mar 10, 2026 Don't see what you're looking for? See all available trips from Columbus to Sikeston [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-04-12/2026-04-19/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=STL&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=PKG_SPRING_PROMO_6058766) ### Discover the most popular places to visit in Sikeston #### Central Park 4/5(25 reviews) Explore the great outdoors at Central Park, a lovely green space in Sikeston. While in this relaxing area, you can savor the top-notch restaurants. [](https://expedia.com/Central-Park-Sikeston.d6305608.Vacation-Attraction) #### Sikeston Depot Museum 4/5(15 reviews) You can spend time exploring the galleries in Sikeston Depot Museum in Sikeston. While in this relaxing area, you can savor the top-notch restaurants. [](https://expedia.com/Sikeston-Depot-Museum-Sikeston.d6305602.Vacation-Attraction) ## Sikeston Hotel Deals ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Inn & Suites Sikeston, MO 2608 East Malone Ave, Miner Sikeston MO Fully refundableReserve now, pay when you stay $94 nightly $108 total Mar 15 - Mar 16 Total with taxes and fees 9.4/10 Exceptional! (1,002 reviews) Very nice comfortable room. Lots of space and great beds and pillows. Reviewed on Mar 11, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F15%2F2026&endDate=3%2F16%2F2026&selected=24210&PinnedHotelID=24210&HadPinnedHotel=true®ionId=6058766) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hampton Inn Sikeston 1240 Commerce Drive Sikeston MO Fully refundableReserve now, pay when you stay $92 nightly $104 total Apr 12 - Apr 13 Total with taxes and fees 9/10 Wonderful! (498 reviews) East, friendly check in. Beautiful, large room. Reviewed on Mar 9, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F12%2F2026&endDate=4%2F13%2F2026&selected=25178175&PinnedHotelID=25178175&HadPinnedHotel=true®ionId=6058766) ![Best Western Plus Sikeston I-55](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Best Western Plus Sikeston I-55 120 S Interstate Drive Sikeston MO Fully refundableReserve now, pay when you stay $82 nightly $93 total Mar 26 - Mar 27 Total with taxes and fees 8.4/10 Very Good! (1,007 reviews) nice and covenant have stay here a few times, staff always has a smile. Reviewed on Mar 10, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F26%2F2026&endDate=3%2F27%2F2026&selected=8420572&PinnedHotelID=8420572&HadPinnedHotel=true®ionId=6058766) [See all 285 properties in Sikeston](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=3%2F13%2F2026&endDate=3%2F14%2F2026®ionId=6058766) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Find the Best Sikeston Vacation Packages ## Sikeston Essential Information | Language | English | | --------------- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ | | Currency | U.S dollars | | Closest Airport | Cape Girardeau Municipal Airport (CGI) | | Population | 16,400 | | Max Temp Winter | 45ºF | | Max Temp Summer | 85ºF | | Top Sights | [Sikeston Depot Museum](https://www.expedia.com/Sikeston-Depot-Museum-Sikeston.d6305602.Vacation-Attraction), [Central Park](https://www.expedia.com/Central-Park-Sikeston.d6305608.Vacation-Attraction) and [The Book Bug](https://www.expedia.com/The-Book-Bug-Sikeston.d553248621532655751.Vacation-Attraction) | ## More vacations you might like 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