Find hotels in Illinois Medical District, Chicago

Start date: Check-in selected.
To Date
End date: Check-out
  • Upfront pricing

    Our total price for your stay includes taxes and fees
  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Discover Illinois Medical District hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Hyatt House Chicago Medical/University District

3.5 star property
Illinois Medical District
9.0 out of 10, Wonderful, (1226)
"Good place to stay "
United States
Matthew
$93 nightly
The price is $109
Dec 17 - Dec 18
Total with taxes and fees
Hyatt House Chicago Medical/University District

Hyatt Place Chicago Medical/University District

3.0 star property
Illinois Medical District
9.0 out of 10, Wonderful, (1407)
"We definitely enjoyed our stay. Very nice clean room comfortable bed we didn’t want to get out of and excellent customer service at check in and out. Definitely recommend staying here 10/10 "
United States
Brenden
$88 nightly
The price is $104
Dec 19 - Dec 20
Total with taxes and fees
Hyatt Place Chicago Medical/University District

Hampton Inn & Suites Chicago Medical District UIC

2.5 star property
Illinois Medical District
9.6 out of 10, Exceptional, (353)
"Would stay there again...loved it!"
United States
Deborah
$87 nightly
The price is $102
Dec 14 - Dec 15
Total with taxes and fees
Hampton Inn & Suites Chicago Medical District UIC

Hilton Garden Inn Chicago Downtown/Magnificent Mile

3.0 star property
River North, 2.9 mi from Illinois Medical District
8.4 out of 10, Very Good, (4214)
"Great location. "
United States
Rodger
$82 nightly
The price is $96
Dec 18 - Dec 19
Total with taxes and fees
Hilton Garden Inn Chicago Downtown/Magnificent Mile

Hilton Chicago/Magnificent Mile Suites

3.5 star property
Streeterville, 3.4 mi from Illinois Medical District
9.0 out of 10, Wonderful, (3432)
"Great hotel located in nice area."
United States
Robert
$105 nightly
The price is $123
Dec 14 - Dec 15
Total with taxes and fees
Hilton Chicago/Magnificent Mile Suites

Hyatt Regency Chicago

4.0 star property
The Loop, 3 mi from Illinois Medical District
9.4 out of 10, Exceptional, (3379)
"Nice hotel"
United States
Dick
$161 nightly
The price is $189
Dec 22 - Dec 23
Total with taxes and fees
Hyatt Regency Chicago

Embassy Suites by Hilton Chicago Downtown Magnificent Mile

4.0 star property
Streeterville, 3.2 mi from Illinois Medical District
8.4 out of 10, Very Good, (2738)
"Great food clean room friendly staff"
United States
MARINA
$115 nightly
The price is $135
Dec 23 - Dec 24
Total with taxes and fees
Embassy Suites by Hilton Chicago Downtown Magnificent Mile

Aloft Chicago Mag Mile

3.0 star property
Streeterville, 3.2 mi from Illinois Medical District
8.6 out of 10, Excellent, (2944)
"Great location and great staff!!"
United States
lynne
$90 nightly
The price is $106
Jan 1 - Jan 2, 2026
Total with taxes and fees
Aloft Chicago Mag Mile

The Wade

4.5 star property
Streeterville, 3.5 mi from Illinois Medical District
8.4 out of 10, Very Good, (1501)
"Great location, walkable to so many area attractions. Would definitely stay here again. "
United States
Debbie
$101 nightly
The price is $119
Dec 10 - Dec 11
Total with taxes and fees
The Wade

Swissotel - Chicago

4.5 star property
3.1 mi from Illinois Medical District
9.0 out of 10, Wonderful, (2989)
"Great stay"
Canada
Lorrington Ashford
$139 nightly
The price is $163
Jan 2 - Jan 3, 2026
Total with taxes and fees
Swissotel - Chicago

Silversmith Hotel Chicago Downtown

4.0 star property
Theatre District, 2.7 mi from Illinois Medical District
9.2 out of 10, Wonderful, (2098)
"Would stay again. "
United States
Montroy
$127 nightly
The price is $149
Jan 4 - Jan 5, 2026
Total with taxes and fees
Silversmith Hotel Chicago Downtown

The Godfrey Hotel Chicago

4.5 star property
River North, 2.8 mi from Illinois Medical District
8.6 out of 10, Excellent, (1910)
"Awesome staff and great location "
United States
Luis C
$120 nightly
The price is $141
Dec 29 - Dec 30
Total with taxes and fees
The Godfrey Hotel Chicago

Club Quarters Hotel Wacker at Michigan, Chicago

4.0 star property
The Loop, 2.8 mi from Illinois Medical District
8.8 out of 10, Excellent, (1965)
"A good place for stay "
United States
Julio
$99 nightly
The price is $116
Dec 7 - Dec 8
Total with taxes and fees
Club Quarters Hotel Wacker at Michigan, Chicago

Hyatt Centric Chicago Magnificent Mile

4.0 star property
Streeterville, 3.2 mi from Illinois Medical District
9.0 out of 10, Wonderful, (1045)
"Great Hotel!"
United States
Wendy
$123 nightly
The price is $144
Jan 3 - Jan 4, 2026
Total with taxes and fees
Hyatt Centric Chicago Magnificent Mile

Palmer House a Hilton Hotel

4.0 star property
Theatre District, 2.6 mi from Illinois Medical District
8.4 out of 10, Very Good, (2116)
"Loved and enjoyed our stay"
United States
Luis
$128 nightly
The price is $145
Dec 28 - Dec 29
Total with taxes and fees
Palmer House a Hilton Hotel

DoubleTree by Hilton Chicago - Magnificent Mile

4.0 star property
Streeterville, 3.3 mi from Illinois Medical District
8.8 out of 10, Excellent, (2173)
"Great stay "
United States
Melinda
$89 nightly
The price is $105
Dec 21 - Dec 22
Total with taxes and fees
DoubleTree by Hilton Chicago - Magnificent Mile

Embassy Suites by Hilton Chicago Downtown River North

4.0 star property
River North, 2.9 mi from Illinois Medical District
8.6 out of 10, Excellent, (5353)
"excellent hotel "
United States
Myounghee
$94 nightly
The price is $111
Dec 18 - Dec 19
Total with taxes and fees
Embassy Suites by Hilton Chicago Downtown River North

Warwick Allerton - Chicago

4.0 star property
Magnificent Mile, 3.2 mi from Illinois Medical District
8.4 out of 10, Very Good, (2994)
"Enjoyed this hotel stay. "
United States
Kimberly
$93 nightly
The price is $109
Jan 4 - Jan 5, 2026
Total with taxes and fees
Warwick Allerton - Chicago

citizenM Chicago Downtown

4.0 star property
Theatre District, 2.8 mi from Illinois Medical District
9.4 out of 10, Exceptional, (4080)
"I enjoyed my stay with this hotel and would stay here again"
United States
Kim Leticia Terrelle
$107 nightly
The price is $126
Dec 14 - Dec 15
Total with taxes and fees
citizenM Chicago Downtown

voco Chicago Downtown - Riverwalk by IHG

3.5 star property
River North, 2.3 mi from Illinois Medical District
8.8 out of 10, Excellent, (3431)
"Great hotel"
United States
Clara
$110 nightly
The price is $129
Dec 7 - Dec 8
Total with taxes and fees
voco Chicago Downtown - Riverwalk by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Illinois Medical District

Find the best Illinois Medical District areas and neighborhoods for the activities you enjoy most.

Downtown Chicago

The heart of the Midwest’s glittering metropolis has many offerings, from shopping and dining to parks, museums and exciting contemporary public art.

Magnificent Mile

Upscale shopping district with luxury department stores, boutiques, and acclaimed restaurants, featuring landmarks like the Wrigley Building and Chicago Water Tower. The Magnificent Mile is easily accessible by public transit and seasonal trolley service.

The Loop

Chicago's central business district boasts numerous global businesses, retail establishments, and theaters. Explore the Loop Retail Historic District, Chicago Landmark Historic Michigan Boulevard District, and visit iconic attractions like the Art Institute of Chicago.

River North

Artistic spirit thrives here, with art galleries and a design district featuring luxury interior furnishings. Explore Kingsbury Park, enjoy vibrant nightlife on Hubbard Street, and visit the iconic Contemporaine Building.

Theatre District

While you're in Theatre District, take in top sights like Michigan Avenue or State Street, and hop on the metro to see more the city at Washington Station or Monroe Station (Blue Line).

Top Illinois Medical District Hotel Reviews

Frequently asked questions

What are the best hotels in Illinois Medical District that travelers recommend?
Nobu Hotel Chicago is a standout option in the Illinois Medical District, boasting an exceptional score of 9.4. This luxurious hotel superbly blends elegance with comfort, featuring exquisite amenities like deep soaking bathtubs, designer toiletries, and a serene indoor pool. Guests appreciate the indulgent spa services, including couples treatment rooms, making it an ideal retreat for couples seeking a romantic getaway or anyone looking to unwind after a busy day.

For business travelers, The Emily Hotel shines with a great rating of 9.2. Equipped with a 24-hour fitness center and accessible meeting rooms, it's designed to meet the needs of professionals on the go. The hotel also offers complimentary WiFi and a business center, ensuring that you stay connected and productive. The stylish design and thoughtful amenities create a seamless experience for those balancing work and leisure.

Families will find Hyatt Place Chicago Medical/University District particularly appealing, rated at 9.0 by guests. This hotel offers free buffet breakfast, making mornings easier for parents and kids alike. With spacious rooms, the option for rollaway beds, and accessible parking, it caters to the needs of families traveling together. The convenient location near local attractions adds to its family-friendly charm, allowing for easy exploration.

For a more hip and trendy experience, The Hoxton Chicago, also rated 9.0, offers a vibrant atmosphere with unique amenities like a seasonal outdoor pool and a lively poolside bar. It's pet-friendly, ensuring that your furry family members can join the fun. The hotel's focus on comfort with premium bedding and child-friendly designs makes it an excellent choice for families wanting a stylish stay.

Lastly, Crowne Plaza Chicago West Loop by IHG, with a rating of 8.8, combines convenience and comfort. This hotel features spacious rooms with balconies—a lovely touch for enjoying the city views. It caters to both leisure and business travelers, offering 24-hour business services and family-friendly amenities, including free cribs and rollaway beds.
What are the best family hotels in Illinois Medical District?
For families looking to stay in the Illinois Medical District, the Hampton Inn & Suites Chicago Medical District UIC stands out as a top choice. With an outstanding score of 9.8, this hotel offers a welcoming environment complete with a pool for splashing around after a day of adventure. Families will appreciate the convenience of connecting rooms, which provide extra space and privacy, as well as the availability of sofa beds and travel cribs to accommodate little ones comfortably.

Another excellent option is the Nobu Hotel Chicago, rated 9.4 by guests. This stylish hotel not only features connecting rooms but also offers free amenities for children, making it a budget-friendly choice for families. The on-site pool is great for unwinding together after a busy day exploring the city.

The Emily Hotel, with a rating of 9.2, goes the extra mile to cater to families by providing free cribs and rollaway beds. Alongside daily housekeeping and a snack bar, it ensures that parents have everything they need for a stress-free stay.

For families with specific safety needs, The Hoxton Chicago is a great pick, boasting a child-friendly window design and free amenities for children. With a rating of 9.0, it strikes a balance between modern comfort and family-friendly amenities, ensuring that both parents and kids feel at home.

Lastly, the Crowne Plaza Chicago West Loop by IHG, rated 8.8, offers a cozy atmosphere with options for cribs and rollaway beds. Families can enjoy complimentary breakfast for children, making mornings a little easier while on vacation.
What are the best 5-star hotels in Illinois Medical District?
Nobu Hotel Chicago is a premier 5-star hotel located in the heart of the Illinois Medical District, boasting an impressive traveler review score of 9.4. This luxurious hotel seamlessly blends modern elegance with a touch of Japanese influence, creating an inclusive setting for guests seeking both comfort and sophistication.
What are the best spa hotels in Illinois Medical District?
For a luxurious retreat in the Illinois Medical District, the Nobu Hotel Chicago offers an exquisite blend of contemporary design and high-end amenities, earning a stellar rating of 9.4 out of 10 from guests. This stylish hotel features a top spa with accessible services and couples treatment rooms, making it an ideal choice for those seeking a relaxing escape with a partner.
What hotels in Illinois Medical District offer free breakfast?
The Hampton Inn & Suites Chicago Medical District UIC is a standout option for travelers seeking a comfortable stay with family-friendly amenities. With an impressive customer review rating of 9.8, this hotel offers a lovely indoor pool great for kids to splash around, while parents can enjoy the convenience of a complimentary full breakfast to kick-start their day. Its accessible fitness center ensures that everyone can maintain their routine even while away from home.

Another excellent choice in the Illinois Medical District is the Hyatt Place Chicago Medical/University District, which boasts a review score of 9.0. Families will appreciate the buffet breakfast included in their stay, along with the spacious rooms that provide a relaxing retreat after a day of exploring the city. The hotel's 24-hour fitness facilities and business center cater to both leisure and business travelers, making it a well-rounded option for various audiences.
What are the best budget hotels in Illinois Medical District?
The Hampton Inn & Suites Chicago Medical District UIC stands out as a premier choice for those seeking budget-friendly accommodations without compromising on quality. With an impressive traveler review rating of 9.8, this hotel offers a complimentary full breakfast to fuel your family's adventures, while the indoor pool provides a fun place for kids to splash around after a day of exploring the city. Families will appreciate the spacious rooms, equipped with free WiFi and essential toiletries, ensuring a comfortable stay.

Another excellent option is the Hyatt Place Chicago Medical/University District, which boasts a review score of 9.0. This hotel features a delightful buffet breakfast, superb for families looking to start their day with variety. The 24-hour fitness center allows parents to maintain their workout routines, while kids can enjoy the nearby attractions. With self-parking and accessible facilities, convenience is at your fingertips.

For parents traveling with young children, the Crowne Plaza Chicago West Loop offers amenities that cater to families, including free cribs and rollaway beds. Rated 8.8, this hotel also features a balcony in select rooms, providing a lovely space to unwind after a busy day.

If you're looking for a comfortable stay that prioritizes family needs, these hotels provide the superb blend of convenience, quality, and value, making your trip to the Illinois Medical District enjoyable for both parents and kids alike.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Illinois Medical District.
How can I save on a Illinois Medical District hotel booking with Expedia?
One Key™ - Expedia's free travel rewards program - gives you instant access to perks and Member Prices on Illinois Medical District hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings.

*OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Illinois Medical District hotel?
Hotel prices in Illinois Medical District often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.

Explore a world of travel with Expedia