An aerial view of a coastal landscape with a river, dense forest, and a beach.

Find hotels in Dewees Island, SC from $95

Q: What are some of the best vacation rentals in Dewees Island?

Featured "HGTV Dream Home" - Best View on the Oceanfront! : This vacation home rental near Dewees Island is located on the beach and has a fireplace, a balcony, and a barbecue grill to put you at ease in your new surroundings. It has 5 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Make the most of the garden in this rental home to help you unwind. See all vacation rentals in Dewees Island .

Dates

November 2026

December 2026

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Our top choices for Dewees Island hotels

A hotel lobby with seating areas, a reception desk, and decorative lighting.

1. Tru by Hilton Mt Pleasant Charleston

Mount Pleasant

Angela

$92 nightly

Dec 7 - Dec 8

Total with taxes and fees

A swimming pool with lounge chairs and umbrellas, surrounded by trees and a building with multiple windows.

2. Holiday Inn Express & Suites Mt. Pleasant by IHG

Mount Pleasant

Thomas

$103 nightly

Nov 15 - Nov 16

Total with taxes and fees

A spacious dining area with multiple tables and chairs, large windows, and potted plants.

3. Hampton Inn & Suites Charleston/Mt. Pleasant-Isle Of Palms

Mount Pleasant

Erik

$106 nightly

Nov 29 - Nov 30

Total with taxes and fees

A modern bar area with a wooden ceiling, bar stools, and a counter.

4. Cambria Hotel Mount Pleasant – Charleston

Mount Pleasant

william

$106 nightly

Nov 23 - Nov 24

Total with taxes and fees

A bar area with a curved counter, multiple seating options including round tables and chairs, and a patterned floor.

5. DoubleTree by Hilton Charleston Mount Pleasant

Mount Pleasant

Brandon

$91 nightly

Dec 10 - Dec 11

Total with taxes and fees

A modern hotel room with a bed, bedside tables, a desk, and a balcony with a view.

6. The Palms Oceanfront Hotel

Downtown Isle of Palms

Troy O

$109 nightly

Nov 29 - Nov 30

Total with taxes and fees

A modern living room with a sectional sofa, a flat-screen TV, and a small coffee table.

7. Hyatt House Charleston / Mount Pleasant

Mount Pleasant

Cindy

$113 nightly

Nov 22 - Nov 23

Total with taxes and fees

A spacious lobby with high ceilings, large windows, and elegant furniture.

8. Courtyard by Marriott Charleston Mount Pleasant

Mount Pleasant

Cynthia

$95 nightly

Nov 22 - Nov 23

Total with taxes and fees

A hotel room with a blue sofa, two brown ottomans, a bed with white linens, and three framed pictures on the wall.

9. Comfort Suites at Isle Of Palms Connector

Mount Pleasant

Corey

$85 nightly

Dec 1 - Dec 2

Total with taxes and fees

A modern kitchen with a large island, bar stools, framed pictures on the wall, and a view of the outside.

10. Quality Inn Mt. Pleasant - Charleston

Mount Pleasant

GENELL

$83 nightly

Dec 6 - Dec 7

Total with taxes and fees

A cozy outdoor patio with a circular fire pit, seating, and string lights.

11. Home2 Suites By Hilton Mt Pleasant Charleston

Mount Pleasant

Marilyn

$105 nightly

Nov 16 - Nov 17

Total with taxes and fees

A hotel lobby with reception desks, seating areas, and a wooden ceiling.

12. Holiday Inn Express & Suites Charleston NE Mt Pleasant US17 by IHG

Mount Pleasant

Patrick

$101 nightly

Nov 22 - Nov 23

Total with taxes and fees

A spacious dining area with high ceilings, large windows, and a variety of seating options including tables and chairs.

13. Hampton Inn Charleston - Daniel Island

Charleston

Teresa

$106 nightly

Nov 23 - Nov 24

Total with taxes and fees

A corridor with a view of the sunset over the ocean, palm trees, and a balcony with a railing.

14. Seaside Inn Oceanfront

Downtown Isle of Palms

Amanda

$92 nightly

Nov 29 - Nov 30

Total with taxes and fees

A hotel room with two beds, a wooden floor, and a large window with curtains.

15. Extended Stay America Suites Charleston Mt Pleasant

Mount Pleasant

Michelle

$67 nightly

Nov 16 - Nov 17

Total with taxes and fees

A covered outdoor area with a pool, palm trees, and lounge chairs.

16. The Beach Club at Charleston Harbor Resort and Marina

Mount Pleasant

Robert

$157 nightly

Nov 23 - Nov 24

Total with taxes and fees

A pool area with lounge chairs and palm trees, surrounded by a building with a sign that reads 'hotel indigo'.

17. Hotel Indigo Mount Pleasant by IHG

Mount Pleasant

Mary Beth

$116 nightly

Dec 8 - Dec 9

Total with taxes and fees

A hotel reception area with a wooden reception desk, a digital screen, and a wall-mounted sign.

18. Sleep Inn Mt. Pleasant - Charleston

Mount Pleasant

Matthew

$87 nightly

Dec 1 - Dec 2

Total with taxes and fees

A spacious lobby with a high ceiling, a mezzanine level, and multiple seating areas including sofas and chairs.

19. Comfort Inn & Suites Patriots Point

Mount Pleasant

Vita

$93 nightly

Nov 30 - Dec 1

Total with taxes and fees

A hotel with multiple swimming pools, outdoor seating areas, and a large building with balconies.

20. Wild Dunes Resort – Sweetgrass Inn and Boardwalk Inn

Isle of Palms

Rebecca

$177 nightly

Nov 15 - Nov 16

Total with taxes and fees

View all properties

Learn more about Dewees Island

Check out the local area in Dewees Island as you venture to sights like Dewees Island Beach.

See all hotels in Dewees Island

An outdoor patio area with a fire pit, seating, and a covered section.

Home2 Suites by Hilton Charleston Daniel Island

Charleston

10/10 Excellent

Annika

A modern lobby with a candy store, seating area, and a TV screen.

Candlewood Suites Charleston Mt Pleasant by IHG

Mount Pleasant

10/10 Excellent

Derek

Hyatt Place Mount Pleasant Towne Centre

Mount Pleasant

10/10 Excellent

Seems like a new building. That’s how clean it is. Didn’t expect the hotel to be right in the middle of shopping center giving us convenience of shopping dining parking etc. daily house keeping is awesome very friendly staff. Only two things I would love it if they can improve. First the breakfast menu. I’m staying here from Sunday to Friday but the breakfast menus are almost same every day. Scrambled eggs boiled eggs grits and bagels stays the same daily. Only thing changing is sausage and...

A hotel lobby with a bar area, multiple dining tables, and chairs.

Hilton Garden Inn Charleston / Mt. Pleasant

Mount Pleasant

10/10 Excellent

Paritosh

Quality Inn Mt. Pleasant - Charleston

Mount Pleasant

10/10 Excellent

Elaine

Frequently Asked Questions

What are some of the best vacation rentals in Dewees Island?

Featured "HGTV Dream Home" - Best View on the Oceanfront!: This vacation home rental near Dewees Island is located on the beach and has a fireplace, a balcony, and a barbecue grill to put you at ease in your new surroundings. It has 5 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Make the most of the garden in this rental home to help you unwind. See all vacation rentals in Dewees Island.

If I need to cancel my hotel reservation in Dewees Island, will I receive a refund?

Yes, the majority of hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, you might still have the option to cancel and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Dewees Island.

Where can I learn more about changing or cancelling my trip to Dewees Island?

For additional details about changing or cancelling your trip to Dewees Island, click here.

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Charleston Vacation Rentals
Standard Link for Charleston Vacation Rentals

Find hotels in Dewees Island, SC from $95

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Treat yourself

Be picky

Go beyond your typical stay in Dewees Island

Check prices for these dates

Filter by

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Our top choices for Dewees Island hotels

1. Tru by Hilton Mt Pleasant Charleston

2. Holiday Inn Express & Suites Mt. Pleasant by IHG

3. Hampton Inn & Suites Charleston/Mt. Pleasant-Isle Of Palms

4. Cambria Hotel Mount Pleasant – Charleston

5. DoubleTree by Hilton Charleston Mount Pleasant

6. The Palms Oceanfront Hotel

7. Hyatt House Charleston / Mount Pleasant

8. Courtyard by Marriott Charleston Mount Pleasant

9. Comfort Suites at Isle Of Palms Connector

10. Quality Inn Mt. Pleasant - Charleston

11. Home2 Suites By Hilton Mt Pleasant Charleston

12. Holiday Inn Express & Suites Charleston NE Mt Pleasant US17 by IHG

13. Hampton Inn Charleston - Daniel Island

14. Seaside Inn Oceanfront

15. Extended Stay America Suites Charleston Mt Pleasant

16. The Beach Club at Charleston Harbor Resort and Marina

17. Hotel Indigo Mount Pleasant by IHG

18. Sleep Inn Mt. Pleasant - Charleston

19. Comfort Inn & Suites Patriots Point

20. Wild Dunes Resort – Sweetgrass Inn and Boardwalk Inn

Learn more about Dewees Island

Top Dewees Island Hotel Reviews

Holiday Inn Express & Suites Mt. Pleasant by IHG

10/10 Excellent

Frequently Asked Questions

What are some of the best vacation rentals in Dewees Island?

If I need to cancel my hotel reservation in Dewees Island, will I receive a refund?

Where can I learn more about changing or cancelling my trip to Dewees Island?

Explore a world of travel with Expedia