Osco Vacation Rentals

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Our top choices for Osco vacation rentals

10.0 out of 10, Exceptional, (79)
"Wonderful property and host. Highly recommend."
United States
Keith H.
$216 nightly
The price is $242
Jan 2 - Jan 3, 2026
Total with taxes and fees
Historic Cottage in LeClaire w/full river views and 3 decks. Dogs welcome
9.6 out of 10, Exceptional, (7)
"Close to everything, yet off the beaten path enough for privacy!"
United States
Mike Y.
$140 nightly
The price is $148
Jan 5 - Jan 6, 2026
Total with taxes and fees
Enchanting river front spot with deck and Tiki bar in charming Hampton, Illinois

Vacation Home in Le Claire

Aire Leclaire 2 bedroom home
10.0 out of 10, Exceptional, (59)
"This little cottage gave us a perfect start for our drive from PA to MT. It was a great location, quiet and peaceful. It was a wonderful neighborhood for walking our dog and the little town provided everything we needed. Thank you!"
United States
Jane F.
$158 nightly
The price is $176
Jan 1 - Jan 2, 2026
Total with taxes and fees
Aire Leclaire 2 bedroom home
9.6 out of 10, Exceptional, (79)
"Great easy stay"
United States
Sean B.
$119 nightly
The price is $126
Jan 4 - Jan 5, 2026
Total with taxes and fees
Lucy’s House Single Family Bungalow
9.4 out of 10, Exceptional, (6)
"Loved the area, Mostly sat on deck!"
United States
Jeanne W.
$177 nightly
The price is $187
Jan 7 - Jan 8, 2026
Total with taxes and fees
Home on Historic Campbell's Island with Mighty Mississippi River in the backyard

Apartment in Moline

Minutes from anywhere
10.0 out of 10, Exceptional, (125)
"We really enjoyed our stay and the location was perfect!"
United States
Brittany S.
$68 nightly
The price is $72
Jan 4 - Jan 5, 2026
Total with taxes and fees
Minutes from anywhere

Apartment in Downtown Davenport

The Nelson Lofts - Unit 2 (1 BR)
9.8 out of 10, Exceptional, (11)
"I absolutely love staying here! Love the area, and apartments! "
United States
Kristina E.
$211 nightly
The price is $236
Jan 3 - Jan 4, 2026
Total with taxes and fees
The Nelson Lofts - Unit 2 (1 BR)
9.2 out of 10, Wonderful, (33)
"Great location, cozy home and the host made check-in very easy and straight forward!"
United States
Steve U.
$206 nightly
The price is $230
Jan 1 - Jan 2, 2026
Total with taxes and fees
Charming 1920s, pet friendly home, centrally located!

Vacation Home in East Moline

River Front House
8.0 out of 10, Very Good, (21)
"The owner was easy to get in touch with and very helpful. My coworker and I stayed here for a 3 week job."
United States
Lauren K.
$215 nightly
The price is $228
Jan 1 - Jan 2, 2026
Total with taxes and fees
River Front House
9.6 out of 10, Exceptional, (11)
"Very cute property, great location, fast and easy communication with Laura."
United States
Kirsten L.
$209 nightly
The price is $234
Jan 1 - Jan 2, 2026
Total with taxes and fees
Historical riverfront home in beautiful LeClaire. Kid and pet friendly!
9.8 out of 10, Exceptional, (41)
"The location was great for all of the activities we had planned. Check in and out was very easy and the host was quick to respond to messages. Would stay again!"
United States
Amanda L.
$274 nightly
The price is $307
Jan 1 - Jan 2, 2026
Total with taxes and fees
3BR/2BA Beauty near TBK sports complex. Right off I74, close to everything!
10.0 out of 10, Exceptional, (4)
"Great location. Comfy beds. Super clean. We really enjoyed and would recommend. "
United States
Matt T.
$315 nightly
The price is $327
Jan 6 - Jan 7, 2026
Total with taxes and fees
Renovated Historic Duplex East Davenport Village

Vacation Home in Davenport

Lewis M. Fisher House
$369 nightly
The price is $413
Jan 5 - Jan 6, 2026
Total with taxes and fees
Lewis M. Fisher House
10.0 out of 10, Exceptional, (5)
"Overall it was a very clean comfortable home and in a very convenient location."
United States
Mike M.
$265 nightly
The price is $281
Jan 1 - Jan 2, 2026
Total with taxes and fees
Airport Oasis - Remolded home less than 5 minutes from the airport
10.0 out of 10, Exceptional, (31)
"Everything about our stay was very nice. We look forward to staying again."
United States
Deb R.
$353 nightly
The price is $358
Jan 3 - Jan 4, 2026
Total with taxes and fees
Charming 3 bedroom Condo in Bettendorf with King Master Suite
10.0 out of 10, Exceptional, (2)
"We enjoyed our stay. Home was clean, host communicated well, although backs up to I80, home was very quiet. Would stay again. "
United States
Laura B.
$353 nightly
The price is $358
Jan 3 - Jan 4, 2026
Total with taxes and fees
Bettendorf Gem: 3BR Apartment w/ King Suite & Office!
9.4 out of 10, Exceptional, (34)
"Great place for a weekend getaway! "
United States
matt l.
$215 nightly
The price is $226
Jan 5 - Jan 6, 2026
Total with taxes and fees
Riverfront Cabin:Wrap Around Deck & 3 Season Room

Vacation Home in Moline

Your Cozy Escape on the Rock River
10.0 out of 10, Exceptional, (1)
"Awesome property, super clean. Very well appointed, we wanted for nothing. Hosts were as nice and responsive as one could hope for. I have recommended this property to other extended family members that travel to the Quad Cities. A true gem!"
United States
Mary S.
$265 nightly
The price is $281
Jan 3 - Jan 4, 2026
Total with taxes and fees
Your Cozy Escape on the Rock River
10.0 out of 10, Exceptional, (7)
"Amazing property! This property had everything we needed, and was walking distance to everything. Great outdoor spaces too. Would definitely recommend!"
United States
Kelly S.
$412 nightly
The price is $461
Jan 1 - Jan 2, 2026
Total with taxes and fees
Stay Where History Has a Heartbeat - Mike Wolfe's Two Lanes Guesthouse

Apartment in Downtown Davenport

The Nelson Lofts - Unit 7 (2 BR)
9.8 out of 10, Exceptional, (28)
"We had a wonderful week of family time in the quad cities. This apartment was perfect for our needs- great location, great size and very modern and comfortable! Highly recommend!"
United States
Geri M.
$260 nightly
The price is $291
Jan 2 - Jan 3, 2026
Total with taxes and fees
The Nelson Lofts - Unit 7 (2 BR)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Osco Hotel Reviews

Find out more about Osco

Everything you need to know about Osco vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Osco vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Osco vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Osco vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Osco. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Osco in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $72 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Osco rentals

At Expedia, we put the best Osco vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Osco rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Osco vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Osco. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Can I find a vacation rental in Osco?

Yes, you can find vacation rentals near popular local attractions in Osco, or you can select a secluded option if you'd like a relaxing place to stay.

What are some of the best vacation home rentals in Osco?

3BR/2BA Beauty near TBK sports complex. Right off I74, close to everything! : Visitors like this Osco vacation home rental. It is equipped with a fireplace, air-conditioning, and laundry facilities to help you feel comfortable during your stay.

What’s there to see and do in Osco?

Explore the area and family-friendly sights such as Niabi Zoo, or get out into nature at a spot like Geneseo City Park. TPC Deere Run Golf Course and Deere and Company World Headquarters are a couple of places you'll find in the larger area.

What’s a vacation rental in Osco like?

Vacation rentals are privately owned properties you can stay in for short or long periods in Osco. Vacation rentals offer extras such as hot tubs, fire pits, and patios so you'll have a home away from home. If you're concerned about a sanitized environment, vacation rentals can provide a sense of safety away from public hotel elevators and busy concierge desks while still allowing you the experience of travel. You'll also find more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is a popular choice for families.